메뉴 건너뛰기




Volumn 21, Issue 1, 2017, Pages 31-39

Review of systemic treatment options for adult atopic dermatitis

Author keywords

Adults; Atopic dermatitis; Biologics; Dupilumab; IL 13; IL 4; Systemic therapy

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; DUPILUMAB; INFLIXIMAB; MEPOLIZUMAB; METHOTREXATE; OMALIZUMAB; RITUXIMAB; USTEKINUMAB; BIOLOGICAL PRODUCT; MONOCLONAL ANTIBODY;

EID: 85014366260     PISSN: 12034754     EISSN: None     Source Type: Journal    
DOI: 10.1177/1203475416670364     Document Type: Review
Times cited : (36)

References (79)
  • 1
    • 84892747320 scopus 로고    scopus 로고
    • New insights into the epidemiology of childhood atopic dermatitis
    • Flohr C, Mann J. New insights into the epidemiology of childhood atopic dermatitis. Allergy. 2014;69:3-16.
    • (2014) Allergy , vol.69 , pp. 3-16
    • Flohr, C.1    Mann, J.2
  • 2
    • 84887022793 scopus 로고    scopus 로고
    • Adult eczema prevalence and associations with asthma and other health and demographic factors: A US population-based study
    • Silverberg JI, Hanifin JM. Adult eczema prevalence and associations with asthma and other health and demographic factors: a US population-based study. J Allergy Clin Immunol. 2013;132:1132-1138.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 1132-1138
    • Silverberg, J.I.1    Hanifin, J.M.2
  • 3
    • 84891539297 scopus 로고    scopus 로고
    • Immunology of atopic dermatitis: Novel insights into mechanisms and immunomodulatory therapies
    • Harskamp CT, Armstrong AW. Immunology of atopic dermatitis: novel insights into mechanisms and immunomodulatory therapies. Semin Cutan Med Surg. 2013;32:132-139.
    • (2013) Semin Cutan Med Surg , vol.32 , pp. 132-139
    • Harskamp, C.T.1    Armstrong, A.W.2
  • 4
    • 0034487293 scopus 로고    scopus 로고
    • Health-related quality of life in patients with psoriasis and atopic dermatitis measured with SF-36, DLQI and subjective measure of disease activity
    • Lundberg L, Johannesson M, Silverdahl M, Hermansson C, Lindberg M. Health-related quality of life in patients with psoriasis and atopic dermatitis measured with SF-36, DLQI and subjective measure of disease activity. Acta Derm Venerol. 2000;80:430-434.
    • (2000) Acta Derm Venerol , vol.80 , pp. 430-434
    • Lundberg, L.1    Johannesson, M.2    Silverdahl, M.3    Hermansson, C.4    Lindberg, M.5
  • 5
    • 84895060607 scopus 로고    scopus 로고
    • Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis: A systemic review
    • Roekevisch E, Spuls PI, Kuester D, Limpens J, Schmitt J. Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis: a systemic review. J Allergy Clin Immunol. 2014;133(2):429-438.
    • (2014) J Allergy Clin Immunol , vol.133 , Issue.2 , pp. 429-438
    • Roekevisch, E.1    Spuls, P.I.2    Kuester, D.3    Limpens, J.4    Schmitt, J.5
  • 6
    • 84863852536 scopus 로고    scopus 로고
    • Investigating international time trends in the incidence and prevalence of atopic eczema 1990-2010: A systematic review of epidemiological studies
    • Deckers IA, McLean S, Linssen S, Mommers M, van Schayck CP, Sheikh A. Investigating international time trends in the incidence and prevalence of atopic eczema 1990-2010: a systematic review of epidemiological studies. PLoS One. 2012;7:e39803.
    • (2012) PLoS One , vol.7
    • Deckers, I.A.1    McLean, S.2    Linssen, S.3    Mommers, M.4    Van Schayck, C.P.5    Sheikh, A.6
  • 7
    • 37749025593 scopus 로고    scopus 로고
    • Mechanisms of disease: Atopic dermatitis
    • Bieber T. Mechanisms of disease: atopic dermatitis. N Engl J Med. 2008;358(4):1483-1494.
    • (2008) N Engl J Med , vol.358 , Issue.4 , pp. 1483-1494
    • Bieber, T.1
  • 8
    • 77955228542 scopus 로고    scopus 로고
    • From atopic dermatitis to asthma: The atopic march
    • Spergel JM. From atopic dermatitis to asthma: the atopic march. Ann Allergy Asthma Immunol. 2010;105:99-106.
    • (2010) Ann Allergy Asthma Immunol , vol.105 , pp. 99-106
    • Spergel, J.M.1
  • 9
    • 84892678278 scopus 로고    scopus 로고
    • Section 1.Diagnosis and assessment of atopic dermatitis
    • Eichenfield LF, Tom WL, Chamlin SL, et al. Section 1.Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol. 2014;70:338-351.
