-
1
-
-
79953733693
-
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
-
Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ, Hazen SL. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 2011;472:57-63.
-
(2011)
Nature
, vol.472
, pp. 57-63
-
-
Wang, Z.1
Klipfell, E.2
Bennett, B.J.3
Koeth, R.4
Levison, B.S.5
Dugar, B.6
Feldstein, A.E.7
Britt, E.B.8
Fu, X.9
Chung, Y.M.10
Wu, Y.11
Schauer, P.12
Smith, J.D.13
Allayee, H.14
Tang, W.H.15
DiDonato, J.A.16
Lusis, A.J.17
Hazen, S.L.18
-
2
-
-
84876563088
-
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
-
Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y, Hazen SL. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med 2013;368:1575-1584.
-
(2013)
N Engl J Med
, vol.368
, pp. 1575-1584
-
-
Tang, W.H.1
Wang, Z.2
Levison, B.S.3
Koeth, R.A.4
Britt, E.B.5
Fu, X.6
Wu, Y.7
Hazen, S.L.8
-
3
-
-
84877331372
-
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
-
Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 2013;19:576-585.
-
(2013)
Nat Med
, vol.19
, pp. 576-585
-
-
Koeth, R.A.1
Wang, Z.2
Levison, B.S.3
Buffa, J.A.4
Org, E.5
Sheehy, B.T.6
Britt, E.B.7
Fu, X.8
Wu, Y.9
Li, L.10
Smith, J.D.11
DiDonato, J.A.12
Chen, J.13
Li, H.14
Wu, G.D.15
Lewis, J.D.16
Warrier, M.17
Brown, J.M.18
Krauss, R.M.19
Tang, W.H.20
Bushman, F.D.21
Lusis, A.J.22
Hazen, S.L.23
more..
-
4
-
-
84923913674
-
Transmission of atherosclerosis susceptibility with gut microbial transplantation
-
Gregory JC, Buffa JA, Org E, Wang Z, Levison BS, Zhu W, Wagner MA, Bennett BJ, Li L, DiDonato JA, Lusis AJ, Hazen SL. Transmission of atherosclerosis susceptibility with gut microbial transplantation. J Biol Chem 2015;290:5647-5660.
-
(2015)
J Biol Chem
, vol.290
, pp. 5647-5660
-
-
Gregory, J.C.1
Buffa, J.A.2
Org, E.3
Wang, Z.4
Levison, B.S.5
Zhu, W.6
Wagner, M.A.7
Bennett, B.J.8
Li, L.9
DiDonato, J.A.10
Lusis, A.J.11
Hazen, S.L.12
-
5
-
-
84959922537
-
Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk
-
Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, Sartor RB, McIntyre TM, Silverstein RL, Tang WH, DiDonato JA, Brown JM, Lusis AJ, Hazen SL. Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk. Cell 2016;165:111-124.
-
(2016)
Cell
, vol.165
, pp. 111-124
-
-
Zhu, W.1
Gregory, J.C.2
Org, E.3
Buffa, J.A.4
Gupta, N.5
Wang, Z.6
Li, L.7
Fu, X.8
Wu, Y.9
Mehrabian, M.10
Sartor, R.B.11
McIntyre, T.M.12
Silverstein, R.L.13
Tang, W.H.14
DiDonato, J.A.15
Brown, J.M.16
Lusis, A.J.17
Hazen, S.L.18
-
6
-
-
84872139636
-
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation
-
Bennett BJ, de Aguiar Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab 2013;17:49-60.
-
(2013)
Cell Metab
, vol.17
, pp. 49-60
-
-
Bennett, B.J.1
De Aguiar Vallim, T.Q.2
Wang, Z.3
Shih, D.M.4
Meng, Y.5
Gregory, J.6
Allayee, H.7
Lee, R.8
Graham, M.9
Crooke, R.10
Edwards, P.A.11
Hazen, S.L.12
Lusis, A.J.13
-
7
-
-
84898859680
-
Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide
-
Wang Z, Tang WH, Buffa JA, Fu X, Britt EB, Koeth RA, Levison BS, Fan Y, Wu Y, Hazen SL. Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide. Eur Heart J 2014;35:904-910.
