Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

Nature Medicine

Volumn 23, Issue 4, 2017, Pages 501-507

  Kracht, Maria J L ^a   Van Lummel, Menno ^a   Nikolic, Tatjana ^a   Joosten, Antoinette M ^a   Laban, Sandra ^a   Van Der Slik, Arno R ^a   Van Veelen, Peter A ^a   Carlotti, Françoise ^a   De Koning, Eelco J P ^a   Hoeben, Rob C ^a   Zaldumbide, Arnaud ^a   Roep, Bart O ^a,b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Beckman Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; MESSENGER RNA; AUTOANTIGEN; HLA DQ ANTIGEN; PEPTIDE;

ALLELE; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; AUTOIMMUNITY; CD8+ T LYMPHOCYTE; CYTOTOXIC T LYMPHOCYTE; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; GENE LINKAGE DISEQUILIBRIUM; GENE PRODUCT; GLYCOSYLATION; HAPLOTYPE; HLA SYSTEM; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; OPEN READING FRAME; PANCREAS ISLET; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSLATION INITIATION; WESTERN BLOTTING; ADOLESCENT; ADULT; CHILD; DENDRITIC CELL; FEMALE; GENETICS; IMMUNOLOGY; MALE; PANCREAS ISLET BETA CELL; PROTEIN SYNTHESIS; YOUNG ADULT;

ADOLESCENT; ADULT; AUTOANTIGENS; AUTOIMMUNITY; CD8-POSITIVE T-LYMPHOCYTES; CHILD; DENDRITIC CELLS; DIABETES MELLITUS, TYPE 1; FEMALE; HLA-DQ ANTIGENS; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN-SECRETING CELLS; MALE; OPEN READING FRAMES; PEPTIDES; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; T-LYMPHOCYTES, CYTOTOXIC; YOUNG ADULT;

EID: 85014513366     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4289     Document Type: Article

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