Role of Lysosomes in Intracellular Degradation

Encyclopedia of Cell Biology

Volumn 1, Issue , 2016, Pages 612-620

  Hafner Cesen M ^a   Stoka, V ^a   Turk, B ^a,b  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b Centre of Excellence for Integrated Approaches in Chemistry and Biology of Proteins   (Slovenia)

Author keywords

Antigen processing and presentation; Cathepsin; Endosome; Glycosidase; Hydrolase; Lipase; Lysosomal storage disorders (LSDs); Lysosome

Indexed keywords

EID: 85013349557     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-394447-4.10071-9     Document Type: Chapter

References (75)

1. Aits S., Jaattela M. Lysosomal cell death at a glance. Journal of Cell Science 2013, 126:1905-1912.
2. Appelqvist H., Johansson A.C., Linderoth E., et al. Lysosome-mediated apoptosis is associated with cathepsin D-specific processing of bid at Phe24, Trp48, and Phe183. Annals of Clinical Laboratory Science 2012, 42:231-242.
3. Appelqvist H., Waster P., Kagedal K., Ollinger K. The lysosome: From waste bag to potential therapeutic target. Journal of Molecular Cell Biology 2013, 5:214-226.
4. Behrends C., Sowa M.E., Gygi S.P., Harper J.W. Network organization of the human autophagy system. Nature 2010, 466:68-76.
5. Blomgran R., Zheng L., Stendahl O. Cathepsin-cleaved Bid promotes apoptosis in human neutrophils via oxidative stress-induced lysosomal membrane permeabilization. Journal of Leukocyte Biology 2007, 81:1213-1223.
6. Blum J.S., Wearsch P.A., Cresswell P. Pathways of antigen processing. Annual Review of Immunology 2013, 31:443-473.
7. Braulke T., Bonifacino J.S. Sorting of lysosomal proteins. Biochimica et Biophysica Acta 2009, 1793:605-614.
8. Cassinerio E., Graziadei G., Poggiali E. Gaucher disease: A diagnostic challenge for internists. European Journal of Internal Medicine 2014, 25:117-124.
9. Cheng Z., Fang Q. Danon disease: Focusing on heart. Journal of Human Genetics 2012, 57:407-410.
10. Cirman T., Orešĭ K., Droga-Mazovec G., et al. Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. Journal of Biological Chemistry 2004, 279:3578-3587.
11. Codogno P., Mehrpour M., Proikas-Cezanne T. Canonical and non-canonical autophagy: Variations on a common theme of self-eating?. Nature Reviews. Molecular Cell Biology 2012, 13:7-12.
12. Colbert J.D., Matthews S.P., Miller G., Watts C. Diverse regulatory roles for lysosomal proteases in the immune response. European Journal of Immunology 2009, 39:2955-2965.
13. Cresswell P. Invariant chain structure and MHC class II function. Cell 1996, 84:505-507.
14. de Duve C. Lysosomes, a new group of cytoplasmic particles. Subcellular Particles 1959, The Ronald Press Co, New York, NY. T. Hayashi (Ed.).
15. de Duve C., de Barsy T., Poole B., et al. Commentary. lysosomotropic agents. Biochemical Pharmacology 1974, 23:2495-2531.
16. Dell'Angelica E.C., Mullins C., Caplan S., Bonifacino J.S. Lysosome-related organelles. Faseb Journal 2000, 14:1265-1278.
17. Doherty G.J., McMahon H.T. Mechanisms of endocytosis. Annual Review of Biochemistry 2009, 78:857-902.
18. Droga-Mazovec G., Boji L., Petelin A., et al. Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues. Journal of Biological Chemistry 2008, 283:19140-19150.
19. Duncan E.M., Muratore-Schroeder T.L., Cook R.G., et al. Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation. Cell 2008, 135:284-294.
20. Eskelinen E.L., Saftig P. Autophagy: A lysosomal degradation pathway with a central role in health and disease. Biochimica et Biophysica Acta 2009, 1793:664-673.
21. Ferraz M.J., Kallemeijn W.W., Mirzaian M., et al. Gaucher disease and Fabry disease: New markers and insights in pathophysiology for two distinct glycosphingolipidoses. Biochimica et Biophysica Acta 2014, 1841:811-825.
22. Fonović M., Turk B. Cysteine cathepsins and extracellular matrix degradation. Biochimica et Biophysica Acta 2014, 1840:2560-2570.
