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Volumn 58, Issue 11, 2015, Pages 2627-2636

Fatty acids from fat cell lipolysis do not activate an inflammatory response but are stored as triacylglycerols in adipose tissue macrophages

Author keywords

Adipocyte; Adipose tissue; De novo lipogenesis; Fatty acids; Inflammatory response; Insulin resistance; Lipolysis; Macrophage; TLR4; Triacylglycerol

Indexed keywords

CD36 ANTIGEN; CD68 ANTIGEN; FATTY ACID; FATTY ACID BINDING PROTEIN 4; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LINOLEIC ACID; LINOLENIC ACID; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PALMITIC ACID; PALMITOLEIC ACID; STEARIC ACID; TOLL LIKE RECEPTOR 4; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR; VACCENIC ACID; 1,3 DIOXOLANE DERIVATIVE; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; DISODIUM (R,R)-5-(2-((2-(3-CHLOROPHENYL)-2-HYDROXYETHYL)-AMINO)PROPYL)-1,3-BENZODIOXOLE-2,3-DICARBOXYLATE;

EID: 84942986677     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3719-0     Document Type: Article
Times cited : (29)

References (46)
  • 1
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • COI: 1:CAS:528:DC%2BC3MXnsVais7Y%3D, PID: 21633179
    • Lumeng CN, Saltiel AR (2011) Inflammatory links between obesity and metabolic disease. J Clin Invest 121:2111–2117
    • (2011) J Clin Invest , vol.121 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 2
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • COI: 1:CAS:528:DC%2BC3cXktFKkt70%3D, PID: 20148674
    • Olefsky JM, Glass CK (2010) Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 72:219–246
    • (2010) Annu Rev Physiol , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 3
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • COI: 1:CAS:528:DC%2BD3sXhtVSmtLvO, PID: 14679176
    • Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796–1808
    • (2003) J Clin Invest , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1    McCann, D.2    Desai, M.3    Rosenbaum, M.4    Leibel, R.L.5    Ferrante, A.W.6
  • 4
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • COI: 1:CAS:528:DC%2BD3sXhtVSmtLvI, PID: 14679177
    • Xu H, Barnes GT, Yang Q et al (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821–1830
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3
  • 5
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
    • COI: 1:CAS:528:DyaK28XptVyhtQ%3D%3D, PID: 8571133
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM (1996) IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 271:665–668
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 6
    • 33745216724 scopus 로고    scopus 로고
    • MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    • COI: 1:CAS:528:DC%2BD28XlsFWrtLo%3D, PID: 16691291
    • Kanda H, Tateya S, Tamori Y et al (2006) MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 116:1494–1505
    • (2006) J Clin Invest , vol.116 , pp. 1494-1505
    • Kanda, H.1    Tateya, S.2    Tamori, Y.3
  • 8
    • 33748871923 scopus 로고    scopus 로고
    • Importance of TNFalpha and neutral lipases in human adipose tissue lipolysis
    • COI: 1:CAS:528:DC%2BD28XpvV2lur0%3D, PID: 16938460
    • Langin D, Arner P (2006) Importance of TNFalpha and neutral lipases in human adipose tissue lipolysis. Trends Endocrinol Metab 17:314–320
    • (2006) Trends Endocrinol Metab , vol.17 , pp. 314-320
    • Langin, D.1    Arner, P.2
  • 9
    • 77953868236 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance: unravelling the mechanism
    • COI: 1:CAS:528:DC%2BC3cXotVagtrk%3D, PID: 20609972
    • Samuel VT, Petersen KF, Shulman GI (2010) Lipid-induced insulin resistance: unravelling the mechanism. Lancet 375:2267–2277
    • (2010) Lancet , vol.375 , pp. 2267-2277
    • Samuel, V.T.1    Petersen, K.F.2    Shulman, G.I.3
  • 10
    • 26244448904 scopus 로고    scopus 로고
    • A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha
    • COI: 1:CAS:528:DC%2BD2MXhtVCltrnK, PID: 16123319
