Bifidobacterium longum 1714 as a translational psychobiotic: Modulation of stress, electrophysiology and neurocognition in healthy volunteers

Translational Psychiatry

Volumn 6, Issue 11, 2016, Pages

  Allen, A P ^a,b   Hutch, W ^b   Borre, Y E ^a   Kennedy, P J ^a,b   Temko, A ^b   Boylan, G ^b   Murphy, E ^c   Cryan, J F ^a,b   Dinan, T G ^a,b   Clarke, G ^a,b  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c ALIMENTARY HEALTH LTD   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE; PLACEBO; PROBIOTIC AGENT;

ACUTE STRESS; ADULT; ANXIETY; ARTICLE; BIFIDOBACTERIUM LONGUM; BRAIN FUNCTION; COGNITION; COLD PRESSOR TEST; ELECTROENCEPHALOGRAPHY; ELECTROPHYSIOLOGY; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; INTESTINE; MALE; MEMORY; NEUROCOGNITION; NONHUMAN; NORMAL HUMAN; PAIRED ASSOCIATE LEARNING; SATISFACTION; SOCIAL COGNITION; ACUTE STRESS DISORDER; AROUSAL; BLOOD; BRAIN; CASE CONTROL STUDY; COGNITIVE DEFECT; COLD; COMPLICATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECTS; FEMALE; MENTAL STRESS; NEUROPSYCHOLOGICAL TEST; PSYCHOLOGY; PSYCHOMETRY; RECALL; STATISTICS AND NUMERICAL DATA; TRANSLATIONAL RESEARCH;

ADULT; AROUSAL; BIFIDOBACTERIUM LONGUM; BRAIN; CASE-CONTROL STUDIES; COGNITION DISORDERS; COLD TEMPERATURE; ELECTROENCEPHALOGRAPHY; FEMALE; HIPPOCAMPUS; HUMANS; HYDROCORTISONE; MALE; MENTAL RECALL; NEUROPSYCHOLOGICAL TESTS; PROBIOTICS; PSYCHOMETRICS; STRESS DISORDERS, TRAUMATIC, ACUTE; STRESS, PSYCHOLOGICAL; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84994275309     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2016.191     Document Type: Article

References (53)