23. Fucho R., Martinez L., Baulies A., et al. ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis. Journal of Hepatology 2014, 61:1126-1134.
24. Granger B.L., Green S.A., Gabel C.A., et al. Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells. Journal of Biological Chemistry 1990, 265:12036-12043.
25. Huang S.C., Everts B., Ivanova Y., et al. Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nature Immunology 2014, 15:846-855.
26. Huotari J., Helenius A. Endosome maturation. EMBO Journal 2011, 30:3481-3500.
27. Idol R.A., Wozniak D.F., Fujiwara H., et al. Neurologic abnormalities in mouse models of the lysosomal storage disorders mucolipidosis II and mucolipidosis III gamma. PloS One 2014, 9:e109768.
28. Johansen T., Lamark T. Selective autophagy mediated by autophagic adapter proteins. Autophagy 2011, 7:279-296.
29. Kågedal K., Zhao M., Svensson I., Brunk U.T. Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochemical Journal 2001, 359:335-343.
30. van Kasteren S.I., Overkleeft H.S. Endo-lysosomal proteases in antigen presentation. Current Opinion in Chemical Biology 2014, 23C:8-15.
31. Katunuma N. Posttranslational processing and modification of cathepsins and cystatins. Journal of Signal Transduction 2010, 2010:1-8.
32. Kirkegaard T., Jaattela M. Lysosomal involvement in cell death and cancer. Biochimica et Biophysica Acta 2009, 1793:746-754.
33. Kirkin V., McEwan D.G., Novak I., Dikic I. A role for ubiquitin in selective autophagy. Molecular Cell 2009, 34:259-269.
34. Kleiger G., Mayor T. Perilous journey: A tour of the ubiquitin-proteasome system. Trends in Cell Biology 2014, 24:352-359.
35. Kraft C., Reggiori F., Peter M. Selective types of autophagy in yeast. Biochimica et Biophysica Acta 2009, 1793:1404-1412.
36. Kumari S., Mg S., Mayor S. Endocytosis unplugged: Multiple ways to enter the cell. Cell Research 2010, 20:256-275.
37. Lamb C.A., Dooley H.C., Tooze S.A. Endocytosis and autophagy: Shared machinery for degradation. BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology 2013, 35:34-45.
38. Luzio J.P., Pryor P.R., Bright N.A. Lysosomes: Fusion and function. Nature Reviews Molecular Cell Biology 2007, 8:622-632.
39. Maxfield F.R. Role of endosomes and lysosomes in human disease. Cold Spring Harbor Perspectives in Biology 2014, 6:1-15.
40. Mijaljica D., Prescott M., Devenish R.J. Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum. Autophagy 2011, 7:673-682.
41. Miller D.K., Griffiths E., Lenard J., Firestone R.A. Cell killing by lysosomotropic detergents. Journal of Cell Biology 1983, 97:1841-1851.
42. Mizushima N., Yoshimori T., Ohsumi Y. The role of Atg proteins in autophagosome formation. Annual Review of Cell and Developmental Biology 2011, 27:107-132.
43. Oczypok E.A., Oury T.D., Chu C.T. It's a cell-eat-cell world: Autophagy and phagocytosis. The American Journal of Pathology 2013, 182:612-622.
44. Okamoto K. Organellophagy: Eliminating cellular building blocks via selective autophagy. Journal of Cell Biology 2014, 205:435-445.
45. Park C., Cuervo A.M. Selective autophagy: Talking with the UPS. Cell Biochemistry and Biophysics 2013, 67:3-13.
46. Parkinson-Lawrence E.J., Shandala T., Prodoehl M., et al. Lysosomal storage disease: Revealing lysosomal function and physiology. Physiology (Bethesda) 2010, 25:102-115.
47. Pompe J. Over idiopatische hypertrophie van het hart. Nederlands Tijdschrift voor Geneeskunde 1932, 76:304-312.
48. Porto A.F. Lysosomal acid lipase deficiency: Diagnosis and treatment of Wolman and cholesteryl ester storage diseases. Pediatric Endocrinology Reviews 2014, 12(Suppl. 1):125-132.
49. Rajapakshe A.R., Podyma-Inoue K.A., Terasawa K., et al. Lysosome-associated membrane proteins (LAMPs) regulate intracellular positioning of mitochondria in MC3T3-E1 cells. Experimental Cell Research 2014, 331:211-222.