    • (2014) J Am Acad Dermatol , vol.70 , pp. 338-351
    • Eichenfield, L.F.1    Tom, W.L.2    Chamlin, S.L.3
  • 10
    • 33644851871 scopus 로고    scopus 로고
    • Life quality assessment among patients with atopic eczema
    • Holm EA, Wulf HC, Stegman H, Jemec GBE. Life quality assessment among patients with atopic eczema. Br J Dermatol. 2006;154:719-725.
    • (2006) Br J Dermatol , vol.154 , pp. 719-725
    • Holm, E.A.1    Wulf, H.C.2    Stegman, H.3    Jemec, G.B.E.4
  • 12
    • 84908102577 scopus 로고    scopus 로고
    • Chronic disease influences over 40 major life-changing decisions (MLCDs): A qualitative study in dermatology and general medicine
    • Bhatti ZU, Finlay AY, Bolton CE, et al. Chronic disease influences over 40 major life-changing decisions (MLCDs): a qualitative study in dermatology and general medicine. J Eur Acad Dermatol Venereol. 2014;28:1344-1355.
    • (2014) J Eur Acad Dermatol Venereol , vol.28 , pp. 1344-1355
    • Bhatti, Z.U.1    Finlay, A.Y.2    Bolton, C.E.3
  • 13
    • 12444306412 scopus 로고    scopus 로고
    • Measurement of the impact of atopic dermatitis on patients' quality of life: A cross-sectional and longitudinal questionnaire study using the Japanese version of Skindex-16
    • Higaki Y, Kawamoto K, Kamo T, Ueda S, Arikawa J, Kawashima M. Measurement of the impact of atopic dermatitis on patients' quality of life: a cross-sectional and longitudinal questionnaire study using the Japanese version of Skindex-16. J Dermatol. 2004;31:977-982.
    • (2004) J Dermatol , vol.31 , pp. 977-982
    • Higaki, Y.1    Kawamoto, K.2    Kamo, T.3    Ueda, S.4    Arikawa, J.5    Kawashima, M.6
  • 14
    • 4243133675 scopus 로고    scopus 로고
    • The Quality of Life Scale (QOLS): Reliability, validity, and utilization
    • Burckhardt CS, Anderson KL. The Quality of Life Scale (QOLS): reliability, validity, and utilization. Health Qual Life Outcomes. 2003;1:60.
    • (2003) Health Qual Life Outcomes , vol.1 , pp. 60
    • Burckhardt, C.S.1    Anderson, K.L.2
  • 15
    • 84893292656 scopus 로고    scopus 로고
    • The development and validation of the Family Reported Outcome Measure (FROM-16) to assess the impact of disease on the partner or family member
    • Golics CJ, Basra MKA, Finlay AY, Salek S. The development and validation of the Family Reported Outcome Measure (FROM-16) to assess the impact of disease on the partner or family member. Qual Life Res. 2014;23:317-326.
    • (2014) Qual Life Res , vol.23 , pp. 317-326
    • Golics, C.J.1    Basra, M.K.A.2    Finlay, A.Y.3    Salek, S.4
  • 16
    • 33846988561 scopus 로고    scopus 로고
    • The Family Dermatology Life Quality Index: Measuring the secondary impact of skin disease
    • Basra MK, Sue-Ho R, Finlay AY. The Family Dermatology Life Quality Index: measuring the secondary impact of skin disease. Br J Dermatol. 2007;156:528-538.
    • (2007) Br J Dermatol , vol.156 , pp. 528-538
    • Basra, M.K.1    Sue-Ho, R.2    Finlay, A.Y.3
  • 17
    • 34247340559 scopus 로고    scopus 로고
    • The family impact of skin diseases: The Greater Patient concept
    • Basra MK, Finlay AY: The family impact of skin diseases: the Greater Patient concept. Br J Dermatol. 2007;156:929-937.
    • (2007) Br J Dermatol , vol.156 , pp. 929-937
    • Basra, M.K.1    Finlay, A.Y.2
  • 18
    • 85027949797 scopus 로고    scopus 로고
    • Harmonising Outcome Measures for Atopic Dermatitis (HOME) initiative: Assessment of clinical signs of atopic dermatitis: A systematic review and recommendation
    • Schmitt J, Langan S, Deckert S, et al. Harmonising Outcome Measures for Atopic Dermatitis (HOME) initiative: assessment of clinical signs of atopic dermatitis: a systematic review and recommendation. J Allergy Clin Immunol. 2013;132:1337-1347.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 1337-1347
    • Schmitt, J.1    Langan, S.2    Deckert, S.3
  • 19
    • 84952783604 scopus 로고    scopus 로고
    • Parental perceptions of child vulnerability in a community-based sample: Association with chronic illness and health-related quality of life
    • Houtzager BA, Möller EL, Maurice-Stam H, Last BF, Grootenhuis MA. Parental perceptions of child vulnerability in a community-based sample: association with chronic illness and health-related quality of life. J Child Health Care. 2015;19(4):454-465.
