Effects of short-chain galacto- and long-chain fructo-oligosaccharides on systemic and local immune status during pregnancy

Journal of Reproductive Immunology

Volumn 94, Issue 2, 2012, Pages 161-168

  van Vlies, N ^a,c   Hogenkamp, A ^a   Thijssen, S ^a   Dingjan, G M ^a,b   Knipping, K ^a,b   Garssen, J ^a,b   Knippels, L M J ^a,b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b DANONE RESEARCH   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Delayed type hypersensitivity response; Fructo oligosaccharide; Galacto oligosaccharide; Immune modulation; Prebiotics; Pregnancy

Indexed keywords

FIBROBLAST GROWTH FACTOR; FRUCTOSE OLIGOSACCHARIDE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P35; INTERLEUKIN 12P40; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LONG CHAIN GALACTO FRUCTOSE OLIGOSACCHARIDE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; SHORT CHAIN GALACTO FRUCTOSE OLIGOSACCHARIDE; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIET SUPPLEMENTATION; FEMALE; GENE EXPRESSION; HYPERSENSITIVITY; IMMUNE RESPONSE; IMMUNOMODULATION; MATERNAL NUTRITION; MOUSE; NONHUMAN; PLACENTA; PREGNANCY OUTCOME; PRIORITY JOURNAL; SPLEEN CELL; TH1 CELL; VACCINATION;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; DIETARY SUPPLEMENTS; FEMALE; FRUCTOSE; GALACTOSE; HYPERSENSITIVITY, DELAYED; IMMUNE TOLERANCE; INFLUENZA VACCINES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; OLIGOSACCHARIDES; PREGNANCY; TH1 CELLS; TH1-TH2 BALANCE;

EID: 84861189315     PISSN: 01650378     EISSN: 18727603     Source Type: Journal    
DOI: 10.1016/j.jri.2012.02.007     Document Type: Article

References (43)