    • Suganami T, Nishida J, Ogawa Y (2005) A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol 25:2062–2068
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 2062-2068
    • Suganami, T.1    Nishida, J.2    Ogawa, Y.3
  • 11
    • 0035907302 scopus 로고    scopus 로고
    • Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
    • COI: 1:CAS:528:DC%2BD3MXjvFGju78%3D, PID: 11278967
    • Lee JY, Sohn KH, Rhee SH, Hwang D (2001) Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem 276:16683–16689
    • (2001) J Biol Chem , vol.276 , pp. 16683-16689
    • Lee, J.Y.1    Sohn, K.H.2    Rhee, S.H.3    Hwang, D.4
  • 12
    • 36849005372 scopus 로고    scopus 로고
    • A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
    • COI: 1:CAS:528:DC%2BD2sXhtlCrtLzP, PID: 17916553
    • Nguyen MT, Favelyukis S, Nguyen AK et al (2007) A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem 282:35279–35292
    • (2007) J Biol Chem , vol.282 , pp. 35279-35292
    • Nguyen, M.T.1    Favelyukis, S.2    Nguyen, A.K.3
  • 13
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • COI: 1:CAS:528:DC%2BD28XhtFyrsLfE, PID: 17053832
    • Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116:3015–3025
    • (2006) J Clin Invest , vol.116 , pp. 3015-3025
    • Shi, H.1    Kokoeva, M.V.2    Inouye, K.3    Tzameli, I.4    Yin, H.5    Flier, J.S.6
  • 14
    • 33846323706 scopus 로고    scopus 로고
    • Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages
    • COI: 1:CAS:528:DC%2BD28XhtlSrsb7F, PID: 17082484
    • Suganami T, Tanimoto-Koyama K, Nishida J et al (2007) Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol 27:84–91
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 84-91
    • Suganami, T.1    Tanimoto-Koyama, K.2    Nishida, J.3
  • 15
    • 34547602916 scopus 로고    scopus 로고
    • Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
    • COI: 1:CAS:528:DC%2BD2sXos12qsrY%3D, PID: 17519423
    • Tsukumo DM, Carvalho-Filho MA, Carvalheira JB et al (2007) Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56:1986–1998
    • (2007) Diabetes , vol.56 , pp. 1986-1998
    • Tsukumo, D.M.1    Carvalho-Filho, M.A.2    Carvalheira, J.B.3
  • 16
    • 67650522935 scopus 로고    scopus 로고
    • Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes
    • COI: 1:CAS:528:DC%2BD1MXnslegtb8%3D, PID: 19433586
    • Bezaire V, Mairal A, Ribet C et al (2009) Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes. J Biol Chem 284:18282–18291
    • (2009) J Biol Chem , vol.284 , pp. 18282-18291
    • Bezaire, V.1    Mairal, A.2    Ribet, C.3
  • 17
    • 0028891640 scopus 로고
    • Molecular mechanisms underlying regional variations of catecholamine-induced lipolysis in rat adipocytes
    • COI: 1:CAS:528:DyaK2MXmvVGks7k%3D, PID: 7611389
    • Tavernier G, Galitzky J, Valet P et al (1995) Molecular mechanisms underlying regional variations of catecholamine-induced lipolysis in rat adipocytes. Am J Physiol 268:E1135–E1142
    • (1995) Am J Physiol , vol.268 , pp. E1135-E1142
    • Tavernier, G.1    Galitzky, J.2    Valet, P.3
  • 18
    • 30744477567 scopus 로고    scopus 로고
    • Adipocyte lipases and defect of lipolysis in human obesity
    • COI: 1:CAS:528:DC%2BD2MXht1Siu7fL, PID: 16249444
    • Langin D, Dicker A, Tavernier G et al (2005) Adipocyte lipases and defect of lipolysis in human obesity. Diabetes 54:3190–3197
    • (2005) Diabetes , vol.54 , pp. 3190-3197
    • Langin, D.1    Dicker, A.2    Tavernier, G.3
  • 19
    • 0030789804 scopus 로고    scopus 로고
    • Selective release of human adipocyte fatty acids according to molecular structure
    • COI: 1:CAS:528:DyaK2sXktlCmsLw%3D, PID: 9210416
    • Raclot T, Langin D, Lafontan M, Groscolas R (1997) Selective release of human adipocyte fatty acids according to molecular structure. Biochem J 324:911–915
    • (1997) Biochem J , vol.324 , pp. 911-915
    • Raclot, T.1    Langin, D.2    Lafontan, M.3    Groscolas, R.4
  • 20
    • 84862616885 scopus 로고    scopus 로고
    • Pro-inflammatory phospholipid arachidonic acid/eicosapentaenoic acid ratio of dysmetabolic severely obese women
