-
2
-
-
79956135979
-
The treatment of cancer of the prostate: (The 1943 Address in Surgery before the Royal College of Physicians and Surgeons of Canada)
-
Huggins C. The treatment of cancer of the prostate: (The 1943 Address in Surgery before the Royal College of Physicians and Surgeons of Canada). Can Med Assoc J 1944;50:301-7.
-
(1944)
Can Med Assoc J
, vol.50
, pp. 301-307
-
-
Huggins, C.1
-
3
-
-
79959233647
-
Targeting continued androgen receptor signaling in prostate cancer
-
Massard C, Fizazi K. Targeting continued androgen receptor signaling in prostate cancer. Clin Cancer Res 2011;17:3876-83.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 3876-3883
-
-
Massard, C.1
Fizazi, K.2
-
4
-
-
79953320228
-
New strategies in metastatic prostate cancer: Targeting the androgen receptor signaling pathway
-
Attard G, Richards J, de Bono JS. New strategies in metastatic prostate cancer: targeting the androgen receptor signaling pathway. Clin Cancer Res 2011;17:1649-57.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1649-1657
-
-
Attard, G.1
Richards, J.2
De Bono, J.S.3
-
5
-
-
84055207680
-
Development and clinical utility of abiraterone acetate as an androgen synthesis inhibitor
-
Bryce A, Ryan CJ. Development and clinical utility of abiraterone acetate as an androgen synthesis inhibitor. Clin Pharmacol Ther 2012;91:101-8.
-
(2012)
Clin Pharmacol Ther
, vol.91
, pp. 101-108
-
-
Bryce, A.1
Ryan, C.J.2
-
6
-
-
80053071543
-
Androgen receptor rediscovered: The new biology and targeting the androgen receptor therapeutically
-
Ryan CJ, Tindall DJ. Androgen receptor rediscovered: the new biology and targeting the androgen receptor therapeutically. J Clin Oncol 2011;29:3651-8.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3651-3658
-
-
Ryan, C.J.1
Tindall, D.J.2
-
7
-
-
60149089419
-
Androgen deprivation therapy: Progress in understanding mechanisms of resistance and optimizing androgen depletion
-
Harris WP, Mostaghel EA, Nelson PS, Montgomery B. Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion. Nat Clin Pract Urol 2009;6:76-85.
-
(2009)
Nat Clin Pract Urol
, vol.6
, pp. 76-85
-
-
Harris, W.P.1
Mostaghel, E.A.2
Nelson, P.S.3
Montgomery, B.4
-
8
-
-
4744366279
-
Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
-
TAX 327 Investigators
-
Tannock IF, de Wit R, Berry WR, Horti J, Pluzanska A, Chi KN, et al. TAX 327 Investigators. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 2004; 351:1502-12.
-
(2004)
N Engl J Med
, vol.351
, pp. 1502-1512
-
-
Tannock, I.F.1
De Wit, R.2
Berry, W.R.3
Horti, J.4
Pluzanska, A.5
Chi, K.N.6
-
9
-
-
4744337716
-
Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer
-
Petrylak DP, Tangen CM, Hussain MH, Lara PN Jr, Jones JA, Taplin ME, et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med 2004;351:1513-20.
-
(2004)
N Engl J Med
, vol.351
, pp. 1513-1520
-
-
Petrylak, D.P.1
Tangen, C.M.2
Hussain, M.H.3
Lara Jr., P.N.4
Jones, J.A.5
Taplin, M.E.6
-
10
-
-
1942438028
-
Microtubules as a target for anticancer drugs
-
Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer 2004;4:253-65.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 253-265
-
-
Jordan, M.A.1
Wilson, L.2
-
11
-
-
0032529464
-
Mechanisms of Taxol-induced cell death are concentration dependent
-
Torres K, Horwitz SB. Mechanisms of Taxol-induced cell death are concentration dependent. Cancer Res 1998;58:3620-6.
