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Volumn 19, Issue 2, 2017, Pages

Mechanisms of Therapeutic Resistance in Prostate Cancer

Author keywords

Castration resistant prostate cancer; Prostate cancer; Therapeutic resistance

Indexed keywords

ABIRATERONE; ABIRATERONE ACETATE; ANDROGEN RECEPTOR; ANTIANDROGEN; APALUTAMIDE; BICALUTAMIDE; DOCETAXEL; ENZALUTAMIDE; FLUTAMIDE; GALUNISERTIB; NILUTAMIDE; OLAPARIB; SIPULEUCEL T; TAXANE DERIVATIVE; TUMOR MARKER;

EID: 85013648982     PISSN: 15233790     EISSN: 15346269     Source Type: Journal    
DOI: 10.1007/s11912-017-0568-7     Document Type: Review
Times cited : (109)

References (137)
  • 2
    • 0001189211 scopus 로고
    • Studies on prostatic cancer: II. The effects of castration on advanced carcinoma of the prostate gland
    • COI: 1:CAS:528:DyaH3MXlt1WqtQ%3D%3D
    • Huggins C, Stevens Jr RE, Hodges CV. Studies on prostatic cancer: II. The effects of castration on advanced carcinoma of the prostate gland. Arch Surg. 1941;43:209–23.
    • (1941) Arch Surg , vol.43 , pp. 209-223
    • Huggins, C.1    Stevens, R.E.2    Hodges, C.V.3
  • 3
    • 22144484150 scopus 로고    scopus 로고
    • Androgen deprivation therapy for prostate cancer
    • COI: 1:CAS:528:DC%2BD2MXmtlSlt7g%3D, PID: 16014598
    • Sharifi N, Gulley JL, Dahut WL. Androgen deprivation therapy for prostate cancer. JAMA. 2005;294:238–44.
    • (2005) JAMA , vol.294 , pp. 238-244
    • Sharifi, N.1    Gulley, J.L.2    Dahut, W.L.3
  • 4
    • 60149089419 scopus 로고    scopus 로고
    • Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion
    • COI: 1:CAS:528:DC%2BD1MXhsFenu7Y%3D, PID: 19198621
    • Harris WP, Mostaghel EA, Nelson PS, Montgomery B. Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion. Nat Clin Pract Urol. 2009;6:76–85.
    • (2009) Nat Clin Pract Urol , vol.6 , pp. 76-85
    • Harris, W.P.1    Mostaghel, E.A.2    Nelson, P.S.3    Montgomery, B.4
  • 5
    • 0029011116 scopus 로고
    • Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer
    • COI: 1:CAS:528:DyaK2MXmvVWnsbs%3D, PID: 7723794
    • Taplin ME, Bubley GJ, Shuster TD, Frantz ME, Spooner AE, Ogata GK, et al. Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. N Engl J Med. 1995;332:1393–8.
    • (1995) N Engl J Med , vol.332 , pp. 1393-1398
    • Taplin, M.E.1    Bubley, G.J.2    Shuster, T.D.3    Frantz, M.E.4    Spooner, A.E.5    Ogata, G.K.6
  • 6
    • 80755169423 scopus 로고    scopus 로고
    • New and emerging agents for the treatment of castration-resistant prostate cancer
    • COI: 1:CAS:528:DC%2BC3MXhsVOltLrP, PID: 22074657
    • Higano CS, Crawford ED. New and emerging agents for the treatment of castration-resistant prostate cancer. Urol Oncol. 2011;29:S1–8.
    • (2011) Urol Oncol , vol.29 , pp. S1-S8
    • Higano, C.S.1    Crawford, E.D.2
  • 7
    • 0035361340 scopus 로고    scopus 로고
    • A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy
    • COI: 1:CAS:528:DC%2BD3MXktlSquro%3D, PID: 11389051
    • Gregory CW, He B, Johnson RT, Ford OH, Mohler JL, French FS, et al. A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy. Cancer Res. 2001;61:4315–9.
    • (2001) Cancer Res , vol.61 , pp. 4315-4319
    • Gregory, C.W.1    He, B.2    Johnson, R.T.3    Ford, O.H.4    Mohler, J.L.5    French, F.S.6
  • 9
    • 84866770294 scopus 로고    scopus 로고
    • Increased survival with enzalutamide in prostate cancer after chemotherapy
    • COI: 1:CAS:528:DC%2BC38XhsVKhsLvK, PID: 22894553
    • Scher HI, Fizazi K, Saad F, Taplin M-E, Sternberg CN, Miller K, et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med. 2012;367:1187–97.
    • (2012) N Engl J Med , vol.367 , pp. 1187-1197
    • Scher, H.I.1    Fizazi, K.2    Saad, F.3    Taplin, M.-E.4    Sternberg, C.N.5    Miller, K.6
  • 10
    • 84898823273 scopus 로고    scopus 로고
    • Updated prognostic model for predicting overall survival in first-line chemotherapy for patients with metastatic castration-resistant prostate cancer
    • PID: 24449231
    • Halabi S, Lin C-Y, Kelly WK, Fizazi KS, Moul JW, Kaplan EB, et al. Updated prognostic model for predicting overall survival in first-line chemotherapy for patients with metastatic castration-resistant prostate cancer. J Clin Oncol. 2014;32:671–7.
    • (2014) J Clin Oncol , vol.32 , pp. 671-677
    • Halabi, S.1    Lin, C.-Y.2    Kelly, W.K.3    Fizazi, K.S.4    Moul, J.W.5    Kaplan, E.B.6
  • 11
    • 77957682309 scopus 로고    scopus 로고
    • Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial
    • PID: 20888992
    • de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, et al. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010;376:1147–54.
    • (2010) Lancet , vol.376 , pp. 1147-1154
    • de Bono, J.S.1    Oudard, S.2    Ozguroglu, M.3    Hansen, S.4    Machiels, J.P.5    Kocak, I.6
  • 12
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • COI: 1:CAS:528:DC%2BC3cXhtVGlurrN, PID: 20818862
    • Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363:411–22.
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3    Berger, E.R.4    Small, E.J.5    Penson, D.F.6
  • 13
    • 84880428467 scopus 로고    scopus 로고
    • Alpha emitter radium-223 and survival in metastatic prostate cancer
    • COI: 1:CAS:528:DC%2BC3sXhtFKls77M, PID: 23863050
    • Parker C, Nilsson S, Heinrich D, Helle SI, O’Sullivan JM, Fosså SD, et al. Alpha emitter radium-223 and survival in metastatic prostate cancer. N Engl J Med. 2013;369:213–23.
    • (2013) N Engl J Med , vol.369 , pp. 213-223
    • Parker, C.1    Nilsson, S.2    Heinrich, D.3    Helle, S.I.4    O’Sullivan, J.M.5    Fosså, S.D.6
  • 14
    • 4744366279 scopus 로고    scopus 로고
    • Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
    • COI: 1:CAS:528:DC%2BD2cXot1Kmu7s%3D, PID: 15470213
    • Tannock IF, de Wit R, Berry WR, Horti J, Pluzanska A, Chi KN, et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med. 2004;351:1502–12.
    • (2004) N Engl J Med , vol.351 , pp. 1502-1512
    • Tannock, I.F.1    de Wit, R.2    Berry, W.R.3    Horti, J.4    Pluzanska, A.5    Chi, K.N.6
  • 15
    • 84926250651 scopus 로고    scopus 로고
    • Sequencing current therapies in the treatment of metastatic prostate cancer
    • Valenca LB, Sweeney CJ, Pomerantz MM. Sequencing current therapies in the treatment of metastatic prostate cancer. Cancer Treat Rev. 41:332–40.
    • Cancer Treat Rev , vol.41 , pp. 332-340
    • Valenca, L.B.1    Sweeney, C.J.2    Pomerantz, M.M.3
  • 16
    • 84900507214 scopus 로고    scopus 로고
    • Treatment sequencing in metastatic castrate-resistant prostate cancer
    • COI: 1:CAS:528:DC%2BC2cXhtlajtbvE, PID: 24675654
    • Sartor O, Gillessen S. Treatment sequencing in metastatic castrate-resistant prostate cancer. Asian Journal of Andrology. 2014;16:426–31.
    • (2014) Asian Journal of Andrology , vol.16 , pp. 426-431
    • Sartor, O.1    Gillessen, S.2
  • 17
    • 84929989515 scopus 로고    scopus 로고
    • Targeting the androgen receptor confers in vivo cross-resistance between enzalutamide and docetaxel, but not cabazitaxel, in castration-resistant prostate cancer
    • PID: 25484141
    • van Soest RJ, de Morree ES, Kweldam CF, de Ridder CM, Wiemer EA, Mathijssen RH, et al. Targeting the androgen receptor confers in vivo cross-resistance between enzalutamide and docetaxel, but not cabazitaxel, in castration-resistant prostate cancer. Eur Urol. 2015;67:981–5.
    • (2015) Eur Urol , vol.67 , pp. 981-985
    • van Soest, R.J.1    de Morree, E.S.2    Kweldam, C.F.3    de Ridder, C.M.4    Wiemer, E.A.5    Mathijssen, R.H.6
  • 18
    • 84926142870 scopus 로고    scopus 로고
    • Efficacy of enzalutamide following abiraterone acetate in chemotherapy-naive metastatic castration-resistant prostate cancer patients
    • COI: 1:CAS:528:DC%2BC2cXhtFCgu73O, PID: 25018038
    • Azad AA, Eigl BJ, Murray RN, Kollmannsberger C, Chi KN. Efficacy of enzalutamide following abiraterone acetate in chemotherapy-naive metastatic castration-resistant prostate cancer patients. Eur Urol. 2015;67:23–9.
