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Volumn 187, Issue 3, 2017, Pages 476-486

Changes in the Luminal Environment of the Colonic Epithelial Cells and Physiopathological Consequences

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA;

EID: 85013168468     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2016.11.015     Document Type: Review
Times cited : (91)

References (100)
  • 1
    • 84891007206 scopus 로고    scopus 로고
    • Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration
    • 1 Barker, N., Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration. Nat Rev Mol Cell Biol 15 (2014), 19–33.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 19-33
    • Barker, N.1
  • 2
    • 34247345257 scopus 로고    scopus 로고
    • Cell exfoliation in the human colon: myth, reality and implications for colorectal cancer screening
    • 2 Loktionov, A., Cell exfoliation in the human colon: myth, reality and implications for colorectal cancer screening. Int J Cancer 120 (2007), 2281–2289.
    • (2007) Int J Cancer , vol.120 , pp. 2281-2289
    • Loktionov, A.1
  • 3
    • 84896851032 scopus 로고    scopus 로고
    • Intestinal epithelial cells: regulators of barrier function and immune homeostasis
    • 3 Peterson, L.W., Artis, D., Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol 14 (2014), 141–153.
    • (2014) Nat Rev Immunol , vol.14 , pp. 141-153
    • Peterson, L.W.1    Artis, D.2
  • 6
    • 84862116034 scopus 로고    scopus 로고
    • Gut bacteria in health and disease: a survey on the interface between intestinal microbiology and colorectal cancer
    • 6 Boleij, A., Tjalsma, H., Gut bacteria in health and disease: a survey on the interface between intestinal microbiology and colorectal cancer. Biol Rev Camb Philos Soc 87 (2012), 701–730.
    • (2012) Biol Rev Camb Philos Soc , vol.87 , pp. 701-730
    • Boleij, A.1    Tjalsma, H.2
  • 7
    • 0030628034 scopus 로고    scopus 로고
    • Human colonic microbiota: ecology, physiology and metabolic potential of intestinal bacteria
    • 7 Macfarlane, G.T., Macfarlane, S., Human colonic microbiota: ecology, physiology and metabolic potential of intestinal bacteria. Scand J Gastroenterol Suppl 222 (1997), 3–9.
    • (1997) Scand J Gastroenterol Suppl , vol.222 , pp. 3-9
    • Macfarlane, G.T.1    Macfarlane, S.2
  • 8
    • 33847233644 scopus 로고    scopus 로고
    • Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces
    • 8 Duncan, S.H., Belenguer, A., Holtrop, G., Johnstone, A.M., Flint, H.J., Lobley, G.E., Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces. Appl Environ Microbiol 73 (2007), 1073–1078.
    • (2007) Appl Environ Microbiol , vol.73 , pp. 1073-1078
    • Duncan, S.H.1    Belenguer, A.2    Holtrop, G.3    Johnstone, A.M.4    Flint, H.J.5    Lobley, G.E.6
  • 9
    • 0024399885 scopus 로고
    • Biochemical epidemiology of colon cancer: effect of types of dietary fiber on fecal mutagens, acid, and neutral sterols in healthy subjects
    • 9 Reddy, B., Engle, A., Katsifis, S., Simi, B., Bartram, H.P., Perrino, P., Mahan, C., Biochemical epidemiology of colon cancer: effect of types of dietary fiber on fecal mutagens, acid, and neutral sterols in healthy subjects. Cancer Res 49 (1989), 4629–4635.
    • (1989) Cancer Res , vol.49 , pp. 4629-4635
    • Reddy, B.1    Engle, A.2    Katsifis, S.3    Simi, B.4    Bartram, H.P.5    Perrino, P.6    Mahan, C.7
  • 10
    • 84855310228 scopus 로고    scopus 로고
    • Relevance of protein fermentation to gut health
    • 10 Windey, K., De Preter, V., Verbeke, K., Relevance of protein fermentation to gut health. Mol Nutr Food Res 56 (2012), 184–196.
