Methotrexate for treatment of atopic dermatitis in children and adolescents

International Journal of Dermatology

Volumn 53, Issue 8, 2014, Pages 1037-1041

  Deo, Maneka ^a   Yung, Anthony ^a   Hill, Sarah ^a   Rademaker, Marius ^a  

^a WAIKATO HOSPITAL   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; FOLIC ACID; LIVER ENZYME; METHOTREXATE; IMMUNOSUPPRESSIVE AGENT;

ABNORMAL LABORATORY RESULT; ADOLESCENT; ADULT; ANEMIA; ARTICLE; ATOPIC DERMATITIS; CHILD; CLINICAL ARTICLE; DISEASE EXACERBATION; DRUG EFFICACY; DRUG SAFETY; ENZYME BLOOD LEVEL; FEMALE; HUMAN; LOW DRUG DOSE; MALE; NAUSEA; NEW ZEALAND; RETROSPECTIVE STUDY; TREATMENT DURATION; TREATMENT RESPONSE; CHEMICALLY INDUCED; DERMATITIS, ATOPIC; PRESCHOOL CHILD;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; DERMATITIS, ATOPIC; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; METHOTREXATE; NAUSEA; RETROSPECTIVE STUDIES;

EID: 84904291404     PISSN: 00119059     EISSN: 13654632     Source Type: Journal    
DOI: 10.1111/ijd.12314     Document Type: Article

References (20)

1. Kemp AS. Cost of illness of atopic dermatitis in children: a societal perspective. Pharmacoeconomics 2003; 21: 105-113.
2. Odhiambo JA, Williams HC, Clayton TO, et al., Group IPTS. Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three. J Allergy Clin Immunol 2009; 124: 1251-1258.e23.
3. Tan E, Lim D, Rademaker M. Narrowband UVB phototherapy in children: a New Zealand experience. Australas J Dermatol 2010; 51: 268-273.
4. Ring J, Alomar A, Bieber T, et al. Guidelines for treatment of atopic eczema (atopic dermatitis) Part II. J Eur Acad Dermatol Venereol 2012; 26: 1176-1193.
5. Schram ME, Roekevisch E, Leeflang MMG, et al. A randomized trial of methotrexate versus azathioprine for severe atopic eczema. J Allergy Clin Immunol 2011; 128: 353-359.
6. Weatherhead SC, Wahie S, Reynolds NJ, et al. An open-label, dose-ranging study of methotrexate for moderate-to-severe adult atopic eczema. Br J Dermatol 2007; 156: 346-351.
7. Lyakhovitsky A, Barzilai A, Heyman R, et al. Low-dose methotrexate treatment for moderate-to-severe atopic dermatitis in adults. J Eur Acad Dermatol Venereol 2010; 24: 43-49.
8. Zoller L, Ramon M, Bergman R. Low dose methotrexate therapy is effective in late-onset atopic dermatitis and idiopathic eczema. Isr Med Assoc J 2008; 10: 413-414.
9. Giannini EH, Brewer EJ, Kuzmina N, et al. Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The Pediatric Rheumatology Collaborative Study Group and the Cooperative Children's Study Group. N Engl J Med 1992; 326: 1043-1049.
10. Silverman E, Mouy R, Spiegel L, et al. Leflunomide or methotrexate for juvenile rheumatoid arthritis. N Engl J Med 2005; 352: 1655-1666.
11. Weiss B, Lerner A, Shapiro R, et al. Methotrexate treatment in pediatric Crohn disease patients intolerant or resistant to purine analogues. J Pediatr Gastroenterol Nutr 2009; 48: 526-530.
12. Roberts H, Orchard D. Methotrexate is a safe and effective treatment for paediatric discoid (nummular) eczema: a case series of 25 children. Australas J Dermatol 2010; 51: 128-130.
13. Trivedi P, Cheeseman P, Portmann B, et al. Variation in serum type III procollagen peptide with age in healthy subjects and its comparative value in the assessment of disease activity in children and adults with chronic active hepatitis. Eur J Clin Invest 1985; 15: 69-74.
14. Berends MAM, Snoek J, de Jong EMGJ, et al. Biochemical and biophysical assessment of MTX-induced liver fibrosis in psoriasis patients: Fibrotest predicts the presence and Fibroscan predicts the absence of significant liver fibrosis. Liver Int 2007; 27: 639-645.
15. Sigmundsdottir H, Johnston A, Gudjonsson JE, et al. Methotrexate markedly reduces the expression of vascular E-selectin, cutaneous lymphocyte-associated antigen and the numbers of mononuclear leucocytes in psoriatic skin. Exp Dermatol 2004; 13: 426-434.
16. Johnston A, Gudjonsson JE, Sigmundsdottir H, et al. The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules. Clin Immunol 2005; 114: 154-163.
17. Goujon C, Berard F, Dahel K, et al. Methotrexate for the treatment of adult atopic dermatitis. Eur J Dermatol 2006; 16: 155-158.
18. Murphy LA, Atherton D. A retrospective evaluation of azathioprine in severe childhood atopic eczema, using thiopurine methyltransferase levels to exclude patients at high risk of myelosuppression. Br J Dermatol 2002; 147: 308-315.
19. Berth-Jones J, Finlay AY, Zaki I, et al. Cyclosporine in severe childhood atopic dermatitis: a multicenter study. J Am Acad Dermatol 1996; 34: 1016-1021.
20. El-Khalawany MA, Hassan H, Shaaban D, et al. Methotrexate versus cyclosporine in the treatment of severe atopic dermatitis in children: a multicenter experience from Egypt. Eur J Pediatr 2013; 172: 351-356.