    • (2015) Eur Urol , vol.67 , pp. 23-29
    • Azad, A.A.1    Eigl, B.J.2    Murray, R.N.3    Kollmannsberger, C.4    Chi, K.N.5
  • 19
    • 84936986429 scopus 로고    scopus 로고
    • Exploring the clinical benefit of docetaxel or enzalutamide after disease progression during abiraterone acetate and prednisone treatment in men with metastatic castration-resistant prostate cancer
    • PID: 25708161
    • Zhang T, Dhawan MS, Healy P, George DJ, Harrison MR, Oldan J, et al. Exploring the clinical benefit of docetaxel or enzalutamide after disease progression during abiraterone acetate and prednisone treatment in men with metastatic castration-resistant prostate cancer. Clinical Genitourinary Cancer. 2015;13:392–9.
    • (2015) Clinical Genitourinary Cancer , vol.13 , pp. 392-399
    • Zhang, T.1    Dhawan, M.S.2    Healy, P.3    George, D.J.4    Harrison, M.R.5    Oldan, J.6
  • 20
    • 84877068636 scopus 로고    scopus 로고
    • Management of biochemically recurrent prostate cancer after local therapy: evolving standards of care and new directions
    • Paller CJ, Antonarakis ES. Management of biochemically recurrent prostate cancer after local therapy: evolving standards of care and new directions. Clinical Advances in Hematology & Oncology: H&O. 2013;11:14–23.
    • (2013) Clinical Advances in Hematology & Oncology: H&O , vol.11 , pp. 14-23
    • Paller, C.J.1    Antonarakis, E.S.2
  • 21
    • 0033520806 scopus 로고    scopus 로고
    • Prostate cancer cell cycle regulators: response to androgen withdrawal and development of androgen independence
    • COI: 1:CAS:528:DyaK1MXns1ClsbY%3D, PID: 10547394
    • Agus DB, Cordon-Cardo C, Fox W, Drobnjak M, Koff A, Golde DW, et al. Prostate cancer cell cycle regulators: response to androgen withdrawal and development of androgen independence. J Natl Cancer Inst. 1999;91:1869–76.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1869-1876
    • Agus, D.B.1    Cordon-Cardo, C.2    Fox, W.3    Drobnjak, M.4    Koff, A.5    Golde, D.W.6
  • 22
    • 84959018543 scopus 로고    scopus 로고
    • Targeting cancer stem cells in castration-resistant prostate cancer
    • COI: 1:CAS:528:DC%2BC28XitFeqs78%3D, PID: 26490309
    • Yun EJ, Zhou J, Lin CJ, Hernandez E, Fazli L, Gleave M, et al. Targeting cancer stem cells in castration-resistant prostate cancer. Clinical Cancer Research. 2016;22:670–9.
    • (2016) Clinical Cancer Research , vol.22 , pp. 670-679
    • Yun, E.J.1    Zhou, J.2    Lin, C.J.3    Hernandez, E.4    Fazli, L.5    Gleave, M.6
  • 23
    • 33644675811 scopus 로고    scopus 로고
    • Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis
    • COI: 1:CAS:528:DC%2BD2MXht1yntbnL, PID: 16278481
    • Scher HI, Sawyers CL. Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis. J Clin Oncol. 2005;23:8253–61.
    • (2005) J Clin Oncol , vol.23 , pp. 8253-8261
    • Scher, H.I.1    Sawyers, C.L.2
  • 24
    • 0028944138 scopus 로고
    • In vivo amplification of the androgen receptor gene and progression of human prostate cancer
    • COI: 1:CAS:528:DyaK2MXkvV2jurc%3D, PID: 7795646
    • Visakorpi T, Hyytinen E, Koivisto P, Tanner M, Keinanen R, Palmberg C, et al. In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nat Genet. 1995;9:401–6.
    • (1995) Nat Genet , vol.9 , pp. 401-406
    • Visakorpi, T.1    Hyytinen, E.2    Koivisto, P.3    Tanner, M.4    Keinanen, R.5    Palmberg, C.6
  • 25
    • 15644368237 scopus 로고    scopus 로고
    • Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer
    • COI: 1:CAS:528:DyaK2sXntFKhug%3D%3D, PID: 9000575
    • Koivisto P, Kononen J, Palmberg C, Tammela T, Hyytinen E, Isola J, et al. Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer. Cancer Res. 1997;57:314–9.
    • (1997) Cancer Res , vol.57 , pp. 314-319
    • Koivisto, P.1    Kononen, J.2    Palmberg, C.3    Tammela, T.4    Hyytinen, E.5    Isola, J.6
  • 26
    • 0033557839 scopus 로고    scopus 로고
    • Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays
    • COI: 1:CAS:528:DyaK1MXht1Sjurc%3D, PID: 10029066
    • Bubendorf L, Kononen J, Koivisto P, Schraml P, Moch H, Gasser TC, et al. Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays. Cancer Res. 1999;59:803–6.
    • (1999) Cancer Res , vol.59 , pp. 803-806
    • Bubendorf, L.1    Kononen, J.2    Koivisto, P.3    Schraml, P.4    Moch, H.5    Gasser, T.C.6
  • 27
  • 28
    • 84922864661 scopus 로고    scopus 로고
    • Is there an antiandrogen withdrawal syndrome with enzalutamide?
    • COI: 1:CAS:528:DC%2BC2MXivVegtb4%3D, PID: 24906049
    • Rodriguez-Vida A, Bianchini D, Van Hemelrijck M, Hughes S, Malik Z, Powles T, et al. Is there an antiandrogen withdrawal syndrome with enzalutamide? BJU Int. 2015;115:373–80.
    • (2015) BJU Int , vol.115 , pp. 373-380
    • Rodriguez-Vida, A.1    Bianchini, D.2    Van Hemelrijck, M.3    Hughes, S.4    Malik, Z.5    Powles, T.6
  • 29
    • 0037226103 scopus 로고    scopus 로고
    • Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome
    • COI: 1:CAS:528:DC%2BD3sXjvFKgsg%3D%3D, PID: 12517791
    • Hara T, Miyazaki J, Araki H, Yamaoka M, Kanzaki N, Kusaka M, et al. Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome. Cancer Res. 2003;63:149–53.
    • (2003) Cancer Res , vol.63 , pp. 149-153
    • Hara, T.1    Miyazaki, J.2    Araki, H.3    Yamaoka, M.4    Kanzaki, N.5    Kusaka, M.6
  • 30
    • 27844611242 scopus 로고    scopus 로고
    • Structural basis for accommodation of nonsteroidal ligands in the androgen receptor
    • COI: 1:CAS:528:DC%2BD2MXhtF2isrbL, PID: 16129672
    • Bohl CE, Miller DD, Chen J, Bell CE, Dalton JT. Structural basis for accommodation of nonsteroidal ligands in the androgen receptor. J Biol Chem. 2005;280:37747–54.
    • (2005) J Biol Chem , vol.280 , pp. 37747-37754
    • Bohl, C.E.1    Miller, D.D.2    Chen, J.3    Bell, C.E.4    Dalton, J.T.5
  • 31
    • 17844376217 scopus 로고    scopus 로고
    • Structural basis for antagonism and resistance of bicalutamide in prostate cancer
    • COI: 1:CAS:528:DC%2BD2MXkt1ClsLs%3D, PID: 15833816
    • Bohl CE, Gao W, Miller DD, Bell CE, Dalton JT. Structural basis for antagonism and resistance of bicalutamide in prostate cancer. Proc Natl Acad Sci U S A. 2005;102:6201–6.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 6201-6206
    • Bohl, C.E.1    Gao, W.2    Miller, D.D.3    Bell, C.E.4    Dalton, J.T.5
  • 32
    • 0034125195 scopus 로고    scopus 로고
    • Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor
    • COI: 1:CAS:528:DC%2BD3cXkt12itrw%3D, PID: 10835690
    • Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, et al. Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor. Nat Med. 2000;6:703–6.
    • (2000) Nat Med , vol.6 , pp. 703-706
    • Zhao, X.Y.1    Malloy, P.J.2    Krishnan, A.V.3    Swami, S.4    Navone, N.M.5    Peehl, D.M.6
  • 33
    • 67650758019 scopus 로고    scopus 로고
    • Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
    • Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J, et al. Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell. 138:245–56.
    • Cell , vol.138 , pp. 245-256
    • Wang, Q.1    Li, W.2    Zhang, Y.3    Yuan, X.4    Xu, K.5    Yu, J.6
  • 34
    • 84890555121 scopus 로고    scopus 로고
    • Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate-resistance and novel therapeutic approaches
    • COI: 1:CAS:528:DC%2BC3sXptV2nur4%3D, PID: 23752182
    • Karantanos T, Corn PG, Thompson TC. Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate-resistance and novel therapeutic approaches. Oncogene. 2013;32:5501–11.
    • (2013) Oncogene , vol.32 , pp. 5501-5511
    • Karantanos, T.1    Corn, P.G.2    Thompson, T.C.3
  • 35
    • 53049103521 scopus 로고    scopus 로고
    • The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth
    • COI: 1:CAS:528:DC%2BD1cXpslKmtr8%3D, PID: 18701501
    • Jin RJ, Lho Y, Connelly L, Wang Y, Yu X, Saint Jean L, et al. The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth. Cancer Res. 2008;68:6762–9.