    • (2012) Mol Nutr Food Res , vol.56 , pp. 184-196
    • Windey, K.1    De Preter, V.2    Verbeke, K.3
  • 11
    • 3242683393 scopus 로고    scopus 로고
    • Adaptative increase of ornithine production and decrease of ammonia metabolism in rat colonocytes after hyperproteic diet ingestion
    • 11 Mouille, B., Robert, V., Blachier, F., Adaptative increase of ornithine production and decrease of ammonia metabolism in rat colonocytes after hyperproteic diet ingestion. Am J Physiol Gastrointest Liver Physiol 287 (2004), G344–G351.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287 , pp. G344-G351
    • Mouille, B.1    Robert, V.2    Blachier, F.3
  • 12
    • 84864329574 scopus 로고    scopus 로고
    • Inulin modifies the bifidobacteria population, fecal lactate concentration, and fecal pH but does not influence iron absorption in women with low iron status
    • 12 Petry, N., Egli, I., Chassard, C., Lacroix, C., Hurrell, R., Inulin modifies the bifidobacteria population, fecal lactate concentration, and fecal pH but does not influence iron absorption in women with low iron status. Am J Clin Nutr 96 (2012), 325–331.
    • (2012) Am J Clin Nutr , vol.96 , pp. 325-331
    • Petry, N.1    Egli, I.2    Chassard, C.3    Lacroix, C.4    Hurrell, R.5
  • 14
    • 0031684010 scopus 로고    scopus 로고
    • Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria
    • 14 Zoetendal, E.G., Akkermans, A.D., De Vos, W.M., Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria. Appl Environ Microbiol 64 (1998), 3854–3859.
    • (1998) Appl Environ Microbiol , vol.64 , pp. 3854-3859
    • Zoetendal, E.G.1    Akkermans, A.D.2    De Vos, W.M.3
  • 18
    • 84929073100 scopus 로고    scopus 로고
    • Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn's disease and healthy individuals
    • 18 Bjerrum, J.T., Wang, Y., Hao, F., Coskun, M., Ludwig, C., Gunther, U., Nielsen, O.H., Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn's disease and healthy individuals. Metabolomics 11 (2015), 122–133.
    • (2015) Metabolomics , vol.11 , pp. 122-133
    • Bjerrum, J.T.1    Wang, Y.2    Hao, F.3    Coskun, M.4    Ludwig, C.5    Gunther, U.6    Nielsen, O.H.7
  • 19
    • 84966389294 scopus 로고    scopus 로고
    • Diet, microbiota, and dysbiosis: a “recipe” for colorectal cancer
    • 19 Vipperla, K., O'Keefe, S.J., Diet, microbiota, and dysbiosis: a “recipe” for colorectal cancer. Food Funct 7 (2016), 1731–1740.
    • (2016) Food Funct , vol.7 , pp. 1731-1740
    • Vipperla, K.1    O'Keefe, S.J.2
  • 20
    • 84896078883 scopus 로고    scopus 로고
    • Microbes, microbiota, and colon cancer
    • 20 Sears, C.L., Garrett, W.S., Microbes, microbiota, and colon cancer. Cell Host Microbe 15 (2014), 317–328.
    • (2014) Cell Host Microbe , vol.15 , pp. 317-328
    • Sears, C.L.1    Garrett, W.S.2
  • 21
    • 70349578566 scopus 로고    scopus 로고
    • Metabolism and functions of L-glutamate in the epithelial cells of the small and large intestines
    • 21 Blachier, F., Boutry, C., Bos, C., Tome, D., Metabolism and functions of L-glutamate in the epithelial cells of the small and large intestines. Am J Clin Nutr 90 (2009), 814S–821S.
    • (2009) Am J Clin Nutr , vol.90 , pp. 814S-821S
    • Blachier, F.1    Boutry, C.2    Bos, C.3    Tome, D.4
  • 22
    • 84902305073 scopus 로고    scopus 로고
    • Oxygen in the regulation of intestinal epithelial transport
    • 22 Ward, J.B., Keely, S.J., Keely, S.J., Oxygen in the regulation of intestinal epithelial transport. J Physiol 592 (2014), 2473–2489.
    • (2014) J Physiol , vol.592 , pp. 2473-2489
    • Ward, J.B.1    Keely, S.J.2    Keely, S.J.3
  • 24
    • 84873299448 scopus 로고    scopus 로고
    • Role of oxygen gradients in shaping redox relationships between the human intestine and its microbiota
    • 24 Espey, M.G., Role of oxygen gradients in shaping redox relationships between the human intestine and its microbiota. Free Radic Biol Med 55 (2013), 130–140.