    • COI: 1:STN:280:DC%2BC38rgslOhtg%3D%3D, PID: 22460550
    • Caspar-Bauguil S, Fioroni A, Galinier A et al (2012) Pro-inflammatory phospholipid arachidonic acid/eicosapentaenoic acid ratio of dysmetabolic severely obese women. Obes Surg 22:935–944
    • (2012) Obes Surg , vol.22 , pp. 935-944
    • Caspar-Bauguil, S.1    Fioroni, A.2    Galinier, A.3
  • 21
    • 84874692963 scopus 로고    scopus 로고
    • Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass
    • COI: 1:CAS:528:DC%2BC3sXkt1Wnu78%3D, PID: 23431266
    • Girousse A, Tavernier G, Valle C et al (2013) Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass. PLoS Biol 11:e1001485
    • (2013) PLoS Biol , vol.11
    • Girousse, A.1    Tavernier, G.2    Valle, C.3
  • 22
    • 84866943614 scopus 로고    scopus 로고
    • Determinants of human adipose tissue gene expression: impact of diet, sex, metabolic status, and cis genetic regulation
    • COI: 1:CAS:528:DC%2BC38XhsV2jtb7L, PID: 23028366
    • Viguerie N, Montastier E, Maoret JJ et al (2012) Determinants of human adipose tissue gene expression: impact of diet, sex, metabolic status, and cis genetic regulation. PLoS Genet 8:e1002959
    • (2012) PLoS Genet , vol.8
    • Viguerie, N.1    Montastier, E.2    Maoret, J.J.3
  • 23
    • 33645097021 scopus 로고    scopus 로고
    • A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling
    • COI: 1:CAS:528:DC%2BD28XjtlKntLs%3D, PID: 16373689
    • Ii M, Matsunaga N, Hazeki K et al (2006) A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling. Mol Pharmacol 69:1288–1295
    • (2006) Mol Pharmacol , vol.69 , pp. 1288-1295
    • Ii, M.1    Matsunaga, N.2    Hazeki, K.3
  • 24
    • 84901263952 scopus 로고    scopus 로고
    • Immune cell Toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis
    • COI: 1:CAS:528:DC%2BC2cXnsVWku78%3D, PID: 24794440
    • Vila IK, Badin PM, Marques MA et al (2014) Immune cell Toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis. Cell Rep 7:1116–1129
    • (2014) Cell Rep , vol.7 , pp. 1116-1129
    • Vila, I.K.1    Badin, P.M.2    Marques, M.A.3
  • 25
    • 0038143617 scopus 로고    scopus 로고
    • Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids
    • COI: 1:CAS:528:DC%2BD3sXitlCkurc%3D, PID: 12562875
    • Lee JY, Plakidas A, Lee WH et al (2003) Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. J Lipid Res 44:479–486
    • (2003) J Lipid Res , vol.44 , pp. 479-486
    • Lee, J.Y.1    Plakidas, A.2    Lee, W.H.3
  • 26
    • 73949110679 scopus 로고    scopus 로고
    • Saturated fatty acids do not directly stimulate Toll-like receptor signaling
    • COI: 1:CAS:528:DC%2BD1MXht1ymsr7F, PID: 19661481
    • Erridge C, Samani NJ (2009) Saturated fatty acids do not directly stimulate Toll-like receptor signaling. Arterioscler Thromb Vasc Biol 29:1944–1949
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1944-1949
    • Erridge, C.1    Samani, N.J.2
  • 27
    • 58149310977 scopus 로고    scopus 로고
    • Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity
    • COI: 1:CAS:528:DC%2BD1MXhsVCitrs%3D, PID: 18624726
    • Schaeffler A, Gross P, Buettner R et al (2009) Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity. Immunology 126:233–245
    • (2009) Immunology , vol.126 , pp. 233-245
    • Schaeffler, A.1    Gross, P.2    Buettner, R.3
  • 28
    • 84864696458 scopus 로고    scopus 로고
    • Fetuin-A: the missing link in lipid-induced inflammation
    • COI: 1:CAS:528:DC%2BC38XhtFCrt7jJ, PID: 22869185
    • Heinrichsdorff J, Olefsky JM (2012) Fetuin-A: the missing link in lipid-induced inflammation. Nat Med 18:1182–1183
    • (2012) Nat Med , vol.18 , pp. 1182-1183
    • Heinrichsdorff, J.1    Olefsky, J.M.2
  • 29
    • 84864657351 scopus 로고    scopus 로고
    • Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
    • COI: 1:CAS:528:DC%2BC38XhtFWms73L, PID: 22842477
    • Pal D, Dasgupta S, Kundu R et al (2012) Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat Med 18:1279–1285
