메뉴 건너뛰기




Volumn 19, Issue 1, 2013, Pages 79-89

Targeting the apoptosis pathway in prostate cancer

Author keywords

apoptosis; Metastatic prostate cancer; programmed cell death

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ABT 236; AEG 35156; ANTINEOPLASTIC AGENT; AT 406; BH3 PROTEIN; BI 97C 1; BIM PROTEIN; BIRINAPANT; CASPASE; CHAPERONE; CLUSTERIN; CUSTIRSEN; DEATH RECEPTOR; DEATH RECEPTOR 5; FAS ANTIGEN; GATAPARSEN; GDC 0152; GOSSYPOL; HGS 1029; INHIBITOR OF APOPTOSIS PROTEIN; ISOSORBIDE; LCL 161; NAVITOCLAX; OBATOCLAX; OBLIMERSEN; PROTEIN BAD; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN MCL 1; PROTEIN NOXA; PUMA PROTEIN; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SEPANTRONIUM BROMIDE; SGI 1176; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TW 37; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84873853968     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0b013e3182801cf7     Document Type: Review
Times cited : (46)

References (108)
  • 1
    • 79957443342 scopus 로고    scopus 로고
    • Abiraterone and increased survival in metastatic prostate cancer
    • de Bono JS, Logothetis CJ, Molina A, et al. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med. 2011;364: 1995-2005.
    • (2011) N Engl J Med. , vol.364 , pp. 1995-2005
    • De Bono, J.S.1    Logothetis, C.J.2    Molina, A.3
  • 2
    • 77957682309 scopus 로고    scopus 로고
    • Prednisone plus cabazi-taxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: A randomised open-label trial
    • de Bono JS, Oudard S, Ozguroglu M, et al. Prednisone plus cabazi-taxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010;376:1147-1154.
    • (2010) Lancet. , vol.376 , pp. 1147-1154
    • De Bono, J.S.1    Oudard, S.2    Ozguroglu, M.3
  • 3
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunother-apy for castration-resistant prostate cancer
    • Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunother-apy for castration-resistant prostate cancer. N Engl J Med. 2010;363: 411-422.
    • (2010) N Engl J Med. , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 4
    • 84860854128 scopus 로고    scopus 로고
    • Overall survival benefit and safety profile of radium-223 chloride, a first-in-class alpha-pharmaceutical: Results from a phase II randomized trial (ALSYMPCA) in patients with castration-resistant prostate cancer (CRPC) with bone metastases
    • Parker C, Heinrich D, Sartor AO, et al. Overall survival benefit and safety profile of radium-223 chloride, a first-in-class alpha-pharmaceutical: results from a phase II randomized trial (ALSYMPCA) in patients with castration-resistant prostate cancer (CRPC) with bone metastases. J Clin Oncol. 2012;30(suppl 5). Abstract 8).
    • (2012) J Clin Oncol. , vol.30 , Issue.SUPPL. 5 , pp. 8
    • Parker, C.1    Heinrich, D.2    Sartor, A.O.3
  • 5
    • 84866770294 scopus 로고    scopus 로고
    • Increased survival with enzalutamide in prostate cancer after chemotherapy
    • Scher HI, Fizazi K, Saad F, et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med. 2012.
    • (2012) N Engl J Med.
    • Scher, H.I.1    Fizazi, K.2    Saad, F.3
  • 6
    • 0035148171 scopus 로고    scopus 로고
    • Flutamide versus prednisone in patients with prostate cancer symptomatically progressing after androgen-ablative therapy: A phase III study of the European organization for research and treatment of cancer genitourinary group
    • Fossa SD, Slee PH, Brausi M, et al. Flutamide versus prednisone in patients with prostate cancer symptomatically progressing after androgen-ablative therapy: a phase III study of the European organization for research and treatment of cancer genitourinary group. J Clin Oncol. 2001;19:62-71.
    • (2001) J Clin Oncol. , vol.19 , pp. 62-71
    • Fossa, S.D.1    Slee, P.H.2    Brausi, M.3
  • 7
    • 4744366279 scopus 로고    scopus 로고
    • Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
    • Tannock IF, de Wit R, Berry WR, et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med. 2004;351:1502-1512.
    • (2004) N Engl J Med. , vol.351 , pp. 1502-1512
    • Tannock, I.F.1    De Wit, R.2    Berry, W.R.3
  • 8
    • 0027252452 scopus 로고
    • Results of a randomized phase-III trial to evaluate the efficacy of strontium-89 adjuvant to local field external beam irradiation in the management of endocrine resistant metastatic prostate cancer
    • Porter AT, McEwan AJ, Powe JE, et al. Results of a randomized phase-III trial to evaluate the efficacy of strontium-89 adjuvant to local field external beam irradiation in the management of endocrine resistant metastatic prostate cancer. Int J Radiat Oncol Biol Phys. 1993;25: 805-813.
    • (1993) Int J Radiat Oncol Biol Phys. , vol.25 , pp. 805-813
    • Porter, A.T.1    McEwan, A.J.2    Powe, J.E.3
  • 9
    • 4644237335 scopus 로고    scopus 로고
    • Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer
    • Rocchi P, So A, Kojima S, et al. Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer. Cancer Res. 2004;64:6595-6602.
    • (2004) Cancer Res. , vol.64 , pp. 6595-6602
    • Rocchi, P.1    So, A.2    Kojima, S.3
  • 10
    • 0033978525 scopus 로고    scopus 로고
    • Testosterone-repressed prostate message-2 is an antiapoptotic gene involved in progression to andro-gen independence in prostate cancer
    • Miyake H, Nelson C, Rennie PS. Testosterone-repressed prostate message-2 is an antiapoptotic gene involved in progression to andro-gen independence in prostate cancer. Cancer Res. 2000;60:170-176.
    • (2000) Cancer Res. , vol.60 , pp. 170-176
    • Miyake, H.1    Nelson, C.2    Rennie, P.S.3
  • 11
    • 0033567003 scopus 로고    scopus 로고
    • Antisense Bcl-2 oligodeoxynucleo-tides inhibit progression to androgen-independence after castration in the Shionogi tumor model
    • Miyake H, Tolcher A, Gleave ME. Antisense Bcl-2 oligodeoxynucleo-tides inhibit progression to androgen-independence after castration in the Shionogi tumor model. Cancer Res. 1999;59:4030-4034.