    • (2013) Free Radic Biol Med , vol.55 , pp. 130-140
    • Espey, M.G.1
  • 25
    • 77952092406 scopus 로고    scopus 로고
    • Hypoxia: an alarm signal during intestinal inflammation
    • 25 Colgan, S.P., Taylor, C.T., Hypoxia: an alarm signal during intestinal inflammation. Nat Rev Gastroenterol Hepatol 7 (2010), 281–287.
    • (2010) Nat Rev Gastroenterol Hepatol , vol.7 , pp. 281-287
    • Colgan, S.P.1    Taylor, C.T.2
  • 26
    • 0027936404 scopus 로고
    • Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia
    • 26 Yao, K.S., Xanthoudakis, S., Curran, T., O'Dwyer, P.J., Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia. Mol Cell Biol 14 (1994), 5997–6003.
    • (1994) Mol Cell Biol , vol.14 , pp. 5997-6003
    • Yao, K.S.1    Xanthoudakis, S.2    Curran, T.3    O'Dwyer, P.J.4
  • 27
    • 0029842459 scopus 로고    scopus 로고
    • Oxygen sensing and molecular adaptation to hypoxia
    • 27 Bunn, H.F., Poyton, R.O., Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 76 (1996), 839–885.
    • (1996) Physiol Rev , vol.76 , pp. 839-885
    • Bunn, H.F.1    Poyton, R.O.2
  • 29
    • 36448955373 scopus 로고    scopus 로고
    • Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences
    • 29 Blachier, F., Mariotti, F., Huneau, J.F., Tome, D., Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences. Amino Acids 33 (2007), 547–562.
    • (2007) Amino Acids , vol.33 , pp. 547-562
    • Blachier, F.1    Mariotti, F.2    Huneau, J.F.3    Tome, D.4
  • 30
    • 0019940133 scopus 로고
    • Utilization of nutrients by isolated epithelial cells of the rat colon
    • 30 Roediger, W.E., Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroenterology 83 (1982), 424–429.
    • (1982) Gastroenterology , vol.83 , pp. 424-429
    • Roediger, W.E.1
  • 32
    • 58149145317 scopus 로고    scopus 로고
    • Butyrate metabolism in human colon carcinoma cells: implications concerning its growth-inhibitory effect
    • 32 Andriamihaja, M., Chaumontet, C., Tome, D., Blachier, F., Butyrate metabolism in human colon carcinoma cells: implications concerning its growth-inhibitory effect. J Cell Physiol 218 (2009), 58–65.
    • (2009) J Cell Physiol , vol.218 , pp. 58-65
    • Andriamihaja, M.1    Chaumontet, C.2    Tome, D.3    Blachier, F.4
  • 37
    • 84880690612 scopus 로고    scopus 로고
    • Tumor-derived hydrogen sulfide, produced by cystathionine-beta-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer
    • 37 Szabo, C., Coletta, C., Chao, C., Modis, K., Szczesny, B., Papapetropoulos, A., Hellmich, M.R., Tumor-derived hydrogen sulfide, produced by cystathionine-beta-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer. Proc Natl Acad Sci U S A 110 (2013), 12474–12479.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 12474-12479
    • Szabo, C.1    Coletta, C.2    Chao, C.3    Modis, K.4    Szczesny, B.5    Papapetropoulos, A.6    Hellmich, M.R.7
  • 39
    • 77952541558 scopus 로고    scopus 로고
    • The sites and topology of mitochondrial superoxide production
    • 39 Brand, M.D., The sites and topology of mitochondrial superoxide production. Exp Gerontol 45 (2010), 466–472.
    • (2010) Exp Gerontol , vol.45 , pp. 466-472
    • Brand, M.D.1
  • 40
    • 10344221083 scopus 로고    scopus 로고
    • Complex III releases superoxide to both sides of the inner mitochondrial membrane
    • 40 Muller, F.L., Liu, Y., Van Remmen, H., Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem 279 (2004), 49064–49073.
