Inhibition of TNF receptor signaling by anti-TNFα biologicals primes naïve CD4+ T cells towards IL-10+ T cells with a regulatory phenotype and function

Clinical Immunology

Volumn 151, Issue 2, 2014, Pages 136-145

  Boks, Martine A ^a   Kager Groenland, Judith R ^a   Mousset, Charlotte M ^a   van Ham, S Marieke ^a   Ten Brinke, Anja ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Anti TNF therapy; IL 10; Regulatory T cells; T cell polarization; TNF receptor

Indexed keywords

ADALIMUMAB; ETANERCEPT; INFLIXIMAB; INTERLEUKIN 10; TUMOR NECROSIS FACTOR RECEPTOR;

ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL FUNCTION; CELL ISOLATION; CONTROLLED STUDY; DENDRITIC CELL; GENE EXPRESSION; GENOME; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INTERLEUKIN 10+ T LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATOR GENE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTI-TNFΑ THERAPY; IL-10; REGULATORY T CELLS; T CELL POLARIZATION; TNF RECEPTOR;

ANTI-INFLAMMATORY AGENTS; ANTIBODIES, MONOCLONAL, HUMANIZED; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DENDRITIC CELLS; GENE EXPRESSION; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-10; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84895966383     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2014.02.008     Document Type: Article

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