메뉴 건너뛰기




Volumn 48, Issue , 2015, Pages 165-173

Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour

Author keywords

Adolescence; Antibiotics; Anxiety; BDNF; Cognition; Gut microbiota; Vasopressin

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MONOAMINE; NEUROPEPTIDE; OXYTOCIN; TRYPTOPHAN; VASOPRESSIN; ANTIINFECTIVE AGENT;

EID: 84938273954     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2015.04.004     Document Type: Article
Times cited : (561)

References (51)
  • 1
    • 79551681952 scopus 로고    scopus 로고
    • Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation
    • Bailey, M.T., Dowd, S.E., Galley, J.D., Hufnagle, A.R., Allen, R.G., Lyte, M., 2011. Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation. Brain Behav. Immun. 25, 397-407.
    • (2011) Brain Behav. Immun. , vol.25 , pp. 397-407
    • Bailey, M.T.1    Dowd, S.E.2    Galley, J.D.3    Hufnagle, A.R.4    Allen, R.G.5    Lyte, M.6
  • 2
    • 84967190674 scopus 로고    scopus 로고
    • Toward a unified biological hypothesis for the BDNF Val66Met-associated memory deficits in humans: a model of impaired dendritic mRNA trafficking
    • Baj, G., Carlino, D., Gardossi, L., Tongiorgi, E., 2013. Toward a unified biological hypothesis for the BDNF Val66Met-associated memory deficits in humans: a model of impaired dendritic mRNA trafficking. Front Neurosci. 7, 188.
    • (2013) Front Neurosci. , vol.7 , pp. 188
    • Baj, G.1    Carlino, D.2    Gardossi, L.3    Tongiorgi, E.4
  • 3
    • 80051535923 scopus 로고    scopus 로고
    • The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice
    • 609.e591-609.e593
    • Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., et al., 2011. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology 141, 599-609, 609.e591-609.e593.
    • (2011) Gastroenterology , vol.141 , pp. 599-609
    • Bercik, P.1    Denou, E.2    Collins, J.3    Jackson, W.4    Lu, J.5    Jury, J.6
  • 4
    • 84883012986 scopus 로고    scopus 로고
    • Microbiota in health and irritable bowel syndrome: current knowledge, perspectives and therapeutic options
    • Bonfrate, L., Tack, J., Grattagliano, I., Cuomo, R., Portincasa, P., 2013. Microbiota in health and irritable bowel syndrome: current knowledge, perspectives and therapeutic options. Scand. J. Gastroenterol. 48, 995-1009.
    • (2013) Scand. J. Gastroenterol. , vol.48 , pp. 995-1009
    • Bonfrate, L.1    Tack, J.2    Grattagliano, I.3    Cuomo, R.4    Portincasa, P.5
  • 5
    • 13844253335 scopus 로고    scopus 로고
    • Early developmental exposure to BDE 99 or Aroclor 1254 affects neurobehavioural profile: interference from the administration route
    • Branchi, I., Capone, F., Vitalone, A., Madia, F., Santucci, D., Alleva, E., et al., 2005. Early developmental exposure to BDE 99 or Aroclor 1254 affects neurobehavioural profile: interference from the administration route. Neurotoxicology 26, 183-192.
    • (2005) Neurotoxicology , vol.26 , pp. 183-192
    • Branchi, I.1    Capone, F.2    Vitalone, A.3    Madia, F.4    Santucci, D.5    Alleva, E.6
  • 6
    • 80052965474 scopus 로고    scopus 로고
    • Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
    • Bravo, J.A., Forsythe, P., Chew, M.V., Escaravage, E., Savignac, H.M., Dinan, T.G., et al., 2011. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc. Natl. Acad. Sci. U.S.A. 108, 16050-16055.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 16050-16055
    • Bravo, J.A.1    Forsythe, P.2    Chew, M.V.3    Escaravage, E.4    Savignac, H.M.5    Dinan, T.G.6
  • 7
    • 79960053063 scopus 로고    scopus 로고
    • The social brain in adolescence: evidence from functional magnetic resonance imaging and behavioural studies
    • Burnett, S., Sebastian, C., Cohen Kadosh, K., Blakemore, S.J., 2011. The social brain in adolescence: evidence from functional magnetic resonance imaging and behavioural studies. Neurosci. Biobehav. Rev. 35, 1654-1664.