    • (2004) J Biol Chem , vol.279 , pp. 49064-49073
    • Muller, F.L.1    Liu, Y.2    Van Remmen, H.3
  • 41
    • 84884169659 scopus 로고    scopus 로고
    • Peroxynitrite, a stealthy biological oxidant
    • 41 Radi, R., Peroxynitrite, a stealthy biological oxidant. J Biol Chem 288 (2013), 26464–26472.
    • (2013) J Biol Chem , vol.288 , pp. 26464-26472
    • Radi, R.1
  • 42
    • 0038678001 scopus 로고    scopus 로고
    • Glucose alleviates ammonia-induced inhibition of short-chain fatty acid metabolism in rat colonic epithelial cells
    • 42 Cremin, J.D. Jr., Fitch, M.D., Fleming, S.E., Glucose alleviates ammonia-induced inhibition of short-chain fatty acid metabolism in rat colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol 285 (2003), G105–G114.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.285 , pp. G105-G114
    • Cremin, J.D.1    Fitch, M.D.2    Fleming, S.E.3
  • 44
    • 70349584141 scopus 로고    scopus 로고
    • Colonic luminal ammonia and portal blood L-glutamine and L-arginine concentrations: a possible link between colon mucosa and liver ureagenesis
    • 44 Eklou-Lawson, M., Bernard, F., Neveux, N., Chaumontet, C., Bos, C., Davila-Gay, A.M., Tome, D., Cynober, L., Blachier, F., Colonic luminal ammonia and portal blood L-glutamine and L-arginine concentrations: a possible link between colon mucosa and liver ureagenesis. Amino Acids 37 (2009), 751–760.
    • (2009) Amino Acids , vol.37 , pp. 751-760
    • Eklou-Lawson, M.1    Bernard, F.2    Neveux, N.3    Chaumontet, C.4    Bos, C.5    Davila-Gay, A.M.6    Tome, D.7    Cynober, L.8    Blachier, F.9
  • 46
    • 62549154150 scopus 로고    scopus 로고
    • A mitochondrial DNA mutation linked to colon cancer results in proton leaks in cytochrome c oxidase
    • 46 Namslauer, I., Brzezinski, P., A mitochondrial DNA mutation linked to colon cancer results in proton leaks in cytochrome c oxidase. Proc Natl Acad Sci U S A 106 (2009), 3402–3407.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 3402-3407
    • Namslauer, I.1    Brzezinski, P.2
  • 48
    • 77951626542 scopus 로고    scopus 로고
    • DNA damage and toxicogenomic analyses of hydrogen sulfide in human intestinal epithelial FHs 74 Int cells
    • 48 Attene-Ramos, M.S., Nava, G.M., Muellner, M.G., Wagner, E.D., Plewa, M.J., Gaskins, H.R., DNA damage and toxicogenomic analyses of hydrogen sulfide in human intestinal epithelial FHs 74 Int cells. Environ Mol Mutagen 51 (2010), 304–314.
    • (2010) Environ Mol Mutagen , vol.51 , pp. 304-314
    • Attene-Ramos, M.S.1    Nava, G.M.2    Muellner, M.G.3    Wagner, E.D.4    Plewa, M.J.5    Gaskins, H.R.6
  • 49
    • 0023886105 scopus 로고
    • Formation of a mutagenic diazoquinone by interaction of phenol with nitrite
    • 49 Kikugawa, K., Kato, T., Formation of a mutagenic diazoquinone by interaction of phenol with nitrite. Food Chem Toxicol 26 (1988), 209–214.
    • (1988) Food Chem Toxicol , vol.26 , pp. 209-214
    • Kikugawa, K.1    Kato, T.2
  • 50
    • 0023605365 scopus 로고
    • Fecal mutagen fecapentaene-12 damages mammalian colon epithelial DNA
    • 50 Hinzman, M.J., Novotny, C., Ullah, A., Shamsuddin, A.M., Fecal mutagen fecapentaene-12 damages mammalian colon epithelial DNA. Carcinogenesis 8 (1987), 1475–1479.
    • (1987) Carcinogenesis , vol.8 , pp. 1475-1479
    • Hinzman, M.J.1    Novotny, C.2    Ullah, A.3    Shamsuddin, A.M.4
  • 53
    • 79955037673 scopus 로고    scopus 로고
    • Channelling of arginine in NO and polyamine pathways in colonocytes and consequences
    • 53 Blachier, F., Davila, A.M., Benamouzig, R., Tome, D., Channelling of arginine in NO and polyamine pathways in colonocytes and consequences. Front Biosci (Landmark Ed) 16 (2011), 1331–1343.
