Enhanced angiogenic and cardiomyocyte differentiation capacity of epigenetically reprogrammed mouse and human endothelial progenitor cells augments their efficacy for ischemic myocardial repair

Circulation Research

Volumn 111, Issue 2, 2012, Pages 180-190

  Thal, Melissa A ^a   Krishnamurthy, Prasanna ^a   MacKie, Alexander R ^a   Hoxha, Eneda ^a   Lambers, Erin ^a   Verma, Suresh ^a   Ramirez, Veronica ^a   Qin, Gangjian ^a   Losordo, Douglas W ^a   Kishore, Raj ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

cardiomyogenesis; cell therapy; endothelial progenitor cell; epigenetic modification; histone acetylation; myocardial ischemia; transdifferentiation

Indexed keywords

ATAXIN 1; AZACITIDINE; CD11B ANTIGEN; CD31 ANTIGEN; MESSENGER RNA; N (1 BENZYL 4 PIPERIDINYL) 2 (HEXAHYDRO 4 METHYL 1H 1,4 DIAZEPIN 1 YL) 6,7 DIMETHOXY 4 QUINAZOLINAMINE; TRANSCRIPTOME; VALPROIC ACID;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CAPILLARY DENSITY; CELL DIFFERENTIATION; CELL SPECIFICITY; CONTROLLED STUDY; ENDOTHELIAL PROGENITOR CELL; EPIGENETICS; GENETIC TRANSCRIPTION; HEART CELL CULTURE; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; HEART VENTRICLE FUNCTION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL TRANSPLANTATION;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; EPIGENESIS, GENETIC; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCARDIAL ISCHEMIA; MYOCYTES, CARDIAC; NEOVASCULARIZATION, PHYSIOLOGIC; STEM CELL TRANSPLANTATION; STEM CELLS; TREATMENT OUTCOME; UP-REGULATION;

EID: 84863723828     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.270462     Document Type: Article

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