-
(2014)
Eur Heart J
, vol.35
, pp. 904-910
-
-
Wang, Z.1
Tang, W.H.2
Buffa, J.A.3
Fu, X.4
Britt, E.B.5
Koeth, R.A.6
Levison, B.S.7
Fan, Y.8
Wu, Y.9
Hazen, S.L.10
-
8
-
-
84908377019
-
Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: Refining the gut hypothesis
-
Tang WH, Wang Z, Fan Y, Levison B, Hazen JE, Donahue LM, Wu Y, Hazen SL. Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis. J Am Coll Cardiol 2014;64:1908-1914.
-
(2014)
J Am Coll Cardiol
, vol.64
, pp. 1908-1914
-
-
Tang, W.H.1
Wang, Z.2
Fan, Y.3
Levison, B.4
Hazen, J.E.5
Donahue, L.M.6
Wu, Y.7
Hazen, S.L.8
-
9
-
-
84921863158
-
Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction, and adverse clinical outcomes in chronic systolic heart failure
-
Tang WH, Wang Z, Shrestha K, Borowski AG, Wu Y, Troughton RW, Klein AL, Hazen SL. Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction, and adverse clinical outcomes in chronic systolic heart failure. J Card Fail 2015;21:91-96.
-
(2015)
J Card Fail
, vol.21
, pp. 91-96
-
-
Tang, W.H.1
Wang, Z.2
Shrestha, K.3
Borowski, A.G.4
Wu, Y.5
Troughton, R.W.6
Klein, A.L.7
Hazen, S.L.8
-
10
-
-
84925862053
-
Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease
-
Tang WH, Wang Z, Kennedy DJ, Wu Y, Buffa JA, Agatisa-Boyle B, Li XS, Levison BS, Hazen SL. Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circ Res 2015;116:448-455.
-
(2015)
Circ Res
, vol.116
, pp. 448-455
-
-
Tang, W.H.1
Wang, Z.2
Kennedy, D.J.3
Wu, Y.4
Buffa, J.A.5
Agatisa-Boyle, B.6
Li, X.S.7
Levison, B.S.8
Hazen, S.L.9
-
11
-
-
84940788860
-
The relationship between trimethylamine-n-oxide and prevalent cardiovascular disease in a multiethnic population living in Canada
-
Mente A, Chalcraft K, Ak H, Davis AD, Lonn E, Miller R, Potter MA, Yusuf S, Anand SS, McQueen MJ. The relationship between trimethylamine-n-oxide and prevalent cardiovascular disease in a multiethnic population living in Canada. Can J Cardiol 2015;31:1189-1194.
-
(2015)
Can J Cardiol
, vol.31
, pp. 1189-1194
-
-
Mente, A.1
Chalcraft, K.2
Ak, H.3
Davis, A.D.4
Lonn, E.5
Miller, R.6
Potter, M.A.7
Yusuf, S.8
Anand, S.S.9
McQueen, M.J.10
-
12
-
-
84954450626
-
Serum trimethylamine-Noxide is elevated in CKD and correlates with coronary atherosclerosis burden
-
Stubbs JR, House JA, Ocque AJ, Zhang S, Johnson C, Kimber C, Schmidt K, Gupta A, Wetmore JB, Nolin TD, Spertus JA, Yu AS. Serum trimethylamine-Noxide is elevated in CKD and correlates with coronary atherosclerosis burden. J Am Soc Nephrol 2016;27:305-313.
-
(2016)
J Am Soc Nephrol
, vol.27
, pp. 305-313
-
-
Stubbs, J.R.1
House, J.A.2
Ocque, A.J.3
Zhang, S.4
Johnson, C.5
Kimber, C.6
Schmidt, K.7
Gupta, A.8
Wetmore, J.B.9
Nolin, T.D.10
Spertus, J.A.11
Yu, A.S.12
-
13
-
-
84949936110
-
Associations among serum trimethylamine-N-oxide (TMAO) levels, kidney function and infarcted coronary artery number in patients undergoing cardiovascular surgery: A cross-sectional study
-
Mafune A, Iwamoto T, Tsutsumi Y, Nakashima A, Yamamoto I, Yokoyama K, Yokoo T, Urashima M. Associations among serum trimethylamine-N-oxide (TMAO) levels, kidney function and infarcted coronary artery number in patients undergoing cardiovascular surgery: A cross-sectional study. Clin Exp Nephrol 2016;20:731-739.