    • (2015) J Child Health Care , vol.19 , Issue.4 , pp. 454-465
    • Houtzager, B.A.1    Möller, E.L.2    Maurice-Stam, H.3    Last, B.F.4    Grootenhuis, M.A.5
  • 20
    • 33746117203 scopus 로고    scopus 로고
    • Quality of life and childhood atopic dermatitis: The misery of living with childhood eczema
    • Lewis-Jones S: Quality of life and childhood atopic dermatitis: the misery of living with childhood eczema. Int J Clin Pract. 2006;60:984-992.
    • (2006) Int J Clin Pract , vol.60 , pp. 984-992
    • Lewis-Jones, S.1
  • 21
    • 49249117495 scopus 로고    scopus 로고
    • Quality of life of children with atopic dermatitis and their families
    • McKenna SP, Doward AC: Quality of life of children with atopic dermatitis and their families. Curr Opin Allergy Clin Immunol. 2008;8:228-231.
    • (2008) Curr Opin Allergy Clin Immunol , vol.8 , pp. 228-231
    • McKenna, S.P.1    Doward, A.C.2
  • 22
    • 13844253879 scopus 로고    scopus 로고
    • International development of the Parents' Index of Quality of Life in Atopic Dermatitis (PIQoL-AD)
    • McKenna SP, Whalley D, Dewar AL, et al. International development of the Parents' Index of Quality of Life in Atopic Dermatitis (PIQoL-AD). Qual Life Res. 2005;14:231-241.
    • (2005) Qual Life Res , vol.14 , pp. 231-241
    • McKenna, S.P.1    Whalley, D.2    Dewar, A.L.3
  • 23
    • 77951737835 scopus 로고    scopus 로고
    • The influence of childhood atopic dermatitis on health of mothers, and its impact on Asian families
    • Ho RCM, Giam YC, Ng TP, et al. The influence of childhood atopic dermatitis on health of mothers, and its impact on Asian families. Pediatr Allergy Immunol. 2010;21:501-507.
    • (2010) Pediatr Allergy Immunol , vol.21 , pp. 501-507
    • Ho, R.C.M.1    Giam, Y.C.2    Ng, T.P.3
  • 24
    • 84878772728 scopus 로고    scopus 로고
    • An international multicenter study on quality of life and family quality of life in children with atopic dermatitis
    • Chernyshov PV, Jirakova A, Ho RC, et al. An international multicenter study on quality of life and family quality of life in children with atopic dermatitis. Indian J Dermatol Venereol Leprol. 2013;79:52-58.
    • (2013) Indian J Dermatol Venereol Leprol , vol.79 , pp. 52-58
    • Chernyshov, P.V.1    Jirakova, A.2    Ho, R.C.3
  • 25
    • 33644885452 scopus 로고    scopus 로고
    • Effect of childhood eczema and asthma on parental sleep and well-being: A prospective comparative study
    • Moore K, David TJ, Murray F, et al. Effect of childhood eczema and asthma on parental sleep and well-being: a prospective comparative study. Br J Dermatol. 2006;154:514-518.
    • (2006) Br J Dermatol , vol.154 , pp. 514-518
    • Moore, K.1    David, T.J.2    Murray, F.3
  • 26
    • 84903303598 scopus 로고    scopus 로고
    • Guidelines of care for the management of atopic dermatitis. Section 2. Management and treatment of atopic dermatitis with topical therapies
    • Eichenfield LF, Tom WL, Berger TG, et al. Guidelines of care for the management of atopic dermatitis. Section 2. Management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol. 2014;71(6):116-132.
    • (2014) J Am Acad Dermatol , vol.71 , Issue.6 , pp. 116-132
    • Eichenfield, L.F.1    Tom, W.L.2    Berger, T.G.3
  • 27
    • 33144456515 scopus 로고    scopus 로고
    • Canadian practical guide for the treatment and management of atopic dermatitis
    • Lynde C, Barber K, Claveau J. Canadian practical guide for the treatment and management of atopic dermatitis. J Cutan Med Surg. 2005;8(suppl 5):1-9.
    • (2005) J Cutan Med Surg , vol.8 , pp. 1-9
    • Lynde, C.1    Barber, K.2    Claveau, J.3
  • 28
    • 0031657805 scopus 로고    scopus 로고
    • Tacrolimus ointment does not affect collagen synthesis: Results of a single-center randomized trial
    • Reitamo S, Rissanen J, Remitz A, et al. Tacrolimus ointment does not affect collagen synthesis: results of a single-center randomized trial. J Invest Dermatol. 1998;111(3):396-398.