    • (2011) Neurosci. Biobehav. Rev. , vol.35 , pp. 1654-1664
    • Burnett, S.1    Sebastian, C.2    Cohen Kadosh, K.3    Blakemore, S.J.4
  • 8
    • 84865477413 scopus 로고    scopus 로고
    • Antibiotics in early life alter the murine colonic microbiome and adiposity
    • Cho, I., Yamanishi, S., Cox, L., Methe, B.A., Zavadil, J., Li, K., et al., 2012. Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature 488, 621-626.
    • (2012) Nature , vol.488 , pp. 621-626
    • Cho, I.1    Yamanishi, S.2    Cox, L.3    Methe, B.A.4    Zavadil, J.5    Li, K.6
  • 9
    • 84856033373 scopus 로고    scopus 로고
    • Review article: probiotics for the treatment of irritable bowel syndrome-focus on lactic acid bacteria
    • Clarke, G., Cryan, J.F., Dinan, T.G., Quigley, E.M., 2012. Review article: probiotics for the treatment of irritable bowel syndrome-focus on lactic acid bacteria. Aliment. Pharmacol. Ther. 35, 403-413.
    • (2012) Aliment. Pharmacol. Ther. , vol.35 , pp. 403-413
    • Clarke, G.1    Cryan, J.F.2    Dinan, T.G.3    Quigley, E.M.4
  • 10
    • 84878241830 scopus 로고    scopus 로고
    • The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
    • Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R.D., Shanahan, F., et al., 2013. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol. Psychiatry 18, 666-673.
    • (2013) Mol. Psychiatry , vol.18 , pp. 666-673
    • Clarke, G.1    Grenham, S.2    Scully, P.3    Fitzgerald, P.4    Moloney, R.D.5    Shanahan, F.6
  • 11
    • 49649104532 scopus 로고    scopus 로고
    • Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice
    • Clipperton, A.E., Spinato, J.M., Chernets, C., Pfaff, D.W., Choleris, E., 2008. Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice. Neuropsychopharmacology 33, 2362-2375.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 2362-2375
    • Clipperton, A.E.1    Spinato, J.M.2    Chernets, C.3    Pfaff, D.W.4    Choleris, E.5
  • 12
    • 84907563983 scopus 로고    scopus 로고
    • Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences
    • Cox, L.M., Yamanishi, S., Sohn, J., Alekseyenko, A.V., Leung, J.M., Cho, I., et al., 2014. Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell 158, 705-721.
    • (2014) Cell , vol.158 , pp. 705-721
    • Cox, L.M.1    Yamanishi, S.2    Sohn, J.3    Alekseyenko, A.V.4    Leung, J.M.5    Cho, I.6
  • 14
    • 84885156813 scopus 로고    scopus 로고
    • Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified
    • De Angelis, M., Piccolo, M., Vannini, L., Siragusa, S., De Giacomo, A., Serrazzanetti, D.I., et al., 2013. Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified. PLoS ONE 8, e76993.
    • (2013) PLoS ONE , vol.8
    • De Angelis, M.1    Piccolo, M.2    Vannini, L.3    Siragusa, S.4    De Giacomo, A.5    Serrazzanetti, D.I.6
  • 16
    • 53049087266 scopus 로고    scopus 로고
    • The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat
    • Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., Dinan, T.G., 2008. The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat. J. Psychiatr. Res. 43, 164-174.
    • (2008) J. Psychiatr. Res. , vol.43 , pp. 164-174
    • Desbonnet, L.1    Garrett, L.2    Clarke, G.3    Bienenstock, J.4    Dinan, T.G.5
  • 17
    • 77957142793 scopus 로고    scopus 로고
    • Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
    • Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J.F., Dinan, T.G., 2010. Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience 170, 1179-1188.
    • (2010) Neuroscience , vol.170 , pp. 1179-1188
    • Desbonnet, L.1    Garrett, L.2    Clarke, G.3    Kiely, B.4    Cryan, J.F.5    Dinan, T.G.6
  • 19
    • 84886724158 scopus 로고    scopus 로고
    • Psychobiotics: a novel class of psychotropic
    • Dinan, T.G., 2013. Psychobiotics: a novel class of psychotropic. PLoS Biol. 74, 720-726.
    • (2013) PLoS Biol. , vol.74 , pp. 720-726
    • Dinan, T.G.1
  • 20
    • 84881295719 scopus 로고    scopus 로고
    • Melancholic microbes: a link between gut microbiota and depression?