-
(2016)
Clin Exp Nephrol
, vol.20
, pp. 731-739
-
-
Mafune, A.1
Iwamoto, T.2
Tsutsumi, Y.3
Nakashima, A.4
Yamamoto, I.5
Yokoyama, K.6
Yokoo, T.7
Urashima, M.8
-
14
-
-
84959162934
-
Trimethylamine N-oxide and prognosis in acute heart failure
-
Suzuki T, Heaney LM, Bhandari SS, Jones DJ, Ng LL. Trimethylamine N-oxide and prognosis in acute heart failure. Heart 2016;102:841-848.
-
(2016)
Heart
, vol.102
, pp. 841-848
-
-
Suzuki, T.1
Heaney, L.M.2
Bhandari, S.S.3
Jones, D.J.4
Ng, L.L.5
-
15
-
-
84954497042
-
Serum trimethylamine-N-oxide is strongly related to renal function and predicts outcome in chronic kidney disease
-
Missailidis C, Hallqvist J, Qureshi AR, Barany P, Heimburger O, Lindholm B, Stenvinkel P, Bergman P. Serum trimethylamine-N-oxide is strongly related to renal function and predicts outcome in chronic kidney disease. PLoS One 2016;11:e0141738.
-
(2016)
PLoS One
, vol.11
, pp. e0141738
-
-
Missailidis, C.1
Hallqvist, J.2
Qureshi, A.R.3
Barany, P.4
Heimburger, O.5
Lindholm, B.6
Stenvinkel, P.7
Bergman, P.8
-
16
-
-
84971299234
-
Relationship of serum trimethylamine N-oxide (TMAO) levels with early atherosclerosis in humans
-
Randrianarisoa E, Lehn-Stefan A, Wang X, Hoene M, Peter A, Heinzmann SS, Zhao X, Konigsrainer I, Konigsrainer A, Balletshofer B, Machann J, Schick F, Fritsche A, Haring HU, Xu G, Lehmann R, Stefan N. Relationship of serum trimethylamine N-oxide (TMAO) levels with early atherosclerosis in humans. Sci Rep 2016;6:26745.
-
(2016)
Sci Rep
, vol.6
, pp. 26745
-
-
Randrianarisoa, E.1
Lehn-Stefan, A.2
Wang, X.3
Hoene, M.4
Peter, A.5
Heinzmann, S.S.6
Zhao, X.7
Konigsrainer, I.8
Konigsrainer, A.9
Balletshofer, B.10
Machann, J.11
Schick, F.12
Fritsche, A.13
Haring, H.U.14
Xu, G.15
Lehmann, R.16
Stefan, N.17
-
17
-
-
84964670746
-
Diabetes is associated with higher trimethylamine N-oxide plasma levels
-
Dambrova M, Latkovskis G, Kuka J, Strele I, Konrade I, Grinberga S, Hartmane D, Pugovics O, Erglis A, Liepinsh E. Diabetes is associated with higher trimethylamine N-oxide plasma levels. Exp Clin Endocrinol Diabetes 2016;124:251-256.
-
(2016)
Exp Clin Endocrinol Diabetes
, vol.124
, pp. 251-256
-
-
Dambrova, M.1
Latkovskis, G.2
Kuka, J.3
Strele, I.4
Konrade, I.5
Grinberga, S.6
Hartmane, D.7
Pugovics, O.8
Erglis, A.9
Liepinsh, E.10
-
18
-
-
84964690602
-
Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events
-
Kim RB, Morse BL, Djurdjev O, Tang M, Muirhead N, Barrett B, Holmes DT, Madore F, Clase CM, Rigatto C, Levin A, Can PI. Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events. Kidney Int 2016;89:1144-1152.
-
(2016)
Kidney Int
, vol.89
, pp. 1144-1152
-
-
Kim, R.B.1
Morse, B.L.2
Djurdjev, O.3
Tang, M.4
Muirhead, N.5
Barrett, B.6
Holmes, D.T.7
Madore, F.8
Clase, C.M.9
Rigatto, C.10
Levin, A.11
Can, P.I.12
-
19
-
-
84977669212
-
Plasma trimethylamine N-Oxide, a gut microbe-generated phosphatidylcholine metabolite, is associated with atherosclerotic burden
-
Senthong V, Li XS, Hudec T, Coughlin J, Wu Y, Levison B, Wang Z, Hazen SL, Tang WH. Plasma trimethylamine N-Oxide, a gut microbe-generated phosphatidylcholine metabolite, is associated with atherosclerotic burden. J Am Coll Cardiol 2016;67:2620-2628.
