pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner

Science

Volumn 353, Issue 6302, 2016, Pages 929-932

  Guo, Jianping ^a   Chakraborty, Abhishek A ^b   Liu, Pengda ^a   Gan, Wenjian ^a   Zheng, Xingnan ^c   Inuzuka, Hiroyuki ^a   Wang, Bin ^a   Zhang, Jinfang ^a   Zhang, Linli ^a   Yuan, Min ^a   Novak, Jesse ^b   Cheng, Jin Q ^d   Toker, Alex ^a   Signoretti, Sabina ^b   Zhang, Qing ^c   Asara, John M ^a   Kaelin, William G ^b,e   Wei, Wenyi ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CULLIN; HYPOXIA INDUCIBLE FACTOR 2ALPHA; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROLINE DERIVATIVE; PROTEIN KINASE B; THREONINE; VON HIPPEL LINDAU PROTEIN; EGLN1 PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE; PROLINE;

CANCER; CELLS AND CELL COMPONENTS; ENZYME ACTIVITY; HYPOXIA; MUTATION; OXYGEN; PROTEIN; SURVIVAL; TUMOR;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL METABOLISM; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE MUTATION; HYDROXYLATION; HYPOXIA; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; UBIQUITINATION; ANTAGONISTS AND INHIBITORS; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; MUTATION; NEOPLASM; PHOSPHORYLATION; TUMOR CELL LINE; TUMOR HYPOXIA; TUMOR MICROENVIRONMENT;

CELL LINE, TUMOR; ENZYME ACTIVATION; HUMANS; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR-PROLINE DIOXYGENASES; MUTATION; NEOPLASMS; PHOSPHORYLATION; PROLINE; PROTO-ONCOGENE PROTEINS C-AKT; TUMOR HYPOXIA; TUMOR MICROENVIRONMENT; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 85013697298     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad5755     Document Type: Article

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