    • (1998) J Invest Dermatol , vol.111 , Issue.3 , pp. 396-398
    • Reitamo, S.1    Rissanen, J.2    Remitz, A.3
  • 29
    • 63149097158 scopus 로고    scopus 로고
    • Topical calcineurin inhibitors in atopic dermatitis: A systematic review and meta-analysis
    • El-Batawy MM, Bosseila MA, Mashaly HM, Hafez VS. Topical calcineurin inhibitors in atopic dermatitis: a systematic review and meta-analysis. J Dermatol Sci. 2009;54:76-87.
    • (2009) J Dermatol Sci , vol.54 , pp. 76-87
    • El-Batawy, M.M.1    Bosseila, M.A.2    Mashaly, H.M.3    Hafez, V.S.4
  • 30
    • 84925223476 scopus 로고    scopus 로고
    • Guidelines of care for the management of atopic dermatitis. Section 4. Prevention and flares and use of adjunctive therapies and approaches
    • Eichenfield LF, Tom WL, Berger TG, et al. Guidelines of care for the management of atopic dermatitis. Section 4. Prevention and flares and use of adjunctive therapies and approaches. J Am Acad Dermatol. 2014;71(8):1218-1233.
    • (2014) J Am Acad Dermatol , vol.71 , Issue.8 , pp. 1218-1233
    • Eichenfield, L.F.1    Tom, W.L.2    Berger, T.G.3
  • 31
    • 84904729244 scopus 로고    scopus 로고
    • Guidelines of care for the management of atopic dermatitis: Section 3. Management and treatment with phototherapy and systemic agents
    • Sidbury R, Davis DM, Cohen DE, et al. Guidelines of care for the management of atopic dermatitis: Section 3. Management and treatment with phototherapy and systemic agents. J Am Acad Dermatol. 2014;71(6):327-349.
    • (2014) J Am Acad Dermatol , vol.71 , Issue.6 , pp. 327-349
    • Sidbury, R.1    Davis, D.M.2    Cohen, D.E.3
  • 32
    • 33846085514 scopus 로고    scopus 로고
    • Stealth monitoring of adherence to topical medication: Adherence is very poor in children with atopic dermatitis
    • Krejci-Manwaring J, Tusa MG, Carroll C, et al. Stealth monitoring of adherence to topical medication: adherence is very poor in children with atopic dermatitis. J Am Acad Dermatol. 2007;56:211-216.
    • (2007) J Am Acad Dermatol , vol.56 , pp. 211-216
    • Krejci-Manwaring, J.1    Tusa, M.G.2    Carroll, C.3
  • 33
    • 84903887689 scopus 로고    scopus 로고
    • Dupilumab treatment in adults with moderate-to-severe atopic dermatitis
    • Beck LA, Thaci D, Hamilton JD, et al. Dupilumab treatment in adults with moderate-to-severe atopic dermatitis. N Engl J Med. 2014;371:130-139.
    • (2014) N Engl J Med , vol.371 , pp. 130-139
    • Beck, L.A.1    Thaci, D.2    Hamilton, J.D.3
  • 34
    • 84954271885 scopus 로고    scopus 로고
    • Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: A randomised, placebo-controlled, dose-ranging phase 2b trial
    • 10013
    • Thaçi D, Simpson EL, Beck LA, et al. Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial. Lancet. 2016;387(10013):40-52.
    • (2016) Lancet , vol.387 , pp. 40-52
    • Thaçi, D.1    Simpson, E.L.2    Beck, L.A.3
  • 35
    • 20244375866 scopus 로고    scopus 로고
    • Anti-IL-5 recombinant humanized monoclonal antibody (mepolizumab) for the treatment of atopic dermatitis
    • Oldhoff J, Darsow U, Werfel T, et al. Anti-IL-5 recombinant humanized monoclonal antibody (mepolizumab) for the treatment of atopic dermatitis. Allergy. 2005;60:693-696.
    • (2005) Allergy , vol.60 , pp. 693-696
    • Oldhoff, J.1    Darsow, U.2    Werfel, T.3
  • 36
    • 24944536778 scopus 로고    scopus 로고
    • Infliximab in the treatment of moderate to severe atopic dermatitis
    • Jacobi A, Antoni C, Manger B, et al. Infliximab in the treatment of moderate to severe atopic dermatitis. J Am Acad Dermatol. 2005;52:522-526.
    • (2005) J Am Acad Dermatol , vol.52 , pp. 522-526
    • Jacobi, A.1    Antoni, C.2    Manger, B.3
  • 38
    • 29244441138 scopus 로고    scopus 로고
    • Treatment of recalcitrant atopic dermatitis with omalizumab
    • Lane JE, Cheyney JM, Lane TN, et al. Treatment of recalcitrant atopic dermatitis with omalizumab. J Am Acad Dermatol. 2006;54:68-72.