-
(2016)
J Am Coll Cardiol
, vol.67
, pp. 2620-2628
-
-
Senthong, V.1
Li, X.S.2
Hudec, T.3
Coughlin, J.4
Wu, Y.5
Levison, B.6
Wang, Z.7
Hazen, S.L.8
Tang, W.H.9
-
20
-
-
84991523409
-
Intestinal microbiota-generated metabolite trimethylamine-N-oxide and 5-year mortality risk in stable coronary artery disease: The contributory role of intestinal microbiota in a COURAGE-like patient cohort
-
Senthong V, Wang Z, Li XS, Fan Y, Wu Y, Tang WH, Hazen SL. Intestinal microbiota-generated metabolite trimethylamine-N-oxide and 5-year mortality risk in stable coronary artery disease: The contributory role of intestinal microbiota in a COURAGE-like patient cohort. J Am Heart Assoc 2016;5:pii: e002816.
-
(2016)
J Am Heart Assoc
, vol.5
-
-
Senthong, V.1
Wang, Z.2
Li, X.S.3
Fan, Y.4
Wu, Y.5
Tang, W.H.6
Hazen, S.L.7
-
21
-
-
0025280866
-
Platelet hyperreactivity and prognosis in survivors of myocardial infarction
-
Trip MD, Cats VM, van Capelle FJ, Vreeken J. Platelet hyperreactivity and prognosis in survivors of myocardial infarction. N Engl J Med 1990;322:1549-1554.
-
(1990)
N Engl J Med
, vol.322
, pp. 1549-1554
-
-
Trip, M.D.1
Cats, V.M.2
Van Capelle, F.J.3
Vreeken, J.4
-
22
-
-
84908200873
-
Global platelet hyperreactivity and elevated C-reactive protein levels predict long term mortality in STEMI patients
-
Marcucci R, Valente S, Gori AM, Chiostri M, Paniccia R, Giusti B, Cau V, Lazzeri C, Gensini GF, Abbate R. Global platelet hyperreactivity and elevated C-reactive protein levels predict long term mortality in STEMI patients. Thromb Res 2014;134:884-888.
-
(2014)
Thromb Res
, vol.134
, pp. 884-888
-
-
Marcucci, R.1
Valente, S.2
Gori, A.M.3
Chiostri, M.4
Paniccia, R.5
Giusti, B.6
Cau, V.7
Lazzeri, C.8
Gensini, G.F.9
Abbate, R.10
-
23
-
-
85002925090
-
Trimethylamine N-oxide promotes vascular inflammation through signaling of mitogen-activated protein kinase and nuclear factor-kappaB
-
Seldin MM, Meng Y, Qi H, Zhu W, Wang Z, Hazen SL, Lusis AJ, Shih DM. Trimethylamine N-oxide promotes vascular inflammation through signaling of mitogen-activated protein kinase and nuclear factor-kappaB. J Am Heart Assoc 2016;5:pii: e002767.
-
(2016)
J Am Heart Assoc
, vol.5
-
-
Seldin, M.M.1
Meng, Y.2
Qi, H.3
Zhu, W.4
Wang, Z.5
Hazen, S.L.6
Lusis, A.J.7
Shih, D.M.8
-
24
-
-
65649142017
-
A new equation to estimate glomerular filtration rate
-
Ckd EPI
-
Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF III, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J; Ckd EPI. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009;150:604-612.
-
(2009)
Ann Intern Med
, vol.150
, pp. 604-612
-
-
Levey, A.S.1
Stevens, L.A.2
Schmid, C.H.3
Zhang, Y.L.4
Castro, A.F.5
Feldman, H.I.6
Kusek, J.W.7
Eggers, P.8
Van Lente, F.9
Greene, T.10
Coresh, J.11
-
25
-
-
84899457029
-
Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry
-
Wang Z, Levison BS, Hazen JE, Donahue L, Li XM, Hazen SL. Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry. Anal Biochem 2014;455:35-40.