    • (2011) Front Biosci (Landmark Ed) , vol.16 , pp. 1331-1343
    • Blachier, F.1    Davila, A.M.2    Benamouzig, R.3    Tome, D.4
  • 55
    • 84870936271 scopus 로고    scopus 로고
    • Gut microbial activity, implications for health and disease: the potential role of metabolite analysis
    • 55 Nyangale, E.P., Mottram, D.S., Gibson, G.R., Gut microbial activity, implications for health and disease: the potential role of metabolite analysis. J Proteome Res 11 (2012), 5573–5585.
    • (2012) J Proteome Res , vol.11 , pp. 5573-5585
    • Nyangale, E.P.1    Mottram, D.S.2    Gibson, G.R.3
  • 56
    • 0036710057 scopus 로고    scopus 로고
    • Diet and cancer: assessing the risk
    • 56 Gill, C.I., Rowland, I.R., Diet and cancer: assessing the risk. Br J Nutr 88:Suppl 1 (2002), S73–S87.
    • (2002) Br J Nutr , vol.88 , pp. S73-S87
    • Gill, C.I.1    Rowland, I.R.2
  • 57
    • 0026786802 scopus 로고
    • Effects of short-chain fatty acids on growth and differentiation of the human colon-cancer cell line HT29
    • 57 Gamet, L., Daviaud, D., Denis-Pouxviel, C., Remesy, C., Murat, J.C., Effects of short-chain fatty acids on growth and differentiation of the human colon-cancer cell line HT29. Int J Cancer 52 (1992), 286–289.
    • (1992) Int J Cancer , vol.52 , pp. 286-289
    • Gamet, L.1    Daviaud, D.2    Denis-Pouxviel, C.3    Remesy, C.4    Murat, J.C.5
  • 60
    • 0344395575 scopus 로고    scopus 로고
    • Inhibition of human colon carcinoma cell growth by ammonia: a non-cytotoxic process associated with polyamine synthesis reduction
    • 60 Mouille, B., Delpal, S., Mayeur, C., Blachier, F., Inhibition of human colon carcinoma cell growth by ammonia: a non-cytotoxic process associated with polyamine synthesis reduction. Biochim Biophys Acta 1624 (2003), 88–97.
    • (2003) Biochim Biophys Acta , vol.1624 , pp. 88-97
    • Mouille, B.1    Delpal, S.2    Mayeur, C.3    Blachier, F.4
  • 61
    • 23444455491 scopus 로고    scopus 로고
    • Effects of agmatine accumulation in human colon carcinoma cells on polyamine metabolism, DNA synthesis and the cell cycle
    • 61 Mayeur, C., Veuillet, G., Michaud, M., Raul, F., Blottiere, H.M., Blachier, F., Effects of agmatine accumulation in human colon carcinoma cells on polyamine metabolism, DNA synthesis and the cell cycle. Biochim Biophys Acta 1745 (2005), 111–123.
    • (2005) Biochim Biophys Acta , vol.1745 , pp. 111-123
    • Mayeur, C.1    Veuillet, G.2    Michaud, M.3    Raul, F.4    Blottiere, H.M.5    Blachier, F.6
  • 64
    • 31644437054 scopus 로고    scopus 로고
    • Hemoglobin and hemin induce DNA damage in human colon tumor cells HT29 clone 19A and in primary human colonocytes
    • 64 Glei, M., Klenow, S., Sauer, J., Wegewitz, U., Richter, K., Pool-Zobel, B.L., Hemoglobin and hemin induce DNA damage in human colon tumor cells HT29 clone 19A and in primary human colonocytes. Mutat Res 594 (2006), 162–171.
    • (2006) Mutat Res , vol.594 , pp. 162-171
    • Glei, M.1    Klenow, S.2    Sauer, J.3    Wegewitz, U.4    Richter, K.5    Pool-Zobel, B.L.6
  • 65
    • 79551690942 scopus 로고    scopus 로고
    • Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved
    • 65 Bastide, N.M., Pierre, F.H., Corpet, D.E., Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved. Cancer Prev Res (Phila) 4 (2011), 177–184.