    • (2006) J Am Acad Dermatol , vol.54 , pp. 68-72
    • Lane, J.E.1    Cheyney, J.M.2    Lane, T.N.3
  • 39
    • 22144475442 scopus 로고    scopus 로고
    • Failure of omalizumab for treatment of severe adult atopic dermatitis
    • Krathen RA, Hsu S. Failure of omalizumab for treatment of severe adult atopic dermatitis. J Am Acad Dermatol. 2005;53:338-340.
    • (2005) J Am Acad Dermatol , vol.53 , pp. 338-340
    • Krathen, R.A.1    Hsu, S.2
  • 40
    • 35748968191 scopus 로고    scopus 로고
    • Low-dose anti-IgE therapy in patients with atopic eczema with high serum IgE levels
    • Belloni B, Ziai M, Lim A, et al. Low-dose anti-IgE therapy in patients with atopic eczema with high serum IgE levels. J Allergy Clin Immunol. 2007;120:1223-1225.
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 1223-1225
    • Belloni, B.1    Ziai, M.2    Lim, A.3
  • 41
    • 78650201074 scopus 로고    scopus 로고
    • Omalizumab therapy in atopic dermatitis: Depletion of IgE does not improve the clinical course - A randomized, placebo-controlled and double blind pilot study
    • Heil PM, Maurer D, Klein B, et al. Omalizumab therapy in atopic dermatitis: depletion of IgE does not improve the clinical course - a randomized, placebo-controlled and double blind pilot study. Dtsch Dermatol Ges. 2010;8:990-998.
    • (2010) Dtsch Dermatol Ges , vol.8 , pp. 990-998
    • Heil, P.M.1    Maurer, D.2    Klein, B.3
  • 42
    • 84879496768 scopus 로고    scopus 로고
    • Immunologic effects of omalizumab in children with severe refractory atopic dermatitis: A randomized, placebo-controlled clinical trial
    • Iyengar SR, Hoyte EG, Loza A, et al. Immunologic effects of omalizumab in children with severe refractory atopic dermatitis: a randomized, placebo-controlled clinical trial. Int Arch Allergy Immunol. 2013;162:89-93.
    • (2013) Int Arch Allergy Immunol , vol.162 , pp. 89-93
    • Iyengar, S.R.1    Hoyte, E.G.2    Loza, A.3
  • 43
    • 54049087804 scopus 로고    scopus 로고
    • Efficacy of omalizumab in the treatment of atopic dermatitis: A pilot study
    • Sheinkopf LE, Rafi AW, Do LT, et al. Efficacy of omalizumab in the treatment of atopic dermatitis: a pilot study. Allergy Asthma Proc. 2008;29:530-537.
    • (2008) Allergy Asthma Proc , vol.29 , pp. 530-537
    • Sheinkopf, L.E.1    Rafi, A.W.2    Do, L.T.3
  • 44
    • 38149055540 scopus 로고    scopus 로고
    • Anti-CD20 (rituximab) treatment improves atopic eczema
    • Simon D, Hosli S, Kostylina G, et al. Anti-CD20 (rituximab) treatment improves atopic eczema. J Allergy Clin Immunol. 2008;121:122-128.
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 122-128
    • Simon, D.1    Hosli, S.2    Kostylina, G.3
  • 46
    • 84982952552 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab treatment in adults with moderate-to-severe atopic dermatitis
    • published online June 15
    • Khattri S, Brunner PM, Garcet S, et al. Efficacy and safety of ustekinumab treatment in adults with moderate-to-severe atopic dermatitis [published online June 15, 2016]. Exp Dermatol. doi:10.1111/exd.13112.
    • (2016) Exp Dermatol
    • Khattri, S.1    Brunner, P.M.2    Garcet, S.3
  • 47
    • 84870294267 scopus 로고    scopus 로고
    • Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis
    • Gittler JK, Shemer A, Suárez-Fariñas M, et al. Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis. J Allergy Clin Immunol. 2012;130:1344-1354.
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 1344-1354
    • Gittler, J.K.1    Shemer, A.2    Suárez-Fariñas, M.3
  • 48
    • 42149101196 scopus 로고    scopus 로고
    • "Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis
    • Elias PM, Steinhoff M. "Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis. J Invest Dermatol. 2008;128(5):1067-1070.
    • (2008) J Invest Dermatol , vol.128 , Issue.5 , pp. 1067-1070
    • Elias, P.M.1    Steinhoff, M.2
  • 49
    • 24044510849 scopus 로고    scopus 로고
    • The genetics of atopic dermatitis: Recent findings and future options
    • Hoffjan S, Epplen JT. The genetics of atopic dermatitis: recent findings and future options. J Mol Med (Berl). 2005;83(9):682-692.
