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Volumn 213, Issue 7, 2016, Pages 1241-1253

Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF-TNF-RII binding in rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; CD14 ANTIGEN; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; STAT5 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 2;

EID: 84977632681     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20151255     Document Type: Article
Times cited : (150)

References (42)
  • 1
    • 67650495486 scopus 로고    scopus 로고
    • Numbers matter: quantitative and dynamic analysis of the formation of an immunological synapse using imaging flow cytometry
    • Ahmed, F., S. Friend, T.C. George, N. Barteneva, and J. Lieberman. 2009. Numbers matter: quantitative and dynamic analysis of the formation of an immunological synapse using imaging flow cytometry. J. Immunol. Methods. 347:79-86. http://dx.doi.org/10.1016/j.jim.2009.05.014
    • (2009) J. Immunol. Methods , vol.347 , pp. 79-86
    • Ahmed, F.1    Friend, S.2    George, T.C.3    Barteneva, N.4    Lieberman, J.5
  • 3
    • 34347267600 scopus 로고    scopus 로고
    • Clinical response to adalimumab: relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis
    • Bartelds, G.M., C.A. Wijbrandts, M.T. Nurmohamed, S. Stapel, W.F. Lems, L. Aarden, B.A. Dijkmans, P.P. Tak, and G.J. Wolbink. 2007. Clinical response to adalimumab: relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis. Ann. Rheum. Dis. 66:921-926. http://dx.doi.org/10.1136/ard.2006.065615
    • (2007) Ann. Rheum. Dis , vol.66 , pp. 921-926
    • Bartelds, G.M.1    Wijbrandts, C.A.2    Nurmohamed, M.T.3    Stapel, S.4    Lems, W.F.5    Aarden, L.6    Dijkmans, B.A.7    Tak, P.P.8    Wolbink, G.J.9
  • 9
    • 79954559096 scopus 로고    scopus 로고
    • T-cell tolerance and the multifunctional role of IL-2R signaling in T-regulatory cells
    • Cheng, G., A. Yu, and T.R. Malek. 2011. T-cell tolerance and the multifunctional role of IL-2R signaling in T-regulatory cells. Immunol. Rev. 241:63-76. http://dx.doi.org/10.1111/j.1600-065X.2011.01004.x
    • (2011) Immunol. Rev , vol.241 , pp. 63-76
    • Cheng, G.1    Yu, A.2    Malek, T.R.3
  • 11
    • 84865627767 scopus 로고    scopus 로고
    • Differential effects of infliximab on absolute circulating blood leucocyte counts of innate immune cells in early and late rheumatoid arthritis patients
    • Coulthard, L.R., J. Geiler, R.J. Mathews, L.D. Church, L.J. Dickie, D.L. Cooper, C. Wong, S. Savic, D. Bryer, M.H. Buch, et al. 2012. Differential effects of infliximab on absolute circulating blood leucocyte counts of innate immune cells in early and late rheumatoid arthritis patients. Clin. Exp. Immunol. 170:36-46. http://dx.doi.org/10.1111/j.1365-2249.2012.04626.x
    • (2012) Clin. Exp. Immunol , vol.170 , pp. 36-46
    • Coulthard, L.R.1    Geiler, J.2    Mathews, R.J.3    Church, L.D.4    Dickie, L.J.5    Cooper, D.L.6    Wong, C.7    Savic, S.8    Bryer, D.9    Buch, M.H.10
  • 13
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy
    • Ehrenstein, M.R., J.G. Evans, A. Singh, S. Moore, G. Warnes, D.A. Isenberg, and C. Mauri. 2004. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy. J. Exp. Med. 200:277-285. http://dx.doi.org/10.1084/jem.20040165
    • (2004) J. Exp. Med , vol.200 , pp. 277-285
    • Ehrenstein, M.R.1    Evans, J.G.2    Singh, A.3    Moore, S.4    Warnes, G.5    Isenberg, D.A.6    Mauri, C.7
  • 14
    • 65549165389 scopus 로고    scopus 로고
    • In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses
    • Evans, H.G., N.J. Gullick, S. Kelly, C. Pitzalis, G.M. Lord, B.W. Kirkham, and L.S. Taams. 2009. In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses. Proc. Natl. Acad. Sci. USA. 106:6232-6237. http://dx.doi.org/10.1073/pnas.0808144106