1. Dinan TG, Stanton C, Cryan JF. Psychobiotics: a novel class of psychotropic. Biol Psychiatry. 2013; 74: 720-726
2. Cryan JF, Dinan TG. Mind-Altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 2012; 13: 701-712
3. Dinan TG, Stilling RM, Stanton C, Cryan JF. Collective unconscious: How gut microbes shape human behavior. J Psychiatr Res 2015; 63: 1-9
4. Desbonnet L, Garrett L, Clarke G, Kiely B, Cryan JF, Dinan TG. Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience 2010; 170: 1179-1188
5. Messaoudi M, Lalonde R, Violle N, Javelot H, Desor D, Nejdi A, et al. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr 2011; 105: 755-764
6. Bercik P, Denou E, Collins J, Jackson W, Lu J, Jury J, et al. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology 2011; 141: 599-609.e3
7. Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci USA 2011; 108: 16050-16055
8. Whorwell PJ, Altringer L, Morel J, Bond Y, Charbonneau D, O'Mahony L, et al. Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome. Am J Gastroenterol 2006; 101: 1581-1590
9. O'Mahony L, McCarthy J, Kelly P, Hurley G, Luo F, Chen K, et al. Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles. Gastroenterology 2005; 128: 541-551
10. Whitehead WE, Palsson O, Jones KR. Systematic review of the comorbidity of irritable bowel syndrome with other disorders: What are the causes and implications?. Gastroenterology 2002; 122: 1140-1156
11. Kennedy PJ, Cryan JF, Quigley EMM, Dinan TG, Clarke G A sustained hypothalamic-pituitary-Adrenal axis response to acute psychosocial stress in irritable bowel syndrome. Psychol Med 2014 44 3123-3134
12. Kennedy PJ, Allen AP, O'Neill A, Quigley EM, Cryan JF, Dinan TG, et al. Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome. Psychopharmacology (Berl) 2015; 232: 1357-1371
13. Kennedy PJ, Clarke G, O?Neill A, Groeger JA, Quigley EMM, Shanahan F, et al. Cognitive performance in irritable bowel syndrome: evidence of a stress-related impairment in visuospatial memory. Psychol Med 2014; 44: 1553-1566
14. Benton D, Williams C, Brown A. Impact of consuming a milk drink containing a probiotic on mood and cognition. Eur J Clin Nutr 2007; 61: 355-361
15. Tillisch K, Labus J, Kilpatrick L, Jiang Z, Stains J, Ebrat B, et al. Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology 2013; 144: 1394-401.e4
16. Schmidt K, Cowen PJ, Harmer CJ, Tzortzis G, Errington S, Burnet PWJ. Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Psychopharmacology (Berl) 2014; 232: 1793-1801
17. Steenbergen L, Sellaro R, van Hemert S, Bosch JA, Colzato LS A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain Behav Immun 2015 48 258-264
18. Chung Y-C, Jin H-M, Cui Y, Kim DS, Jung JM, Park J-I, et al. Fermented milk of Lactobacillus helveticus IDCC3801 improves cognitive functioning during cognitive fatigue tests in healthy older adults. J Func Foods 2014; 10: 465-474
19. Savignac HM, Kiely B, Dinan TG, Cryan JF. Bifidobacteria exert strain-specific effects on stress-related behavior and physiology in BALB/c mice. Neurogastroenterol Motil 2014; 26: 1615-1627
20. Savignac HM, Tramullas M, Kiely B, Dinan TG, Cryan JF. Bifidobacteria modulate cognitive processes in an anxious mouse strain. Behav Brain Res 2015; 287: 59-72
21. Schwabe L, Haddad L, Schachinger H. HPA axis activation by a socially evaluated cold-pressor test. Psychoneuroendocrinology 2008; 33: 890-895
22. Schwabe L, Wolf OT. Socially evaluated cold pressor stress after instrumental learning favors habits over goal-directed action. Psychoneuroendocrinology 2010; 35: 977-986
23. Hales JB, Israel SL, Swann NC, Brewer JB. Dissociation of frontal and medial temporal lobe activity in maintenance and binding of sequentially presented paired associates. J Cogn Neurosci 2009; 21: 1244-1254
24. Coull JT, Frith CD, Frackowiak RSJ, Grasby PM A fronto-parietal network for rapid visual information processing: a PET study of sustained attention and working memory. Neuropsychologia 1996 34 1085-1095
25. Fukami G, Hashimoto T, Shirayama Y, Hasegawa T, Watanabe H, Fujisaki M, et al. Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects. Ann Gen Psychiatry 2010; 9: 37
26. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998; 59: 22-33
27. Faul F, Erdfelder E, Lang AG, Buchner A G∗Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007 39 175-191
28. Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav 1983; 24: 385-396
29. Schmitz LPTC. LimeSurvey: an Open Source Survey Tool. Limesurvey Project: Hamburg, Germany, 2015
30. Robbins TW, Sahakian B. Computer methods of assessment of cognitive function. In Copeland JRM, Abou-Saleh MT, Blazer DG (eds). Principles and Practice of Geriatric Psychiatry. John Wiley & Sons Ltd: Chichester, UK, 1994 pp 205-209
31. de Rover M, Pironti VA, McCabe JA, Acosta-Cabronero J, Arana FS, Morein-Zamir S, et al. Hippocampal dysfunction in patients with mild cognitive impairment: a functional neuroimaging study of a visuospatial paired associates learning task. Neuropsychologia 2011; 49: 2060-2070
32. Allen AP, Jacob TJC, Smith AP. Effects and after-effects of chewing gum on vigilance, heart rate, EEG and mood. Physiol Behav 2014; 133: 244-251
33. Strauss E, Sherman EMS, Spreen O. A Compendium of Neuropsychological Tests: Administration, Norms, & Commentary. 3rd edn, Oxford University Press: New York, USA, 2006
34. Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 2000; 4: 215-222
35. Etkin A, Egner T, Peraza DM, Kandel ER, Hirsch J. Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron 2006; 51: 871-882
36. Larsen RJ, Mercer KA, Balota DA, Strube MJ. Not all negative words slow down lexical decision and naming speed: Importance of word arousal. Emotion 2008; 8: 445-452
37. Romano-Torres M, Borja-Lascurain E, Chao-Rebolledo C, del-Rio-Portilla Y, Corsi- Cabrera M. Effect of diazepam on EEG power and coherent activity: sex differences. Psychoneuroendocrinology 2002; 27: 821-833
38. Gudmundsson S, Runarsson TP, Sigurdsson S, Eiriksdottir G, Johnsen K. Reliability of quantitative EEG features. Clin Neurophysiol 2007; 118: 2162-2171
39. Minkley N, Schröder TP, Wolf OT, Kirchner WH. The socially evaluated cold-pressor test (SECPT) for groups: Effects of repeated administration of a combined physiological and psychological stressor. Psychoneuroendocrinology 2014; 45: 119-127
40. Spielberger CD, Gorsuch RL, Lushene RE. The State-Trait Anxiety Inventory. Consulting Psychology Press: Palo Alto, CA, USA, 1970
41. Barbanoj MJ, Anderer P, Antonijoan RM, Torrent J, Saletu B, Jané F. Topographic pharmaco-EEG mapping of increasing doses of buspirone and its comparison with diazepam. Hum Psychopharmacol 1994; 9: 101-109
42. Hjorth B. EEG analysis based on time domain properties. Electroencephalogr Clin Neurophysiol 1970; 29: 306-310
43. Pruessner JC, Kirschbaum C, Meinlschmid G, Hellhammer DH. Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology 2003; 28: 916-931
44. Asada H, Fukuda Y, Tsunoda S, Yamaguchi M, Tonoike M. Frontal midline theta rhythms reflect alternative activation of prefrontal cortex and anterior cingulate cortex in humans. Neurosci Lett 1999; 274: 29-32
45. Martin-Loeches M, Garcia-Trapero J, Gil P, Rubia FJ. Topography of mobility and complexity parameters of the EEG in Alzheimer's disease. Biol Psychiatry 1991; 30: 1111-1121
46. Sperling RA, Dickerson BC, Pihlajamaki M, Vannini P, LaViolette PS, Vitolo OV, et al. Functional alterations in memory networks in early Alzheimer?s disease. Neuromolecular Med 2010; 12: 27-43
47. Klimesch W. EEG alpha and theta oscillations reflect cognitive and memory performance: A review and analysis. Brain Res Rev 1999; 29: 169-195
48. Eichenbaum H, Bunsey M. On the binding of associations in memory: clues from studies on the role of the hippocampal region in paired-Associate learning. Curr Direct Psychol Sci 1995; 4: 19-23
49. McEwen BS. Stress and the aging hippocampus. Front Neuroendocrinol 1999; 20: 49-70
50. Bercik P, Verdu EF, Foster JA, Macri J, Potter M, Huang X, et al. Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice. Gastroenterology 2010; 139: 2102-12.e1
51. O'Sullivan E, Barrett E, Grenham S, Fitzgerald P, Stanton C, Ross R, et al. BDNF expression in the hippocampus of maternally separated rats: does Bifidobacterium breve 6330 alter BDNF levels?. Benef Microbes 2011; 2: 199-207
52. Beck AT, Steer RA, Brown GK. Manual for the Beck Depression Inventory-II. Psychological Corporation: San Antonio, USA, 1996
53. Nelson H, Willison J. National adult reading test (NART): test manual, 2nd edn. NFER Nelson: Windsor, ON, Canada, 1991