    • (2005) J Mol Med (Berl) , vol.83 , Issue.9 , pp. 682-692
    • Hoffjan, S.1    Epplen, J.T.2
  • 50
    • 79956161200 scopus 로고    scopus 로고
    • Combined occurrence of filaggrin mutations and IL-10 or IL-13 polymorphisms predisposes to atopic dermatitis
    • Lesiak A, Kuna P, Zakrzewski M, et al. Combined occurrence of filaggrin mutations and IL-10 or IL-13 polymorphisms predisposes to atopic dermatitis. Exp Dermatol. 2011;20:491-495.
    • (2011) Exp Dermatol , vol.20 , pp. 491-495
    • Lesiak, A.1    Kuna, P.2    Zakrzewski, M.3
  • 51
    • 31944434114 scopus 로고    scopus 로고
    • IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma
    • Kabesch M, Schedel M, Carr D, et al. IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma. J Allergy Clin Immunol. 2006;117:269-274.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 269-274
    • Kabesch, M.1    Schedel, M.2    Carr, D.3
  • 52
    • 33646950455 scopus 로고    scopus 로고
    • Association of IL13 with total IgE: Evidence against an inverse association of atopy and diabetes
    • Maier LM, Howson JM, Walker N, et al. Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes. J Allergy Clin Immunol. 2006;117:1306-1313.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 1306-1313
    • Maier, L.M.1    Howson, J.M.2    Walker, N.3
  • 53
    • 0034921320 scopus 로고    scopus 로고
    • A novel polymorphism in the 5′ promoter region of the human interleukin-4 receptor alpha-chain gene is associated with decreased soluble interleukin-4 receptor protein levels
    • Hackstein H, Hecker M, Kruse S, et al. A novel polymorphism in the 5′ promoter region of the human interleukin-4 receptor alpha-chain gene is associated with decreased soluble interleukin-4 receptor protein levels. Immunogenetics. 2001;53:264-269.
    • (2001) Immunogenetics , vol.53 , pp. 264-269
    • Hackstein, H.1    Hecker, M.2    Kruse, S.3
  • 54
    • 84863377817 scopus 로고    scopus 로고
    • The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptor alpha chain gene between atopic dermatitis and Japanese cedar pollinosis
    • Tanaka T, Hitomi Y, Kambayashi Y, et al. The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptor alpha chain gene between atopic dermatitis and Japanese cedar pollinosis. Allergol Int. 2012;61:57-63.
    • (2012) Allergol Int , vol.61 , pp. 57-63
    • Tanaka, T.1    Hitomi, Y.2    Kambayashi, Y.3
  • 55
    • 80055097824 scopus 로고    scopus 로고
    • The signal transducer and activator of transcription 6 gene (STAT6) increases the propensity of patients with atopic dermatitis toward disseminated viral skin infections
    • Howell MD, Gao P, Kim BE, et al. The signal transducer and activator of transcription 6 gene (STAT6) increases the propensity of patients with atopic dermatitis toward disseminated viral skin infections. J Allergy Clin Immunol. 2011;128:1006-1014.
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 1006-1014
    • Howell, M.D.1    Gao, P.2    Kim, B.E.3
  • 56
    • 49549108250 scopus 로고    scopus 로고
    • Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation
    • Howell MD, Fairchild HR, Kim BE, et al. Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation. J Invest Dermatol. 2008;128(9):2248-2258.
    • (2008) J Invest Dermatol , vol.128 , Issue.9 , pp. 2248-2258
    • Howell, M.D.1    Fairchild, H.R.2    Kim, B.E.3
  • 57
    • 34250828434 scopus 로고    scopus 로고
    • Cytokine modulation of atopic dermatitis filaggrin skin expression
    • Howell MD, Kim BE, Gao P, et al. Cytokine modulation of atopic dermatitis filaggrin skin expression. J Allergy Clin Immunol. 2007;120(1):150-155.
    • (2007) J Allergy Clin Immunol , vol.120 , Issue.1 , pp. 150-155
    • Howell, M.D.1    Kim, B.E.2    Gao, P.3
  • 58
    • 39149098125 scopus 로고    scopus 로고
    • Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6
    • Kim BE, Leung DY, Boguniewicz M, et al. Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6. Clin Immunol. 2008;126(3):332-337.
    • (2008) Clin Immunol , vol.126 , Issue.3 , pp. 332-337
    • Kim, B.E.1    Leung, D.Y.2    Boguniewicz, M.3
  • 59
    • 77951890216 scopus 로고    scopus 로고
    • IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation
    • Sehra S, Yao Y, Howell MD, et al. IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation. J Immunol. 2010;184:3186-3190.
    • (2010) J Immunol , vol.184 , pp. 3186-3190
    • Sehra, S.1    Yao, Y.2    Howell, M.D.3
  • 60
    • 84919635394 scopus 로고    scopus 로고
    • Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis
    • Hamilton JD, Suarez-Farinas M, Dhingra N, et al. Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis. J Allergy Clin Immunol. 2014;134:1293-1300.