    • (1999) Cancer Res. , vol.59 , pp. 4030-4034
    • Miyake, H.1    Tolcher, A.2    Gleave, M.E.3
  • 12
    • 0023786047 scopus 로고
    • Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
    • Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature. 1988;335:440-442.
    • (1988) Nature. , vol.335 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3
  • 13
    • 0025251664 scopus 로고
    • Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and Bcl-2
    • Strasser A, Harris AW, Bath ML, et al. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and Bcl-2. Nature. 1990;348:331-333.
    • (1990) Nature. , vol.348 , pp. 331-333
    • Strasser, A.1    Harris, A.W.2    Bath, M.L.3
  • 14
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281: 1309-1312.
    • (1998) Science. , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 15
    • 26444489119 scopus 로고    scopus 로고
    • Connected to death: The (unex-purgated) mitochondrial pathway of apoptosis
    • Spierings D, McStay G, Saleh M, et al. Connected to death: the (unex-purgated) mitochondrial pathway of apoptosis. Science. 2005;310: 66-67.
    • (2005) Science. , vol.310 , pp. 66-67
    • Spierings, D.1    McStay, G.2    Saleh, M.3
  • 16
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: Critical control points
    • Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell. 2004;116:205-219.
    • (2004) Cell. , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 17
    • 0142117313 scopus 로고    scopus 로고
    • The Bcl-2 family: Roles in cell survival and oncogenesis
    • Cory S, Huang DC, Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene. 2003;22:8590-8607.
    • (2003) Oncogene. , vol.22 , pp. 8590-8607
    • Cory, S.1    Huang, D.C.2    Adams, J.M.3
  • 18
    • 77953496226 scopus 로고    scopus 로고
    • Chemosensitization of prostate cancer by modulating Bcl-2 family proteins
    • Karnak D, Xu L. Chemosensitization of prostate cancer by modulating Bcl-2 family proteins. Curr Drug Targets. 2010;11:699-707.
    • (2010) Curr Drug Targets. , vol.11 , pp. 699-707
    • Karnak, D.1    Xu, L.2
  • 19
    • 3442886811 scopus 로고    scopus 로고
    • The pathophysiology of mitochondrial cell death
    • Green DR, Kroemer G. The pathophysiology of mitochondrial cell death. Science. 2004;305:626-629.
    • (2004) Science. , vol.305 , pp. 626-629
    • Green, D.R.1    Kroemer, G.2
  • 20
    • 3943071150 scopus 로고    scopus 로고
    • Cytochrome cYmediated apoptosis
    • Jiang X, Wang X. Cytochrome cYmediated apoptosis. Annu Rev Bio-chem. 2004;73:87-106.
    • (2004) Annu Rev Bio-chem. , vol.73 , pp. 87-106
    • Jiang, X.1    Wang, X.2
  • 21
    • 14944348965 scopus 로고    scopus 로고
    • The role of BH3-only proteins in the immune system
    • Strasser A. The role of BH3-only proteins in the immune system. Nat Rev Immunol. 2005;5:189-200.
    • (2005) Nat Rev Immunol. , vol.5 , pp. 189-200
    • Strasser, A.1
  • 22
    • 48449097403 scopus 로고    scopus 로고
    • Commitment in apoptosis: Slightly dead but mostly alive
    • Sheridan C, Martin SJ. Commitment in apoptosis: slightly dead but mostly alive. Trends Cell Biol. 2008;18:353-357.
    • (2008) Trends Cell Biol. , vol.18 , pp. 353-357
    • Sheridan, C.1    Martin, S.J.2
  • 23
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-674.
    • (2011) Cell. , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 24
    • 33749510073 scopus 로고    scopus 로고
    • + leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
    • + leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Proc Natl Acad Sci USA. 2006;103:14907-14912.
    • (2006) Proc Natl Acad Sci USA. , vol.103 , pp. 14907-14912
    • Kuroda, J.1    Puthalakath, H.2    Cragg, M.S.3
  • 25
    • 0037169358 scopus 로고    scopus 로고
    • Apoptosis: A link between cancer genetics and chemotherapy
    • Johnstone RW, Ruefli AA, Lowe SW. Apoptosis: a link between cancer genetics and chemotherapy. Cell. 2002;108:153-164.
    • (2002) Cell. , vol.108 , pp. 153-164
    • Johnstone, R.W.1    Ruefli, A.A.2    Lowe, S.W.3
  • 26
    • 0038786580 scopus 로고    scopus 로고
    • Apoptosis-targeted therapies for cancer
    • Reed JC. Apoptosis-targeted therapies for cancer. Cancer Cell. 2003;3: 17-22.
    • (2003) Cancer Cell. , vol.3 , pp. 17-22
    • Reed, J.C.1
  • 28
    • 49749106638 scopus 로고    scopus 로고
    • FLIP-ping out: Death receptor signaling in the prostate
    • Nastiuk KL, Krolewski JJ. FLIP-ping out: death receptor signaling in the prostate. Cancer Biol Ther. 2008;7:1171-1179.
    • (2008) Cancer Biol Ther. , vol.7 , pp. 1171-1179
    • Nastiuk, K.L.1    Krolewski, J.J.2
  • 29
    • 47949126042 scopus 로고    scopus 로고
    • FOXO3a mediates the androgen-dependent regulation of FLIP and contributes to TRAIL-induced apoptosis of LNCaP cells
    • Cornforth AN, Davis JS, Khanifar E, et al. FOXO3a mediates the androgen-dependent regulation of FLIP and contributes to TRAIL-induced apoptosis of LNCaP cells. Oncogene. 2008;27:4422-4433.
    • (2008) Oncogene. , vol.27 , pp. 4422-4433
    • Cornforth, A.N.1    Davis, J.S.2    Khanifar, E.3
  • 30
    • 3042522791 scopus 로고    scopus 로고
    • The androgen receptor in hormone-refractory prostate cancer: Relevance of different mechanisms of androgen receptor signaling [review]
    • Cronauer MV, Schulz WA, Burchardt T, et al. The androgen receptor in hormone-refractory prostate cancer: relevance of different mechanisms of androgen receptor signaling [review]. Int J Oncol. 2003;23: 1095-1102.
