Palmitoleate reverses high fat-induced proinflammatory macrophage polarization via AMP-activated protein kinase (AMPK)

Journal of Biological Chemistry

Volumn 290, Issue 27, 2015, Pages 16979-16988

  Chan, Kenny L ^a,b   Pillon, Nicolas J ^a   Sivaloganathan, Darshan M ^a   Costford, Sheila R ^a   Liu, Zhi ^a   Théret, Marine ^c   Chazaud, Benedicte ^c   Klip, Amira ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c CENTRE DE GÉNÉTIQUE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ACTIVITY; FATTY ACIDS; INSULIN; MONOUNSATURATED FATTY ACIDS; POLARIZATION; SATURATED FATTY ACIDS;

AMP-ACTIVATED PROTEIN KINASE; ANTI-INFLAMMATORIES; INSULIN RESISTANCE; LIPID MEDIATORS; MACROPHAGE PHENOTYPES; PALMITOLEATE; PROINFLAMMATORY; SATURATED FATS;

MACROPHAGES;

CXCL1 CHEMOKINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; I KAPPA B ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 6; PALMITOLEIC ACID; SATURATED FATTY ACID; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR; UNSATURATED FATTY ACID; FAT INTAKE; MONOUNSATURATED FATTY ACID;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CXCL1 GENE; CYTOKINE RELEASE; ENZYME INHIBITION; ENZYME MECHANISM; EX VIVO STUDY; FATTY ACID OXIDATION; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; IL10 GENE; IL6 GENE; IN VIVO STUDY; INFLAMMATION; INSULIN RESISTANCE; LIPID DIET; MACROPHAGE; MACROPHAGE POLARIZATION; MALE; MGL2 GENE; MOUSE; MRC1 GENE; NONHUMAN; NOS2 GENE; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TGFB1 GENE; TNF GENE; UPREGULATION; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; CELL POLARITY; CHEMISTRY; CYTOLOGY; ENZYMOLOGY; FAT INTAKE; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; OBESITY;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL POLARITY; DIET, HIGH-FAT; DIETARY FATS; FATTY ACIDS, MONOUNSATURATED; HUMANS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY;

EID: 84936817998     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.646992     Document Type: Article

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