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 177-184
    • Bastide, N.M.1    Pierre, F.H.2    Corpet, D.E.3
  • 67
    • 84888053605 scopus 로고    scopus 로고
    • Review of the association between meat consumption and risk of colorectal cancer
    • 67 Kim, E., Coelho, D., Blachier, F., Review of the association between meat consumption and risk of colorectal cancer. Nutr Res 33 (2013), 983–994.
    • (2013) Nutr Res , vol.33 , pp. 983-994
    • Kim, E.1    Coelho, D.2    Blachier, F.3
  • 68
    • 0036144976 scopus 로고    scopus 로고
    • Phenol toxicity and conjugation in human colonic epithelial cells
    • 68 Pedersen, G., Brynskov, J., Saermark, T., Phenol toxicity and conjugation in human colonic epithelial cells. Scand J Gastroenterol 37 (2002), 74–79.
    • (2002) Scand J Gastroenterol , vol.37 , pp. 74-79
    • Pedersen, G.1    Brynskov, J.2    Saermark, T.3
  • 69
    • 84875255442 scopus 로고    scopus 로고
    • Bile acids in the colon, from healthy to cytotoxic molecules
    • 69 Barrasa, J.I., Olmo, N., Lizarbe, M.A., Turnay, J., Bile acids in the colon, from healthy to cytotoxic molecules. Toxicol In Vitro 27 (2013), 964–977.
    • (2013) Toxicol In Vitro , vol.27 , pp. 964-977
    • Barrasa, J.I.1    Olmo, N.2    Lizarbe, M.A.3    Turnay, J.4
  • 71
    • 76249101130 scopus 로고    scopus 로고
    • The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation
    • 71 Bansal, T., Alaniz, R.C., Wood, T.K., Jayaraman, A., The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation. Proc Natl Acad Sci U S A 107 (2010), 228–233.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 228-233
    • Bansal, T.1    Alaniz, R.C.2    Wood, T.K.3    Jayaraman, A.4
  • 72
    • 69549114504 scopus 로고    scopus 로고
    • Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers
    • 72 Peng, L., Li, Z.R., Green, R.S., Holzman, I.R., Lin, J., Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers. J Nutr 139 (2009), 1619–1625.
    • (2009) J Nutr , vol.139 , pp. 1619-1625
    • Peng, L.1    Li, Z.R.2    Green, R.S.3    Holzman, I.R.4    Lin, J.5
  • 73
    • 0035084176 scopus 로고    scopus 로고
    • Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs
    • 73 Nugent, S.G., Kumar, D., Rampton, D.S., Evans, D.F., Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs. Gut 48 (2001), 571–577.
    • (2001) Gut , vol.48 , pp. 571-577
    • Nugent, S.G.1    Kumar, D.2    Rampton, D.S.3    Evans, D.F.4
  • 76
    • 10644230086 scopus 로고    scopus 로고
    • The importance of butyrate transport to the regulation of gene expression in the colonic epithelium
    • 76 Cuff, M.A., Shirazi-Beechey, S.P., The importance of butyrate transport to the regulation of gene expression in the colonic epithelium. Biochem Soc Trans 32 (2004), 1100–1102.
    • (2004) Biochem Soc Trans , vol.32 , pp. 1100-1102
    • Cuff, M.A.1    Shirazi-Beechey, S.P.2
  • 77
    • 84870389262 scopus 로고    scopus 로고
    • The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation
    • 77 Donohoe, D.R., Collins, L.B., Wali, A., Bigler, R., Sun, W., Bultman, S.J., The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. Mol Cell 48 (2012), 612–626.
    • (2012) Mol Cell , vol.48 , pp. 612-626
    • Donohoe, D.R.1    Collins, L.B.2    Wali, A.3    Bigler, R.4    Sun, W.5    Bultman, S.J.6
  • 79
    • 0023940637 scopus 로고
    • Bicarbonate secretion modulates ammonium absorption in rat distal colon in vivo
    • 79 Cohen, R.M., Stephenson, R.L., Feldman, G.M., Bicarbonate secretion modulates ammonium absorption in rat distal colon in vivo. Am J Physiol 254 (1988), F657–F667.