    • (2003) Int J Oncol. , vol.23 , pp. 1095-1102
    • Cronauer, M.V.1    Schulz, W.A.2    Burchardt, T.3
  • 31
    • 40349087128 scopus 로고    scopus 로고
    • Androgen receptorYdependent regulation of Bcl-xL expression: Implication in prostate cancer progression
    • Sun A, Tang J, Hong Y, et al. Androgen receptorYdependent regulation of Bcl-xL expression: implication in prostate cancer progression. Prostate. 2008;68:453-461.
    • (2008) Prostate. , vol.68 , pp. 453-461
    • Sun, A.1    Tang, J.2    Hong, Y.3
  • 32
    • 32644473650 scopus 로고    scopus 로고
    • How the Bcl-2 family of proteins interact to regulate apoptosis
    • van Delft MF, Huang DC. How the Bcl-2 family of proteins interact to regulate apoptosis. Cell Res. 2006;16:203-213.
    • (2006) Cell Res. , vol.16 , pp. 203-213
    • Van Delft, M.F.1    Huang, D.C.2
  • 33
    • 67650360358 scopus 로고    scopus 로고
    • Docetaxel plus oblimer-sen sodium (Bcl-2 antisense oligonucleotide): An EORTC multicenter, randomized phase II study in patients with castration-resistant prostate cancer
    • Sternberg CN, Dumez H, Van Poppel H, et al. Docetaxel plus oblimer-sen sodium (Bcl-2 antisense oligonucleotide): an EORTC multicenter, randomized phase II study in patients with castration-resistant prostate cancer. Ann Oncol. 2009;20:1264-1269.
    • (2009) Ann Oncol. , vol.20 , pp. 1264-1269
    • Sternberg, C.N.1    Dumez, H.2    Van Poppel, H.3
  • 34
    • 65649130832 scopus 로고    scopus 로고
    • An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer
    • Liu G, Kelly WK, Wilding G, et al. An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer. Clin Cancer Res. 2009;15:3172-3176.
    • (2009) Clin Cancer Res. , vol.15 , pp. 3172-3176
    • Liu, G.1    Kelly, W.K.2    Wilding, G.3
  • 35
    • 84859423230 scopus 로고    scopus 로고
    • Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer
    • Sonpavde G, Matveev V, Burke JM, et al. Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer. Ann Oncol. 2012; 23:1803-1808.
    • (2012) Ann Oncol. , vol.23 , pp. 1803-1808
    • Sonpavde, G.1    Matveev, V.2    Burke, J.M.3
  • 36
    • 37649023004 scopus 로고    scopus 로고
    • Small molecule obato-clax (GX15-070) antagonizes Mcl-1 and overcomes Mcl-1Ymediated resistance to apoptosis
    • Nguyen M, Marcellus RC, Roulston A, et al. Small molecule obato-clax (GX15-070) antagonizes Mcl-1 and overcomes Mcl-1Ymediated resistance to apoptosis. Proc Natl Acad Sci USA. 2007;104: 19512-19517.
    • (2007) Proc Natl Acad Sci USA. , vol.104 , pp. 19512-19517
    • Nguyen, M.1    Marcellus, R.C.2    Roulston, A.3
  • 37
    • 79957689156 scopus 로고    scopus 로고
    • Apogossypol derivative BI-97C1 (sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to MDA-7/IL-24Ymediated toxicity
    • Dash R, Azab B, Quinn BA, et al. Apogossypol derivative BI-97C1 (sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to MDA-7/IL-24Ymediated toxicity. Proc Natl Acad Sci USA. 2011;108: 8785-8790.
    • (2011) Proc Natl Acad Sci USA. , vol.108 , pp. 8785-8790
    • Dash, R.1    Azab, B.2    Quinn, B.A.3
  • 38
    • 0029919668 scopus 로고    scopus 로고
    • Immunohistochemical analysis of Bcl-2, Bax, Bcl-X, and Mcl-1 expression in prostate cancers
    • Krajewska M, Krajewski S, Epstein JI, et al. Immunohistochemical analysis of Bcl-2, Bax, Bcl-X, and Mcl-1 expression in prostate cancers. Am J Pathol. 1996;148:1567-1576.
    • (1996) Am J Pathol. , vol.148 , pp. 1567-1576
    • Krajewska, M.1    Krajewski, S.2    Epstein, J.I.3
  • 39
    • 11144322016 scopus 로고    scopus 로고
    • Expression patterns of potential therapeutic targets in prostate cancer
    • Zellweger T, Ninck C, Bloch M, et al. Expression patterns of potential therapeutic targets in prostate cancer. Int J Cancer. 2005;113: 619-628.
    • (2005) Int J Cancer. , vol.113 , pp. 619-628
    • Zellweger, T.1    Ninck, C.2    Bloch, M.3
  • 40
    • 33750723137 scopus 로고    scopus 로고
    • Bcl-2 expression as a predictive marker of hormone-refractory prostate cancer treated with taxane-based chemotherapy
    • Yoshino T, Shiina H, Urakami S, et al. Bcl-2 expression as a predictive marker of hormone-refractory prostate cancer treated with taxane-based chemotherapy. Clin Cancer Res. 2006;12(20 pt 1):6116-6124.
    • (2006) Clin Cancer Res. , vol.12 , Issue.20 PART 1 , pp. 6116-6124
    • Yoshino, T.1    Shiina, H.2    Urakami, S.3
  • 41
    • 34250733046 scopus 로고    scopus 로고
    • Bcl-2 and Bax expression predict prostate cancer outcome in men treated with androgen deprivation and radiotherapy on radiation therapy oncology group protocol 92-02
    • Khor LY, Moughan J, Al-Saleem T, et al. Bcl-2 and Bax expression predict prostate cancer outcome in men treated with androgen deprivation and radiotherapy on radiation therapy oncology group protocol 92-02. Clin Cancer Res. 2007;13:3585-3590.