1. Albers R., Antoine J.M., Bourdet-Sicard R., Calder P.C., Gleeson M., Lesourd B., et al. Markers to measure immunomodulation in human nutrition intervention studies. Br. J. Nutr. 2005, 94(3):452-481.
2. Aluvihare V.R., Betz A.G. The role of regulatory T cells in alloantigen tolerance. Immunol. Rev. 2006, 212:330-343.
3. Arslanoglu S., Moro G.E., Boehm G. Early supplementation of prebiotic oligosaccharides protects formula-fed infants against infections during the first 6 months of life. J. Nutr. 2007, 137(11):2420-2424.
4. Arslanoglu S., Moro G.E., Schmitt J., Tandoi L., Rizzardi S., Boehm G. Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life. J. Nutr. 2008, 138(6):1091-1095.
5. Barthlott T., Moncrieffe H., Veldhoen M., Atkins C.J., Christensen J., O'Garra A., et al. CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production. Int. Immunol. 2005, 17(3):279-288.
6. Blois S.M., Joachim R., Kandil J., Margni R., Tometten M., Klapp B.F., et al. Depletion of CD8+ cells abolishes the pregnancy protective effect of progesterone substitution with dydrogesterone in mice by altering the Th1/Th2 cytokine profile. J. Immunol. 2004, 172(10):5893-5899.
7. Boehm G., Moro G. Structural and functional aspects of prebiotics used in infant nutrition. J. Nutr. 2008, 138(9):1818S-1828S.
8. Bowen J.M., Chamley L., Keelan J.A., Mitchell M.D. Cytokines of the placenta and extra-placental membranes: roles and regulation during human pregnancy and parturition. Placenta 2002, 23(4):257-273.
9. Buddington R.K., Kelly-Quagliana K., Buddington K.K., Kimura Y. Non-digestible oligosaccharides and defense functions: lessons learned from animal models. Br. J. Nutr. 2002, 87(Suppl. 2):S231-S239.
10. Cani P.D., Neyrinck A.M., Fava F., Knauf C., Burcelin R.G., Tuohy K.M., et al. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 2007, 50(11):2374-2383.
11. Cani P.D., Possemiers S., Van de Wiele T., Guiot Y., Everard A., Rottier O., et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 2009, 58(8):1091-1103.
12. Chaouat G. The Th1/Th2 paradigm: still important in pregnancy?. Semin. Immunopathol. 2007, 29(2):95-113.
13. Chaouat G., Petitbarat M., Dubanchet S., Rahmati M., Ledee N. Tolerance to the foetal allograft?. Am. J. Reprod. Immunol. 2010, 63(6):624-636.
14. de la Rosa M., Rutz S., Dorninger H., Scheffold A. Interleukin-2 is essential for CD4+ CD25+ regulatory T cell function. Eur. J. Immunol. 2004, 34(9):2480-2488.
15. Faber J., Vos P., Kegler D., van Norren K., Argiles J.M., Laviano A., et al. Beneficial immune modulatory effects of a specific nutritional combination in a murine model for cancer cachexia. Br. J. Cancer 2008, 99(12):2029-2036.
16. Fallon P.G., Jolin H.E., Smith P., Emson C.L., Townsend M.J., Fallon R., et al. IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. Immunity 2002, 17(1):7-17.
17. Fujiwara R., Watanabe J., Sonoyama K. Assessing changes in composition of intestinal microbiota in neonatal BALB/c mice through cluster analysis of molecular markers. Br. J. Nutr. 2008, 99(6):1174-1177.
18. Fujiwara R., Takemura N., Watanabe J., Sonoyama K. Maternal consumption of fructo-oligosaccharide diminishes the severity of skin inflammation in offspring of NC/Nga mice. Br. J. Nutr. 2010, 103(4):530-538.
19. Gibson G.R., Probert H.M., Loo J.V., Rastall R.A., Roberfroid M.B. Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr. Res. Rev. 2004, 17(2):259-275.
20. Hogenkamp A., van Vlies N., Fear A.L., van Esch B.C., Hofman G.A., Garssen J., et al. Dietary fatty acids affect the immune system in male mice sensitized to ovalbumin or vaccinated with influenza. J. Nutr. 2011, 141(4):698-702.
21. Holland D., Bretscher P., Russell A.S. Immunologic and inflammatory responses during pregnancy. J. Clin. Lab. Immunol. 1984, 14(4):177-179.
22. Karimi K., Arck P.C. Natural Killer cells: keepers of pregnancy in the turnstile of the environment. Brain Behav. Immun. 2010, 24(3):339-347.
23. Krishnan L., Guilbert L.J., Russell A.S., Wegmann T.G., Mosmann T.R., Belosevic M. Pregnancy impairs resistance of C57BL/6 mice to Leishmania major infection and causes decreased antigen-specific IFN-gamma response and increased production of T helper 2 cytokines. J. Immunol. 1996, 156(2):644-652.