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 6232-6237
    • Evans, H.G.1    Gullick, N.J.2    Kelly, S.3    Pitzalis, C.4    Lord, G.M.5    Kirkham, B.W.6    Taams, L.S.7
  • 15
    • 58049196774 scopus 로고    scopus 로고
    • Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis
    • Flores-Borja, F., E.C. Jury, C. Mauri, and M.R. Ehrenstein. 2008. Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA. 105:19396-19401. http://dx.doi.org/10.1073/pnas.0806855105
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 19396-19401
    • Flores-Borja, F.1    Jury, E.C.2    Mauri, C.3    Ehrenstein, M.R.4
  • 16
    • 18744438211 scopus 로고    scopus 로고
    • Detection of membrane-bound tumor necrosis factor (TNF): An analysis of TNF-specific reagents
    • Gerspach, J., A. Götz, G. Zimmermann, C. Kolle, H. Böttinger, and M. Grell. 2000. Detection of membrane-bound tumor necrosis factor (TNF): An analysis of TNF-specific reagents. Microsc. Res. Tech. 50:243-250. http://dx.doi.org/10.1002/1097-0029(20000801)50:3<243::AID-JEMT8>3.0.CO;2-B
    • (2000) Microsc. Res. Tech , vol.50 , pp. 243-250
    • Gerspach, J.1    Götz, A.2    Zimmermann, G.3    Kolle, C.4    Böttinger, H.5    Grell, M.6
  • 18
    • 77954232611 scopus 로고    scopus 로고
    • Transmembrane TNF-α: structure, function and interaction with anti-TNF agents
    • Horiuchi, T., H. Mitoma, S. Harashima, H. Tsukamoto, and T. Shimoda. 2010. Transmembrane TNF-α: structure, function and interaction with anti-TNF agents. Rheumatology (Oxford). 49:1215-1228. http://dx.doi.org/10.1093/rheumatology/keq031
    • (2010) Rheumatology (Oxford) , vol.49 , pp. 1215-1228
    • Horiuchi, T.1    Mitoma, H.2    Harashima, S.3    Tsukamoto, H.4    Shimoda, T.5
  • 19
    • 84884557784 scopus 로고    scopus 로고
    • Comparison of the inhibition mechanisms of adalimumab and infliximab in treating tumor necrosis factor α-associated diseases from a molecular view
    • Hu, S., S. Liang, H. Guo, D. Zhang, H. Li, X. Wang, W. Yang, W. Qian, S. Hou, H. Wang, et al. 2013. Comparison of the inhibition mechanisms of adalimumab and infliximab in treating tumor necrosis factor α-associated diseases from a molecular view. J. Biol. Chem. 288:27059-27067. http://dx.doi.org/10.1074/jbc.M113.491530
    • (2013) J. Biol. Chem , vol.288 , pp. 27059-27067
    • Hu, S.1    Liang, S.2    Guo, H.3    Zhang, D.4    Li, H.5    Wang, X.6    Yang, W.7    Qian, W.8    Hou, S.9    Wang, H.10
  • 20
    • 77956395771 scopus 로고    scopus 로고
    • Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells
    • Kleijwegt, F.S., S. Laban, G. Duinkerken, A.M. Joosten, A. Zaldumbide, T. Nikolic, and B.O. Roep. 2010. Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells. J. Immunol. 185:1412-1418. http://dx.doi.org/10.4049/jimmunol.1000560
    • (2010) J. Immunol , vol.185 , pp. 1412-1418
    • Kleijwegt, F.S.1    Laban, S.2    Duinkerken, G.3    Joosten, A.M.4    Zaldumbide, A.5    Nikolic, T.6    Roep, B.O.7
  • 21
    • 84899475568 scopus 로고    scopus 로고
    • Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells
    • Mahmud, S.A., L.S. Manlove, H.M. Schmitz, Y. Xing, Y. Wang, D.L. Owen, J.M. Schenkel, J.S. Boomer, J.M. Green, H. Yagita, et al. 2014. Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. Nat. Immunol. 15:473-481. http://dx.doi.org/10.1038/ni.2849
    • (2014) Nat. Immunol , vol.15 , pp. 473-481
    • Mahmud, S.A.1    Manlove, L.S.2    Schmitz, H.M.3    Xing, Y.4    Wang, Y.5    Owen, D.L.6    Schenkel, J.M.7    Boomer, J.S.8    Green, J.M.9    Yagita, H.10
  • 22
    • 84908365717 scopus 로고    scopus 로고
    • Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collageninduced arthritis
