Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by MIR Combo

Circulation Research

Volumn 120, Issue 9, 2017, Pages 1403-1413

  Dal Pra, Sophie ^a   Hodgkinson, Conrad P ^a   Mirotsou, Maria ^a   Kirste, Imke ^a   Dzau, Victor J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cardiac myocytes; Cellular reprogramming; Chromatin; Epigenomics; MicroRNAs; Regeneration

Indexed keywords

HISTONE H3; HISTONE METHYLTRANSFERASE; MICRORNA; MICRORNA 1; MICRORNA 133; MICRORNA 208; MICRORNA 499; POLYCOMB REPRESSIVE COMPLEX 2; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR HAND2; TRANSCRIPTION FACTOR MEF2C; TRANSCRIPTION FACTOR TBX5; UNCLASSIFIED DRUG; ENZYME INHIBITOR; HISTONE; HISTONE DEMETHYLASE; KDM6B PROTEIN, MOUSE; UTX PROTEIN, MOUSE;

ANIMAL CELL; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA METHYLATION; EPIGENETIC REPRESSION; EPIGENETICS; FLUORESCENCE ACTIVATED CELL SORTING; HEART FIBROBLAST; HISTONE ACETYLATION; HISTONE DEMETHYLATION; HISTONE METHYLATION; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; MOUSE; NEWBORN; NONHUMAN; NUCLEAR REPROGRAMMING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS; REVIEW; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CARDIAC MUSCLE CELL; CELL REPROGRAMMING TECHNIQUE; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; METHYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, NEWBORN; CELLULAR REPROGRAMMING; CELLULAR REPROGRAMMING TECHNIQUES; DNA METHYLATION; ENZYME INHIBITORS; EPIGENESIS, GENETIC; FIBROBLASTS; GENE EXPRESSION REGULATION; HEK293 CELLS; HISTONE DEMETHYLASES; HISTONES; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; METHYLATION; MICE, INBRED C57BL; MICRORNAS; MYOCYTES, CARDIAC; POLYCOMB REPRESSIVE COMPLEX 2; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 85013472499     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.308741     Document Type: Review

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