    • (2007) Clin Cancer Res. , vol.13 , pp. 3585-3590
    • Khor, L.Y.1    Moughan, J.2    Al-Saleem, T.3
  • 42
    • 42449147919 scopus 로고    scopus 로고
    • Bcl-2 antagonist apogossy-pol (NSC736630) displays single-agent activity in Bcl-2Ytransgenic mice and has superior efficacy with less toxicity compared with gossy-pol (NSC19048)
    • Kitada S, Kress CL, Krajewska M, et al. Bcl-2 antagonist apogossy-pol (NSC736630) displays single-agent activity in Bcl-2Ytransgenic mice and has superior efficacy with less toxicity compared with gossy-pol (NSC19048). Blood. 2008;111:3211-3219.
    • (2008) Blood. , vol.111 , pp. 3211-3219
    • Kitada, S.1    Kress, C.L.2    Krajewska, M.3
  • 43
    • 34247529341 scopus 로고    scopus 로고
    • Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of Bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1
    • Mohammad RM, Goustin AS, Aboukameel A, et al. Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of Bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1. Clin Cancer Res. 2007;13:2226-2235.
    • (2007) Clin Cancer Res. , vol.13 , pp. 2226-2235
    • Mohammad, R.M.1    Goustin, A.S.2    Aboukameel, A.3
  • 44
    • 84863116430 scopus 로고    scopus 로고
    • Substantial susceptibility of chronic lymphocytic leukemia to Bcl2 inhibition: Results of a phase i study of navitoclax in patients with relapsed or refractory disease
    • Roberts AW, Seymour JF, Brown JR, et al. Substantial susceptibility of chronic lymphocytic leukemia to Bcl2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease. J Clin Oncol. 2012;30:488-496.
    • (2012) J Clin Oncol. , vol.30 , pp. 488-496
    • Roberts, A.W.1    Seymour, J.F.2    Brown, J.R.3
  • 45
    • 33745872296 scopus 로고    scopus 로고
    • Comparison of chemical inhibitors of antiapoptotic Bcl-2Yfamily proteins
    • Zhai D, Jin C, Satterthwait AC, et al. Comparison of chemical inhibitors of antiapoptotic Bcl-2Yfamily proteins. Cell Death Differ. 2006;13: 1419-1421.
    • (2006) Cell Death Differ. , vol.13 , pp. 1419-1421
    • Zhai, D.1    Jin, C.2    Satterthwait, A.C.3
  • 46
    • 79952291173 scopus 로고    scopus 로고
    • Phase i study of navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors
    • Gandhi L, Camidge DR, Ribeiro de Oliveira M, et al. Phase I study of navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors. J Clin Oncol. 2011;29:909-916.
    • (2011) J Clin Oncol. , vol.29 , pp. 909-916
    • Gandhi, L.1    Camidge, D.R.2    Ribeiro De Oliveira, M.3
  • 47
    • 0030200892 scopus 로고    scopus 로고
    • Physical mapping of chromosome 8p22 markers and their homozygous deletion in a metastatic prostate cancer
    • Bova GS, MacGrogan D, Levy A, et al. Physical mapping of chromosome 8p22 markers and their homozygous deletion in a metastatic prostate cancer. Genomics. 1996;35:46-54.
    • (1996) Genomics. , vol.35 , pp. 46-54
    • Bova, G.S.1    MacGrogan, D.2    Levy, A.3
  • 48
    • 33845332700 scopus 로고    scopus 로고
    • Differential expression of TRAIL and its receptors in benign and malignant prostate tissues
    • Sanlioglu AD, Koksal IT, Ciftcioglu A, et al. Differential expression of TRAIL and its receptors in benign and malignant prostate tissues. J Urol. 2007;177:359-364.
    • (2007) J Urol. , vol.177 , pp. 359-364
    • Sanlioglu, A.D.1    Koksal, I.T.2    Ciftcioglu, A.3
  • 50
    • 0036598992 scopus 로고    scopus 로고
    • Targeting death and decoy receptors of the tumour-necrosis factor superfamily
    • Ashkenazi A. Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat Rev Cancer. 2002;2:420-430.
    • (2002) Nat Rev Cancer. , vol.2 , pp. 420-430
    • Ashkenazi, A.1
  • 51
    • 45749137688 scopus 로고    scopus 로고
    • A phase Ib study to assess the safety of lexatumumab, a human monoclonal antibody that activates TRAIL-R2, in combination with gemcitabine, pemetrexed, doxo-rubicin or FOLFIRI. 2007 ASCO Annual Meeting Proceedings Part i
    • Supplement 14006
    • Sikic BI, Wakelee HA, von Mehren M, et al. A phase Ib study to assess the safety of lexatumumab, a human monoclonal antibody that activates TRAIL-R2, in combination with gemcitabine, pemetrexed, doxo-rubicin or FOLFIRI. 2007 ASCO Annual Meeting Proceedings Part I. J Clin Oncol. 2007;25:18S. Supplement 14006.
    • (2007) J Clin Oncol. , vol.25
    • Sikic, B.I.1    Wakelee, H.A.2    Von Mehren, M.3
  • 52
    • 0038121755 scopus 로고    scopus 로고
    • Androgen regulation of FLICE-like inhibitory protein gene expression in the rat prostate
    • Nastiuk KL, Kim JW, Mann M, et al. Androgen regulation of FLICE-like inhibitory protein gene expression in the rat prostate. J Cell Physiol. 2003;196:386-393.
    • (2003) J Cell Physiol. , vol.196 , pp. 386-393
    • Nastiuk, K.L.1    Kim, J.W.2    Mann, M.3
  • 53
    • 0034623308 scopus 로고    scopus 로고
    • Caspase-3 and inhibitor of apoptosis protein(s) interactions in Saccharomyces cerevisiae and mammalian cells
    • Wright ME, Han DK, Hockenbery DM. Caspase-3 and inhibitor of apoptosis protein(s) interactions in Saccharomyces cerevisiae and mammalian cells. FEBS Lett. 2000;481:13-18.