-
(1998)
Cancer Res
, vol.58
, pp. 3620-3626
-
-
Torres, K.1
Horwitz, S.B.2
-
13
-
-
0029045402
-
Implication of cell kinetic changes during the progression of human prostatic cancer
-
Berges RR, Vukanovic J, Epstein JI, CarMichel M, Cisek L, Johnson DE, et al. Implication of cell kinetic changes during the progression of human prostatic cancer. Clin Cancer Res 1995;1:473-80.
-
(1995)
Clin Cancer Res
, vol.1
, pp. 473-480
-
-
Berges, R.R.1
Vukanovic, J.2
Epstein, J.I.3
CarMichel, M.4
Cisek, L.5
Johnson, D.E.6
-
15
-
-
33747636559
-
Knockdown of MBP-1 in human prostate cancer cells delays cell cycle progression
-
Ghosh AK, Steele R, Ray RB. Knockdown of MBP-1 in human prostate cancer cells delays cell cycle progression. J Biol Chem 2006;281: 23652-7.
-
(2006)
J Biol Chem
, vol.281
, pp. 23652-23657
-
-
Ghosh, A.K.1
Steele, R.2
Ray, R.B.3
-
16
-
-
47049091483
-
Hypoxia selects for androgen independent LNCaP cells with a more malignant geno- And phenotype
-
Butterworth KT, McCarthy HO, Devlin A, Ming L, Robson T, McKeown SR, et al. Hypoxia selects for androgen independent LNCaP cells with a more malignant geno- and phenotype. Int J Cancer 2008;123:760-8.
-
(2008)
Int J Cancer
, vol.123
, pp. 760-768
-
-
Butterworth, K.T.1
McCarthy, H.O.2
Devlin, A.3
Ming, L.4
Robson, T.5
McKeown, S.R.6
-
17
-
-
84855431740
-
Inhibitors targeting mitosis: Tales of how great drugs against a promising target were brought down by a flawed rationale
-
Komlodi-Pasztor E, Sackett DL, Fojo AT. Inhibitors targeting mitosis: tales of how great drugs against a promising target were brought down by a flawed rationale. Clin Cancer Res 2012;18:51-63.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 51-63
-
-
Komlodi-Pasztor, E.1
Sackett, D.L.2
Fojo, A.T.3
-
18
-
-
48449098623
-
Cancer cells display profound intra- And interline variation following prolonged exposure to antimitotic drugs
-
Gascoigne KE, Taylor SS. Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs. Cancer Cell 2008;14:111-22.
-
(2008)
Cancer Cell
, vol.14
, pp. 111-122
-
-
Gascoigne, K.E.1
Taylor, S.S.2
-
20
-
-
80054940508
-
Role of ERK1/2 activation in microtubule stabilization and glucose transport in cardiomyocytes
-
Asrih M, Pellieux C, Papageorgiou I, Lerch R, Montessuit C. Role of ERK1/2 activation in microtubule stabilization and glucose transport in cardiomyocytes. Am J Physiol Endocrinol Metab 2011;301:E836-43.
-
(2011)
Am J Physiol Endocrinol Metab
, vol.301
-
-
Asrih, M.1
Pellieux, C.2
Papageorgiou, I.3
Lerch, R.4
Montessuit, C.5
-
21
-
-
79959337059
-
Lymphocyte signaling converges on microtubules
-
Babich A, Burkhardt JK. Lymphocyte signaling converges on microtubules. Immunity 2011;34:825-7.
-
(2011)
Immunity
, vol.34
, pp. 825-827
-
-
Babich, A.1
Burkhardt, J.K.2
-
22
-
-
75749155892
-
From signaling pathways to microtubule dynamics: The key players
-
Etienne-Manneville S. From signaling pathways to microtubule dynamics: the key players. Curr Opin Cell Biol 2010;22:104-11.
