Relationships between serotonergic and cannabinoid system in depressive-like behavior: A PET study with [11C]-DASB

Journal of Neurochemistry

Volumn 130, Issue 1, 2014, Pages 126-135

  Burokas, Aurelijus ^a   Martín García, Elena ^a   Gutiérrez Cuesta, Javier ^a   Rojas, Santiago ^b   Herance, José Raúl ^b   Gispert, Juan Domingo ^b   Serra, Miquel Ángel ^a   Maldonado, Rafael ^a  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b Barcelona Biomedical Research Park   (Spain)

Author keywords

chronic stress; DASB; depression; PET; serotonin transporter

Indexed keywords

CANNABINOID; CANNABINOID 1 RECEPTOR; CARBON 11; CARBON N,N DIMETHYL 2 (2 AMINO 4 CYANOPHENYLTHIO)BENZYLAMINE C 11; RADIOPHARMACEUTICAL AGENT; SEROTONIN; SEROTONIN TRANSPORTER; SUCROSE; UNCLASSIFIED DRUG; 3-AMINO-4-(2-DIMETHYLAMINOMETHYLPHENYLSULFANYL)BENZONITRILE; ANILINE DERIVATIVE; CARBON; SLC6A4 PROTEIN, MOUSE; SULFIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN LEVEL; CHRONIC STRESS; CONTROLLED STUDY; DEPRESSION; DISEASE ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; FOOD INTAKE; FORCED SWIM TEST; IMAGE ANALYSIS; IN VIVO STUDY; MALE; MOLECULAR DYNAMICS; MOLECULAR IMAGING; MOUSE; NEUROIMAGING; NEUROTRANSMISSION; NONHUMAN; PHENOTYPE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN DETERMINATION; QUANTITATIVE ANALYSIS; SEROTONINERGIC SYSTEM; TAIL SUSPENSION TEST; VISUAL MEMORY; WILD TYPE; ANIMAL; BRAIN; DEFICIENCY; DIAGNOSTIC USE; KNOCKOUT MOUSE; MENTAL STRESS; METABOLISM; PHYSIOLOGY; PROCEDURES; PSYCHOLOGY; SCINTISCANNING;

ANILINE COMPOUNDS; ANIMALS; BRAIN; CARBON RADIOISOTOPES; DEPRESSION; MALE; MICE; MICE, KNOCKOUT; POSITRON-EMISSION TOMOGRAPHY; RECEPTOR, CANNABINOID, CB1; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRESS, PSYCHOLOGICAL; SULFIDES;

EID: 84902979398     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12716     Document Type: Article

References (53)