    • (1988) Am J Physiol , vol.254 , pp. F657-F667
    • Cohen, R.M.1    Stephenson, R.L.2    Feldman, G.M.3
  • 81
    • 0022607849 scopus 로고
    • Relationship between colonic luminal pH, cell proliferation, and colon carcinogenesis in 1,2-dimethylhydrazine treated rats fed high fiber diets
    • 81 Jacobs, L.R., Lupton, J.R., Relationship between colonic luminal pH, cell proliferation, and colon carcinogenesis in 1,2-dimethylhydrazine treated rats fed high fiber diets. Cancer Res 46 (1986), 1727–1734.
    • (1986) Cancer Res , vol.46 , pp. 1727-1734
    • Jacobs, L.R.1    Lupton, J.R.2
  • 82
    • 0030941310 scopus 로고    scopus 로고
    • Bile acid metabolism by colonic bacteria in continuous culture: effects of starch and pH
    • 82 Christl, S.U., Bartram, H.P., Paul, A., Kelber, E., Scheppach, W., Kasper, H., Bile acid metabolism by colonic bacteria in continuous culture: effects of starch and pH. Ann Nutr Metab 41 (1997), 45–51.
    • (1997) Ann Nutr Metab , vol.41 , pp. 45-51
    • Christl, S.U.1    Bartram, H.P.2    Paul, A.3    Kelber, E.4    Scheppach, W.5    Kasper, H.6
  • 83
    • 78650883928 scopus 로고    scopus 로고
    • The impact of pre- and/or probiotics on human colonic metabolism: does it affect human health?
    • 83 De Preter, V., Hamer, H.M., Windey, K., Verbeke, K., The impact of pre- and/or probiotics on human colonic metabolism: does it affect human health?. Mol Nutr Food Res 55 (2011), 46–57.
    • (2011) Mol Nutr Food Res , vol.55 , pp. 46-57
    • De Preter, V.1    Hamer, H.M.2    Windey, K.3    Verbeke, K.4
  • 84
    • 33847265296 scopus 로고    scopus 로고
    • Acidic extracellular pH shifts colorectal cancer cell death from apoptosis to necrosis upon exposure to propionate and acetate, major end-products of the human probiotic propionibacteria
    • 84 Lan, A., Lagadic-Gossmann, D., Lemaire, C., Brenner, C., Jan, G., Acidic extracellular pH shifts colorectal cancer cell death from apoptosis to necrosis upon exposure to propionate and acetate, major end-products of the human probiotic propionibacteria. Apoptosis 12 (2007), 573–591.
    • (2007) Apoptosis , vol.12 , pp. 573-591
    • Lan, A.1    Lagadic-Gossmann, D.2    Lemaire, C.3    Brenner, C.4    Jan, G.5
  • 85
    • 0028289608 scopus 로고
    • Low external pH and osmotic shock increase the expression of human MDR protein
    • 85 Wei, L.Y., Roepe, P.D., Low external pH and osmotic shock increase the expression of human MDR protein. Biochemistry 33 (1994), 7229–7238.
    • (1994) Biochemistry , vol.33 , pp. 7229-7238
    • Wei, L.Y.1    Roepe, P.D.2
  • 86
    • 84865363567 scopus 로고    scopus 로고
    • Diarrhea caused by carbohydrate malabsorption
    • 86 Hammer, H.F., Hammer, J., Diarrhea caused by carbohydrate malabsorption. Gastroenterol Clin North Am 41 (2012), 611–627.
    • (2012) Gastroenterol Clin North Am , vol.41 , pp. 611-627
    • Hammer, H.F.1    Hammer, J.2
  • 87
    • 79955567067 scopus 로고    scopus 로고
    • Src kinase pathway is involved in NFAT5-mediated S100A4 induction by hyperosmotic stress in colon cancer cells
    • 87 Chen, M., Sastry, S.K., O'Connor, K.L., Src kinase pathway is involved in NFAT5-mediated S100A4 induction by hyperosmotic stress in colon cancer cells. Am J Physiol Cell Physiol 300 (2011), C1155–C1163.