-
(2010)
Curr Opin Cell Biol
, vol.22
, pp. 104-111
-
-
Etienne-Manneville, S.1
-
23
-
-
0034306461
-
P53 is associated with cellular microtubules and is transported to the nucleus by dynein
-
Giannakakou P, Sackett DL, Ward Y, Webster KR, Blagosklonny MV, Fojo T. p53 is associated with cellular microtubules and is transported to the nucleus by dynein. Nat Cell Biol 2000;2:709-17.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 709-717
-
-
Giannakakou, P.1
Sackett, D.L.2
Ward, Y.3
Webster, K.R.4
Blagosklonny, M.V.5
Fojo, T.6
-
24
-
-
0036678880
-
Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics
-
Giannakakou P, Nakano M, Nicolaou KC, O'Brate A, Yu J, Blagosklonny MV, et al. Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. Proc Natl Acad Sci U S A 2002;99:10855-60.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 10855-10860
-
-
Giannakakou, P.1
Nakano, M.2
Nicolaou, K.C.3
O'Brate, A.4
Yu, J.5
Blagosklonny, M.V.6
-
25
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
Mabjeesh NJ, Escuin D, LaVallee TM, Pribluda VS, Swartz GM, Johnson MS, et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 2003;3:363- 75.
-
(2003)
Cancer Cell
, vol.3
, pp. 363-375
-
-
Mabjeesh, N.J.1
Escuin, D.2
LaVallee, T.M.3
Pribluda, V.S.4
Swartz, G.M.5
Johnson, M.S.6
-
26
-
-
78651338243
-
Microtubule disruption targets HIF-1alpha mRNA to cytoplasmic P-bodies for translational repression
-
Carbonaro M, O'Brate A, Giannakakou P. Microtubule disruption targets HIF-1alpha mRNA to cytoplasmic P-bodies for translational repression. J Cell Biol 2011;192:83-99.
-
(2011)
J Cell Biol
, vol.192
, pp. 83-99
-
-
Carbonaro, M.1
O'Brate, A.2
Giannakakou, P.3
-
27
-
-
84859495330
-
Microtubules regulate hypoxia-inducible factor-1a protein trafficking and activity: Implications for taxane therapy
-
Carbonaro M, Escuin D, O'Brate A, Thadani-Mulero M, Giannakakou P. Microtubules regulate hypoxia-inducible factor-1a protein trafficking and activity: implications for taxane therapy. J Biol Chem 2012; 287:11859-69.
-
(2012)
J Biol Chem
, vol.287
, pp. 11859-11869
-
-
Carbonaro, M.1
Escuin, D.2
O'Brate, A.3
Thadani-Mulero, M.4
Giannakakou, P.5
-
28
-
-
34249045739
-
Amicrotubule-facilitated nuclear import pathway for cancer regulatory proteins
-
Roth DM, Moseley GW, Glover D, Pouton CW, Jans DA. Amicrotubule- facilitated nuclear import pathway for cancer regulatory proteins. Traffic 2007;8:673-86.
-
(2007)
Traffic
, vol.8
, pp. 673-686
-
-
Roth, D.M.1
Moseley, G.W.2
Glover, D.3
Pouton, C.W.4
Jans, D.A.5
-
29
-
-
11144225831
-
Evidence for glucocorticoid receptor transport on microtubules by dynein
-
Harrell JM, Murphy PJ, Morishima Y, Chen H, Mansfield JF, Galigniana MD, et al. Evidence for glucocorticoid receptor transport on microtubules by dynein. J Biol Chem 2004;279:54647- 54.
-
(2004)
J Biol Chem
, vol.279
, pp. 54647-54654
-
-
Harrell, J.M.1
Murphy, P.J.2
Morishima, Y.3
Chen, H.4
Mansfield, J.F.5
Galigniana, M.D.6
-
30
-
-
0036159923
-
Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules
-
Lam MH, Thomas RJ, Loveland KL, Schilders S, Gu M, Martin TJ, et al. Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules. Mol Endocrinol 2002;16:390-401.
