Infant formula with galacto-oligosaccharides (OM55N) stimulates the growth of indigenous bifidobacteria in healthy term infants

Beneficial Microbes

Volumn 7, Issue 4, 2016, Pages 453-461

  Matsuki, T ^a   Tajima, S ^a   Hara, T ^a   Yahagi, K ^a   Ogawa, E ^b   Kodama, H ^b  

^a YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

^b TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

16S rRNA gene amplicon; Bifidobacteriaceae; Galacto oligosaccharides; Infant formula; Oligomate 55N (OM55N)

Indexed keywords

CARBOHYDRATE; CARBOXYLIC ACID; DOCOSAHEXAENOIC ACID; FAT; GALACTOSE OLIGOSACCHARIDE; INOSITOL; LACTOFERRIN; LACTOSE; LINOLEIC ACID; MALTODEXTRIN; NUCLEOTIDE; PROTEIN; BACTERIAL RNA; GALACTOSE; OLIGOSACCHARIDE; RNA 16S;

ACIDAMINOCOCCACEAE; ARTICLE; ARTIFICIAL MILK; BACTERIAL GROWTH; BACTEROIDACEAE; BIFIDOBACTERIACEAE; BREAST FEEDING; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENTEROBACTERIACEAE; ENTEROCOCCACEAE; FECES ANALYSIS; FEMALE; HUMAN; HUMAN EXPERIMENT; INFANT; INTESTINE FLORA; MALE; MICROBIAL DIVERSITY; MICROFLORA; NORMAL HUMAN; PH; PHYLOGENY; RANDOMIZED CONTROLLED TRIAL; STAPHYLOCOCCACEAE; STREPTOCOCCACEAE; BIFIDOBACTERIUM; CHEMISTRY; DIETARY SUPPLEMENT; GENETICS; GROWTH, DEVELOPMENT AND AGING;

BIFIDOBACTERIUM; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; GALACTOSE; HUMANS; INFANT; INFANT FORMULA; MALE; MICROBIOTA; OLIGOSACCHARIDES; RNA, BACTERIAL; RNA, RIBOSOMAL, 16S;

EID: 84988849392     PISSN: 18762883     EISSN: 18762891     Source Type: Journal    
DOI: 10.3920/BM2015.0168     Document Type: Article

References (34)

