Topical calcineurin inhibitors in atopic dermatitis: A systematic review and meta-analysis

Journal of Dermatological Science

Volumn 54, Issue 2, 2009, Pages 76-87

  El Batawy, Mohammad Maged Y ^a   Bosseila, Manal A W ^a   Mashaly, Heba M ^a   Hafez, Vanessa Suzan G A ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Atopic dermatitis; Meta analysis; Pimecrolimus; Randomized control trials; Systematic review; Tacrolimus; Topical calcineurin inhibitors

Indexed keywords

BETAMETHASONE VALERATE; CALCINEURIN INHIBITOR; HYDROCORTISONE ACETATE; HYDROCORTISONE BUTYRATE; PIMECROLIMUS; PLACEBO; TACROLIMUS; TRIAMCINOLONE ACETONIDE;

ATOPIC DERMATITIS; CLINICAL TRIAL; COMPARATIVE STUDY; DRUG EFFICACY; DRUG POTENCY; ELECTRONICS; ERYTHEMA; FACE; HUMAN; MEDICAL LITERATURE; MEDLINE; META ANALYSIS; OINTMENT; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PRURITUS; REVIEW; SYSTEMATIC REVIEW; TREATMENT INDICATION;

ADRENAL CORTEX HORMONES; CALCINEURIN; DERMATITIS, ATOPIC; ENZYME INHIBITORS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; TACROLIMUS;

EID: 63149097158     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2009.02.002     Document Type: Review

References (35)

