Gypenoside Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting Cardiomyocytes Apoptosis via Inhibition of CHOP Pathway and Activation of PI3K/Akt Pathway in Vivo and in Vitro

Cellular Physiology and Biochemistry

Volumn 39, Issue 1, 2016, Pages 123-136

  Yu, Haijie ^a   Zhang, Haishan ^a   Zhao, Weihua ^a   Guo, Liang ^a   Li, Xueyuan ^a   Li, Yang ^a   Zhang, Xingang ^a   Sun, Yingxian ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Akt; Apoptosis; Cardiomyocytes; Endoplasmic reticulum stress; Gypenoside; Ischemia reperfusion injury

Indexed keywords

CASPASE 3; CREATINE KINASE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GYPENOSIDE; LACTATE DEHYDROGENASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; APOPTOSIS REGULATORY PROTEIN; CARDIOTONIC AGENT; DDIT3 PROTEIN, RAT; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIAC MUSCLE CELL; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFICACY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; HEART; HEART FUNCTION; HEART HEMODYNAMICS; HEART PROTECTION; IN VITRO STUDY; IN VIVO STUDY; LACTATE DEHYDROGENASE BLOOD LEVEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TREATMENT DURATION; ANIMAL; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; FLOW CYTOMETRY; GYNOSTEMMA; MALE; METABOLISM; MYOCARDIAL ISCHEMIA REPERFUSION INJURY; PATHOPHYSIOLOGY; PHYTOTHERAPY; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CARDIOTONIC AGENTS; CELL LINE; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; GYNOSTEMMA; MALE; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PHOSPHATIDYLINOSITOL 3-KINASES; PHYTOTHERAPY; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; RATS, WISTAR; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP;

EID: 84976321984     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000445611     Document Type: Article

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