    • McCann, F.E., D.P. Perocheau, G. Ruspi, K. Blazek, M.L. Davies, M. Feldmann, J.L. Dean, A.A. Stoop, and R.O. Williams. 2014. Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collageninduced arthritis. Arthritis Rheumatol. 66:2728-2738. http://dx.doi.org/10.1002/art.38755
    • (2014) Arthritis Rheumatol , vol.66 , pp. 2728-2738
    • McCann, F.E.1    Perocheau, D.P.2    Ruspi, G.3    Blazek, K.4    Davies, M.L.5    Feldmann, M.6    Dean, J.L.7    Stoop, A.A.8    Williams, R.O.9
  • 23
    • 84869020571 scopus 로고    scopus 로고
    • reg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy
    • reg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy. Arthritis Rheum. 64:3129-3138. http://dx.doi.org/10.1002/art.34565
    • (2012) Arthritis Rheum , vol.64 , pp. 3129-3138
    • McGovern, J.L.1    Nguyen, D.X.2    Notley, C.A.3    Mauri, C.4    Isenberg, D.A.5    Ehrenstein, M.R.6
  • 24
    • 49049117606 scopus 로고    scopus 로고
    • + T cells: roles for TNF-α receptor signaling and chromatin structure
    • + T cells: roles for TNF-α receptor signaling and chromatin structure. J. Immunol. 181:1272-1281. http://dx.doi.org/10.4049/jimmunol.181.2.1272
    • (2008) J. Immunol , vol.181 , pp. 1272-1281
    • McKarns, S.C.1    Schwartz, R.H.2
  • 25
    • 69449088802 scopus 로고    scopus 로고
    • Outside-to-inside signaling through transmembrane tumor necrosis factor reverses pathologic interleukin-1β production and deficient apoptosis of rheumatoid arthritis monocytes
    • Meusch, U., M. Rossol, C. Baerwald, S. Hauschildt, and U. Wagner. 2009. Outside-to-inside signaling through transmembrane tumor necrosis factor reverses pathologic interleukin-1β production and deficient apoptosis of rheumatoid arthritis monocytes. Arthritis Rheum. 60:2612-2621. http://dx.doi.org/10.1002/art.24778
    • (2009) Arthritis Rheum , vol.60 , pp. 2612-2621
    • Meusch, U.1    Rossol, M.2    Baerwald, C.3    Hauschildt, S.4    Wagner, U.5
  • 26
    • 84941778190 scopus 로고    scopus 로고
    • Transmembrane TNFTNFR2 impairs Th17 differentiation by promoting Il2 expression
    • Miller, P.G., M.B. Bonn, and S.C. McKarns. 2015. Transmembrane TNFTNFR2 impairs Th17 differentiation by promoting Il2 expression. J. Immunol. 195:2633-2647. http://dx.doi.org/10.4049/jimmunol.1500286
    • (2015) J. Immunol , vol.195 , pp. 2633-2647
    • Miller, P.G.1    Bonn, M.B.2    McKarns, S.C.3
  • 29
    • 77951640552 scopus 로고    scopus 로고
    • TNF activates a NF-κB-regulated cellular program in human CD45RA-regulatory T cells that modulates their suppressive function
    • Nagar, M., J. Jacob-Hirsch, H. Vernitsky, Y. Berkun, S. Ben-Horin, N. Amariglio, I. Bank, Y. Kloog, G. Rechavi, and I. Goldstein. 2010. TNF activates a NF-κB-regulated cellular program in human CD45RA-regulatory T cells that modulates their suppressive function. J. Immunol. 184:3570-3581. http://dx.doi.org/10.4049/jimmunol.0902070
    • (2010) J. Immunol , vol.184 , pp. 3570-3581
    • Nagar, M.1    Jacob-Hirsch, J.2    Vernitsky, H.3    Berkun, Y.4    Ben-Horin, S.5    Amariglio, N.6    Bank, I.7    Kloog, Y.8    Rechavi, G.9    Goldstein, I.10
  • 30
    • 84875153425 scopus 로고    scopus 로고
    • Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis
    • Nie, H., Y. Zheng, R. Li, T.B. Guo, D. He, L. Fang, X. Liu, L. Xiao, X. Chen, B. Wan, et al. 2013. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis. Nat. Med. 19:322-328. http://dx.doi.org/10.1038/nm.3085
    • (2013) Nat. Med , vol.19 , pp. 322-328
    • Nie, H.1    Zheng, Y.2    Li, R.3    Guo, T.B.4    He, D.5    Fang, L.6    Liu, X.7    Xiao, L.8    Chen, X.9    Wan, B.10
  • 31
    • 84873129604 scopus 로고    scopus 로고
    • Comparative effectiveness of anti-TNF agents for Crohn's disease in a tertiary referral IBD practice