    • (2000) FEBS Lett. , vol.481 , pp. 13-18
    • Wright, M.E.1    Han, D.K.2    Hockenbery, D.M.3
  • 55
    • 0142188706 scopus 로고    scopus 로고
    • Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: Implication for cancer specific therapy
    • Yang L, Cao Z, Yan H, et al. Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: implication for cancer specific therapy. Cancer Res. 2003;63:6815-6824.
    • (2003) Cancer Res. , vol.63 , pp. 6815-6824
    • Yang, L.1    Cao, Z.2    Yan, H.3
  • 56
    • 7944229824 scopus 로고    scopus 로고
    • Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics
    • McManus DC, Lefebvre CA, Cherton-Horvat G, et al. Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics. Oncogene. 2004; 23:8105-8117.
    • (2004) Oncogene. , vol.23 , pp. 8105-8117
    • McManus, D.C.1    Lefebvre, C.A.2    Cherton-Horvat, G.3
  • 57
    • 84865661651 scopus 로고    scopus 로고
    • Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xeno-graft models of prostate cancer
    • Jackson RS 2nd, Placzek W, Fernandez A, et al. Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xeno-graft models of prostate cancer. Neoplasia. 2012;14:656-665.
    • (2012) Neoplasia. , vol.14 , pp. 656-665
    • Jackson III, R.S.1    Placzek, W.2    Fernandez, A.3
  • 58
    • 20444486559 scopus 로고    scopus 로고
    • An inhibitor of Bcl-2 family proteins induces regression of solid tumours
    • Oltersdorf T, Elmore SW, Shoemaker AR, et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature. 2005;435: 677-681.
    • (2005) Nature. , vol.435 , pp. 677-681
    • Oltersdorf, T.1    Elmore, S.W.2    Shoemaker, A.R.3
  • 59
    • 44849112219 scopus 로고    scopus 로고
    • ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
    • Tse C, Shoemaker AR, Adickes J, et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 2008;68:3421-3428.
    • (2008) Cancer Res. , vol.68 , pp. 3421-3428
    • Tse, C.1    Shoemaker, A.R.2    Adickes, J.3
  • 60
    • 3343007095 scopus 로고    scopus 로고
    • Pim-1 kinase promotes inacti-vation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site
    • Aho TL, Sandholm J, Peltola KJ, et al. Pim-1 kinase promotes inacti-vation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site. FEBS Lett. 2004;571:43-49.
    • (2004) FEBS Lett. , vol.571 , pp. 43-49
    • Aho, T.L.1    Sandholm, J.2    Peltola, K.J.3
  • 61
    • 0242580961 scopus 로고    scopus 로고
    • The PIM-2 kinase phosphorylates Bad on serine 112 and reverses Bad-induced cell death
    • Yan B, Zemskova M, Holder S, et al. The PIM-2 kinase phosphorylates Bad on serine 112 and reverses Bad-induced cell death. J Biol Chem. 2003;278:45358-45367.
    • (2003) J Biol Chem. , vol.278 , pp. 45358-45367
    • Yan, B.1    Zemskova, M.2    Holder, S.3
  • 62
    • 0034794571 scopus 로고    scopus 로고
    • The survivin saga goes in vivo
    • Reed JC. The survivin saga goes in vivo. J Clin Invest. 2001;108: 965-969.
    • (2001) J Clin Invest. , vol.108 , pp. 965-969
    • Reed, J.C.1
  • 63
    • 0032410818 scopus 로고    scopus 로고
    • The inhibitors of apopto-sis (IAPs) and their emerging role in cancer
    • LaCasse EC, Baird S, Korneluk RG, et al. The inhibitors of apopto-sis (IAPs) and their emerging role in cancer. Oncogene. 1998;17: 3247-3259.
    • (1998) Oncogene. , vol.17 , pp. 3247-3259
    • Lacasse, E.C.1    Baird, S.2    Korneluk, R.G.3
  • 64
    • 63749097010 scopus 로고    scopus 로고
    • Phase i trial of AEG35156 administered as a 7-day and 3-day continuous intravenous infusion in patients with advanced refractory cancer
    • Dean E, Jodrell D, Connolly K, et al. Phase I trial of AEG35156 administered as a 7-day and 3-day continuous intravenous infusion in patients with advanced refractory cancer. J Clin Oncol. 2009;27: 1660-1666.
    • (2009) J Clin Oncol. , vol.27 , pp. 1660-1666
    • Dean, E.1    Jodrell, D.2    Connolly, K.3
  • 65
    • 70350450612 scopus 로고    scopus 로고
    • Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonu-cleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia
    • Schimmer AD, Estey EH, Borthakur G, et al. Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonu-cleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia. J Clin Oncol. 2009;27:4741-4746.
    • (2009) J Clin Oncol. , vol.27 , pp. 4741-4746
    • Schimmer, A.D.1    Estey, E.H.2    Borthakur, G.3
  • 66
    • 84856173058 scopus 로고    scopus 로고
    • Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study
    • Schimmer AD, Herr W, Hanel M, et al. Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study. Clin Lymphoma Myeloma Leuk. 2011;11:433-438.
    • (2011) Clin Lymphoma Myeloma Leuk. , vol.11 , pp. 433-438
    • Schimmer, A.D.1    Herr, W.2    Hanel, M.3
  • 67
    • 84878882634 scopus 로고    scopus 로고
    • Phase i trial of AEG35156 an antisense oligonucleotide to XIAP plus gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma
    • Mahadevan D, Chalasani P, Rensvold D, et al. Phase I trial of AEG35156 an antisense oligonucleotide to XIAP plus gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma. Am J Clin Oncol. 2012.
    • Am J Clin Oncol. , vol.2012
    • Mahadevan, D.1    Chalasani, P.2    Rensvold, D.3
  • 68
    • 84856455103 scopus 로고    scopus 로고
    • Safety, pharmacokinetics (PK), and pharmacodynamics (PD) of HGS1029, an inhibitor of apoptosis protein (IAP) inhibitor, in patients (Pts) with advanced solid tumors: Results of a phase i study
    • Sikic BI, Eckhardt SG, Gallant G, et al. Safety, pharmacokinetics (PK), and pharmacodynamics (PD) of HGS1029, an inhibitor of apoptosis protein (IAP) inhibitor, in patients (Pts) with advanced solid tumors: results of a phase I study. J Clin Oncol. 2011;29 (suppl; abstract 3008).