    • (2008) Cancer Res , vol.68 , pp. 6762-6769
    • Jin, R.J.1    Lho, Y.2    Connelly, L.3    Wang, Y.4    Yu, X.5    Saint Jean, L.6
  • 36
    • 68449103870 scopus 로고    scopus 로고
    • NF-kappaB regulates androgen receptor expression and prostate cancer growth
    • COI: 1:CAS:528:DC%2BD1MXhtVGqtrvE, PID: 19628766
    • Zhang L, Altuwaijri S, Deng F, Chen L, Lal P, Bhanot UK, et al. NF-kappaB regulates androgen receptor expression and prostate cancer growth. Am J Pathol. 2009;175:489–99.
    • (2009) Am J Pathol , vol.175 , pp. 489-499
    • Zhang, L.1    Altuwaijri, S.2    Deng, F.3    Chen, L.4    Lal, P.5    Bhanot, U.K.6
  • 37
    • 84901255009 scopus 로고    scopus 로고
    • NF-kappaB gene signature predicts prostate cancer progression
    • COI: 1:CAS:528:DC%2BC2cXnvF2hsL0%3D, PID: 24686169
    • Jin R, Yi Y, Yull FE, Blackwell TS, Clark PE, Koyama T, et al. NF-kappaB gene signature predicts prostate cancer progression. Cancer Res. 2014;74:2763–72.
    • (2014) Cancer Res , vol.74 , pp. 2763-2772
    • Jin, R.1    Yi, Y.2    Yull, F.E.3    Blackwell, T.S.4    Clark, P.E.5    Koyama, T.6
  • 39
    • 79958764107 scopus 로고    scopus 로고
    • Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth
    • COI: 1:STN:280:DC%2BC3MrpsF2htg%3D%3D, PID: 21620777
    • Mulholland David J, Tran Linh M, Li Y, Cai H, Morim A, Wang S, et al. Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell. 2011;19:792–804.
    • (2011) Cancer Cell , vol.19 , pp. 792-804
    • Mulholland David, J.1    Tran Linh, M.2    Li, Y.3    Cai, H.4    Morim, A.5    Wang, S.6
  • 40
    • 84900471149 scopus 로고    scopus 로고
    • PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance
    • COI: 1:CAS:528:DC%2BC2cXhtlajtL7J, PID: 24759575
    • Edlind MP, Hsieh AC. PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance. Asian Journal of Andrology. 2014;16:378–86.
    • (2014) Asian Journal of Andrology , vol.16 , pp. 378-386
    • Edlind, M.P.1    Hsieh, A.C.2
  • 41
    • 84925295476 scopus 로고    scopus 로고
    • PTEN loss in biopsy tissue predicts poor clinical outcomes in prostate cancer
    • COI: 1:CAS:528:DC%2BC2cXitVektrrI, PID: 25099119
    • Mithal P, Allott E, Gerber L, Reid J, Welbourn W, Tikishvili E, et al. PTEN loss in biopsy tissue predicts poor clinical outcomes in prostate cancer. Int J Urol. 2014;21:1209–14.
    • (2014) Int J Urol , vol.21 , pp. 1209-1214
    • Mithal, P.1    Allott, E.2    Gerber, L.3    Reid, J.4    Welbourn, W.5    Tikishvili, E.6
  • 42
    • 0028113415 scopus 로고
    • Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor
    • COI: 1:CAS:528:DyaK2cXmsVKltLg%3D, PID: 7522959
    • Culig Z, Hobisch A, Cronauer MV, Radmayr C, Trapman J, Hittmair A, et al. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Cancer Res. 1994;54:5474–8.
    • (1994) Cancer Res , vol.54 , pp. 5474-5478
    • Culig, Z.1    Hobisch, A.2    Cronauer, M.V.3    Radmayr, C.4    Trapman, J.5    Hittmair, A.6
  • 43
    • 37349118115 scopus 로고    scopus 로고
    • Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex
    • COI: 1:CAS:528:DC%2BD1cXhtVKlsrk%3D, PID: 17940184
    • Heemers HV, Tindall DJ. Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex. Endocr Rev. 2007;28:778–808.
    • (2007) Endocr Rev , vol.28 , pp. 778-808
    • Heemers, H.V.1    Tindall, D.J.2
  • 44
    • 84885468685 scopus 로고    scopus 로고
    • Androgen receptors in hormone-dependent and castration-resistant prostate cancer
    • COI: 1:CAS:528:DC%2BC3sXht1SjtLrL, PID: 23859952
    • Shafi AA, Yen AE, Weigel NL. Androgen receptors in hormone-dependent and castration-resistant prostate cancer. Pharmacol Ther. 2013;140:223–38.
    • (2013) Pharmacol Ther , vol.140 , pp. 223-238
    • Shafi, A.A.1    Yen, A.E.2    Weigel, N.L.3
  • 45
    • 0032510686 scopus 로고    scopus 로고
    • From estrogen to androgen receptor: a new pathway for sex hormones in prostate
    • COI: 1:CAS:528:DyaK1cXjtFWktLw%3D, PID: 9576916
    • Yeh S, Miyamoto H, Shima H, Chang C. From estrogen to androgen receptor: a new pathway for sex hormones in prostate. Proc Natl Acad Sci U S A. 1998;95:5527–32.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 5527-5532
    • Yeh, S.1    Miyamoto, H.2    Shima, H.3    Chang, C.4
  • 46
    • 76749108107 scopus 로고    scopus 로고
    • FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells
    • COI: 1:CAS:528:DC%2BC3cXjtFajtbc%3D, PID: 20048054
    • Ni L, Yang CS, Gioeli D, Frierson H, Toft DO, Paschal BM. FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells. Mol Cell Biol. 2010;30:1243–53.
    • (2010) Mol Cell Biol , vol.30 , pp. 1243-1253
    • Ni, L.1    Yang, C.S.2    Gioeli, D.3    Frierson, H.4    Toft, D.O.5    Paschal, B.M.6
  • 48
    • 84927544573 scopus 로고    scopus 로고
    • Does degree of androgen suppression matter in hormone-sensitive
    • COI: 1:CAS:528:DC%2BC2MXntFensbo%3D, PID: 25732171
    • Suzman DL, Antonarakis ES. Does degree of androgen suppression matter in hormone-sensitive. Journal of Clinical Oncology. 2015;33:1098–100.
    • (2015) Journal of Clinical Oncology , vol.33 , pp. 1098-1100
    • Suzman, D.L.1    Antonarakis, E.S.2
  • 49
    • 8444231965 scopus 로고    scopus 로고
    • The influence of androgen deprivation therapy on dihydrotestosterone levels in the prostatic tissue of patients with prostate cancer
    • COI: 1:CAS:528:DC%2BD2cXpsVKltLw%3D
    • Nishiyama T, Hashimoto Y, Takahashi K. The influence of androgen deprivation therapy on dihydrotestosterone levels in the prostatic tissue of patients with prostate cancer. American Association for Cancer Research. 2004;10:7121–6.
    • (2004) American Association for Cancer Research , vol.10 , pp. 7121-7126
    • Nishiyama, T.1    Hashimoto, Y.2    Takahashi, K.3
  • 51
    • 27644452640 scopus 로고    scopus 로고
    • Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer
    • COI: 1:CAS:528:DC%2BD2MXlvVGhtrY%3D, PID: 16000557
    • Titus MA, Schell MJ, Lih FB, Tomer KB, Mohler JL. Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer. Clinical Cancer Research. 2005;11:4653–7.
    • (2005) Clinical Cancer Research , vol.11 , pp. 4653-4657
    • Titus, M.A.1    Schell, M.J.2    Lih, F.B.3    Tomer, K.B.4    Mohler, J.L.5
  • 52
    • 84910013455 scopus 로고    scopus 로고
    • Androgen metabolism in prostate cancer: from molecular mechanisms to clinical consequences
    • COI: 1:CAS:528:DC%2BC2cXos1ehsLo%3D, PID: 24867689
    • Chang K, Ercole CE, Sharifi N. Androgen metabolism in prostate cancer: from molecular mechanisms to clinical consequences. Br J Cancer. 2014;111:1249–54.
    • (2014) Br J Cancer , vol.111 , pp. 1249-1254
    • Chang, K.1    Ercole, C.E.2    Sharifi, N.3
  • 53
    • 49249119358 scopus 로고    scopus 로고
    • Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth
    • COI: 1:CAS:528:DC%2BD1cXmsFKlsr8%3D, PID: 18519708
    • Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, Higano CS, et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res. 2008;68:4447–54.
    • (2008) Cancer Res , vol.68 , pp. 4447-4454
    • Montgomery, R.B.1    Mostaghel, E.A.2    Vessella, R.3    Hess, D.L.4    Kalhorn, T.F.5    Higano, C.S.6
  • 54
    • 33645056171 scopus 로고    scopus 로고
    • Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    • COI: 1:CAS:528:DC%2BD28XhvV2gt7Y%3D, PID: 16510604
    • Stanbrough M, Bubley GJ, Ross K, Golub TR, Rubin MA, Penning TM, et al. Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res. 2006;66:2815–25.
    • (2006) Cancer Res , vol.66 , pp. 2815-2825
    • Stanbrough, M.1    Bubley, G.J.2    Ross, K.3    Golub, T.R.4    Rubin, M.A.5    Penning, T.M.6
  • 55
    • 84883367616 scopus 로고    scopus 로고
    • A gain-of-function mutation in DHT synthesis in castration-resistant prostate cancer
    • COI: 1:CAS:528:DC%2BC3sXhtlGqsb3E, PID: 23993097
    • Chang KH, Li R, Kuri B, Lotan Y, Roehrborn CG, Liu J, et al. A gain-of-function mutation in DHT synthesis in castration-resistant prostate cancer. Cell. 2013;154:1074–84.