    • Patil, S.A., A. Rustgi, P. Langenberg, and R.K. Cross. 2013. Comparative effectiveness of anti-TNF agents for Crohn's disease in a tertiary referral IBD practice. Dig. Dis. Sci. 58:209-215. http://dx.doi.org/10.1007/s10620-012-2323-0
    • (2013) Dig. Dis. Sci , vol.58 , pp. 209-215
    • Patil, S.A.1    Rustgi, A.2    Langenberg, P.3    Cross, R.K.4
  • 32
    • 84879086432 scopus 로고    scopus 로고
    • Mechanisms of action of anti-tumor necrosis factor a agents in Crohn's disease
    • Peake, S.T., D. Bernardo, E.R. Mann, H.O. Al-Hassi, S.C. Knight, and A.L. Hart. 2013. Mechanisms of action of anti-tumor necrosis factor a agents in Crohn's disease. Inflamm. Bowel Dis. 19:1546-1555. http://dx.doi.org/10.1097/MIB.0b013e318281333b
    • (2013) Inflamm. Bowel Dis , vol.19 , pp. 1546-1555
    • Peake, S.T.1    Bernardo, D.2    Mann, E.R.3    Al-Hassi, H.O.4    Knight, S.C.5    Hart, A.L.6
  • 33
    • 0028815803 scopus 로고
    • Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis
    • Prevoo, M.L., M.A. Van'T Hof, H.H. Kuper, M.A. van Leeuwen, L.B. van de Putte, and P.L. van Riel. 1995. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 38:44-48. http://dx.doi.org/10.1002/art.1780380107
    • (1995) Arthritis Rheum , vol.38 , pp. 44-48
    • Prevoo, M.L.1    Van't Hof, M.A.2    Kuper, H.H.3    van Leeuwen, M.A.4    van de Putte, L.B.5    van Riel, P.L.6
  • 34
    • 77951234694 scopus 로고    scopus 로고
    • Membrane tumor necrosis factor (TNF) induces p100 processing via TNF receptor-2 (TNFR2)
    • Rauert, H., A. Wicovsky, N. Müller, D. Siegmund, V. Spindler, J. Waschke, C. Kneitz, and H. Wajant. 2010. Membrane tumor necrosis factor (TNF) induces p100 processing via TNF receptor-2 (TNFR2). J. Biol. Chem. 285:7394-7404. http://dx.doi.org/10.1074/jbc.M109.037341
    • (2010) J. Biol. Chem , vol.285 , pp. 7394-7404
    • Rauert, H.1    Wicovsky, A.2    Müller, N.3    Siegmund, D.4    Spindler, V.5    Waschke, J.6    Kneitz, C.7    Wajant, H.8
  • 35
    • 77954141914 scopus 로고    scopus 로고
    • FOXP3+ regulatory T cells in the human immune system
    • Sakaguchi, S., M. Miyara, C.M. Costantino, and D.A. Hafler. 2010. FOXP3+ regulatory T cells in the human immune system. Nat. Rev. Immunol. 10:490-500. http://dx.doi.org/10.1038/nri2785
    • (2010) Nat. Rev. Immunol , vol.10 , pp. 490-500
    • Sakaguchi, S.1    Miyara, M.2    Costantino, C.M.3    Hafler, D.A.4
  • 36
    • 35448930435 scopus 로고    scopus 로고
    • +FOXP3-T cells by T-cell receptor stimulation is transforming growth factor-β-dependent but does not confer a regulatory phenotype
    • +FOXP3-T cells by T-cell receptor stimulation is transforming growth factor-β-dependent but does not confer a regulatory phenotype. Blood. 110:2983-2990. http://dx.doi.org/10.1182/blood-2007-06-094656
    • (2007) Blood , vol.110 , pp. 2983-2990
    • Tran, D.Q.1    Ramsey, H.2    Shevach, E.M.3
  • 38
    • 4444300314 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid
    • van Amelsfort, J.M., K.M. Jacobs, J.W. Bijlsma, F.P. Lafeber, and L.S. Taams. 2004. CD4+CD25+ regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum. 50:2775-2785. http://dx.doi.org/10.1002/art.20499
    • (2004) Arthritis Rheum , vol.50 , pp. 2775-2785
    • van Amelsfort, J.M.1    Jacobs, K.M.2    Bijlsma, J.W.3    Lafeber, F.P.4    Taams, L.S.5
  • 39
    • 84928586624 scopus 로고    scopus 로고
    • Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes
    • Yu, A., I. Snowhite, F. Vendrame, M. Rosenzwajg, D. Klatzmann, A. Pugliese, and T.R. Malek. 2015. Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes. Diabetes. 64:2172-2183. http://dx.doi.org/10.2337/db14-1322
    • (2015) Diabetes , vol.64 , pp. 2172-2183
    • Yu, A.1    Snowhite, I.2    Vendrame, F.3    Rosenzwajg, M.4    Klatzmann, D.5    Pugliese, A.6    Malek, T.R.7


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