1. Antunes M., and, Biala G., (2012) The novel object recognition memory: neurobiology, test procedure, and its modifications. Cogn. Process. 13, 93-110.
2. Armario A., Valles A., Dal-Zotto S., Marquez C., and, Belda X., (2004) A single exposure to severe stressors causes long-term desensitisation of the physiological response to the homotypic stressor. Stress 7, 157-172. (Pubitemid 39540290)
3. Aso E., Ozaita A., Valdizan E. M., Ledent C., Pazos A., Maldonado R., and, Valverde O., (2008) BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout mice. J. Neurochem. 105, 565-572. (Pubitemid 351490016)
4. Aso E., Renoir T., Mengod G., Ledent C., Hamon M., Maldonado R., Lanfumey L., and, Valverde O., (2009) Lack of CB1 receptor activity impairs serotonergic negative feedback. J. Neurochem. 109, 935-944.
5. Barna I., Zelena D., Arszovszki A. C., and, Ledent C., (2004) The role of endogenous cannabinoids in the hypothalamo-pituitary-adrenal axis regulation: in vivo and in vitro studies in CB1 receptor knockout mice. Life Sci. 75, 2959-2970. (Pubitemid 39349260)
6. Becker C., Zeau B., Rivat C., Blugeot A., Hamon M., and, Benoliel J. J., (2008) Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin. Mol. Psychiatry 13, 1079-1092.
7. Bura S. A., Burokas A., Martin-Garcia E., and, Maldonado R., (2010) Effects of chronic nicotine on food intake and anxiety-like behaviour in CB(1) knockout mice. Eur. Neuropsychopharmacol. 20, 369-378.
8. Caspi A., and, Moffitt T. E., (2006) Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat. Rev. Neurosci. 7, 583-590. (Pubitemid 43995433)
9. Clarke J. R., Rossato J. I., Monteiro S., Bevilaqua L. R., Izquierdo I., and, Cammarota M., (2008) Posttraining activation of CB1 cannabinoid receptors in the CA1 region of the dorsal hippocampus impairs object recognition long-term memory. Neurobiol. Learn. Mem. 90, 374-381.
10. Conrad C. D., (2010) A critical review of chronic stress effects on spatial learning and memory. Prog. Neuropsychopharmacol. Biol. Psychiatry 34, 742-755.
11. Cota D., Marsicano G., Tschop M., et al,. (2003) The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J. Clin. Investig. 112, 423-431. (Pubitemid 38063771)
12. Cota D., Steiner M. A., Marsicano G., et al,. (2007) Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic-pituitary- adrenal axis function. Endocrinology 148, 1574-1581. (Pubitemid 46457104)
13. Crosby K. M., and, Bains J. S., (2012) The intricate link between glucocorticoids and endocannabinoids at stress-relevant synapses in the hypothalamus. Neuroscience 204, 31-37.
14. Di S., Malcher-Lopes R., Halmos K. C., and, Tasker J. G., (2003) Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism. J. Neurosci. 23, 4850-4857. (Pubitemid 36793211)
15. Dubreucq S., Matias I., Cardinal P., Haring M., Lutz B., Marsicano G., and, Chaouloff F., (2012) Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice. Neuropsychopharmacology 37, 1885-1900.
16. Haenisch B., and, Bonisch H., (2011) Depression and antidepressants: insights from knockout of dopamine, serotonin or noradrenaline re-uptake transporters. Pharmacol. Ther. 129, 352-368.
17. Haenisch B., Bilkei-Gorzo A., Caron M. G., and, Bonisch H., (2009) Knockout of the norepinephrine transporter and pharmacologically diverse antidepressants prevent behavioral and brain neurotrophin alterations in two chronic stress models of depression. J. Neurochem. 111, 403-416.
18. Hamer D., (2002) Genetics. Rethinking behavior genetics. Science 298, 71-72.
19. Hariri A. R., Mattay V. S., Tessitore A., Kolachana B., Fera F., Goldman D., Egan M. F., and, Weinberger D. R., (2002) Serotonin transporter genetic variation and the response of the human amygdala. Science 19 (297), 400-403. (Pubitemid 34790769)
20. Heninger G. R., Delgado P. L., and, Charney D. S., (1996) The revised monoamine theory of depression: a modulatory role for monoamines, based on new findings from monoamine depletion experiments in humans. Pharmacopsychiatry 29, 2-11. (Pubitemid 26071332)
21. Hill M. N., and, Gorzalka B. B., (2005) Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test. Eur. Neuropsychopharmacol. 15, 593-599. (Pubitemid 41587409)
22. Hill M. N., Patel S., Carrier E. J., Rademacher D. J., Ormerod B. K., Hillard C. J., and, Gorzalka B. B., (2005) Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress. Neuropsychopharmacology 30, 508-515. (Pubitemid 40271153)
23. Hill M. N., Carrier E. J., McLaughlin R. J., Morrish A. C., Meier S. E., Hillard C. J., and, Gorzalka B. B., (2008) Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment. J. Neurochem. 106, 2322-2336.
24. Hill M. N., Hunter R. G., and, McEwen B. S., (2009) Chronic stress differentially regulates cannabinoid CB1 receptor binding in distinct hippocampal subfields. Eur. J. Pharmacol. 614, 66-69.
25. Hoekzema E., Rojas S., Herance R., et al,. (2011) [(11)C]-DASB MicroPET imaging in the aged rat: frontal and meso-thalamic increases in serotonin transporter binding. Exp. Gerontol. 46, 1020-1025.
