Evaluation of the ROS Inhibiting Activity and Mitochondrial Targeting of Phenolic Compounds in Fibroblast Cells Model System and Enhancement of Efficiency by Natural Deep Eutectic Solvent (NADES) Formulation

Pharmaceutical Research

Volumn 34, Issue 5, 2017, Pages 1134-1146

  Durand, Erwann ^a   Lecomte, Jérôme ^a   Upasani, Rashmi ^b   Chabi, Béatrice ^c   Bayrasy, Christelle ^a   Baréa, Bruno ^a   Jublanc, Elodie ^c   Clarke, Martyn J ^b   Moore, David J ^b   Crowther, Jonathan ^d   Wrutniak Cabello, Chantal ^c   Villeneuve, Pierre ^a  

^a UMR IATE   (France)

^b GLAXOSMITHKLINE   (United States)

^c University of Montpellier   (France)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

antioxidants; mitochondrial targeting; natural deep eutectic solvents; reactive oxygen species

Indexed keywords

DRUG SOLVENT; NATURAL DEEP EUTECTIC SOLVENT; PHENOL DERIVATIVE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ANTIOXIDANT; BENZYLMANDELATE; BIOLOGICAL PRODUCT; MANDELIC ACID DERIVATIVE; SOLVENT;

ANTIOXIDANT ACTIVITY; ANTIOXIDANT ASSAY; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DRUG FORMULATION; DRUG TARGETING; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRION; PRIORITY JOURNAL; SCREENING; CHEMISTRY; DRUG EFFECTS; MEDICINAL CHEMISTRY; METABOLISM; OXIDATION REDUCTION REACTION; PROCEDURES;

ANTIOXIDANTS; BIOLOGICAL PRODUCTS; CHEMISTRY, PHARMACEUTICAL; FIBROBLASTS; HUMANS; MANDELIC ACIDS; MITOCHONDRIA; OXIDATION-REDUCTION; PHENOLS; REACTIVE OXYGEN SPECIES; SOLVENTS;

EID: 85013499591     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-017-2124-4     Document Type: Article

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