    • (2011) J Clin Oncol. , vol.29 , Issue.SUPPL. , pp. 3008
    • Sikic, B.I.1    Eckhardt, S.G.2    Gallant, G.3
  • 69
    • 17844367156 scopus 로고    scopus 로고
    • Survivin mediates resistance to antiandrogen therapy in prostate cancer
    • Zhang M, Latham DE, Delaney MA, et al. Survivin mediates resistance to antiandrogen therapy in prostate cancer. Oncogene. 2005;24: 2474-2482.
    • (2005) Oncogene. , vol.24 , pp. 2474-2482
    • Zhang, M.1    Latham, D.E.2    Delaney, M.A.3
  • 71
    • 33750611276 scopus 로고    scopus 로고
    • The case for survivin as a regulator of microtubule dynamics and cell-death decisions
    • Altieri DC. The case for survivin as a regulator of microtubule dynamics and cell-death decisions. Curr Opin Cell Biol. 2006;18: 609-615.
    • (2006) Curr Opin Cell Biol. , vol.18 , pp. 609-615
    • Altieri, D.C.1
  • 72
    • 0037441888 scopus 로고    scopus 로고
    • Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma
    • Aoki Y, Feldman GM, Tosato G. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood. 2003;101:1535-1542.
    • (2003) Blood. , vol.101 , pp. 1535-1542
    • Aoki, Y.1    Feldman, G.M.2    Tosato, G.3
  • 73
    • 0030746636 scopus 로고    scopus 로고
    • A novel anti-apoptosis gene, sur-vivin, expressed in cancer and lymphoma
    • Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, sur-vivin, expressed in cancer and lymphoma. Nat Med. 1997;3:917-921.
    • (1997) Nat Med. , vol.3 , pp. 917-921
    • Ambrosini, G.1    Adida, C.2    Altieri, D.C.3
  • 74
    • 0032403126 scopus 로고    scopus 로고
    • IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, cas-pases, and anticancer drugs
    • Tamm I, Wang Y, Sausville E, et al. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, cas-pases, and anticancer drugs. Cancer Res. 1998;58:5315-5320.
    • (1998) Cancer Res. , vol.58 , pp. 5315-5320
    • Tamm, I.1    Wang, Y.2    Sausville, E.3
  • 75
    • 0033571983 scopus 로고    scopus 로고
    • Survivin-deltaEx3 and survivin-2B: Two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties
    • Mahotka C, Wenzel M, Springer E, et al. Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties. Cancer Res. 1999;59:6097-6102.
    • (1999) Cancer Res. , vol.59 , pp. 6097-6102
    • Mahotka, C.1    Wenzel, M.2    Springer, E.3
  • 76
    • 84860862938 scopus 로고    scopus 로고
    • Survivin in solid tumors: Rationale for development of inhibitors
    • Church DN, Talbot DC. Survivin in solid tumors: rationale for development of inhibitors. Curr Oncol Rep. 2012;14:120-128.
    • (2012) Curr Oncol Rep. , vol.14 , pp. 120-128
    • Church, D.N.1    Talbot, D.C.2
  • 77
    • 84873862683 scopus 로고    scopus 로고
    • Interim results of a randomized phase II study with window-design to evaluate antitumor activity of the survivin antisense oligonucleotide (ASO) LY2181308 in combination with docetaxel for first-line treatment of castrate-resistant prostate cancer (CRPC)
    • Wiechno PJ, Chlosta P, Smok-Kalwat J, et al. Interim results of a randomized phase II study with window-design to evaluate antitumor activity of the survivin antisense oligonucleotide (ASO) LY2181308 in combination with docetaxel for first-line treatment of castrate-resistant prostate cancer (CRPC). J Clin Oncol. 2011;29: (suppl; abstract 4592).
    • (2011) J Clin Oncol. , vol.29 , Issue.SUPPL. , pp. 4592
    • Wiechno, P.J.1    Chlosta, P.2    Smok-Kalwat, J.3
  • 78
    • 78751626483 scopus 로고    scopus 로고
    • Pharmacodynamic (PD) evaluation of LY2181308 in patients with metastatic malignancies
    • abstract 3507
    • Talbot DC, Davies J, Olsen A, et al. Pharmacodynamic (PD) evaluation of LY2181308 in patients with metastatic malignancies. J Clin Oncol. 2009;27:15s (suppl; abstract 3507).
    • (2009) J Clin Oncol. , vol.27 , Issue.SUPPL.
    • Talbot, D.C.1    Davies, J.2    Olsen, A.3
  • 79
    • 84873830966 scopus 로고    scopus 로고
    • Phase I/II open-label study of YM-155 plus docetaxel and prednisone in men with hormone refractory prostate cancer (HRPC). 2009 Genitourinary Cancers Symposium
    • Tolcher AW, Papadopoulos K, Patnaik A. Phase I/II open-label study of YM-155 plus docetaxel and prednisone in men with hormone refractory prostate cancer (HRPC). 2009 Genitourinary Cancers Symposium. J Clin Oncol. 2009. Abstract 214.
    • (2009) J Clin Oncol. , pp. 214
    • Tolcher, A.W.1    Papadopoulos, K.2    Patnaik, A.3
  • 80
    • 84859422180 scopus 로고    scopus 로고
    • A phase II study of YM155, a novel small-molecule suppressor of survivin, in castration-resistant taxane-pretreated prostate cancer
    • Tolcher AW, Quinn DI, Ferrari A, et al. A phase II study of YM155, a novel small-molecule suppressor of survivin, in castration-resistant taxane-pretreated prostate cancer. Ann Oncol. 2012;23:968-973.
    • (2012) Ann Oncol. , vol.23 , pp. 968-973
    • Tolcher, A.W.1    Quinn, D.I.2    Ferrari, A.3
  • 83
    • 35948950583 scopus 로고    scopus 로고
    • Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity
    • Zoubeidi A, Zardan A, Beraldi E, et al. Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity. Cancer Res. 2007;67:10455-10465.
