Quantitation of acetol in common pharmaceutical excipients using LC-MS

Journal of Pharmaceutical and Biomedical Analysis

Volumn 46, Issue 2, 2008, Pages 316-321

  Beilin, Eugene ^a   Baker, Lee J ^a   Culbert, Paul ^b   Toltl, Nicholas P ^a  

^a ELI LILLY AND COMPANY   (United States)

^b GL Chemtec International Limited   (Canada)

Author keywords

Acetol; Derivatization; Electrophilic impurities; Excipients; Pentafluorobenzylhydroxylamine hydrochloride

Indexed keywords

EXCIPIENT; GLYCEROL; HYDROXYACETONE; HYDROXYLAMINE; O (2,3,4,5,6 PENTAFLUOROBENZYL)HYDROXYLAMINE; PROPYLENE GLYCOL; REAGENT; UNCLASSIFIED DRUG;

ACCURACY; AQUEOUS SOLUTION; ARTICLE; DERIVATIZATION; ELECTROPHILIC IMPURITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; ROOM TEMPERATURE; VALIDATION PROCESS;

ACETONE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EXCIPIENTS; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 37749024423     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.10.022     Document Type: Article

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