4-PBA inhibits LPS-induced inflammation through regulating ER stress and autophagy in acute lung injury models

Toxicology Letters

Volumn 271, Issue , 2017, Pages 26-37

  Zeng, Meichun ^a   Sang, Wenhua ^a   Chen, Sha ^a   Chen, Ran ^a   Zhang, Hailin ^a   Xue, Feng ^a   Li, Zhengmao ^a   Liu, Yu ^a   Gong, Yongsheng ^a   Zhang, Hongyu ^a   Kong, Xiaoxia ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

ALI; Autophagy; Endoplasmic reticulum stress; LPS; NF B

Indexed keywords

4 PHENYL BUTYRIC ACID; BUTYRIC ACID DERIVATIVE; CYTOPROTECTIVE AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; 4-PHENYLBUTYRIC ACID; ANTIINFLAMMATORY AGENT; ARYLBUTYRIC ACID DERIVATIVE; AUTACOID; CYTOKINE; LIPOPOLYSACCHARIDE; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CELL ACTIVATION; CELL DEATH; CELL FUNCTION; CELL INFILTRATION; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DISEASE EXACERBATION; ENDOPLASMIC RETICULUM STRESS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR SIGNALING; LIPOPOLYSACCHARIDE-INDUCED ACUTE LUNG INJURY; LUNG ALVEOLUS EPITHELIUM CELL; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN EXPRESSION; TREATMENT OUTCOME; TYPE 2 EPITHELIAL CELL; WESTERN BLOTTING; ACUTE LUNG INJURY; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; INSTITUTE FOR CANCER RESEARCH MOUSE; LUNG; METABOLISM; PATHOLOGY; PNEUMONIA; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ACUTE LUNG INJURY; ANIMALS; ANTI-INFLAMMATORY AGENTS; AUTOPHAGY; CELL LINE, TUMOR; CYTOKINES; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM STRESS; HUMANS; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; LUNG; MALE; MICE, INBRED ICR; NF-KAPPA B; PHENYLBUTYRATES; PNEUMONIA; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 85014398041     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2017.02.023     Document Type: Article

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