Loss of glyoxalase 1 induces compensatory mechanism to achieve dicarbonyl detoxification in mammalian Schwann cells

Journal of Biological Chemistry

Volumn 292, Issue 8, 2017, Pages 3224-3238

  Morgenstern, Jakob ^a   Fleming, Thomas ^a,b   Schumacher, Dagmar ^c   Eckstein, Volker ^a   Freichel, Marc ^c   Herzig, Stephan ^b,d   Nawroth, Peter ^a,b,d  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d German Institute for Diabetes and Cancer (IDC)   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DETOXIFICATION; ENZYME ACTIVITY; MAMMALS; NEURONS; PEPTIDES;

ADVANCED GLYCATION END PRODUCTS; ALDOSE REDUCTASE; CATALYTIC EFFICIENCIES; ELEVATED CONCENTRATIONS; PATHOLOGICAL CONDITIONS; PROTEIN MODIFICATIONS; REDUCED GLUTATHIONE; S-NITROSYLATION;

CYTOLOGY;

ACETAL DERIVATIVE; ALDEHYDE REDUCTASE; GLUTATHIONE; HEMITHIOACETAL; LACTALDEHYDE; LACTOYLGLUTATHIONE LYASE; METHYLGLYOXAL; UNCLASSIFIED DRUG; ADVANCED GLYCATION END PRODUCT;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRISPR CAS SYSTEM; DETOXIFICATION; ENZYME INHIBITION; MAMMAL CELL; NITROSYLATION; NONHUMAN; OXIDATIVE STRESS; PROTEIN MODIFICATION; REGULATORY MECHANISM; SCHWANN CELL; ANIMAL; CELL CULTURE; CYTOLOGY; GENE DELETION; GENE INACTIVATION; GENETICS; METABOLISM; MOUSE;

ALDEHYDE REDUCTASE; ANIMALS; CELLS, CULTURED; GENE DELETION; GENE KNOCKOUT TECHNIQUES; GLYCOSYLATION END PRODUCTS, ADVANCED; LACTOYLGLUTATHIONE LYASE; MICE; OXIDATIVE STRESS; PYRUVALDEHYDE; SCHWANN CELLS;

EID: 85013860741     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.760132     Document Type: Article

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