    • (2013) Cell , vol.154 , pp. 1074-1084
    • Chang, K.H.1    Li, R.2    Kuri, B.3    Lotan, Y.4    Roehrborn, C.G.5    Liu, J.6
  • 56
    • 84879604525 scopus 로고    scopus 로고
    • Targeting the adrenal gland in castration-resistant prostate cancer: a case for orteronel, a selective CYP-17 17,20-lyase inhibitor
    • COI: 1:CAS:528:DC%2BC3sXjslOgtL4%3D, PID: 23371447
    • Zhu H, Garcia JA. Targeting the adrenal gland in castration-resistant prostate cancer: a case for orteronel, a selective CYP-17 17,20-lyase inhibitor. Curr Oncol Rep. 2013;15:105–12.
    • (2013) Curr Oncol Rep , vol.15 , pp. 105-112
    • Zhu, H.1    Garcia, J.A.2
  • 57
    • 51049098138 scopus 로고    scopus 로고
    • Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
    • COI: 1:CAS:528:DC%2BD1cXpt1Wjt7o%3D, PID: 18676866
    • Locke JA, Guns ES, Lubik AA, Adomat HH, Hendy SC, Wood CA, et al. Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. Cancer Res. 2008;68:6407–15.
    • (2008) Cancer Res , vol.68 , pp. 6407-6415
    • Locke, J.A.1    Guns, E.S.2    Lubik, A.A.3    Adomat, H.H.4    Hendy, S.C.5    Wood, C.A.6
  • 58
    • 84930481600 scopus 로고    scopus 로고
    • The tumor microenvironment in prostate cancer: elucidating molecular pathways for therapy development
    • PID: 22904640
    • Corn PG. The tumor microenvironment in prostate cancer: elucidating molecular pathways for therapy development. Cancer Manag Res. 2012;4:183–93.
    • (2012) Cancer Manag Res , vol.4 , pp. 183-193
    • Corn, P.G.1
  • 59
    • 84862908058 scopus 로고    scopus 로고
    • Androgen deprivation causes epithelial–mesenchymal transition in the prostate: implications for androgen-deprivation therapy
    • COI: 1:CAS:528:DC%2BC38Xos1KktQ%3D%3D, PID: 22108827
    • Sun Y, Wang B-E, Leong KG, Yue P, Li L, Jhunjhunwala S, et al. Androgen deprivation causes epithelial–mesenchymal transition in the prostate: implications for androgen-deprivation therapy. Cancer Res. 2012;72:527–36.
    • (2012) Cancer Res , vol.72 , pp. 527-536
    • Sun, Y.1    Wang, B.-E.2    Leong, K.G.3    Yue, P.4    Li, L.5    Jhunjhunwala, S.6
  • 60
    • 65349132693 scopus 로고    scopus 로고
    • EMT, the cytoskeleton, and cancer cell invasion
    • PID: 19169796
    • Yilmaz M, Christofori G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev. 2009;28:15–33.
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 15-33
    • Yilmaz, M.1    Christofori, G.2
  • 61
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • COI: 1:CAS:528:DC%2BC3cXksFWltA%3D%3D, PID: 19945376
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell. 2009;139:871–90.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 62
    • 77952308856 scopus 로고    scopus 로고
    • Role of androgens and the androgen receptor in epithelial-mesenchymal transition and invasion of prostate cancer cells
    • COI: 1:CAS:528:DC%2BC3cXjtFagsbw%3D, PID: 19901020
    • Zhu M-L, Kyprianou N. Role of androgens and the androgen receptor in epithelial-mesenchymal transition and invasion of prostate cancer cells. FASEB J. 2010;24:769–77.
    • (2010) FASEB J , vol.24 , pp. 769-777
    • Zhu, M.-L.1    Kyprianou, N.2
  • 63
    • 77954674441 scopus 로고    scopus 로고
    • Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells
    • COI: 1:CAS:528:DC%2BC3cXnsl2rt70%3D, PID: 20238234
    • Ouyang G, Wang Z, Fang X, Liu J, Yang CJ. Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells. Cellular and Molecular Life Sciences: CMLS. 2010;67:2605–18.
    • (2010) Cellular and Molecular Life Sciences: CMLS , vol.67 , pp. 2605-2618
    • Ouyang, G.1    Wang, Z.2    Fang, X.3    Liu, J.4    Yang, C.J.5
  • 64
    • 78650310780 scopus 로고    scopus 로고
    • Epithelial plasticity, cancer stem cells and bone metastasis formation
    • PID: 20670698
    • van der Pluijm G. Epithelial plasticity, cancer stem cells and bone metastasis formation. Bone. 2011;48:37–43.
    • (2011) Bone , vol.48 , pp. 37-43
    • van der Pluijm, G.1
  • 65
    • 84973473567 scopus 로고    scopus 로고
    • Epithelial-mesenchymal-transition regulators in prostate cancer: androgens and beyond
    • PID: 27189666
    • Nakazawa M, Kyprianou N. Epithelial-mesenchymal-transition regulators in prostate cancer: androgens and beyond. J Steroid Biochem Mol Biol. 2016;166:84–90.
    • (2016) J Steroid Biochem Mol Biol , vol.166 , pp. 84-90
    • Nakazawa, M.1    Kyprianou, N.2
  • 66
    • 31944448443 scopus 로고    scopus 로고
    • N-cadherin switching occurs in high Gleason grade prostate cancer
    • COI: 1:CAS:528:DC%2BD28Xhs1KmsLo%3D, PID: 16173043
    • Jaggi M, Nazemi T, Abrahams NA, Baker JJ, Galich A, Smith LM, et al. N-cadherin switching occurs in high Gleason grade prostate cancer. Prostate. 2006;66:193–9.
    • (2006) Prostate , vol.66 , pp. 193-199
    • Jaggi, M.1    Nazemi, T.2    Abrahams, N.A.3    Baker, J.J.4    Galich, A.5    Smith, L.M.6
  • 67
    • 37249030356 scopus 로고    scopus 로고
    • A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer
    • COI: 1:CAS:528:DC%2BD2sXhtlyitL7K, PID: 18056176
    • Gravdal K, Halvorsen OJ, Haukaas SA, Akslen LA. A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer. Clin Cancer Res. 2007;13:7003–11.
    • (2007) Clin Cancer Res , vol.13 , pp. 7003-7011
    • Gravdal, K.1    Halvorsen, O.J.2    Haukaas, S.A.3    Akslen, L.A.4
  • 68
    • 84922522895 scopus 로고    scopus 로고
    • Androgen-targeted therapy-induced epithelial mesenchymal plasticity and neuroendocrine transdifferentiation in prostate cancer: an opportunity for intervention
    • Nouri M, Ratther E, Stylianou N, Nelson CC, Hollier BG, Williams ED. Androgen-targeted therapy-induced epithelial mesenchymal plasticity and neuroendocrine transdifferentiation in prostate cancer: an opportunity for intervention. Frontiers in Oncology. 2014;4
    • (2014) Frontiers in Oncology , pp. 4
    • Nouri, M.1    Ratther, E.2    Stylianou, N.3    Nelson, C.C.4    Hollier, B.G.5    Williams, E.D.6
  • 69
    • 85013676604 scopus 로고    scopus 로고
    • Kyprianou N. Molecular exploitation of apoptosis pathways in prostate cancer: World Scientific; 2012
    • Kyprianou N. Molecular exploitation of apoptosis pathways in prostate cancer: World Scientific; 2012.
  • 70
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 144:646–74.
    • Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 71
    • 84873853968 scopus 로고    scopus 로고
    • Targeting the apoptosis pathway in prostate cancer
    • COI: 1:CAS:528:DC%2BC3sXlt1aisrY%3D
    • Zielinski RR, Eigl BJ, Chi KN. Targeting the apoptosis pathway in prostate cancer. Cancer Journal. 2013;19:79–89.
    • (2013) Cancer Journal , vol.19 , pp. 79-89
    • Zielinski, R.R.1    Eigl, B.J.2    Chi, K.N.3
  • 72
    • 0029873670 scopus 로고    scopus 로고
    • Role of programmed (apoptotic) cell death during the progression and therapy for prostate cancer
    • COI: 1:CAS:528:DyaK28Xjt1Wmtrs%3D, PID: 8602401
    • Denmeade SR, Lin XS, Isaacs JT. Role of programmed (apoptotic) cell death during the progression and therapy for prostate cancer. Prostate. 1996;28:251–65.
    • (1996) Prostate , vol.28 , pp. 251-265
    • Denmeade, S.R.1    Lin, X.S.2    Isaacs, J.T.3
  • 73
    • 0034612780 scopus 로고    scopus 로고
    • Apoptosis: translating theory to therapy for prostate cancer
    • COI: 1:STN:280:DC%2BD3M%2Fmt1SntQ%3D%3D, PID: 10974062
    • Isaacs JT. Apoptosis: translating theory to therapy for prostate cancer. J Natl Cancer Inst. 2000;92:1367–9.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1367-1369
    • Isaacs, J.T.1
  • 74
    • 30044447244 scopus 로고    scopus 로고
    • Apoptosis evasion: the role of survival pathways in prostate cancer progression and therapeutic resistance
    • COI: 1:CAS:528:DC%2BD28XivV2lsg%3D%3D, PID: 16216007
    • McKenzie S, Kyprianou N. Apoptosis evasion: the role of survival pathways in prostate cancer progression and therapeutic resistance. J Cell Biochem. 2006;97:18–32.