    • (2007) Cancer Res. , vol.67 , pp. 10455-10465
    • Zoubeidi, A.1    Zardan, A.2    Beraldi, E.3
  • 84
    • 0033589283 scopus 로고    scopus 로고
    • Hormone therapy failure in human prostate cancer: Analysis by complementary DNA and tissue microarrays
    • Bubendorf L, Kolmer M, Kononen J, et al. Hormone therapy failure in human prostate cancer: analysis by complementary DNA and tissue microarrays. J Natl Cancer Inst. 1999;91:1758-1764.
    • (1999) J Natl Cancer Inst. , vol.91 , pp. 1758-1764
    • Bubendorf, L.1    Kolmer, M.2    Kononen, J.3
  • 85
    • 84855826122 scopus 로고    scopus 로고
    • Phase i trial of OGX-427, a 2¶ meth-oxyethyl antisense oligonucleotide (ASO), against heat shock protein 27 (HSP27): Final results
    • abstract 3077
    • Hotte SJ, Yu EY, Hirte HW, et al. Phase I trial of OGX-427, a 2¶ meth-oxyethyl antisense oligonucleotide (ASO), against heat shock protein 27 (HSP27): final results. J Clin Oncol. 2010;28:15s (suppl; abstract 3077).
    • (2010) J Clin Oncol. , vol.28 , Issue.SUPPL.
    • Hotte, S.J.1    Yu, E.Y.2    Hirte, H.W.3
  • 86
    • 84873742677 scopus 로고    scopus 로고
    • A randomized phase II study of OGX-427 plus prednisone (P) versus P alone in patients (pts) with metastatic castration resistant prostate cancer (CRPC)
    • Chi KN, Hotte SJ, Ellard S, et al. A randomized phase II study of OGX-427 plus prednisone (P) versus P alone in patients (pts) with metastatic castration resistant prostate cancer (CRPC). J Clin Oncol. 2012;30:(suppl; abstract 4514).
    • (2012) J Clin Oncol. , vol.30 , Issue.SUPPL. , pp. 4514
    • Chi, K.N.1    Hotte, S.J.2    Ellard, S.3
  • 88
    • 0034192382 scopus 로고    scopus 로고
    • Acquisition of chemoresistant phenotype by overexpression of the antiapoptotic gene testosterone-repressed prostate message-2 in prostate cancer xenograft models
    • Miyake H, Nelson C, Rennie PS, et al. Acquisition of chemoresistant phenotype by overexpression of the antiapoptotic gene testosterone-repressed prostate message-2 in prostate cancer xenograft models. Cancer Res. 2000;60:2547-2554.
    • (2000) Cancer Res. , vol.60 , pp. 2547-2554
    • Miyake, H.1    Nelson, C.2    Rennie, P.S.3
  • 89
    • 0029061350 scopus 로고
    • Prevention of cell death induced by tumor necrosis factor alpha in LNCaP cells by overexpression of sulfated gylocprotein-2 (clusterin)
    • Sensibar JA, Sutkowski DM, Raffo A. Prevention of cell death induced by tumor necrosis factor alpha in LNCaP cells by overexpression of sulfated gylocprotein-2 (clusterin). Cancer Res. 1995;55:2431-2437.
    • (1995) Cancer Res. , vol.55 , pp. 2431-2437
    • Sensibar, J.A.1    Sutkowski, D.M.2    Raffo, A.3
  • 90
    • 0036796026 scopus 로고    scopus 로고
    • Enhanced radiation sensitivity in prostate cancer by inhibition of the cell survival protein clusterin
    • Zellweger T, Chi K, Miyake H. Enhanced radiation sensitivity in prostate cancer by inhibition of the cell survival protein clusterin. Clin Cancer Res. 2002;8:3276-3284.
    • (2002) Clin Cancer Res. , vol.8 , pp. 3276-3284
    • Zellweger, T.1    Chi, K.2    Miyake, H.3
  • 91
    • 0034112089 scopus 로고    scopus 로고
    • Antisense TRPM-2 oligodeoxynu-cleotides chemosensitize human androgen-independent PC-3 prostate cancer cells both in vitro and in vivo
    • Miyake H, Chi KN, Gleave ME. Antisense TRPM-2 oligodeoxynu-cleotides chemosensitize human androgen-independent PC-3 prostate cancer cells both in vitro and in vivo. Clin Cancer Res. 2000;6: 1655-1663.
    • (2000) Clin Cancer Res. , vol.6 , pp. 1655-1663
    • Miyake, H.1    Chi, K.N.2    Gleave, M.E.3
  • 92
    • 4444222462 scopus 로고    scopus 로고
    • Nucleotide-based therapies targeting clus-terin chemosensitize human lung adenocarcinoma cells both in vitro and in vivo
    • July LV, Beraldi E, So A. Nucleotide-based therapies targeting clus-terin chemosensitize human lung adenocarcinoma cells both in vitro and in vivo. Mol Cancer Ther. 2004;3:223-232.
    • (2004) Mol Cancer Ther. , vol.3 , pp. 223-232
    • July, L.V.1    Beraldi, E.2    So, A.3
  • 93
    • 0036144277 scopus 로고    scopus 로고
    • Overexpression of clusterin in transitional cell carcinoma of the bladder is related to disease progression and recurrence
    • Miyake H, Gleave ME, Kamidono S. Overexpression of clusterin in transitional cell carcinoma of the bladder is related to disease progression and recurrence. Urology. 2002;59:150-154.
    • (2002) Urology. , vol.59 , pp. 150-154
    • Miyake, H.1    Gleave, M.E.2    Kamidono, S.3
  • 94
    • 26944445883 scopus 로고    scopus 로고
    • Clusterin inhibits apoptosis by interacting with activated Bax
    • Zhang H, Kim JK, Edwards CA, et al. Clusterin inhibits apoptosis by interacting with activated Bax. Nat Cell Biol. 2005;7:909-915.
    • (2005) Nat Cell Biol. , vol.7 , pp. 909-915
    • Zhang, H.1    Kim, J.K.2    Edwards, C.A.3
  • 95
    • 58849123363 scopus 로고    scopus 로고
    • Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex
    • Trougakos IP, Lourda M, Antonelou MH, et al. Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex. Clin Cancer Res. 2009;15:48-59.
