Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance

Cell Reports

Volumn 18, Issue 10, 2017, Pages 2415-2426

  Chan, Kenny L ^a,b   Tam, Theresa H ^a   Boroumand, Parastoo ^a,b   Prescott, David ^b   Costford, Sheila R ^b   Escalante, Nichole K ^b   Fine, Noah ^c   Tu, YuShan ^a   Robertson, Susan J ^b   Prabaharan, Dilshaayee ^a   Liu, Zhi ^a   Bilan, Philip J ^a   Salter, Michael W ^a,b   Glogauer, Michael ^c   Girardin, Stephen E ^b   Philpott, Dana J ^b   Klip, Amira ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

gut microbiome; inflammation; insulin resistance; macrophage; neutrophil; NOD1; obesity

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 4; CXCL1 CHEMOKINE; GLUCOSE; CARD4 PROTEIN, MOUSE; CHEMOTACTIC FACTOR;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL MIGRATION; CELL SPECIFICITY; CONTROLLED STUDY; DEPLETION; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; INFLAMMATION; INSULIN RESISTANCE; LIPID DIET; MACROPHAGE; METABOLIC DISORDER; MOUSE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; POLARIZATION; SENSOR; WEIGHT GAIN; ANIMAL; BLOOD; CELL MOTION; CELL POLARITY; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GENE DELETION; HEMATOPOIESIS; KNOCKOUT MOUSE; METABOLISM; NEUTROPHIL CHEMOTAXIS; OBESITY; PATHOLOGY;

ADIPOSE TISSUE; ANIMALS; CELL MOVEMENT; CELL POLARITY; CHEMOKINE CXCL1; CHEMOTACTIC FACTORS; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; GENE DELETION; GLUCOSE; HEMATOPOIESIS; INFLAMMATION; INSULIN RESISTANCE; MACROPHAGES; MICE; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; NOD1 SIGNALING ADAPTOR PROTEIN; OBESITY;

EID: 85014538836     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.02.027     Document Type: Article

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