    • (2006) J Cell Biochem , vol.97 , pp. 18-32
    • McKenzie, S.1    Kyprianou, N.2
  • 75
    • 0032871812 scopus 로고    scopus 로고
    • Effect of Bcl-2 overexpression in human prostate cancer cells in vitro and in vivo
    • COI: 1:CAS:528:DyaK1MXmvV2mu7w%3D, PID: 10533903
    • Kajiwara T, Takeuchi T, Ueki T, Moriyama N, Ueki K, Kakizoe T, et al. Effect of Bcl-2 overexpression in human prostate cancer cells in vitro and in vivo. Int J Urol. 1999;6:520–5.
    • (1999) Int J Urol , vol.6 , pp. 520-525
    • Kajiwara, T.1    Takeuchi, T.2    Ueki, T.3    Moriyama, N.4    Ueki, K.5    Kakizoe, T.6
  • 76
    • 63149129655 scopus 로고    scopus 로고
    • Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy
    • COI: 1:CAS:528:DC%2BD1MXitVOksLg%3D, PID: 19228717
    • Kang MH, Reynolds CP. Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clinical Cancer Research. 2009;15:1126–32.
    • (2009) Clinical Cancer Research , vol.15 , pp. 1126-1132
    • Kang, M.H.1    Reynolds, C.P.2
  • 77
    • 29244478619 scopus 로고    scopus 로고
    • Anoikis and survival connections in the tumor microenvironment: is there a role in prostate cancer metastasis?
    • COI: 1:CAS:528:DC%2BD2MXhtlWiurfJ, PID: 16357123
    • Rennebeck G, Martelli M, Kyprianou N. Anoikis and survival connections in the tumor microenvironment: is there a role in prostate cancer metastasis? Cancer Res. 2005;65:11230–5.
    • (2005) Cancer Res , vol.65 , pp. 11230-11235
    • Rennebeck, G.1    Martelli, M.2    Kyprianou, N.3
  • 78
    • 0035480032 scopus 로고    scopus 로고
    • Anoikis mechanisms
    • COI: 1:CAS:528:DC%2BD3MXmsFersLs%3D, PID: 11544023
    • Frisch SM, Screaton RA. Anoikis mechanisms. Curr Opin Cell Biol. 2001;13:555–62.
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 555-562
    • Frisch, S.M.1    Screaton, R.A.2
  • 79
    • 0033118450 scopus 로고    scopus 로고
    • Prostatic carcinoma cell migration via alpha(v)beta3 integrin is modulated by a focal adhesion kinase pathway
    • COI: 1:CAS:528:DyaK1MXisVWku7c%3D, PID: 10197643
    • Zheng DQ, Woodard AS, Fornaro M, Tallini G, Languino LR. Prostatic carcinoma cell migration via alpha(v)beta3 integrin is modulated by a focal adhesion kinase pathway. Cancer Res. 1999;59:1655–64.
    • (1999) Cancer Res , vol.59 , pp. 1655-1664
    • Zheng, D.Q.1    Woodard, A.S.2    Fornaro, M.3    Tallini, G.4    Languino, L.R.5
  • 80
    • 84885214146 scopus 로고    scopus 로고
    • An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide)
    • COI: 1:CAS:528:DC%2BC3sXhsVCgtLzP, PID: 23842682, The first evidence to suggest that the AR mutation F876L confers agonist properties to enzalutamide. While several activating mutations have been identified in the context of first-generation antiandrogens, this is the first mutation to be identified in a second-generation antiandrogen
    • •• Korpal M, Korn JM, Gao X, Rakiec DP, Ruddy DA, Doshi S, et al. An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide). Cancer Discov. 2013;3:1030–43. The first evidence to suggest that the AR mutation F876L confers agonist properties to enzalutamide. While several activating mutations have been identified in the context of first-generation antiandrogens, this is the first mutation to be identified in a second-generation antiandrogen.
    • (2013) Cancer Discov , vol.3 , pp. 1030-1043
    • Korpal, M.1    Korn, J.M.2    Gao, X.3    Rakiec, D.P.4    Ruddy, D.A.5    Doshi, S.6
  • 81
    • 84956577962 scopus 로고    scopus 로고
    • Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients
    • Lallous N, Volik SV, Awrey S, Leblanc E, Tse R, Murillo J, et al. Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients. Genome Biol. 2016;17.
    • (2016) Genome Biol , pp. 17
    • Lallous, N.1    Volik, S.V.2    Awrey, S.3    Leblanc, E.4    Tse, R.5    Murillo, J.6
  • 82
    • 84882274167 scopus 로고    scopus 로고
    • NF-kappaB2/p52 induces resistance to enzalutamide in prostate cancer: role of androgen receptor and its variants
    • COI: 1:CAS:528:DC%2BC3sXht1ChurnL, PID: 23699654
    • Nadiminty N, Tummala R, Liu C, Yang J, Lou W, Evans CP, et al. NF-kappaB2/p52 induces resistance to enzalutamide in prostate cancer: role of androgen receptor and its variants. Mol Cancer Ther. 2013;12:1629–37.
    • (2013) Mol Cancer Ther , vol.12 , pp. 1629-1637
    • Nadiminty, N.1    Tummala, R.2    Liu, C.3    Yang, J.4    Lou, W.5    Evans, C.P.6
  • 83
    • 85010711902 scopus 로고    scopus 로고
    • ANdrogen receptor splice variant 7 and efficacy of taxane chemotherapy in patients with metastatic castration-resistant prostate cancer
    • PID: 26181238, This follow-up study showed that the presence of AR-V7 does not predict a response to taxane chemotherapies, challenging the predictive value of AR-V7 as a treatment selection biomarker for therapeutic resistance to non-antiandrogen treatments in CRPC
    • •• Antonarakis ES, Lu C, Luber B, et al. ANdrogen receptor splice variant 7 and efficacy of taxane chemotherapy in patients with metastatic castration-resistant prostate cancer. JAMA Oncology. 2015;1:582–91. This follow-up study showed that the presence of AR-V7 does not predict a response to taxane chemotherapies, challenging the predictive value of AR-V7 as a treatment selection biomarker for therapeutic resistance to non-antiandrogen treatments in CRPC.
    • (2015) JAMA Oncology , vol.1 , pp. 582-591
    • Antonarakis, E.S.1    Lu, C.2    Luber, B.3
  • 84
    • 84907057471 scopus 로고    scopus 로고
    • AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer
    • PID: 25184630, Clinical evidence defining the association of AR splice variant-7 (AR-V7) with therapeutic resistance to abiraterone and enzalutamide in men with CRPC
    • •• Antonarakis ES, Lu C, Wang H, Luber B, Nakazawa M, Roeser JC, et al. AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer. N Engl J Med. 2014;371:1028–38. Clinical evidence defining the association of AR splice variant-7 (AR-V7) with therapeutic resistance to abiraterone and enzalutamide in men with CRPC.
    • (2014) N Engl J Med , vol.371 , pp. 1028-1038
    • Antonarakis, E.S.1    Lu, C.2    Wang, H.3    Luber, B.4    Nakazawa, M.5    Roeser, J.C.6
  • 85
    • 84946195510 scopus 로고    scopus 로고
    • The molecular taxonomy of primary prostate cancer. Cell. 2015;163:1011–25.
    • (2015) Cell , vol.163 , pp. 1011-1025
  • 86
    • 84866415731 scopus 로고    scopus 로고
    • Androgen receptor on the move: boarding the microtubule expressway to the nucleus
    • COI: 1:CAS:528:DC%2BC38XhtlygtbrF, PID: 22987486
    • Thadani-Mulero M, Nanus DM, Giannakakou P. Androgen receptor on the move: boarding the microtubule expressway to the nucleus. Cancer Res. 2012;72:4611–5.
    • (2012) Cancer Res , vol.72 , pp. 4611-4615
    • Thadani-Mulero, M.1    Nanus, D.M.2    Giannakakou, P.3
  • 87
    • 78049294167 scopus 로고    scopus 로고
    • Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer
    • COI: 1:CAS:528:DC%2BC3cXht1yqs7bM, PID: 20807808
    • Zhu ML, Horbinski CM, Garzotto M, Qian DZ, Beer TM, Kyprianou N. Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer. Cancer Res. 2010;70:7992–8002.
    • (2010) Cancer Res , vol.70 , pp. 7992-8002
    • Zhu, M.L.1    Horbinski, C.M.2    Garzotto, M.3    Qian, D.Z.4    Beer, T.M.5    Kyprianou, N.6
  • 88
    • 0027484720 scopus 로고
    • Removal of beta III isotype enhances taxol induced microtubule assembly
    • COI: 1:CAS:528:DyaK2cXhvVamsrg%3D, PID: 7902216
    • Lu Q, Luduena RF. Removal of beta III isotype enhances taxol induced microtubule assembly. Cell Struct Funct. 1993;18:173–82.
    • (1993) Cell Struct Funct , vol.18 , pp. 173-182
    • Lu, Q.1    Luduena, R.F.2
  • 90
    • 84869160169 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition leads to docetaxel resistance in prostate cancer and is mediated by reduced expression of miR-200c and miR-205
    • COI: 1:CAS:528:DC%2BC38XhvFShsLzO, PID: 23041061
    • Puhr M, Hoefer J, Schafer G, Erb HH, Oh SJ, Klocker H, et al. Epithelial-to-mesenchymal transition leads to docetaxel resistance in prostate cancer and is mediated by reduced expression of miR-200c and miR-205. Am J Pathol. 2012;181:2188–201.