26. Kalueff A. V., Olivier J. D., Nonkes L. J., and, Homberg J. R., (2010) Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes. Neurosci. Biobehav. Rev. 34, 373-386.
27. Katz R. J., (1981) Animal models and human depressive disorders. Neurosci. Biobehav. Rev. 5, 231-246. (Pubitemid 11074537)
28. Keller M. B., (1999) The long-term treatment of depression. J. Clin. Psychiatry 60 Suppl 17, 41-45; discussion 46-8.:41-45. (Pubitemid 29386040)
29. Kendler K. S., Kessler R. C., Walters E. E., MacLean C., Neale M. C., Heath A. C., and, Eaves L. J., (1995) Stressful life events, genetic liability, and onset of an episode of major depression in women. Am. J. Psychiatry 152, 833-842.
30. Kleen J. K., Sitomer M. T., Killeen P. R., and, Conrad C. D., (2006) Chronic stress impairs spatial memory and motivation for reward without disrupting motor ability and motivation to explore. Behav. Neurosci. 120, 842-851. (Pubitemid 44249965)
31. de Kloet E. R., Joels M., and, Holsboer F., (2005) Stress and the brain: from adaptation to disease. Nat. Rev. Neurosci. 6, 463-475. (Pubitemid 40769171)
32. Krishnan V., Han M. H., Graham D. L., et al,. (2007) Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131, 391-404. (Pubitemid 47576141)
33. Ledent C., Valverde O., Cossu G., et al,. (1999) Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science 283, 401-404.
34. Lesch K. P., and, Mossner R., (2006) Inactivation of 5HT transport in mice: modeling altered 5HT homeostasis implicated in emotional dysfunction, affective disorders, and somatic syndromes. Handb. Exp. Pharmacol. 175, 417-456.
35. Maldonado R., Valverde O., and, Berrendero F., (2006) Involvement of the endocannabinoid system in drug addiction. Trends Neurosci. 29, 225-232.
36. Marsicano G., Moosmann B., Hermann H., Lutz B., and, Behl C., (2002) Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1. J. Neurochem. 80, 448-456. (Pubitemid 36383028)
37. Martin M., Ledent C., Parmentier M., Maldonado R., and, Valverde O., (2002) Involvement of CB1 cannabinoid receptors in emotional behaviour. Psychopharmacology 159, 379-387. (Pubitemid 34143362)
38. Massart R., Mongeau R., and, Lanfumey L., (2012) Beyond the monoaminergic hypothesis: neuroplasticity and epigenetic changes in a transgenic mouse model of depression. Philos. Trans. R. Soc. Lond. B Biol. Sci. 367, 2485-2494.
39. Mato S., Aso E., Castro E., Martin M., Valverde O., Maldonado R., and, Pazos A., (2007) CB1 knockout mice display impaired functionality of 5-HT1A and 5-HT2A/C receptors. J. Neurochem. 103, 2111-2120. (Pubitemid 350126641)
40. McEwen B. S., (2006) Protective and damaging effects of stress mediators: central role of the brain. Dialogues Clin. Neurosci. 8, 367-381. (Pubitemid 46102239)
41. Meyer J. H., Wilson A. A., Ginovart N., Goulding V., Hussey D., Hood K., and, Houle S., (2001) Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [(11)C]DASB PET imaging study. Am. J. Psychiatry 158, 1843-1849. (Pubitemid 33054777)
42. Moreira F. A., and, Lutz B., (2008) The endocannabinoid system: emotion, learning and addiction. Addict. Biol. 13, 196-212. (Pubitemid 351698889)
43. Pariante C. M., (2003) Depression, stress and the adrenal axis. J. Neuroendocrinol. 15, 811-812. (Pubitemid 36874378)
44. Porsolt R. D., Le Pichon M., and, Jalfre M., (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266, 730-732. (Pubitemid 8073804)
45. Puighermanal E., Marsicano G., Busquets-Garcia A., Lutz B., Maldonado R., and, Ozaita A., (2009) Cannabinoid modulation of hippocampal long-term memory is mediated by MTOR signaling. Nat. Neurosci. 12, 1152-1158.
46. Sanchis-Segura C., Cline B. H., Marsicano G., Lutz B., and, Spanagel R., (2004) Reduced sensitivity to reward in CB1 knockout mice. Psychopharmacology 176, 223-232. (Pubitemid 39517952)
47. Scharinger C., Rabl U., Sitte H. H., and, Pezawas L., (2010) Imaging genetics of mood disorders. Neuroimage 53, 810-821.
48. Steru L., Chermat R., Thierry B., and, Simon P., (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 85, 367-370. (Pubitemid 15123115)
49. Tai Y. C., Ruangma A., Rowland D., Siegel S., Newport D. F., Chow P. L., and, Laforest R., (2005) Performance evaluation of the microPET focus: a third-generation micropet scanner dedicated to animal imaging. J. Nucl. Med. 46, 455-463. (Pubitemid 43093155)
50. Tzavara E. T., Davis R. J., Perry K. W., Li X., Salhoff C., Bymaster F. P., Witkin J. M., and, Nomikos G. G., (2003) The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications 'for therapeutic actions. Br. J. Pharmacol. 138, 544-553. (Pubitemid 36315302)
51. Uchida S., Hara K., Kobayashi A., Otsuki K., Hobara T., Yamagata H., and, Watanabe Y., (2010) Maternal and genetic factors in stress-resilient and -vulnerable rats: a cross-fostering study. Brain Res. 1316, 43-50.
52. Whittington R. A., and, Virág L., (2006) Isoflurane decreases extracellular serotonin in the mouse hippocampus. Anesth. Analg. 103, 92-98. (Pubitemid 44036039)
53. Willner P., Scheel-Krüger J., and, Belzung C., (2013) The neurobiology of depression and antidepressant action. Neurosci. Biobehav. Rev. 37, 2331-2371.