1. Thestrup-Pedersen K. Tacrolimus treatment of atopic eczema/dermatitis syndrome. Curr Opin Allergy Clin Immunol 3 (2003) 359-362
2. Meurer M., and Wozel G. The treatment of atopic dermatitis in adults with topical calcineurin inhibitors. Hautarzt 54 5 (2003) 424-431
3. Hoare C., Li Wan Po A., and Williams H. Systematic review of treatments for atopic eczema. Health Technol Assess 4 (2000) 1-191
4. Abeck D., and Strom K. Optimal management of atopic dermatitis. Am J Clin Dermatol 1 1 (2000) 41-46
5. Charman C.R., Morris A.D., and Williams H.C. Topical corticosteroid phobia in patients with atopic eczema. Br J Dermatol 142 (2000) 931-936
6. Ortiz De Frutos F.J. New horizons in the treatment of atopic dermatitis. Allergol Immunopathol (Madr) 30 3 (2002) 134-140
7. Breuer K., Werfel T., and Kapp A. Safety and efficacy of topical calcineurin inhibitors in the treatment of childhood atopic dermatitis. Am J Clin Dermatol 6 2 (2005) 65-77
8. Novak N., Kwiek B., and Bieber T. The mode of topical immunomodulators in the immunological network of atopic dermatitis. Clin Exp Dermatol 30 2 (2005) 160-164
9. Moher D., Cook D.J., Eastwood S., Olkin I., Rennie D., and Stroup D.F. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of reporting of meta-analyses. Lancet 354 (1999) 1896-1900
10. Cochrane W. The combination of estimates from different experiments. Biometrics 10 (1954) 101-129
11. Luger T., Van Leent E.J., Graeber M., Hedgecock S., Thurston M., Kandra A., et al. SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis. Br J Deratol 144 m4 (2001) 788-794
12. Kapp A., Papp K., Bingham A., Folster-Holst R., Ortonne J.P., Potter P.C., et al. Long-term management of atopic dermatitis in infants with topical pimecrolimus, a nonsteroid anti-inflammatory drug. J Allergy Clin Immunol 110 2 (2002) 277-284
13. Wahn U., Bos J.D., Goodfield M., Caputo R., Papp K., Manjra A., et al. Efficacy and safety of pimecrolimus cream in the long-term management of atopic dermatitis in children. Pediatrics 10 1 Pt I (2002) e2
14. Meurer M., Folster-Holst R., Wozel G., Weidinger G., Junger M., and Brautigam M. Pimecrolimus cream in the long-term management of atopic dermatitis in adults: a six-month study. Dermatology 205 3 (2002) 271-277
15. Luger T.A., Lahfa M., Folster-Holst R., Gulliver W.P., Alien R., Molloy S., et al. Long-term safety and tolerability of pimecrolimus cream 1% and topical corticosteroids in adults with moderate to severe atopic dermatitis. J Dermatol Treat 15 3 (2004) 169-178
16. Schachner L.A., Lamerson C., Sheehan M.P., Boguniewicz M., Mosser J., Rainier S., et al. Tacrolimus ointment 0.03% is safe and effective for the treatment of mild to moderate atopic dermatitis in pediatric patients: results from a randomized, double-blind, vehicle-controlled study. Pediatrics 116 3 (2005) e334-e342
17. Boguniewicz M., Fiedler V.C., Raimer S., Lawrence I.D., Leung D.Y., and Hanifin J.M. A randomized, vehicle-controlled trial of tacrolimus ointment for treatment of atopic dermatitis in children. Pediatric Tacrolimus Study Group. J Allergy Clin Immunol 102 4Pt l (1998) 637-644
18. Paller A., Eichenfield L.F., Leung D.Y., Stewart D., and Appell M. A 12-week study of tacrolimus ointment for the treatment of atopic dermatitis in pediatric patients. J Am Acad Dermatol 44 1 Suppl. (2001) S47-S57
19. Hanifin J.M., Ling M.R., Langley R., Breneman D., and Rafal E. Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: part I, efficacy. J Am Acad Dermatol 44 1 Suppl. (2001) S28-S38
20. Reitamo S., Rustin M., Ruzicka T., Cambazard F., Kalimo K., Friedmann P.S., et al. Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone butyrate ointment in adult patients with atopic dermatitis. J Allergy Clin Immunol 109 3 (2002) 547-555
21. Reitamo S., Harper J., Bos J.D., Cambazard F., Bruijnzeel-Koomen C., Valk P., et al. 0.03% Tacrolimus ointment applied once or twice daily is more efficacious than 1% hydrocortisone acetate in children with moderate to severe atopic dermatitis: results of a randomized double-blind controlled trial. Br J Dermatol 150 3 (2004) 554-562
22. Reitamo S., Van Leent E.J., Ho V., Harper J., Ruzicka T., Kalimo K., et al. Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone acetate ointment in children with atopic dermatitis. J Allergy Clin Immunol 109 3 (2002) 539-546
23. Reitamo S., Ortonne J.P., Sand C., Cambazard F., Bieber T., Folster-Holst R., et al. A multicentre, randomized, double-blind, controlled study of long-term a treatment with 0.1% tacrolimus ointment in adults with moderate to severe atopic dermatitis. Br J Dermatol 152 6 (2005) 1282-1289
24. Ashcroft D.M., Chen L.C., Garside R., Stein K., and Williams H.C. Topical pimecrolimus for eczema. Cochrane Database Syst Rev 4 (2007) CD005500
25. Hidalgo BP, Knight T, Burls A. A systematic review of effectiveness and cost effectiveness of tacrolimus ointment for topical treatment of atopic dermatitis. http://rep.bham.ac.uk/pdfs/2003/atopic_dermatitis.pdf.
26. Garside R., Stein K., Castelnuovo E., Pitt M., Ashcroft D., Dimmock P., et al. The effectiveness and cost-effectiveness of pimecrolimus and tacrolimus for atopic eczema: a systematic review and economic evaluation. Health Technol Assess (2005) 1-230
27. Ho V.C., Gupta A., Kaufmann R., Todd G., Vanaclocha F., Takaoka R., et al. Safety and efficacy of nonsteroid pimecrolimus cream 1% in the treatment of atopic dermatitis in infants. J Pediatr 142 2 (2003) 155-162
28. Kaufmann R., Bieber T., Helgesen A.L., Andersen B.L., Luger T., Poulin Y., et al. Onset of pruritus relief with pimecrolimus cream 1% in adult patients with atopic dermatitis: a randomized trial. Allergy 61 3 (2006) 375-381
29. Eichenfield L.F., Lucky A.W., Boguniewicz M., Langley R.G., Cherill R., Marshall K., et al. Safety and efficacy of pimecrolimus (ASM 981) cream 1% in the treatment of mild and moderate atopic dermatitis in children and adolescents. J Am Acad Dermatol 46 4 (2002) 495-504
30. Van Leent E.J., Graber M., Thurston M., Wagenaar A., Spuls P.I., and Bos J.D. Effectiveness of the ascomycin macrolactam SDZ ASM 981 in the topical treatment of atopic dermatitis. Arch Dermatol 134 7 (1998) 805-809
31. Seymour J., Keswick B., Hanifin J., et al. Clinical effects of diaper types on the skin of normal infants and infants with atopic dermatitis. J Am Acad Dermatol 17 (1987) 988-997
32. Williams H., Burney P., Pembroke A., and Hay R.J. The UK Working Party's diagnostic criteria for atopic dermatitis: III. Independent hospital validation. Br J Dermatol 131 (1994) 406-416
33. Hanifin J., and Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol 92 (1980) 44-47
34. Rajka G., and Langland T. Grading of the severity of atopic dermatitis. Acta Derm Venereol Suppl (Stock) 144 (1989) 13-14
35. Ruzicka T., Bieber T., Schopf E., Rubins A., Dobozy A., Bos J.D., et al. A short-term trial of tacrolimus ointment for atopic dermatitis. European Tacrolimus Multicenter Atopic Dermatitis Study Group. N Engl J Med 337 12 (1997) 816-821