    • (2011) Am J Physiol Cell Physiol , vol.300 , pp. C1155-C1163
    • Chen, M.1    Sastry, S.K.2    O'Connor, K.L.3
  • 88
    • 64549084094 scopus 로고    scopus 로고
    • Ste20-related proline/alanine-rich kinase (SPAK) regulated transcriptionally by hyperosmolarity is involved in intestinal barrier function
    • 88 Yan, Y., Dalmasso, G., Nguyen, H.T., Obertone, T.S., Sitaraman, S.V., Merlin, D., Ste20-related proline/alanine-rich kinase (SPAK) regulated transcriptionally by hyperosmolarity is involved in intestinal barrier function. PLoS One, 4, 2009, e5049.
    • (2009) PLoS One , vol.4 , pp. e5049
    • Yan, Y.1    Dalmasso, G.2    Nguyen, H.T.3    Obertone, T.S.4    Sitaraman, S.V.5    Merlin, D.6
  • 89
    • 0036735192 scopus 로고    scopus 로고
    • Hyperosmotic stress induces nuclear factor-kappaB activation and interleukin-8 production in human intestinal epithelial cells
    • 89 Nemeth, Z.H., Deitch, E.A., Szabo, C., Hasko, G., Hyperosmotic stress induces nuclear factor-kappaB activation and interleukin-8 production in human intestinal epithelial cells. Am J Pathol 161 (2002), 987–996.
    • (2002) Am J Pathol , vol.161 , pp. 987-996
    • Nemeth, Z.H.1    Deitch, E.A.2    Szabo, C.3    Hasko, G.4
  • 90
    • 0020356477 scopus 로고
    • Influence of osmolality, short chain fatty acids and deoxycholic acid on mucus secretion in the rat colon
    • 90 Rubsamen, K., Hornicke, H., Influence of osmolality, short chain fatty acids and deoxycholic acid on mucus secretion in the rat colon. Pflugers Arch 395 (1982), 306–311.
    • (1982) Pflugers Arch , vol.395 , pp. 306-311
    • Rubsamen, K.1    Hornicke, H.2
  • 91
    • 0035746437 scopus 로고    scopus 로고
    • Epithelial cyclooxygenase-2 expression: a model for pathogenesis of colon cancer
    • 91 Arbabi, S., Rosengart, M.R., Garcia, I., Jelacic, S., Maier, R.V., Epithelial cyclooxygenase-2 expression: a model for pathogenesis of colon cancer. J Surg Res 97 (2001), 60–64.
    • (2001) J Surg Res , vol.97 , pp. 60-64
    • Arbabi, S.1    Rosengart, M.R.2    Garcia, I.3    Jelacic, S.4    Maier, R.V.5
  • 92
    • 77953479589 scopus 로고    scopus 로고
    • Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer
    • 92 Danese, S., Mantovani, A., Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer. Oncogene 29 (2010), 3313–3323.
    • (2010) Oncogene , vol.29 , pp. 3313-3323
    • Danese, S.1    Mantovani, A.2
  • 94
  • 95
    • 0024241538 scopus 로고
    • Organic anions and the diarrhea of inflammatory bowel disease
    • 95 Vernia, P., Gnaedinger, A., Hauck, W., Breuer, R.I., Organic anions and the diarrhea of inflammatory bowel disease. Dig Dis Sci 33 (1988), 1353–1358.
    • (1988) Dig Dis Sci , vol.33 , pp. 1353-1358
    • Vernia, P.1    Gnaedinger, A.2    Hauck, W.3    Breuer, R.I.4
  • 96
    • 84876359287 scopus 로고    scopus 로고
    • Decreased mucosal sulfide detoxification capacity in patients with Crohn's disease
    • 96 Arijs, I., Vanhove, W., Rutgeerts, P., Schuit, F., Verbeke, K., De Preter, V., Decreased mucosal sulfide detoxification capacity in patients with Crohn's disease. Inflamm Bowel Dis 19 (2013), E70–E72.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. E70-E72
    • Arijs, I.1    Vanhove, W.2    Rutgeerts, P.3    Schuit, F.4    Verbeke, K.5    De Preter, V.6
  • 99
    • 84921288028 scopus 로고    scopus 로고
    • Cancer etiology: variation in cancer risk among tissues can be explained by the number of stem cell divisions
    • 99 Tomasetti, C., Vogelstein, B., Cancer etiology: variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 347 (2015), 78–81.
    • (2015) Science , vol.347 , pp. 78-81
    • Tomasetti, C.1    Vogelstein, B.2


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