    • (2009) Clin Cancer Res. , vol.15 , pp. 48-59
    • Trougakos, I.P.1    Lourda, M.2    Antonelou, M.H.3
  • 96
    • 77953407266 scopus 로고    scopus 로고
    • Induction of clusterin by AKTYrole in cytoprotection against docetaxel in prostate tumor cells
    • Zhong B, Sallman DA, Gilvary DL, et al. Induction of clusterin by AKTYrole in cytoprotection against docetaxel in prostate tumor cells. Mol Cancer Ther. 2010;9:1831-1841.
    • (2010) Mol Cancer Ther. , vol.9 , pp. 1831-1841
    • Zhong, B.1    Sallman, D.A.2    Gilvary, D.L.3
  • 97
    • 45149104050 scopus 로고    scopus 로고
    • Clusterin activates survival through the phosphati-dylinositol 3-kinase/Akt pathway
    • Ammar H, Closset JL. Clusterin activates survival through the phosphati-dylinositol 3-kinase/Akt pathway. J Biol Chem. 2008;283:12851-12861.
    • (2008) J Biol Chem. , vol.283 , pp. 12851-12861
    • Ammar, H.1    Closset, J.L.2
  • 98
    • 75149124457 scopus 로고    scopus 로고
    • Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells
    • Zoubeidi A, Ettinger S, Beraldi E, et al. Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells. Mol Cancer Res. 2010;8:119-130.
    • (2010) Mol Cancer Res. , vol.8 , pp. 119-130
    • Zoubeidi, A.1    Ettinger, S.2    Beraldi, E.3
  • 99
    • 1642528843 scopus 로고    scopus 로고
    • Small heat-shock proteins and clusterin: Intra-and extracellular molecular chaperones with a common mechanism of action and function?
    • Carver JA, Rekas A, Thorn DC, et al. Small heat-shock proteins and clusterin: intra-and extracellular molecular chaperones with a common mechanism of action and function? IUBMB Life. 2003;55:661-668.
    • (2003) IUBMB Life. , vol.55 , pp. 661-668
    • Carver, J.A.1    Rekas, A.2    Thorn, D.C.3
  • 100
    • 34247387196 scopus 로고    scopus 로고
    • Stress-induced retrotranslocation of clusterin/ApoJ into the cytosol
    • Nizard P, Tetley S, Le Drean Y, et al. Stress-induced retrotranslocation of clusterin/ApoJ into the cytosol. Traffic. 2007;8:554-565.
    • (2007) Traffic. , vol.8 , pp. 554-565
    • Nizard, P.1    Tetley, S.2    Le Drean, Y.3
  • 101
    • 0034883854 scopus 로고    scopus 로고
    • Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2¶-O-(2-methoxy)ethyl chemistry
    • Zellweger T, Miyake H, Cooper S. Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2¶-O-(2-methoxy)ethyl chemistry. J Pharmacol Exp Ther. 2001;298:934-940.
    • (2001) J Pharmacol Exp Ther. , vol.298 , pp. 934-940
    • Zellweger, T.1    Miyake, H.2    Cooper, S.3
  • 102
    • 47649133156 scopus 로고    scopus 로고
    • Clusterin knockdown using the antisense oligonucleotide OGX-011 re-sensitizes docetaxel-refractory prostate cancer PC-3 cells to chemotherapy
    • Sowery RD, Hadaschik BA, So AI, et al. Clusterin knockdown using the antisense oligonucleotide OGX-011 re-sensitizes docetaxel-refractory prostate cancer PC-3 cells to chemotherapy. BJU Int. 2008;102: 389-397.
    • (2008) BJU Int. , vol.102 , pp. 389-397
    • Sowery, R.D.1    Hadaschik, B.A.2    So, A.I.3
  • 103
    • 80052468423 scopus 로고    scopus 로고
    • Randomized phase II trial of custirsen (OGX-011) in combination with docetaxel or mitoxantrone as second-line therapy in patients with metastatic castrate-resistant prostate cancer progressing after first-line docetaxel: CUOG Trial P-06c
    • Saad F, Hotte S, North S, et al. Randomized phase II trial of custirsen (OGX-011) in combination with docetaxel or mitoxantrone as second-line therapy in patients with metastatic castrate-resistant prostate cancer progressing after first-line docetaxel: CUOG Trial P-06c. Clin Cancer Res. 2011;17:5765-5773.
    • (2011) Clin Cancer Res. , vol.17 , pp. 5765-5773
    • Saad, F.1    Hotte, S.2    North, S.3
  • 104
    • 38949153810 scopus 로고    scopus 로고
    • A phase i study of OGX-011, a 2¶ meth-oxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer
    • Chi K, Siu LL, Hirte H, et al. A phase I study of OGX-011, a 2¶ meth-oxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer. Clin Cancer Res. 2008; 14:833-839.
    • (2008) Clin Cancer Res. , vol.14 , pp. 833-839
    • Chi, K.1    Siu, L.L.2    Hirte, H.3
  • 105
    • 77957957234 scopus 로고    scopus 로고
    • Randomized phase II study of doce-taxel and prednisone with or without OGX-011 in patients with meta-static castration-resistant prostate cancer
    • Chi K, Hotte SJ, Yu EY, et al. Randomized phase II study of doce-taxel and prednisone with or without OGX-011 in patients with meta-static castration-resistant prostate cancer. J Clin Oncol. 2010;28: 4247-4254.
    • (2010) J Clin Oncol. , vol.28 , pp. 4247-4254
    • Chi, K.1    Hotte, S.J.2    Yu, E.Y.3
  • 106
    • 24744470522 scopus 로고    scopus 로고
    • A phase i pharmacokinetic and pharmacodynamic study of OGX-011, a 2¶ methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer
    • Chi K, Eisenhauer E, Fazli L, et al. A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2¶ methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer. J Natl Cancer Inst. 2005;97:1287-1296.
    • (2005) J Natl Cancer Inst. , vol.97 , pp. 1287-1296
    • Chi, K.1    Eisenhauer, E.2    Fazli, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.