1. Ben, X.M., Li, J., Feng, Z.T., Shi, S.Y., Lu, Y.D., Chen, R. and Zhou, X.Y., 2008. Low level of galacto-oligosaccharide in infant formula stimulates growth of intestinal bifidobacteria and lactobacilli. World Journal of Gastroenterology 14: 6564-6568.
2. Benno, Y., Sawada, K. and Mitsuoka, T., 1984. The intestinal microflora of infants: composition of fecal flora in breast-fed and bottle-fed infants. Microbiology and Immunology 28: 975-986.
3. Caporaso, J.G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F.D., Costello, E.K., Fierer, N., Pena, A.G., Goodrich, J.K., Gordon, J.I., Huttley, G.A., Kelley, S.T., Knights, D., Koenig, J.E., Ley, R.E., Lozupone, C.A., McDonald, D., Muegge, B.D., Pirrung, M., Reeder, J., Sevinsky, J.R., Turnbaugh, P.J., Walters, W.A., Widmann, J., Yatsunenko, T., Zaneveld, J. and Knight, R., 2010. QIIME allows analysis of high-throughput community sequencing data. Nature Methods 7: 335-336.
4. Castanys-Munoz, E., Martin, M.J. and Prieto, P.A., 2013. 2'-fucosyllactose: an abundant, genetically determined soluble glycan present in human milk. Nutrition Reviews 71: 773-789.
5. Edgar, R.C., 2004. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Research 32: 1792-1797.
6. Edgar, R.C., 2010. Search and clustering orders of magnitude faster than BLAST. Bioinformatics 26: 2460-2461.
7. Edgar, R.C., Haas, B.J., Clemente, J.C., Quince, C. and Knight, R., 2011. UCHIME improves sensitivity and speed of chimera detection. Bioinformatics 27: 2194-2200.
8. Harmsen, H.J., Wildeboer-Veloo, A.C., Raangs, G.C., Wagendorp, A.A., Klijn, N., Bindels, J.G. and Welling, G.W., 2000. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. Journal of Pediatric Gastroenterology and Nutrition 30: 61-67.
9. Kaneko, K., Watanabe, Y., Kimura, K., Matsumoto, K., Mizobuchi, T. and Onoue, M., 2014. Development of hypoallergenic galactooligosaccharides on the basis of allergen analysis. Bioscience Biotechnology and Biochemistry 78: 100-108.
10. Knol, J., Scholtens, P., Kafka, C., Steenbakkers, J., Gro, S., Helm, K., Klarczyk, M., Schopfer, H., Bockler, H.M. and Wells, J., 2005. Colon microflora in infants fed formula with galacto-and fructooligosaccharides: more like breast-fed infants. Journal of Pediatric Gastroenterology and Nutrition 40: 36-42.
11. Kobayash, T., Ishida, S., Kaneko, K. and Onoue, M., 2013. A 6-week oral gavage toxicity study of a novel galacto-oligosaccharide in juvenile rats. Human and Experimental Toxicology 33: 722-728.
12. Kobayashi, T., Takano, M., Kaneko, K. and Onoue, M., 2013. A onegeneration reproduction toxicity study in rats treated orally with a novel galacto-oligosaccharide. Human and Experimental Toxicology 33: 814-821.
13. Kobayashi, T., Yasutake, N., Uchida, K., Ohyama, W., Kaneko, K. and Onoue, M., 2009. Safety of a novel galacto-oligosaccharide: Genotoxicity and repeated oral dose studies. Human and Experimental Toxicology 28: 619-630.
14. Lane, D.J., 1991. 16S/23S rRNA sequencing. In: E. Stackebrandt and M. Goodfellow (eds.), Nucleic acid techniques in bacterial systematics. John Wiley&Sons Ltd., New York, NY, USA, pp. 115-147.
15. Marchesi, J.R., Sato, T., Weightman, A.J., Martin, T.A., Fry, J.C., Hiom, S.J., Dymock, D. and Wade, W.G., 1998. Design and evaluation of useful bacterium-specific PCR primers that amplify genes coding for bacterial 16S rRNA. Applied and Environmental Microbiology 64: 795-799.
16. Matsuda, K., Tsuji, H., Asahara, T., Kado, Y. and Nomoto, K., 2007. Sensitive quantitative detection of commensal bacteria by rRNAtargeted reverse transcription-PCR. Applied and Environmental Microbiology 73: 32-39.
17. Matsuki, T., 2007. Development of quantitative PCR detection method with 16S rRNA gene-targeted genus-and species-specific primers for the analysis of human intestinal microflora and its application. Japanese Journal of Bacteriology 62: 255-261.
18. Matsuki, T., Watanabe, K., Fujimoto, J., Takada, T. and Tanaka, R., 2004. Use of 16S rRNA gene-targeted group-specific primers for real-time PCR analysis of predominant bacteria in human feces. Applied and Environmental Microbiology 70: 7220-7228.
