Ste20-related proline/alanine-rich kinase (SPAK) regulated transcriptionally by hypersmolarity is involved in intestinal barrier function

PLoS ONE

Volumn 4, Issue 4, 2009, Pages

  Yan, Yutao ^a   Dalmasso, Guillaume ^a   Nguyen, Hang Thi Thu ^a   Obertone, Tracy S ^a   Sitaraman, Shanthi V ^a   Merlin, Didier ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PHOSPHOTRANSFERASE; SMALL INTERFERING RNA; STE20 RELATED PROLINE ALANINE RICH KINASE; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; PROTEIN SERINE THREONINE KINASE; STK39 PROTEIN, HUMAN; STK39 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; C57BL 6 MOUSE; CASE REPORT; COLON; CONTROLLED STUDY; CROHN DISEASE; CULTURE MEDIUM; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPEROSMOLARITY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE BIOPSY; INTESTINE MUCOSA; INTESTINE MUCOSA PERMEABILITY; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; RNA INTERFERENCE; RNA STABILITY; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; UPREGULATION; ANIMAL; C57BL MOUSE; CELL STRAIN CACO 2; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; OSMOLARITY; PHYSIOLOGY; PROMOTER REGION;

MUS; MUS MUSCULUS;

ANIMALS; BINDING SITES; CACO-2 CELLS; COLON; CROHN DISEASE; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NF-KAPPA B; OSMOLAR CONCENTRATION; PROMOTER REGIONS, GENETIC; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC;

EID: 64549084094     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005049     Document Type: Article

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