    • (2012) Nat Med , vol.18 , pp. 1279-1285
    • Pal, D.1    Dasgupta, S.2    Kundu, R.3
  • 30
    • 80051806800 scopus 로고    scopus 로고
    • De novo lipogenesis in the differentiating human adipocyte can provide all fatty acids necessary for maturation
    • COI: 1:CAS:528:DC%2BC3MXhtVKqt7rP, PID: 21677304
    • Collins JM, Neville MJ, Pinnick KE et al (2011) De novo lipogenesis in the differentiating human adipocyte can provide all fatty acids necessary for maturation. J Lipid Res 52:1683–1692
    • (2011) J Lipid Res , vol.52 , pp. 1683-1692
    • Collins, J.M.1    Neville, M.J.2    Pinnick, K.E.3
  • 31
    • 44949160947 scopus 로고    scopus 로고
    • Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake
    • COI: 1:CAS:528:DC%2BD1cXnt1yjtr4%3D, PID: 18435934
    • Hodson L, Skeaff CM, Fielding BA (2008) Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog Lipid Res 47:348–380
    • (2008) Prog Lipid Res , vol.47 , pp. 348-380
    • Hodson, L.1    Skeaff, C.M.2    Fielding, B.A.3
  • 32
    • 84864829032 scopus 로고    scopus 로고
    • Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways
    • COI: 1:CAS:528:DC%2BC38Xht1GhsL%2FJ, PID: 22766885
    • Huang S, Rutkowsky JM, Snodgrass RG et al (2012) Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways. J Lipid Res 53:2002–2013
    • (2012) J Lipid Res , vol.53 , pp. 2002-2013
    • Huang, S.1    Rutkowsky, J.M.2    Snodgrass, R.G.3
  • 33
    • 78650773537 scopus 로고    scopus 로고
    • Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors
    • COI: 1:CAS:528:DC%2BC3MXhvVSjsLk%3D, PID: 20959532
    • Dasu MR, Jialal I (2011) Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. Am J Physiol Endocrinol Metab 300:E145–E154
    • (2011) Am J Physiol Endocrinol Metab , vol.300 , pp. E145-E154
    • Dasu, M.R.1    Jialal, I.2
  • 34
    • 84857633076 scopus 로고    scopus 로고
    • The lipopolysaccharide-induced pro-inflammatory response in RAW264.7 cells is attenuated by an unsaturated fatty acid-bovine serum albumin complex and enhanced by a saturated fatty acid-bovine serum albumin complex
    • COI: 1:CAS:528:DC%2BC38XhtlWitrs%3D, PID: 22094887
    • Chang CF, Chau YP, Kung HN, Lu KS (2012) The lipopolysaccharide-induced pro-inflammatory response in RAW264.7 cells is attenuated by an unsaturated fatty acid-bovine serum albumin complex and enhanced by a saturated fatty acid-bovine serum albumin complex. Inflamm Res 61:151–160
    • (2012) Inflamm Res , vol.61 , pp. 151-160
    • Chang, C.F.1    Chau, Y.P.2    Kung, H.N.3    Lu, K.S.4
  • 35
    • 77949903881 scopus 로고    scopus 로고
    • De novo lipogenesis and stearoyl-CoA desaturase are coordinately regulated in the human adipocyte and protect against palmitate-induced cell injury
    • COI: 1:CAS:528:DC%2BC3cXit1ajtbc%3D, PID: 20032470
    • Collins JM, Neville MJ, Hoppa MB, Frayn KN (2010) De novo lipogenesis and stearoyl-CoA desaturase are coordinately regulated in the human adipocyte and protect against palmitate-induced cell injury. J Biol Chem 285:6044–6052
    • (2010) J Biol Chem , vol.285 , pp. 6044-6052
    • Collins, J.M.1    Neville, M.J.2    Hoppa, M.B.3    Frayn, K.N.4
  • 36
    • 78751518830 scopus 로고    scopus 로고
    • Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages
    • COI: 1:CAS:528:DC%2BC3MXht1alurg%3D, PID: 21078775
    • Ishiyama J, Taguchi R, Akasaka Y et al (2011) Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages. J Lipid Res 52:299–307
    • (2011) J Lipid Res , vol.52 , pp. 299-307
    • Ishiyama, J.1    Taguchi, R.2    Akasaka, Y.3
  • 37
    • 72249085560 scopus 로고    scopus 로고
    • Different impacts of saturated and unsaturated free fatty acids on COX-2 expression in C(2)C(12) myotubes
    • COI: 1:CAS:528:DC%2BD1MXhsFOgsbnO, PID: 19755671
    • Kadotani A, Tsuchiya Y, Hatakeyama H, Katagiri H, Kanzaki M (2009) Different impacts of saturated and unsaturated free fatty acids on COX-2 expression in C(2)C(12) myotubes. Am J Physiol Endocrinol Metab 297:E1291–E1303