-
(2002)
Mol Endocrinol
, vol.16
, pp. 390-401
-
-
Lam, M.H.1
Thomas, R.J.2
Loveland, K.L.3
Schilders, S.4
Gu, M.5
Martin, T.J.6
-
31
-
-
80052808323
-
Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer
-
Darshan MS, Loftus MS, Thadani-Mulero M, Levy BP, Escuin D, Zhou XK, et al. Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer. Cancer Res 2011;71:6019-29.
-
(2011)
Cancer Res
, vol.71
, pp. 6019-6029
-
-
Darshan, M.S.1
Loftus, M.S.2
Thadani-Mulero, M.3
Levy, B.P.4
Escuin, D.5
Zhou, X.K.6
-
32
-
-
78049294167
-
Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer
-
Zhu ML, Horbinski CM, Garzotto M, Qian DZ, Beer TM, Kyprianou N. Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer. Cancer Res 2010;70:7992-8002.
-
(2010)
Cancer Res
, vol.70
, pp. 7992-8002
-
-
Zhu, M.L.1
Horbinski, C.M.2
Garzotto, M.3
Qian, D.Z.4
Beer, T.M.5
Kyprianou, N.6
-
33
-
-
70350532518
-
Inhibition of the androgen receptor as a novel mechanism of taxol chemotherapy in prostate cancer
-
Gan L, Chen S, Wang Y, Watahiki A, Bohrer L, Sun Z, et al. Inhibition of the androgen receptor as a novel mechanism of taxol chemotherapy in prostate cancer. Cancer Res 2009;69:8386-94.
-
(2009)
Cancer Res
, vol.69
, pp. 8386-8394
-
-
Gan, L.1
Chen, S.2
Wang, Y.3
Watahiki, A.4
Bohrer, L.5
Sun, Z.6
-
34
-
-
69449095278
-
Docetaxel down-regulates the expression of androgen receptor and prostatespecific antigen but not prostate-specific membrane antigen in prostate cancer cell lines: Implications for PSA surrogacy
-
Kuroda K, Liu H, Kim S, Guo M, Navarro V, Bander NH. Docetaxel down-regulates the expression of androgen receptor and prostatespecific antigen but not prostate-specific membrane antigen in prostate cancer cell lines: implications for PSA surrogacy. Prostate 2009;69:1579-85.
-
(2009)
Prostate
, vol.69
, pp. 1579-1585
-
-
Kuroda, K.1
Liu, H.2
Kim, S.3
Guo, M.4
Navarro, V.5
Bander, N.H.6
-
35
-
-
1842612441
-
Molecular determinants of resistance to antiandrogen therapy
-
Chen CD, Welsbie DS, Tran C, Baek SH, Chen R, Vessella R, et al. Molecular determinants of resistance to antiandrogen therapy. Nat Med 2004;10:33-9.
-
(2004)
Nat Med
, vol.10
, pp. 33-39
-
-
Chen, C.D.1
Welsbie, D.S.2
Tran, C.3
Baek, S.H.4
Chen, R.5
Vessella, R.6
-
36
-
-
0035496220
-
The development of androgen-independent prostate cancer
-
Feldman BJ, Feldman D. The development of androgen-independent prostate cancer. Nat Rev Cancer 2001;1:34-45.
-
(2001)
Nat Rev Cancer
, vol.1
, pp. 34-45
-
-
Feldman, B.J.1
Feldman, D.2
-
37
-
-
77957682309
-
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: A randomised open-label trial
-
TROPIC Investigators
-
de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, et al.TROPIC Investigators. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet 2010;376:1147-54.
-
(2010)
Lancet
, vol.376
, pp. 1147-1154
-
-
De Bono, J.S.1
Oudard, S.2
Ozguroglu, M.3
Hansen, S.4
Machiels, J.P.5
Kocak, I.6
-
38
-
-
77749322183
-
Clinical significance of ABCB1 genotyping in oncology
-
Hamidovic A, Hahn K, Kolesar J. Clinical significance of ABCB1 genotyping in oncology. J Oncol Pharm Pract 2010;16:39-44.