    • Dinan, T.G., Cryan, J.F., 2013. Melancholic microbes: a link between gut microbiota and depression? Neurogastroenterol. Motil. 25, 713-719.
    • (2013) Neurogastroenterol. Motil. , vol.25 , pp. 713-719
    • Dinan, T.G.1    Cryan, J.F.2
  • 21
    • 84655167934 scopus 로고    scopus 로고
    • State of the art; microbiology in health and disease. Intestinal bacterial flora in autism
    • Finegold, S.M., 2011. State of the art; microbiology in health and disease. Intestinal bacterial flora in autism. Anaerobe 17, 367-368.
    • (2011) Anaerobe , vol.17 , pp. 367-368
    • Finegold, S.M.1
  • 22
  • 23
    • 56549106722 scopus 로고    scopus 로고
    • Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity
    • Fitzgerald, P., Cassidy Eugene, M., Clarke, G., Scully, P., Barry, S., Quigley Eamonn, M.M., et al., 2008. Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity. Neurogastroenterol. Motil. 20, 1291-1297.
    • (2008) Neurogastroenterol. Motil. , vol.20 , pp. 1291-1297
    • Fitzgerald, P.1    Cassidy Eugene, M.2    Clarke, G.3    Scully, P.4    Barry, S.5    Quigley Eamonn, M.M.6
  • 24
    • 0000378637 scopus 로고
    • On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae
    • Fleming, A., 1929. On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae. Br. J. Exp. Pathol. 10, 226-236.
    • (1929) Br. J. Exp. Pathol. , vol.10 , pp. 226-236
    • Fleming, A.1
  • 25
    • 84861723958 scopus 로고    scopus 로고
    • Interplay of oxytocin, vasopressin, and sex hormones in the regulation of social recognition
    • Gabor, C.S., Phan, A., Clipperton-Allen, A.E., Kavaliers, M., Choleris, E., 2012. Interplay of oxytocin, vasopressin, and sex hormones in the regulation of social recognition. Behav. Neurosci. 126, 97-109.
    • (2012) Behav. Neurosci. , vol.126 , pp. 97-109
    • Gabor, C.S.1    Phan, A.2    Clipperton-Allen, A.E.3    Kavaliers, M.4    Choleris, E.5
  • 26
    • 84904084581 scopus 로고    scopus 로고
    • Exposure to a social stressor disrupts the community structure of the colonic mucosa-associated microbiota
    • Galley, J.D., Nelson, M.C., Yu, Z., Dowd, S.E., Walter, J., Kumar, P.S., et al., 2014. Exposure to a social stressor disrupts the community structure of the colonic mucosa-associated microbiota. BMC Microbiol. 14, 189.
    • (2014) BMC Microbiol. , vol.14 , pp. 189
    • Galley, J.D.1    Nelson, M.C.2    Yu, Z.3    Dowd, S.E.4    Walter, J.5    Kumar, P.S.6
  • 27
    • 79851494165 scopus 로고    scopus 로고
    • Bacterial infection causes stress-induced memory dysfunction in mice
    • Gareau, M.G., Wine, E., Rodrigues, D.M., Cho, J.H., Whary, M.T., Philpott, D.J., et al., 2011. Bacterial infection causes stress-induced memory dysfunction in mice. Gut 60, 307-317.
    • (2011) Gut , vol.60 , pp. 307-317
    • Gareau, M.G.1    Wine, E.2    Rodrigues, D.M.3    Cho, J.H.4    Whary, M.T.5    Philpott, D.J.6
  • 28
    • 77954051526 scopus 로고    scopus 로고
    • Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses
    • Hapfelmeier, S., Lawson, M.A., Slack, E., Kirundi, J.K., Stoel, M., Heikenwalder, M., et al., 2010. Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses. Science 328, 1705-1709.
    • (2010) Science , vol.328 , pp. 1705-1709
    • Hapfelmeier, S.1    Lawson, M.A.2    Slack, E.3    Kirundi, J.K.4    Stoel, M.5    Heikenwalder, M.6
  • 29
    • 84894118144 scopus 로고    scopus 로고
    • Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
    • Hsiao, E.Y., McBride, S.W., Hsien, S., Sharon, G., Hyde, E.R., McCue, T., et al., 2014. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155, 1451-1463.
    • (2014) Cell , vol.155 , pp. 1451-1463
    • Hsiao, E.Y.1    McBride, S.W.2    Hsien, S.3    Sharon, G.4    Hyde, E.R.5    McCue, T.6
  • 30
  • 31
    • 84910108172 scopus 로고    scopus 로고
    • Irritable bowel syndrome: a microbiome-gut-brain axis disorder?
