Neonatal prebiotic (BGOS) supplementation increases the levels of synaptophysin, GluN2A-subunits and BDNF proteins in the adult rat hippocampus

Synapse

Volumn 70, Issue 3, 2016, Pages 121-124

  Williams, Sarah ^a   Chen, Li ^a   Savignac, Helene M ^b   Tzortzis, George ^b   Anthony, Daniel C ^a   Burnet, Philip Wj ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Clasado Ltd   (United Kingdom)

Author keywords

BGOS; Glutamate; Neurodevelopment

Indexed keywords

BIMUNO; BRAIN DERIVED NEUROTROPHIC FACTOR; GALACTOSE OLIGOSACCHARIDE; MICROTUBULE ASSOCIATED PROTEIN 2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NEUROMODULIN; PLACEBO; PREBIOTIC AGENT; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; MICROTUBULE ASSOCIATED PROTEIN; MTAP2 PROTEIN, RAT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N-METHYL D-ASPARTATE RECEPTOR SUBTYPE 2A; NMDA RECEPTOR A1; NR2B NMDA RECEPTOR; SYP PROTEIN, RAT;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; HIPPOCAMPUS; INFANT FEEDING; INFANT NUTRITION; INTESTINE FLORA; MALE; NEUROTRANSMISSION; NEWBORN; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SYNAPSE; ANIMAL; DIETARY SUPPLEMENT; GROWTH, DEVELOPMENT AND AGING; METABOLISM; ORAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; BRAIN-DERIVED NEUROTROPHIC FACTOR; DIETARY SUPPLEMENTS; FEMALE; GAP-43 PROTEIN; HIPPOCAMPUS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; PREBIOTICS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPTOPHYSIN;

EID: 84953807132     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.21880     Document Type: Article

References (18)

1. 3H]D-aspartate release and changes in glutamate receptor expression in the hippocampus of the mnd mouse. J Neurosci Res 90:1148-1158.
2. Borre YE, O'Keeffe GW, Clarke G, Stanton C, Dinan TG, Cryan JF. 2014. Microbiota and neurodevelopmental windows: Implications for brain disorders. Trends Mol Med 20:509-518.
3. Costa-Nunes J, Zubareva O, Araújo-Correia M, Valença A, Schroeter CA, Pawluski JL, Vignisse J, Steinbusch H, Hermes D, Phillipines M, Steinbusch HM, Strekalova T. 2014. Altered emotionality, hippocampus-dependent performance and expression of NMDA receptor subunit mRNAs in chronically stressed mice. Stress 17:108-116.
4. Cryan JF, Dinan TG. 2012. Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 13:701-712.
5. Desbonnet L, Clarke G, Shanahan F, Dinan TG, Cryan JF. 2014. Microbiota is essential for social development in the mouse. Mol Psychiatry 19:146-148.
6. Diaz Heijtz R, Wang S, Anuar F, Qian Y, Björkholm B, Samuelsson A, Hibberd ML, Forssberg H, Pettersson S. 2011. Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci USA 108:3047-3052.
7. Hsieh CY, Leslie FM, Metherate R. 2002. Nicotine exposure during a postnatal critical period alters NR2A and NR2B mRNA expression in rat auditory forebrain. Brain Res Dev Brain Res 133:19-25.
8. Hung KL, Wang SJ, Wang YC, Chiang TR, Wang CC. 2014. Upregulation of presynaptic proteins and protein kinases associated with enhanced glutamate release from axonal terminals (synaptosomes) of the medial prefrontal cortex in rats with neuropathic pain. Pain 155:377-387.
9. Mariga A, Zavadil J, Ginsberg SD, Chao MV. 2015. Withdrawal of BDNF from hippocampal cultures leads to changes in genes involved in synaptic function. Dev Neurobiol 75:173-192.
10. Masliah E, Xie F, Dayan S, Rockenstein E, Mante M, Adame A, Patrick CM, Chan AF, Zheng B. 2010. Genetic deletion of Nogo/Rtn4 ameliorates behavioral and neuropathological outcomes in amyloid precursor protein transgenic mice. Neuroscience 169:488-494.
11. Messaoudi M, Lalonde R, Violle N, Javelot H, Desor D, Nejdi A, Bisson JF, Rougeot C, Pichelin M, Cazaubiel M, Cazaubiel JM. 2011. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr 105:755-764.
12. Morel FB, Oozeer R, Piloquet H, Moyon T, Pagniez A, Knol J, Darmaun D, Michel C. 2015. Preweaning modulation of intestinal microbiota by oligosaccharides or amoxicillin can contribute to programming of adult microbiota in rats. Nutrition 31:515-522.
13. Savignac HM, Corona G, Mills H, Chen L, Spencer JP, Tzortzis G, Burnet PW. 2013. Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serine. Neurochem Int 63:756-764.
14. Savignac HM, Tramullas M, Kiely B, Dinan TG, Cryan JF. 2015. Bifidobacteria modulate cognitive processes in an anxious mouse strain. Behav Brain Res 287:59-72.
15. Schmidt K, Cowen PJ, Harmer CJ, Tzortzis G, Errington S, Burnet PW. 2015. Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Psychopharmacology (Berl) 232:1793-1801.
16. Sudo N, Chida Y, Aiba Y, Sonoda J, Oyama N, Yu XN, Kubo C, Koga Y. 2004. Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J Physiol 558:263-275.
17. Verstraelen P, Pintelon I, Nuydens R, Cornelissen F, Meert T, Timmermans JP. 2014. Pharmacological characterization of cultivated neuronal networks: Relevance to synaptogenesis and synaptic connectivity. Cell Mol Neurobiol 34:757-776.
18. Vizi ES, Kisfali M, Lorincz T. 2013. Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: Evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects. Brain Res Bull 93:32-38.