    • (2012) Am J Pathol , vol.181 , pp. 2188-2201
    • Puhr, M.1    Hoefer, J.2    Schafer, G.3    Erb, H.H.4    Oh, S.J.5    Klocker, H.6
  • 91
    • 79952978362 scopus 로고    scopus 로고
    • Cabazitaxel: a novel second-line treatment for metastatic castration-resistant prostate cancer
    • COI: 1:CAS:528:DC%2BC3MXktlCgurg%3D, PID: 21448449
    • Paller CJ, Antonarakis ES. Cabazitaxel: a novel second-line treatment for metastatic castration-resistant prostate cancer. Drug Design, Development and Therapy. 2011;5:117–24.
    • (2011) Drug Design, Development and Therapy , vol.5 , pp. 117-124
    • Paller, C.J.1    Antonarakis, E.S.2
  • 92
    • 84907083697 scopus 로고    scopus 로고
    • Androgen receptor splice variants in the era of enzalutamide and abiraterone
    • COI: 1:CAS:528:DC%2BC2cXht1Sqtb7F
    • Nakazawa M, Antonarakis ES, Luo J. Androgen receptor splice variants in the era of enzalutamide and abiraterone. Hormones & Cancer. 2014;5:265–73.
    • (2014) Hormones & Cancer , vol.5 , pp. 265-273
    • Nakazawa, M.1    Antonarakis, E.S.2    Luo, J.3
  • 93
    • 80054931284 scopus 로고    scopus 로고
    • Alternatively spliced androgen receptor variants
    • COI: 1:CAS:528:DC%2BC3MXhsV2ns7jO, PID: 21778211
    • Dehm SM, Tindall DJ. Alternatively spliced androgen receptor variants. Endocrine-Related Cancer. 2011;18:R183–96.
    • (2011) Endocrine-Related Cancer , vol.18 , pp. R183-R196
    • Dehm, S.M.1    Tindall, D.J.2
  • 94
    • 58249110391 scopus 로고    scopus 로고
    • Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
    • COI: 1:CAS:528:DC%2BD1MXmvFCj, PID: 19117982
    • Hu R, Dunn TA, Wei S, Isharwal S, Veltri RW, Humphreys E, et al. Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res. 2009;69:16–22.
    • (2009) Cancer Res , vol.69 , pp. 16-22
    • Hu, R.1    Dunn, T.A.2    Wei, S.3    Isharwal, S.4    Veltri, R.W.5    Humphreys, E.6
  • 95
    • 65549168746 scopus 로고    scopus 로고
    • A novel androgen receptor splice variant is upregulated during prostate cancer progression and promotes androgen-depletion-resistant growth
    • COI: 1:CAS:528:DC%2BD1MXjtFyqtLo%3D, PID: 19244107
    • Guo Z, Yang X, Sun F, Jiang R, Linn DE, Chen H, et al. A novel androgen receptor splice variant is upregulated during prostate cancer progression and promotes androgen-depletion-resistant growth. Cancer Res. 2009;69:2305–13.
    • (2009) Cancer Res , vol.69 , pp. 2305-2313
    • Guo, Z.1    Yang, X.2    Sun, F.3    Jiang, R.4    Linn, D.E.5    Chen, H.6
  • 96
    • 79959312739 scopus 로고    scopus 로고
    • A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities
    • COI: 1:CAS:528:DC%2BC3MXht1Srs7nN, PID: 21446008
    • Hu R, Isaacs WB, Luo J. A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities. Prostate. 2011;71:1656–67.
    • (2011) Prostate , vol.71 , pp. 1656-1667
    • Hu, R.1    Isaacs, W.B.2    Luo, J.3
  • 97
    • 84872534568 scopus 로고    scopus 로고
    • Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines
    • COI: 1:CAS:528:DC%2BC3sXptlalsg%3D%3D, PID: 23117885
    • Li Y, Chan SC, Brand LJ, Hwang TH, Silverstein KA, Dehm SM. Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines. Cancer Res. 2013;73:483–9.
    • (2013) Cancer Res , vol.73 , pp. 483-489
    • Li, Y.1    Chan, S.C.2    Brand, L.J.3    Hwang, T.H.4    Silverstein, K.A.5    Dehm, S.M.6
  • 98
    • 80052827038 scopus 로고    scopus 로고
    • Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants
    • COI: 1:CAS:528:DC%2BC3MXhtFOitLfM, PID: 21807635
    • Mostaghel EA, Marck BT, Plymate SR, Vessella RL, Balk S, Matsumoto AM, et al. Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants. Clinical Cancer Research. 2011;17:5913–25.
    • (2011) Clinical Cancer Research , vol.17 , pp. 5913-5925
    • Mostaghel, E.A.1    Marck, B.T.2    Plymate, S.R.3    Vessella, R.L.4    Balk, S.5    Matsumoto, A.M.6
  • 99
    • 0034659964 scopus 로고    scopus 로고
    • The natural history, skeletal complications, and management of bone metastases in patients with prostate carcinoma
    • COI: 1:STN:280:DC%2BD3czlsVOjtQ%3D%3D, PID: 10898342
    • Carlin BI, Andriole GL. The natural history, skeletal complications, and management of bone metastases in patients with prostate carcinoma. Cancer. 2000;88:2989–94.
    • (2000) Cancer , vol.88 , pp. 2989-2994
    • Carlin, B.I.1    Andriole, G.L.2
  • 100
    • 11144237716 scopus 로고    scopus 로고
    • Osteoblasts in prostate cancer metastasis to bone
    • COI: 1:CAS:528:DC%2BD2MXlvVel, PID: 15630412
    • Logothetis CJ, Lin S-H. Osteoblasts in prostate cancer metastasis to bone. Nat Rev Cancer. 2005;5:21–8.
    • (2005) Nat Rev Cancer , vol.5 , pp. 21-28
    • Logothetis, C.J.1    Lin, S.-H.2
  • 101
    • 0036718472 scopus 로고    scopus 로고
    • Skeletal fractures negatively correlate with overall survival in men with prostate cancer
    • PID: 12187209
    • Oefelein MG, Ricchiuti V, Conrad W, Resnick MI. Skeletal fractures negatively correlate with overall survival in men with prostate cancer. J Urol. 2002;168:1005–7.
    • (2002) J Urol , vol.168 , pp. 1005-1007
    • Oefelein, M.G.1    Ricchiuti, V.2    Conrad, W.3    Resnick, M.I.4
  • 103
    • 84861116448 scopus 로고    scopus 로고
    • Tumor microenvironment complexity: emerging roles in cancer therapy
    • COI: 1:CAS:528:DC%2BC38XmvF2ntLw%3D, PID: 22414581
    • Swartz MA, Iida N, Roberts EW, Sangaletti S, Wong MH, Yull FE, et al. Tumor microenvironment complexity: emerging roles in cancer therapy. Cancer Res. 2012;72:2473–80.
    • (2012) Cancer Res , vol.72 , pp. 2473-2480
    • Swartz, M.A.1    Iida, N.2    Roberts, E.W.3    Sangaletti, S.4    Wong, M.H.5    Yull, F.E.6
  • 104
    • 84925339649 scopus 로고    scopus 로고
    • Denosumab for the prevention of skeletal complications in metastatic castration-resistant prostate cancer: comparison of skeletal-related events and symptomatic skeletal events
    • COI: 1:STN:280:DC%2BC2MzgvVWmtQ%3D%3D, PID: 25425475
    • Smith MR, Coleman RE, Klotz L, Pittman K, Milecki P, Ng S, et al. Denosumab for the prevention of skeletal complications in metastatic castration-resistant prostate cancer: comparison of skeletal-related events and symptomatic skeletal events. Ann Oncol. 2015;26:368–74.
    • (2015) Ann Oncol , vol.26 , pp. 368-374
    • Smith, M.R.1    Coleman, R.E.2    Klotz, L.3    Pittman, K.4    Milecki, P.5    Ng, S.6
  • 105
    • 84855516339 scopus 로고    scopus 로고
    • Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BC38XkslOqsw%3D%3D, PID: 22093187
    • Smith MR, Saad F, Coleman R, Shore N, Fizazi K, Tombal B, et al. Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trial. Lancet. 2012;379:39–46.
    • (2012) Lancet , vol.379 , pp. 39-46
    • Smith, M.R.1    Saad, F.2    Coleman, R.3    Shore, N.4    Fizazi, K.5    Tombal, B.6
  • 106
    • 84899864278 scopus 로고    scopus 로고
    • RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization
    • COI: 1:CAS:528:DC%2BC2cXpsVSlsb0%3D, PID: 24478054
    • Chu GCY, Zhau HE, Wang R, Rogatko A, Feng X, Zayzafoon M, et al. RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization. Endocrine-related cancer. 2014;21:311–26.
    • (2014) Endocrine-related cancer , vol.21 , pp. 311-326
    • Chu, G.C.Y.1    Zhau, H.E.2    Wang, R.3    Rogatko, A.4    Feng, X.5    Zayzafoon, M.6
  • 107
    • 84961707381 scopus 로고    scopus 로고
    • Targeting bone metastases in metastatic castration-resistant prostate cancer
    • PID: 27042152
    • El-Amm J, Aragon-Ching JB. Targeting bone metastases in metastatic castration-resistant prostate cancer. Clinical Medicine Insights Oncology. 2016;10:11–9.