19. Matsumoto, K., Takada, T., Shimizu, K., Moriyama, K., Kawakami, K., Hirano, K., Kajimoto, O. and Nomoto, K., 2006. Effects of a probiotic fermented milk beverage containing Lactobacillus casei strain Shirota on defecation frequency, intestinal microbiota, and the intestinal environment of healthy individuals with soft stools. Journal of Bioscience and Bioengineering 110: 547-552.
20. Matsumoto, K., Takada, T., Yuki, N., Kawakami, K., Sakai, T., Nomoto, K., Kimura, K., Matsumoto, K. and Iino, H., 2004. Effects of transgalactosylated oligosaccharides mixture (N-GOS) on human intestinal microflora. Journal of Intestinal Microbiology 18: 25-35.
21. Moro, G., Minoli, I., Mosca, M., Fanaro, S., Jelinek, J., Stahl, B. and Boehm, G., 2002. Dosage-related bifidogenic effects of galacto-and fructooligosaccharides in formula-fed term infants. Journal of Pediatric Gastroenterology and Nutrition 34: 291-295.
22. Palmer, C., Bik, E.M., DiGiulio, D.B., Relman, D.A. and Brown, P.O., 2007. Development of the human infant intestinal microbiota. PLoS Biology 5: e177.
23. Penders, J., Thijs, C., Vink, C., Stelma, F.F., Snijders, B., Kummeling, I., van den Brandt, P.A. and Stobberingh, E.E., 2006. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics 118: 511-521.
24. Price, M.N., Dehal, P.S. and Arkin, A.P., 2009. FastTree: computing large minimum evolution trees with profiles instead of a distance matrix. Molecular Biology and Evolution 26: 1641-1650.
25. R Core Team, 2014. A language and environment for statistical computing. R Foundation for Statistical Computing. Available at: http://www.R-project.org/.
26. Rinttila, T., Kassinen, A., Malinen, E., Krogius, L. and Palva, A., 2004. Development of an extensive set of 16S rDNA-targeted primers for quantification of pathogenic and indigenous bacteria in faecal samples by real-time PCR. Journal of Applied Microbiology 97: 1166-1177.
27. Scholtens, P.A., Alles, M.S., Bindels, J.G., van der Linde, E.G., Tolboom, J.J. and Knol, J., 2006. Bifidogenic effects of solid weaning foods with added prebiotic oligosaccharides: a randomised controlled clinical trial. Journal of Pediatric Gastroenterology and Nutrition 42: 553-559.
28. Sela, D.A. and Mills, D.A., 2010. Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides. Trends in Microbiology 18: 298-307.
29. Sierra, C., Bernal, M.J., Blasco, J., Martinez, R., Dalmau, J., Ortuno, I., Espin, B., Vasallo, M.I., Gil, D., Vidal, M.L., Infante, D., Leis, R., Maldonado, J., Moreno, J.M. and Roman, E., 2015. Prebiotic effect during the first year of life in healthy infants fed formula containing GOS as the only prebiotic: a multicentre, randomised, double-blind and placebo-controlled trial. European Journal of Nutrition 54: 89-99.
30. Stark, P.L. and Lee, A., 1982. The microbial ecology of the large bowel of breast-fed and formula-fed infants during the first year of life. Journal of Medical Microbiology 15: 189-203.
31. Sumiyoshi, W., Urashima, T., Nakamura, T., Arai, I., Nagasawa, T., Saito, T., Tsumura, N., Wang, B., Brand-Miller, J., Watanabe, Y. and Kimura, K., 2004. Galactosyllactoses in the milk of japanese women: changes in concentration during the course of lactation. Journal of Applied Glycoscience 51: 341-344.
32. Tsuji, H., Oozeer, R., Matsuda, K., Matsuki, T., Ohta, T., Nomoto, K., Tanaka, R., Kawashima, M., Kawashima, K., Nagata, S. and Yamashiro, Y., 2012. Molecular monitoring of the development of intestinal microbiota in Japanese infants. Beneficial Microbes 3: 113-125.
33. Wada, J., Ando, T., Kiyohara, M., Ashida, H., Kitaoka, M., Yamaguchi, M., Kumagai, H., Katayama, T. and Yamamoto, K., 2008. Bifidobacterium bifidum lacto-N-biosidase, a critical enzyme for the degradation of human milk oligosaccharides with a type 1 structure. Applied and Environmental Microbiology 74: 3996-4004.
34. Wang, Q., Garrity, G.M., Tiedje, J.M. and Cole, J.R., 2007. Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Applied and Environmental Microbiology 73: 5261-5267.