    • (2014) J Allergy Clin Immunol , vol.134 , pp. 1293-1300
    • Hamilton, J.D.1    Suarez-Farinas, M.2    Dhingra, N.3
  • 62
    • 0025910340 scopus 로고
    • Double-blind, controlled, crossover study of cyclosporin in adults with severe refractory atopic dermatitis
    • Sowden JM, Berth-Jones J, Ross JS, et al. Double-blind, controlled, crossover study of cyclosporin in adults with severe refractory atopic dermatitis. Lancet. 1991;338:137-140.
    • (1991) Lancet , vol.338 , pp. 137-140
    • Sowden, J.M.1    Berth-Jones, J.2    Ross, J.S.3
  • 64
    • 0025313619 scopus 로고
    • Antipruritic effect of oral cyclosporine A in atopic dermatitis
    • Wahlgren CF, Scheynius A, Hagermark O. Antipruritic effect of oral cyclosporine A in atopic dermatitis. Acta Derm Venereol. 1990;70:323-329.
    • (1990) Acta Derm Venereol , vol.70 , pp. 323-329
    • Wahlgren, C.F.1    Scheynius, A.2    Hagermark, O.3
  • 65
    • 0033959268 scopus 로고    scopus 로고
    • Cyclosporin for severe childhood atopic dermatitis: Short course versus continuous therapy
    • Harper JI, Ahmed I, Barclay G, et al. Cyclosporin for severe childhood atopic dermatitis: short course versus continuous therapy. Br J Dermatol. 2000;142(1):52-58.
    • (2000) Br J Dermatol , vol.142 , Issue.1 , pp. 52-58
    • Harper, J.I.1    Ahmed, I.2    Barclay, G.3
  • 66
    • 0027425095 scopus 로고
    • Cyclosporin greatly improves the quality of life of adults with severe atopic dermatitis: A randomized, double-blind, placebo-controlled trial
    • Salek MS, Finlay AY, Luscombe DK, et al. Cyclosporin greatly improves the quality of life of adults with severe atopic dermatitis: a randomized, double-blind, placebo-controlled trial. Br J Dermatol. 1993;129:422-430.
    • (1993) Br J Dermatol , vol.129 , pp. 422-430
    • Salek, M.S.1    Finlay, A.Y.2    Luscombe, D.K.3
  • 67
    • 76949095922 scopus 로고    scopus 로고
    • Prednisolone vs. ciclosporin for severe adult eczema: An investigator-initiated double-blind placebo-controlled multicentre trial
    • Schmitt J, Schakel K, Folster-Holst R, et al. Prednisolone vs. ciclosporin for severe adult eczema: an investigator-initiated double-blind placebo-controlled multicentre trial. Br J Dermatol. 2010;162:661-668.
    • (2010) Br J Dermatol , vol.162 , pp. 661-668
    • Schmitt, J.1    Schakel, K.2    Folster-Holst, R.3
  • 68
    • 55449114921 scopus 로고    scopus 로고
    • High doses intravenous immunoglobulin versus oral cyclosporine in the treatment of severe atopic dermatitis
    • Bemanian MH, Movahedi M, Farhoudi A, et al. High doses intravenous immunoglobulin versus oral cyclosporine in the treatment of severe atopic dermatitis. Iran J Allergy Asthma Immunol. 2005;4:139-143.
    • (2005) Iran J Allergy Asthma Immunol , vol.4 , pp. 139-143
    • Bemanian, M.H.1    Movahedi, M.2    Farhoudi, A.3
  • 69
    • 0034999520 scopus 로고    scopus 로고
    • Comparison of cyclosporin and UVAB phototherapy for intermittent one-year treatment of atopic dermatitis
    • Granlund H, Erkko P, Remitz A, et al. Comparison of cyclosporin and UVAB phototherapy for intermittent one-year treatment of atopic dermatitis. Acta Derm Venereol. 2001;81:22-27.
    • (2001) Acta Derm Venereol , vol.81 , pp. 22-27
    • Granlund, H.1    Erkko, P.2    Remitz, A.3
  • 70
    • 79956127410 scopus 로고    scopus 로고
    • Enteric-coated mycophenolate sodium versus cyclosporin A as long-term treatment in adult patients with severe atopic dermatitis: A randomized controlled trial
    • Haeck IM, Knol MJ, Ten BO, van Velsen SG, de Bruin-Weller MS, Bruijnzeel-Koomen CA. Enteric-coated mycophenolate sodium versus cyclosporin A as long-term treatment in adult patients with severe atopic dermatitis: a randomized controlled trial. J Am Acad Dermatol. 2011;64:1074-1084.