    • (2016) Clinical Medicine Insights Oncology , vol.10 , pp. 11-19
    • El-Amm, J.1    Aragon-Ching, J.B.2
  • 108
    • 84940032731 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration approval summary: enzalutamide for the treatment of patients with chemotherapy-naïve metastatic castration-resistant prostate cancer
    • COI: 1:CAS:528:DC%2BC2MXitVGjsrnP, PID: 26070917
    • Ning Y-M, Brave M, Maher VE, Zhang L, Tang S, Sridhara R, et al. U.S. Food and Drug Administration approval summary: enzalutamide for the treatment of patients with chemotherapy-naïve metastatic castration-resistant prostate cancer. Oncologist. 2015;20:960–6.
    • (2015) Oncologist , vol.20 , pp. 960-966
    • Ning, Y.-M.1    Brave, M.2    Maher, V.E.3    Zhang, L.4    Tang, S.5    Sridhara, R.6
  • 109
    • 77952105685 scopus 로고    scopus 로고
    • Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study
    • COI: 1:CAS:528:DC%2BC3cXltFOmsL0%3D, PID: 20398925
    • Scher HI, Beer TM, Higano CS, Anand A, Taplin ME, Efstathiou E, et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet. 2010;375:1437–46.
    • (2010) Lancet , vol.375 , pp. 1437-1446
    • Scher, H.I.1    Beer, T.M.2    Higano, C.S.3    Anand, A.4    Taplin, M.E.5    Efstathiou, E.6
  • 110
    • 84958937320 scopus 로고    scopus 로고
    • Understanding and overcoming the mechanisms of primary and acquired resistance to abiraterone and enzalutamide in castration resistant prostate cancer
    • COI: 1:CAS:528:DC%2BC2MXhsVyrs7bO, PID: 26342718
    • Buttigliero C, Tucci M, Bertaglia V, Vignani F, Bironzo P, Di Maio M, et al. Understanding and overcoming the mechanisms of primary and acquired resistance to abiraterone and enzalutamide in castration resistant prostate cancer. Cancer Treat Rev. 2015;41:884–92.
    • (2015) Cancer Treat Rev , vol.41 , pp. 884-892
    • Buttigliero, C.1    Tucci, M.2    Bertaglia, V.3    Vignani, F.4    Bironzo, P.5    Di Maio, M.6
  • 111
    • 84885210324 scopus 로고    scopus 로고
    • A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN-509
    • COI: 1:CAS:528:DC%2BC3sXhsVCgtLzN, PID: 23779130
    • Joseph JD, Lu N, Qian J, Sensintaffar J, Shao G, Brigham D, et al. A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN-509. Cancer Discov. 2013;3:1020–9.
    • (2013) Cancer Discov , vol.3 , pp. 1020-1029
    • Joseph, J.D.1    Lu, N.2    Qian, J.3    Sensintaffar, J.4    Shao, G.5    Brigham, D.6
  • 112
    • 84890078624 scopus 로고    scopus 로고
    • Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade
    • COI: 1:STN:280:DC%2BC2c3kt1GhtA%3D%3D, PID: 24315100
    • Arora Vivek K, Schenkein E, Murali R, Subudhi Sumit K, Wongvipat J, Balbas Minna D, et al. Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade. Cell. 2013;155:1309–22.
    • (2013) Cell , vol.155 , pp. 1309-1322
    • Arora Vivek, K.1    Schenkein, E.2    Murali, R.3    Subudhi Sumit, K.4    Wongvipat, J.5    Balbas Minna, D.6
  • 113
    • 53749090666 scopus 로고    scopus 로고
    • Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven
    • COI: 1:CAS:528:DC%2BD1cXht1KqtLbF, PID: 18645193
    • Attard G, Reid AH, Yap TA, Raynaud F, Dowsett M, Settatree S, et al. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. Journal of Clinical Oncology. 2008;26:4563–71.
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 4563-4571
    • Attard, G.1    Reid, A.H.2    Yap, T.A.3    Raynaud, F.4    Dowsett, M.5    Settatree, S.6
  • 114
    • 84872078210 scopus 로고    scopus 로고
    • Abiraterone in metastatic prostate cancer without previous chemotherapy
    • COI: 1:CAS:528:DC%2BC3sXovVyhtw%3D%3D, PID: 23228172
    • Ryan CJ, Smith MR, de Bono JS, Molina A, Logothetis CJ, de Souza P, et al. Abiraterone in metastatic prostate cancer without previous chemotherapy. N Engl J Med. 2013;368:138–48.
    • (2013) N Engl J Med , vol.368 , pp. 138-148
    • Ryan, C.J.1    Smith, M.R.2    de Bono, J.S.3    Molina, A.4    Logothetis, C.J.5    de Souza, P.6
  • 115
    • 84856774377 scopus 로고    scopus 로고
    • Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer
    • COI: 1:CAS:528:DC%2BC38XisFOgtbY%3D, PID: 22170708
    • Attard G, Reid AH, Auchus RJ, Hughes BA, Cassidy AM, Thompson E, et al. Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer. J Clin Endocrinol Metab. 2012;97:507–16.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 507-516
    • Attard, G.1    Reid, A.H.2    Auchus, R.J.3    Hughes, B.A.4    Cassidy, A.M.5    Thompson, E.6
  • 116
    • 84907285681 scopus 로고    scopus 로고
    • Tumor clone dynamics in lethal prostate cancer
    • PID: 25232177, A critical study revealing the complexity of therapeutically resistant clones in CRPC associated with regional and temporal heterogeneity, which can be monitored by sequential plasma and tumor biopsies to target lethal disease
    • •• Carreira S, Romanel A, Goodall J, Grist E, Ferraldeschi R, Miranda S, et al. Tumor clone dynamics in lethal prostate cancer. Sci Transl Med. 2014;6:254ra125. A critical study revealing the complexity of therapeutically resistant clones in CRPC associated with regional and temporal heterogeneity, which can be monitored by sequential plasma and tumor biopsies to target lethal disease.
    • (2014) Sci Transl Med , vol.6 , pp. 254ra125
    • Carreira, S.1    Romanel, A.2    Goodall, J.3    Grist, E.4    Ferraldeschi, R.5    Miranda, S.6
  • 117
    • 84981318520 scopus 로고    scopus 로고
    • Phosphoproteome integration reveals patient-specific networks in prostate cancer
    • Drake JM, Paull EO, Graham NA, Lee JK, Smith BA, Titz B, et al. Phosphoproteome integration reveals patient-specific networks in prostate cancer. Cell. 166:1041–54.
    • Cell , vol.166 , pp. 1041-1054
    • Drake, J.M.1    Paull, E.O.2    Graham, N.A.3    Lee, J.K.4    Smith, B.A.5    Titz, B.6
  • 118
    • 84939864061 scopus 로고    scopus 로고
    • Chemohormonal therapy in metastatic hormone-sensitive prostate cancer
    • COI: 1:CAS:528:DC%2BC28XkvFWrsQ%3D%3D, PID: 26244877, Shows a significant overall survival benefit in the addition of docetaxel to first-line ADT in metastatic hormone-sensitive prostate cancer, supporting the importance of targeting androgen sensitive and not CRPC by taxane chemotherapy to overcome cross-resistance
    • •• Sweeney CJ, Chen Y-H, Carducci M, Liu G, Jarrard DF, Eisenberger M, et al. Chemohormonal therapy in metastatic hormone-sensitive prostate cancer. N Engl J Med. 2015;373:737–46. Shows a significant overall survival benefit in the addition of docetaxel to first-line ADT in metastatic hormone-sensitive prostate cancer, supporting the importance of targeting androgen sensitive and not CRPC by taxane chemotherapy to overcome cross-resistance.
    • (2015) N Engl J Med , vol.373 , pp. 737-746
    • Sweeney, C.J.1    Chen, Y.-H.2    Carducci, M.3    Liu, G.4    Jarrard, D.F.5    Eisenberger, M.6
  • 119
    • 84961215473 scopus 로고    scopus 로고
    • Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial
    • COI: 1:CAS:528:DC%2BC2MXitVyqsL%2FL, PID: 26719232, Shows a significant overall survival benefit in the addition of docetaxel to first-line ADT in metastatic hormone-sensitive prostate cancer, supporting the importance of targeting androgen sensitive and not CRPC by taxane chemotherapy to overcome cross-resistance
    • •• James ND, Sydes MR, Clarke NW, Mason MD, Dearnaley DP, Spears MR, et al. Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial. Lancet. 2016;387:1163–77. Shows a significant overall survival benefit in the addition of docetaxel to first-line ADT in metastatic hormone-sensitive prostate cancer, supporting the importance of targeting androgen sensitive and not CRPC by taxane chemotherapy to overcome cross-resistance.
    • (2016) Lancet , vol.387 , pp. 1163-1177
    • James, N.D.1    Sydes, M.R.2    Clarke, N.W.3    Mason, M.D.4    Dearnaley, D.P.5    Spears, M.R.6
  • 120
    • 4744337716 scopus 로고    scopus 로고
    • Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer
    • COI: 1:CAS:528:DC%2BD2cXot1Kmu7c%3D, PID: 15470214
    • Petrylak DP, Tangen CM, Hussain MHA, Lara PNJ, Jones JA, Taplin ME, et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med. 2004;351:1513–20.
    • (2004) N Engl J Med , vol.351 , pp. 1513-1520
    • Petrylak, D.P.1    Tangen, C.M.2    Hussain, M.H.A.3    Lara, P.N.J.4    Jones, J.A.5    Taplin, M.E.6
  • 121
    • 0034795142 scopus 로고    scopus 로고
    • Preclinical mechanisms of action of docetaxel and docetaxel combinations in prostate cancer
    • Pienta KJ. Preclinical mechanisms of action of docetaxel and docetaxel combinations in prostate cancer. Seminars in Oncology; 2001: Elsevier; 2001. p. 3–7.