-
(2010)
J Oncol Pharm Pract
, vol.16
, pp. 39-44
-
-
Hamidovic, A.1
Hahn, K.2
Kolesar, J.3
-
39
-
-
77649191871
-
Microtubules and resistance to tubulin-binding agents
-
Kavallaris M. Microtubules and resistance to tubulin-binding agents. Nat Rev Cancer 2010;10:194-204.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 194-204
-
-
Kavallaris, M.1
-
40
-
-
58249110391
-
Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
-
Hu R, Dunn TA, Wei S, Isharwal S, Veltri RW, Humphreys E, et al. Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res 2009;69:16-22.
-
(2009)
Cancer Res
, vol.69
, pp. 16-22
-
-
Hu, R.1
Dunn, T.A.2
Wei, S.3
Isharwal, S.4
Veltri, R.W.5
Humphreys, E.6
-
41
-
-
65549168746
-
Anovel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth
-
Guo Z, Yang X, Sun F, Jiang R, Linn DE, Chen H, et al. Anovel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth. Cancer Res 2009;69:2305-13.
-
(2009)
Cancer Res
, vol.69
, pp. 2305-2313
-
-
Guo, Z.1
Yang, X.2
Sun, F.3
Jiang, R.4
Linn, D.E.5
Chen, H.6
-
42
-
-
77955296562
-
Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
-
Sun S, Sprenger CC, Vessella RL, Haugk K, Soriano K, Mostaghel EA, et al. Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant. J Clin Invest 2010;120:2715-30.
-
(2010)
J Clin Invest
, vol.120
, pp. 2715-2730
-
-
Sun, S.1
Sprenger, C.C.2
Vessella, R.L.3
Haugk, K.4
Soriano, K.5
Mostaghel, E.A.6
-
43
-
-
78049280194
-
Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor
-
Watson PA, Chen YF, BalbasMD, Wongvipat J, Socci ND, Viale A, et al. Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor. Proc Natl Acad Sci U S A 2010;107:16759-65.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 16759-16765
-
-
Watson, P.A.1
Chen, Y.F.2
Balbas, M.D.3
Wongvipat, J.4
Socci, N.D.5
Viale, A.6
-
44
-
-
80052827038
-
Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: Induction of steroidogenesis and androgen receptor splice variants
-
Mostaghel EA, Marck BT, Plymate SR, Vessella RL, Balk S, Matsumoto AM, et al. Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants. Clin Cancer Res 2011;17:5913-25.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 5913-5925
-
-
Mostaghel, E.A.1
Marck, B.T.2
Plymate, S.R.3
Vessella, R.L.4
Balk, S.5
Matsumoto, A.M.6
-
45
-
-
65649090203
-
Development of a second-generation antiandrogen for treatment of advanced prostate cancer
-
Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 2009;324:787-90.
-
(2009)
Science
, vol.324
, pp. 787-790
-
-
Tran, C.1
Ouk, S.2
Clegg, N.J.3
Chen, Y.4
Watson, P.A.5
Arora, V.6
-
46
-
-
77953280591
-
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor
-
Andersen RJ, Mawji NR, Wang J, Wang G, Haile S, Myung JK, et al. Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell 2010;17:535-46.
-
(2010)
Cancer Cell
, vol.17
, pp. 535-546
-
-
Andersen, R.J.1
Mawji, N.R.2
Wang, J.3
Wang, G.4
Haile, S.5
Myung, J.K.6
-
47
-
-
79951825699
-
Small molecule inhibitors targeting the "achilles' heel" of androgen receptor activity
-
Sadar MD. Small molecule inhibitors targeting the "achilles' heel" of androgen receptor activity. Cancer Res 2011;71:1208-13.
-
(2011)
Cancer Res
, vol.71
, pp. 1208-1213
-
-
Sadar, M.D.1
|