    • Kennedy, P.J., Cryan, J.F., Dinan, T.G., Clarke, G., 2014. Irritable bowel syndrome: a microbiome-gut-brain axis disorder? World J. Gastroenterol. 20, 14105-14125.
    • (2014) World J. Gastroenterol. , vol.20 , pp. 14105-14125
    • Kennedy, P.J.1    Cryan, J.F.2    Dinan, T.G.3    Clarke, G.4
  • 32
    • 84908152766 scopus 로고    scopus 로고
    • Altered brain-gut axis in autism: comorbidity or causative mechanisms?
    • Mayer, E.A., Padua, D., Tillisch, K., 2014. Altered brain-gut axis in autism: comorbidity or causative mechanisms? BioEssays 36, 933-939.
    • (2014) BioEssays , vol.36 , pp. 933-939
    • Mayer, E.A.1    Padua, D.2    Tillisch, K.3
  • 33
    • 0034666119 scopus 로고    scopus 로고
    • Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats
    • Mizuno, M., Yamada, K., Olariu, A., Nawa, H., Nabeshima, T., 2000. Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats. J. Neurosci. 20, 7116-7121.
    • (2000) J. Neurosci. , vol.20 , pp. 7116-7121
    • Mizuno, M.1    Yamada, K.2    Olariu, A.3    Nawa, H.4    Nabeshima, T.5
  • 35
    • 79551713705 scopus 로고    scopus 로고
    • Reduced anxiety-like behavior and central neurochemical change in germ-free mice
    • Neufeld, K.M., Kang, N., Bienenstock, J., Foster, J.A., 2011. Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterol. Motil. 23 (255-264), e119.
    • (2011) Neurogastroenterol. Motil. , vol.23 , Issue.255-264
    • Neufeld, K.M.1    Kang, N.2    Bienenstock, J.3    Foster, J.A.4
  • 36
    • 84889592915 scopus 로고    scopus 로고
    • Adolescent brain vulnerability and psychopathology through the generations role of diet and dopamine.
    • O'Connor, R.M., Cryan, J.F., 2014. Adolescent brain vulnerability and psychopathology through the generations role of diet and dopamine. Biol. Psychiatry 75, 4-6.
    • (2014) Biol. Psychiatry , vol.75 , pp. 4-6
    • O'Connor, R.M.1    Cryan, J.F.2
  • 37
    • 56549127348 scopus 로고    scopus 로고
    • Why do many psychiatric disorders emerge during adolescence?
    • Paus, T., Keshavan, M., Giedd, J.N., 2008. Why do many psychiatric disorders emerge during adolescence? Nat. Rev. Neurosci. 9, 947-957.
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 947-957
    • Paus, T.1    Keshavan, M.2    Giedd, J.N.3
  • 38
    • 79952855316 scopus 로고    scopus 로고
    • Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression
    • Reikvam, D.H., Erofeev, A., Sandvik, A., Grcic, V., Jahnsen, F.L., Gaustad, P., et al., 2011. Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression. PLoS ONE 6, e17996.
    • (2011) PLoS ONE , vol.6
    • Reikvam, D.H.1    Erofeev, A.2    Sandvik, A.3    Grcic, V.4    Jahnsen, F.L.5    Gaustad, P.6
  • 39
    • 84856596122 scopus 로고    scopus 로고
    • Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X Syndrome
    • Rotschafer, S.E., Trujillo, M.S., Dansie, L.E., Ethell, I.M., Razak, K.A., 2012. Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X Syndrome. Brain Res. 1439, 7-14.
    • (2012) Brain Res. , vol.1439 , pp. 7-14
    • Rotschafer, S.E.1    Trujillo, M.S.2    Dansie, L.E.3    Ethell, I.M.4    Razak, K.A.5
  • 40
    • 84901392235 scopus 로고    scopus 로고
    • Metabolic tinkering by the gut microbiome: implications for brain development and function
    • Selkrig, J., Wong, P., Zhang, X., Pettersson, S., 2014. Metabolic tinkering by the gut microbiome: implications for brain development and function. Gut Microbes 5, 369-380.