    • (2009) Am J Physiol Endocrinol Metab , vol.297 , pp. E1291-E1303
    • Kadotani, A.1    Tsuchiya, Y.2    Hatakeyama, H.3    Katagiri, H.4    Kanzaki, M.5
  • 38
    • 84885987718 scopus 로고    scopus 로고
    • Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages
    • PID: 24006511
    • L'Homme L, Esser N, Riva L et al (2013) Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages. J Lipid Res 54:2998–3008
    • (2013) J Lipid Res , vol.54 , pp. 2998-3008
    • L'Homme, L.1    Esser, N.2    Riva, L.3
  • 39
    • 33845512965 scopus 로고    scopus 로고
    • Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-kappaB activation
    • COI: 1:CAS:528:DC%2BD28XhtF2rtr%2FN, PID: 17065351
    • Staiger K, Staiger H, Weigert C, Haas C, Haring HU, Kellerer M (2006) Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-kappaB activation. Diabetes 55:3121–3126
    • (2006) Diabetes , vol.55 , pp. 3121-3126
    • Staiger, K.1    Staiger, H.2    Weigert, C.3    Haas, C.4    Haring, H.U.5    Kellerer, M.6
  • 40
    • 27444437321 scopus 로고    scopus 로고
    • Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    • COI: 1:CAS:528:DC%2BD2MXhtF2iu7vF, PID: 16150820
    • Cinti S, Mitchell G, Barbatelli G et al (2005) Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 46:2347–2355
    • (2005) J Lipid Res , vol.46 , pp. 2347-2355
    • Cinti, S.1    Mitchell, G.2    Barbatelli, G.3
  • 41
    • 70350389389 scopus 로고    scopus 로고
    • Hematopoietic cell-specific deletion of Toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice
    • COI: 1:CAS:528:DC%2BC3cXht1eqs7g%3D, PID: 19883619
    • Saberi M, Woods NB, de Luca C et al (2009) Hematopoietic cell-specific deletion of Toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab 10:419–429
    • (2009) Cell Metab , vol.10 , pp. 419-429
    • Saberi, M.1    Woods, N.B.2    de Luca, C.3
  • 42
    • 77957838795 scopus 로고    scopus 로고
    • Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
    • COI: 1:CAS:528:DC%2BC3cXht1GgtLbI, PID: 20877011
    • Kosteli A, Sugaru E, Haemmerle G et al (2010) Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest 120:3466–3479
    • (2010) J Clin Invest , vol.120 , pp. 3466-3479
    • Kosteli, A.1    Sugaru, E.2    Haemmerle, G.3
  • 43
    • 84906319549 scopus 로고    scopus 로고
    • Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
    • COI: 1:CAS:528:DC%2BC2cXht1GqtrbI, PID: 25086775
    • Huang SC, Everts B, Ivanova Y et al (2014) Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nat Immunol 15:846–855
    • (2014) Nat Immunol , vol.15 , pp. 846-855
    • Huang, S.C.1    Everts, B.2    Ivanova, Y.3
  • 44
    • 84880676488 scopus 로고    scopus 로고
    • Adipocytes modulate the phenotyped of human macrophages through secreted lipids
    • COI: 1:CAS:528:DC%2BC3sXhtFequ7vF, PID: 23817431
    • Klein-Wieringa IR, Andersen SN, Kwekkeboom JC et al (2013) Adipocytes modulate the phenotyped of human macrophages through secreted lipids. J Immunol 191:1356–1363
    • (2013) J Immunol , vol.191 , pp. 1356-1363
    • Klein-Wieringa, I.R.1    Andersen, S.N.2    Kwekkeboom, J.C.3
  • 45
    • 84889663497 scopus 로고    scopus 로고
    • Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation
    • COI: 1:CAS:528:DC%2BC3sXhvFOlurnP, PID: 24315368
    • Xu X, Grijalva A, Skowronski A, van Eijk M, Serlie MJ, Ferrante AW Jr (2013) Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation. Cell Metab 18:816–830
    • (2013) Cell Metab , vol.18 , pp. 816-830
    • Xu, X.1    Grijalva, A.2    Skowronski, A.3    van Eijk, M.4    Serlie, M.J.5    Ferrante, A.W.6
  • 46
    • 79952437112 scopus 로고    scopus 로고
    • Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice
    • COI: 1:CAS:528:DC%2BC3MXktVKksb4%3D, PID: 21266330
    • Prieur X, Mok CY, Velagapudi VR et al (2011) Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes 60:797–809
    • (2011) Diabetes , vol.60 , pp. 797-809
    • Prieur, X.1    Mok, C.Y.2    Velagapudi, V.R.3


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