    • (2011) J Am Acad Dermatol , vol.64 , pp. 1074-1084
    • Haeck, I.M.1    Knol, M.J.2    Ten, B.O.3    Van Velsen, S.G.4    De Bruin-Weller, M.S.5    Bruijnzeel-Koomen, C.A.6
  • 71
    • 2042503032 scopus 로고    scopus 로고
    • Comparing tacrolimus ointment and oral cyclosporine in adult patients affected by atopic dermatitis: A randomized study
    • Pacor ML, Di LG, Martinelli N, Mansueto P, Rini GB, Corrocher R. Comparing tacrolimus ointment and oral cyclosporine in adult patients affected by atopic dermatitis: a randomized study. Clin Exp Allergy. 2004;34:639-645.
    • (2004) Clin Exp Allergy , vol.34 , pp. 639-645
    • Pacor, M.L.1    Di, L.G.2    Martinelli, N.3    Mansueto, P.4    Rini, G.B.5    Corrocher, R.6
  • 72
    • 0345059383 scopus 로고    scopus 로고
    • Comparison of two formulations of cyclosporin A in the treatment of severe atopic dermatitis: A double-blind, single-centre, cross-over pilot study
    • Zurbriggen B, Wuthrich B, Cachelin AB, Wili PB, Kagi MK. Comparison of two formulations of cyclosporin A in the treatment of severe atopic dermatitis: a double-blind, single-centre, cross-over pilot study. Dermatology. 1999;198:56-60.
    • (1999) Dermatology , vol.198 , pp. 56-60
    • Zurbriggen, B.1    Wuthrich, B.2    Cachelin, A.B.3    Wili, P.B.4    Kagi, M.K.5
  • 73
    • 0033926987 scopus 로고    scopus 로고
    • A body-weight-independent dosing regimen of cyclosporine microemulsion is effective in severe atopic dermatitis and improves the quality of life
    • Czech W, Brautigam M, Weidinger G, Schopf E. A body-weight-independent dosing regimen of cyclosporine microemulsion is effective in severe atopic dermatitis and improves the quality of life. J Am Acad Dermatol. 2000;42:653-659.
    • (2000) J Am Acad Dermatol , vol.42 , pp. 653-659
    • Czech, W.1    Brautigam, M.2    Weidinger, G.3    Schopf, E.4
  • 74
    • 0029792152 scopus 로고    scopus 로고
    • The longterm safety and efficacy of cyclosporin in severe refractory atopic dermatitis: A comparison of two dosage regimens
    • Zonneveld IM, De Rie MA, Beljaards RC, et al. The longterm safety and efficacy of cyclosporin in severe refractory atopic dermatitis: a comparison of two dosage regimens. Br J Dermatol. 1996;135(suppl 48):15-20.
    • (1996) Br J Dermatol , vol.135 , pp. 15-20
    • Zonneveld, I.M.1    De Rie, M.A.2    Beljaards, R.C.3
  • 75
    • 0036378083 scopus 로고    scopus 로고
    • Azathioprine in severe adult atopic dermatitis: A double-blind, placebo-controlled, crossover trial
    • Berth-Jones J, Takwale A, Tan E, et al. Azathioprine in severe adult atopic dermatitis: a double-blind, placebo-controlled, crossover trial. Br J Dermatol. 2002;147:324-330.
    • (2002) Br J Dermatol , vol.147 , pp. 324-330
    • Berth-Jones, J.1    Takwale, A.2    Tan, E.3
  • 76
    • 33644837550 scopus 로고    scopus 로고
    • Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe atopic eczema: A double-blind, randomised controlled trial
    • Meggitt SJ, Gray JC, Reynolds NJ. Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe atopic eczema: a double-blind, randomised controlled trial. Lancet. 2006;367:839-846.
    • (2006) Lancet , vol.367 , pp. 839-846
    • Meggitt, S.J.1    Gray, J.C.2    Reynolds, N.J.3
  • 78
    • 33846223886 scopus 로고    scopus 로고
    • An open-label dose-ranging study of methotrexate for moderate-to-severe atopic dermatitis
    • Weatherhead SC, Wahie S, Reynolds NJ, Meggitt SJ. An open-label dose-ranging study of methotrexate for moderate-to-severe atopic dermatitis. Br J Dermatol. 2007;156(2): 346-351.
    • (2007) Br J Dermatol , vol.156 , Issue.2 , pp. 346-351
    • Weatherhead, S.C.1    Wahie, S.2    Reynolds, N.J.3    Meggitt, S.J.4
  • 79
    • 84904291404 scopus 로고    scopus 로고
    • Methotrexate for treatment of atopic dermatitis in children and adolescents
    • Deo M, Yung A, Hill S, Rademaker M. Methotrexate for treatment of atopic dermatitis in children and adolescents. Int J Dermatol. 2014;53:1037-1041.
    • (2014) Int J Dermatol , vol.53 , pp. 1037-1041
    • Deo, M.1    Yung, A.2    Hill, S.3    Rademaker, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.