24. Krishnan L., Pejcic-Karapetrovic B., Gurnani K., Zafer A., Sad S. Pregnancy does not deter the development of a potent maternal protective CD8+ T-cell acquired immune response against Listeria monocytogenes despite preferential placental colonization. Am. J. Reprod. Immunol. 2010, 63(1):54-65.
25. Laitinen K., Poussa T., Isolauri E. Probiotics and dietary counselling contribute to glucose regulation during and after pregnancy: a randomised controlled trial. Br. J. Nutr. 2009, 101(11):1679-1687.
26. Laparra J.M., Sanz Y. Interactions of gut microbiota with functional food components and nutraceuticals. Pharmacol. Res. 2010, 61(3):219-225.
27. Moro G., Arslanoglu S., Stahl B., Jelinek J., Wahn U., Boehm G. A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Arch. Dis. Child. 2006, 91(10):814-819.
28. Mosser D.M., Zhang X. Interleukin-10: new perspectives on an old cytokine. Immunol. Rev. 2008, 226:205-218.
29. Pearson H. Reproductive immunology: immunity's pregnant pause. Nature 2002, 420(6913):265-266.
30. Qiu C., Coughlin K.B., Frederick I.O., Sorensen T.K., Williams M.A. Dietary fiber intake in early pregnancy and risk of subsequent preeclampsia. Am. J. Hypertens. 2008, 21(8):903-909.
31. Renaud S.J., Graham C.H. The role of macrophages in utero-placental interactions during normal and pathological pregnancy. Immunol. Invest. 2008, 37(5):535-564.
32. Schley P.D., Field C.J. The immune-enhancing effects of dietary fibres and prebiotics. Br. J. Nutr. 2002, 87(Suppl. 2):S221-S230.
33. Schouten B., van Esch B.C., Hofman G.A., van Doorn S.A., Knol J., Nauta A.J., et al. Cow milk allergy symptoms are reduced in mice fed dietary synbiotics during oral sensitization with whey. J. Nutr. 2009, 139(7):1398-1403.
34. Schouten B., van Esch B.C., Hofman G.A., Boon L., Knippels L.M., Willemsen L.E., et al. Oligosaccharide-induced whey-specific CD25(+) regulatory T-cells are involved in the suppression of cow milk allergy in mice. J. Nutr. 2010, 140(4):835-841.
35. Schouten B., van Esch B.C., Hofman G.A., de Kivit S., Boon L., Knippels L.M., et al. A potential role for CD25+ regulatory T-cells in the protection against casein allergy by dietary non-digestible carbohydrates. Br. J. Nutr. 2012, 107(4):96-105.
36. Shadid R., Haarman M., Knol J., Theis W., Beermann C., Rjosk-Dendorfer D., et al. Effects of galactooligosaccharide and long-chain fructooligosaccharide supplementation during pregnancy on maternal and neonatal microbiota and immunity - a randomized, double-blind, placebo-controlled study. Am. J. Clin. Nutr. 2007, 86(5):1426-1437.
37. Trowsdale J., Betz A.G. Mother's little helpers: mechanisms of maternal-fetal tolerance. Nat. Immunol. 2006, 7(3):241-246.
38. van Hoffen E., Ruiter B., Faber J., M'Rabet L., Knol E.F., Stahl B., et al. A specific mixture of short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides induces a beneficial immunoglobulin profile in infants at high risk for allergy. Allergy 2009, 64(3):484-487.
39. van't Land B., Schijf M., van Esch B.C., van Bergenhenegouwen J., Bastiaans J., Schouten B., et al. Regulatory T-cells have a prominent role in the immune modulated vaccine response by specific oligosaccharides. Vaccine 2010, 28(35):5711-5717.
40. van Vlies N., Hogenkamp A., Fear A.L., Esch E., Oosting v., Heijning A., et al. Perinatal programming of murine immune responses by poly-unsaturated fatty acids. J. Dev. Orig. Health Dis. 2011, 2(2):112-123.
41. Vos A.P., Haarman M., Buco A., Govers M., Knol J., Garssen J., et al. A specific prebiotic oligosaccharide mixture stimulates delayed-type hypersensitivity in a murine influenza vaccination model. Int. Immunopharmacol. 2006, 6(8):1277-1286.
42. Vos A.P., Haarman M., van Ginkel J.W., Knol J., Garssen J., Stahl B., et al. Dietary supplementation of neutral and acidic oligosaccharides enhances Th1-dependent vaccination responses in mice. Pediatr. Allergy Immunol. 2007, 18(4):304-312.
43. Vos A.P., M'Rabet L., Stahl B., Boehm G., Garssen J. Immune-modulatory effects and potential working mechanisms of orally applied nondigestible carbohydrates. Crit. Rev. Immunol. 2007, 27(2):97-140.