    • (2014) Gut Microbes , vol.5 , pp. 369-380
    • Selkrig, J.1    Wong, P.2    Zhang, X.3    Pettersson, S.4
  • 41
    • 84893440694 scopus 로고    scopus 로고
    • Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills
    • Skuse, D.H., Lori, A., Cubells, J.F., Lee, I., Conneely, K.N., Puura, K., et al., 2014. Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills. Proc. Natl. Acad. Sci. U.S.A. 111, 1987-1992.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 1987-1992
    • Skuse, D.H.1    Lori, A.2    Cubells, J.F.3    Lee, I.4    Conneely, K.N.5    Puura, K.6
  • 42
    • 34249284197 scopus 로고    scopus 로고
    • Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota
    • Smith, K., McCoy, K.D., Macpherson, A.J., 2007. Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota. Semin. Immunol. 19, 59-69.
    • (2007) Semin. Immunol. , vol.19 , pp. 59-69
    • Smith, K.1    McCoy, K.D.2    Macpherson, A.J.3
  • 43
    • 80052735358 scopus 로고    scopus 로고
    • Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data
    • Spear, L.P., 2011. Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data. Dev. Cogn. Neurosci. 1, 392-400.
    • (2011) Dev. Cogn. Neurosci. , vol.1 , pp. 392-400
    • Spear, L.P.1
  • 44
    • 84891628557 scopus 로고    scopus 로고
    • Microbial genes, brain&behaviour - epigenetic regulation of the gut-brain axis
    • Stilling, R.M., Dinan, T.G., Cryan, J.F., 2014. Microbial genes, brain&behaviour - epigenetic regulation of the gut-brain axis. Genes Brain Behav. 13, 69-86.
    • (2014) Genes Brain Behav. , vol.13 , pp. 69-86
    • Stilling, R.M.1    Dinan, T.G.2    Cryan, J.F.3
  • 45
    • 79960041122 scopus 로고    scopus 로고
    • The neurobiology of adolescence: changes in brain architecture, functional dynamics, and behavioral tendencies
    • Sturman, D.A., Moghaddam, B., 2011. The neurobiology of adolescence: changes in brain architecture, functional dynamics, and behavioral tendencies. Neurosci. Biobehav. Rev. 35, 1704-1712.
    • (2011) Neurosci. Biobehav. Rev. , vol.35 , pp. 1704-1712
    • Sturman, D.A.1    Moghaddam, B.2
  • 46
    • 4043161248 scopus 로고    scopus 로고
    • Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice
    • Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X.N., et al., 2004. Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J. Physiol. 558, 263-275.
    • (2004) J. Physiol. , vol.558 , pp. 263-275
    • Sudo, N.1    Chida, Y.2    Aiba, Y.3    Sonoda, J.4    Oyama, N.5    Yu, X.N.6
  • 48
    • 0036742611 scopus 로고    scopus 로고
    • From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning
    • Tyler, W.J., Alonso, M., Bramham, C.R., Pozzo-Miller, L.D., 2002. From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Learn Mem. 9, 224-237.
    • (2002) Learn Mem. , vol.9 , pp. 224-237
    • Tyler, W.J.1    Alonso, M.2    Bramham, C.R.3    Pozzo-Miller, L.D.4
  • 49
    • 84865286121 scopus 로고    scopus 로고
    • Antibiotics, microbiota, and immune defense
    • Ubeda, C., Pamer, E.G., 2012. Antibiotics, microbiota, and immune defense. Trends Immunol. 33, 459-466.
    • (2012) Trends Immunol. , vol.33 , pp. 459-466
    • Ubeda, C.1    Pamer, E.G.2
  • 50
    • 30944444119 scopus 로고    scopus 로고
    • Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice
    • Verdu, E.F., Bercik, P., Verma-Gandhu, M., Huang, X.X., Blennerhassett, P., Jackson, W., et al., 2006. Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice. Gut 55, 182-190.
    • (2006) Gut , vol.55 , pp. 182-190
    • Verdu, E.F.1    Bercik, P.2    Verma-Gandhu, M.3    Huang, X.X.4    Blennerhassett, P.5    Jackson, W.6
  • 51
    • 84899145858 scopus 로고    scopus 로고
    • Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice
    • Zhang, Y., Limaye, P.B., Renaud, H.J., Klaassen, C.D., 2014. Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice. Toxicol. Appl. Pharmacol. 277, 138-145.
    • (2014) Toxicol. Appl. Pharmacol. , vol.277 , pp. 138-145
    • Zhang, Y.1    Limaye, P.B.2    Renaud, H.J.3    Klaassen, C.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.