50. Ravikumar B., Sarkar S., Davies J.E., et al. Regulation of mammalian autophagy in physiology and pathophysiology. Physiological Reviews 2010, 90:1383-1435.
51. Reiser J., Adair B., Reinheckel T. Specialized roles for cysteine cathepsins in health and disease. Journal of Clinical Investigation 2010, 120:3421-3431.
52. Repnik U., Hafner Česen M., Turk B. The endolysosomal system in cell death and survival. Cold Spring Harbor Perspectives in Biology 2013, 5:1-14.
53. Repnik U., Hafner Česen M., Turk B. Lysosomal membrane permeabilization in cell death: Concepts and challenges. Mitochondrion 2014, 19:49-57.
54. Repnik U., Stoka V., Turk V., Turk B. Lysosomes and lysosomal cathepsins in cell death. Biochimica et Biophysica Acta 2012, 1824:22-33.
55. Ruivo R., Anne C., Sagne C., Gasnier B. Molecular and cellular basis of lysosomal transmembrane protein dysfunction. Biochimica et Biophysica Acta 2009, 1793:636-649.
56. Saftig P., Klumperman J. Lysosome biogenesis and lysosomal membrane proteins: Trafficking meets function. Nature Reviews Molecular Cell Biology 2009, 10:623-635.
57. Sardiello M., Palmieri M., Di Ronza A., et al. A gene network regulating lysosomal biogenesis and function. Science 2009, 325:473-477.
58. Schroder B.A., Wrocklage C., Hasilik A., Saftig P. The proteome of lysosomes. Proteomics 2010, 10:4053-4076.
59. Schultz M.L., Tecedor L., Chang M., Davidson B.L. Clarifying lysosomal storage diseases. Trends in Neuroscience 2011, 34:401-410.
60. Settembre C., Fraldi A., Medina D.L., Ballabio A. Signals from the lysosome: A control centre for cellular clearance and energy metabolism. Nature Reviews Molecular Cell Biology 2013, 14:283-296.
61. Shaid S., Brandts C.H., Serve H., Dikic I. Ubiquitination and selective autophagy. Cell Death and Differentiation 2013, 20:21-30.
62. Shayman J.A., Kelly R., Kollmeyer J., He Y., Abe A. Group XV phospholipase A(2), a lysosomal phospholipase A(2). Progress in Lipid Research 2011, 50:1-13.
63. Stern G. Niemann-Pick's and Gaucher's diseases. Parkinsonism & Related Disorders 2014, 20(Suppl. 1):S143-S146.
64. Stoka V., Turk B., Schendel S.L., et al. Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. Journal of Biological Chemistry 2001, 276:3149-3157.
65. Thiele D.L., Lipsky P.E. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: Dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. Proceedings of the National Academy of Sciences of the United States of America 1990, 87:83-87.
66. Turk B., Turk D., Salvesen G.S. Regulating cysteine protease activity: Essential role of protease inhibitors as guardians and regulators. Current Pharmaceutical Design 2002, 8:1623-1637.
67. Turk B., Turk D., Turk V. Protease signaling: The cutting edge. Embo Journal 2012, 31:1630-1643.
68. Turk B., Turk V. Lysosomes as "suicide bags" in cell death: Myth or reality?. Journal of Biological Chemistry 2009, 284:21783-21787.
69. Turk V., Stoka V., Vasiljeva O., et al. Cysteine cathepsins: From structure, function and regulation to new frontiers. Biochimica et Biophysica Acta 2012, 1824:68-88.
70. Turk V., Turk B., Turk D. Lysosomal cysteine proteases: Facts and opportunities. EMBO Journal 2001, 20:4629-4633.
71. Uchimoto T., Nohara H., Kamehara R., et al. Mechanism of apoptosis induced by a lysosomotropic agent, L-Leucyl-L-Leucine methyl ester. Apoptosis 1999, 4:357-362.
72. Vasiljeva O., Reinheckel T., Peters C., et al. Emerging roles of cysteine cathepsins in disease and their potential as drug targets. Current Pharmaceutical Design 2007, 13:387-403.
73. Vernon P.J., Tang D. Eat-me: Autophagy, phagocytosis, and reactive oxygen species signaling. Antioxidants & Redox Signaling 2013, 18:677-691.
74. Wong E., Cuervo A.M. Integration of clearance mechanisms: The proteasome and autophagy. Cold Spring Harbor Perspectives in Biology 2010, 2:1-19.
75. Yang Z., Klionsky D.J. Eaten alive: A history of macroautophagy. Nature Cell Biology 2010, 12:814-822.