    • (2001) Seminars in Oncology; 2001: Elsevier , pp. 3-7
    • Pienta, K.J.1
  • 122
    • 1942438028 scopus 로고    scopus 로고
    • Microtubules as a target for anticancer drugs
    • COI: 1:CAS:528:DC%2BD2cXis1Gmt74%3D, PID: 15057285
    • Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer. 2004;4:253–65.
    • (2004) Nat Rev Cancer , vol.4 , pp. 253-265
    • Jordan, M.A.1    Wilson, L.2
  • 123
    • 80052808323 scopus 로고    scopus 로고
    • Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer
    • COI: 1:CAS:528:DC%2BC3MXhtFKntb3P, PID: 21799031
    • Darshan MS, Loftus MS, Thadani-Mulero M, Levy BP, Escuin D, Zhou XK, et al. Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer. Cancer Res. 2011;71:6019–29.
    • (2011) Cancer Res , vol.71 , pp. 6019-6029
    • Darshan, M.S.1    Loftus, M.S.2    Thadani-Mulero, M.3    Levy, B.P.4    Escuin, D.5    Zhou, X.K.6
  • 125
    • 70249124131 scopus 로고    scopus 로고
    • Increased expression of class III beta-tubulin in castration-resistant human prostate cancer
    • COI: 1:CAS:528:DC%2BD1MXhtV2qsrjI, PID: 19690549
    • Terry S, Ploussard G, Allory Y, Nicolaiew N, Boissiere-Michot F, Maille P, et al. Increased expression of class III beta-tubulin in castration-resistant human prostate cancer. Br J Cancer. 2009;101:951–6.
    • (2009) Br J Cancer , vol.101 , pp. 951-956
    • Terry, S.1    Ploussard, G.2    Allory, Y.3    Nicolaiew, N.4    Boissiere-Michot, F.5    Maille, P.6
  • 126
    • 78549257475 scopus 로고    scopus 로고
    • Class III β-tubulin expression predicts prostate tumor aggressiveness and patient response to docetaxel-based chemotherapy
    • COI: 1:CAS:528:DC%2BC3cXhsVWmsLvF, PID: 21045157
    • Ploussard G, Terry S, Maillé P, Allory Y, Sirab N, Kheuang L, et al. Class III β-tubulin expression predicts prostate tumor aggressiveness and patient response to docetaxel-based chemotherapy. Cancer Res. 2010;70:9253–64.
    • (2010) Cancer Res , vol.70 , pp. 9253-9264
    • Ploussard, G.1    Terry, S.2    Maillé, P.3    Allory, Y.4    Sirab, N.5    Kheuang, L.6
  • 127
    • 84945436172 scopus 로고    scopus 로고
    • Chapter three—Exploitation of the androgen receptor to overcome taxane resistance in advanced prostate ancer
    • Martin SK, Kyprianou N. Chapter three—Exploitation of the androgen receptor to overcome taxane resistance in advanced prostate ancer. In: Paul BF, Kenneth DT, eds. Advances in cancer research. Academic; 2015. p. 123–58.
    • (2015) Advances in cancer research. Academic , pp. 123-158
    • Martin, S.K.1    Kyprianou, N.2    Paul, B.F.3    Kenneth, D.T.4
  • 128
    • 84941629659 scopus 로고    scopus 로고
    • Serial blood-based analysis of AR-V7 in men with advanced prostate cancer
    • COI: 1:STN:280:DC%2BC2MbnslCltw%3D%3D, PID: 26117829
    • Nakazawa M, Lu C, Chen Y, Paller CJ, Carducci MA, Eisenberger MA, et al. Serial blood-based analysis of AR-V7 in men with advanced prostate cancer. Annals of Oncology. 2015;26:1859–65.
    • (2015) Annals of Oncology , vol.26 , pp. 1859-1865
    • Nakazawa, M.1    Lu, C.2    Chen, Y.3    Paller, C.J.4    Carducci, M.A.5    Eisenberger, M.A.6
  • 129
    • 85006699182 scopus 로고    scopus 로고
    • Multinucleation and mesenchymal-to-epithelial transition alleviate resistance to combined cabazitaxel and antiandrogen therapy in advanced prostate cancer
    • Martin SK, Pu H, Penticuff JC, Cao Z, Horbinski C, Kyprianou N. Multinucleation and mesenchymal-to-epithelial transition alleviate resistance to combined cabazitaxel and antiandrogen therapy in advanced prostate cancer. Cancer Res. 2015.
    • (2015) Cancer Res
    • Martin, S.K.1    Pu, H.2    Penticuff, J.C.3    Cao, Z.4    Horbinski, C.5    Kyprianou, N.6
  • 130
    • 84923342301 scopus 로고    scopus 로고
    • N-terminal targeting of androgen receptor variant enhances response of castration resistant prostate cancer to taxane chemotherapy
    • COI: 1:CAS:528:DC%2BC2cXhvFChsr7L
    • Martin SK, Banuelos CA, Sadar MD, Kyprianou N. N-terminal targeting of androgen receptor variant enhances response of castration resistant prostate cancer to taxane chemotherapy. Mol Oncol. 2015;9:628–39.
    • (2015) Mol Oncol , vol.9 , pp. 628-639
    • Martin, S.K.1    Banuelos, C.A.2    Sadar, M.D.3    Kyprianou, N.4
  • 131
    • 84877268097 scopus 로고    scopus 로고
    • The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing
    • COI: 1:CAS:528:DC%2BC3sXnt12ntrs%3D, PID: 23503423
    • Wyatt AW, Mo F, Wang Y, Collins CC. The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing. Asian Journal of Andrology. 2013;15:301–8.
    • (2013) Asian Journal of Andrology , vol.15 , pp. 301-308
    • Wyatt, A.W.1    Mo, F.2    Wang, Y.3    Collins, C.C.4
  • 132
    • 84964700391 scopus 로고    scopus 로고
    • Clinical applications of circulating tumor cells and circulating tumor DNA as liquid biopsy
    • PID: 26969689
    • Alix-Panabières C, Pantel K. Clinical applications of circulating tumor cells and circulating tumor DNA as liquid biopsy. Cancer Discovery. 2016;6:479–91.
    • (2016) Cancer Discovery , vol.6 , pp. 479-491
    • Alix-Panabières, C.1    Pantel, K.2
  • 133
    • 84942882550 scopus 로고    scopus 로고
    • A randomized phase II trial of sipuleucel-T with concurrent versus sequential abiraterone acetate plus prednisone in metastatic castration-resistant prostate cancer
    • COI: 1:CAS:528:DC%2BC2MXhsVCrsLfO
    • Small EJ, Lance RS, Gardner TA, Karsh LI, Fong L, McCoy C, et al. A randomized phase II trial of sipuleucel-T with concurrent versus sequential abiraterone acetate plus prednisone in metastatic castration-resistant prostate cancer. American Association for Cancer Research. 2015;21:3862–9.
    • (2015) American Association for Cancer Research , vol.21 , pp. 3862-3869
    • Small, E.J.1    Lance, R.S.2    Gardner, T.A.3    Karsh, L.I.4    Fong, L.5    McCoy, C.6
  • 134
    • 84905983305 scopus 로고    scopus 로고
    • Design of phase I combination trials: recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee
    • PID: 25125258
    • Paller CJ, Bradbury PA, Ivy SP, Seymour L, LoRusso PM, Baker L, et al. Design of phase I combination trials: recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee. Clinical Cancer Research. 2014;20:4210–7.
    • (2014) Clinical Cancer Research , vol.20 , pp. 4210-4217
    • Paller, C.J.1    Bradbury, P.A.2    Ivy, S.P.3    Seymour, L.4    LoRusso, P.M.5    Baker, L.6
  • 135
    • 84946019429 scopus 로고    scopus 로고
    • DNA-repair defects and olaparib in metastatic prostate cancer
    • COI: 1:CAS:528:DC%2BC28XksVemuro%3D, PID: 26510020
    • Mateo J, Carreira S, Sandhu S, Miranda S, Mossop H, Perez-Lopez R, et al. DNA-repair defects and olaparib in metastatic prostate cancer. N Engl J Med. 2015;373:1697–708.
    • (2015) N Engl J Med , vol.373 , pp. 1697-1708
    • Mateo, J.1    Carreira, S.2    Sandhu, S.3    Miranda, S.4    Mossop, H.5    Perez-Lopez, R.6
  • 136
    • 85013625537 scopus 로고    scopus 로고
    • Pritchard CC, Mateo J, Walsh MF, De Sarkar N, Abida W, Beltran H, et al. Inherited DNA-repair gene mutations in men with metastatic prostate cancer. N Engl J Med.0:null
    • Pritchard CC, Mateo J, Walsh MF, De Sarkar N, Abida W, Beltran H, et al. Inherited DNA-repair gene mutations in men with metastatic prostate cancer. N Engl J Med.0:null.
  • 137
    • 85013634260 scopus 로고    scopus 로고
    • Mechanisms navigating the TGF-β pathway in prostate cancer
    • Cao Z, Kyprianou N. Mechanisms navigating the TGF-β pathway in prostate cancer. Asian Journal of Urology. 2015;2:11–8.
    • (2015) Asian Journal of Urology , vol.2 , pp. 11-18
    • Cao, Z.1    Kyprianou, N.2


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