Inhibitors of suppressive histone modification promote direct reprogramming of fibroblasts to cardiomyocyte-like cells

Cardiovascular Research

Volumn 102, Issue 1, 2014, Pages 189-190

  Hirai, Hiroyuki ^a   Kikyo, Nobuaki ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYCLOHEXYL N (1 ISOPROPYL 4 PIPERIDINYL) 6 METHOXY 7 [3 (1 PYRROLIDINYL)PROPOXY] 4 QUINAZOLINAMINE; GLUCAGON LIKE PEPTIDE; HISTONE H3; POLYCOMB REPRESSIVE COMPLEX 2; PROTEIN P53; TRANSCRIPTION FACTOR EZH2; GSK126; HISTONE; INDOLE DERIVATIVE; PYRIDONE DERIVATIVE;

ANIMAL CELL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVE SITE; ENZYME INHIBITION; FIBROBLAST; GENE REPRESSION; HEART MUSCLE CELL; HISTONE MODIFICATION; IN VIVO STUDY; LETTER; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PRIORITY JOURNAL; PROTEIN METHYLATION; WESTERN BLOTTING; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; METABOLISM; PHYSIOLOGY;

ANIMALS; CELL DIFFERENTIATION; FIBROBLASTS; HISTONES; INDOLES; MICE; MYOCYTES, CARDIAC; PYRIDONES;

EID: 84896944706     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvu023     Document Type: Letter

References (10)

1. Hirai H, Katoku-Kikyo N, Keirstead SA, Kikyo N. Accelerated direct reprogramming of fibroblasts into cardiomyocyte-like cells with the Myo D transactivation domain. Cardiovasc Res 2013;100:105-113.
2. Mc Cabe MT, Ott HM, Ganji G, Korenchuk S, Thompson C, Van Aller GS et al. Ezh2 inhibition as a therapeutic strategy for lymphoma with Ezh2-activating mutations. Nature 2012;492:108-112.
3. Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie Vet al. A chemical probe selectively inhibits G9a and Glp methyltransferase activity in cells. Nat Chem Biol 2011;7:566-574.
4. Addis RC, Ifkovits JL, Pinto F, Kellam LD, Esteso P, Rentschler S et al. Optimization of direct fibroblast re-programming to cardiomyocytes using calcium activity as a functional measure of success. J Mol Cell Cardiol 2013;60:97-106.
5. Li F, Wang X, Capasso JM, Gerdes AM. Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J Mol Cell Cardiol 1996; 28:1737-1746.
6. Papp B, Plath K. Epigenetics of reprogramming to induced pluripotency. Cell 2013;152:1324-1343.
7. Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM et al. Chromatin-modifying enzymes as modulators of reprogramming. Nature 2012;483:598-602.
8. Ling BM, Bharathy N, Chung TK, Kok WK, Li S, Tan YH et al. Lysine methyltransferase G9a methylates the transcription factor Myo D and regulates skel et al muscle differentiation. Proc Natl Acad Sci USA 2012;109: 841-846.
9. Xin M, Olson EN, Bassel-Duby R. Mending broken hearts: cardiac developmentas abasis for adult heart regeneration and repair. Nat Rev Mol Cell Biol 2013;14: 529-541.
10. Mummery CL, Zhang J, Ng ES, Elliott DA, Elefanty AG, Kamp TJ. Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyo-cytes: a methods overview. Circ Res 2012;111:344-358.