-
(2014)
Anal Biochem
, vol.455
, pp. 35-40
-
-
Wang, Z.1
Levison, B.S.2
Hazen, J.E.3
Donahue, L.4
Li, X.M.5
Hazen, S.L.6
-
26
-
-
0142089171
-
Prognostic value of myeloperoxidase in patients with chest pain
-
Brennan ML, Penn MS, Van Lente F, Nambi V, Shishehbor MH, Aviles RJ, Goormastic M, Pepoy ML, McErlean ES, Topol EJ, Nissen SE, Hazen SL. Prognostic value of myeloperoxidase in patients with chest pain. N Engl J Med 2003;349:1595-1604.
-
(2003)
N Engl J Med
, vol.349
, pp. 1595-1604
-
-
Brennan, M.L.1
Penn, M.S.2
Van Lente, F.3
Nambi, V.4
Shishehbor, M.H.5
Aviles, R.J.6
Goormastic, M.7
Pepoy, M.L.8
McErlean, E.S.9
Topol, E.J.10
Nissen, S.E.11
Hazen, S.L.12
-
27
-
-
38849091997
-
Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond
-
discussion 207-212
-
Pencina MJ, D'Agostino RB, Sr., D'Agostino RB, Jr., Vasan RS. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med 2008;27:157-172; discussion 207-212.
-
(2008)
Stat Med
, vol.27
, pp. 157-172
-
-
Pencina, M.J.1
D'Agostino, R.B.2
D'Agostino, R.B.3
Vasan, R.S.4
-
28
-
-
84893257511
-
Net reclassification improvement: Computation, interpretation, and controversies: A literature review and clinician's guide
-
Leening MJ, Vedder MM, Witteman JC, Pencina MJ, Steyerberg EW. Net reclassification improvement: computation, interpretation, and controversies: A literature review and clinician's guide. Ann Intern Med 2014;160:122-131.
-
(2014)
Ann Intern Med
, vol.160
, pp. 122-131
-
-
Leening, M.J.1
Vedder, M.M.2
Witteman, J.C.3
Pencina, M.J.4
Steyerberg, E.W.5
-
30
-
-
84902169662
-
Global perspective on acute coronary syndrome: A burden on the young and poor
-
Vedanthan R, Seligman B, Fuster V. Global perspective on acute coronary syndrome: A burden on the young and poor. Circ Res 2014;114:1959-1975.
-
(2014)
Circ Res
, vol.114
, pp. 1959-1975
-
-
Vedanthan, R.1
Seligman, B.2
Fuster, V.3
-
31
-
-
84959239708
-
Deaths: Leading causes for 2013
-
Heron M. Deaths: leading causes for 2013. Natl Vital Stat Rep 2016;65:1-95.
-
(2016)
Natl Vital Stat Rep
, vol.65
, pp. 1-95
-
-
Heron, M.1
-
32
-
-
84940061805
-
Intestinal immunity and gut microbiota as therapeutic targets for preventing atherosclerotic cardiovascular diseases
-
Yamashita T, Kasahara K, Emoto T, Matsumoto T, Mizoguchi T, Kitano N, Sasaki N, Hirata K. Intestinal immunity and gut microbiota as therapeutic targets for preventing atherosclerotic cardiovascular diseases. Circ J 2015;79:1882-1890.
-
(2015)
Circ J
, vol.79
, pp. 1882-1890
-
-
Yamashita, T.1
Kasahara, K.2
Emoto, T.3
Matsumoto, T.4
Mizoguchi, T.5
Kitano, N.6
Sasaki, N.7
Hirata, K.8
-
33
-
-
84936805972
-
Unraveling the environmental and genetic interactions in atherosclerosis: Central role of the gut microbiota
-
Org E, Mehrabian M, Lusis AJ. Unraveling the environmental and genetic interactions in atherosclerosis: Central role of the gut microbiota. Atherosclerosis 2015;241:387-399.
-
(2015)
Atherosclerosis
, vol.241
, pp. 387-399
-
-
Org, E.1
Mehrabian, M.2
Lusis, A.J.3
-
34
-
-
84995580894
-
Trimethylamine N-oxide and cardiovascular events in hemodialysis patients
-
Shafi T, Powe NR, Meyer TW, Hwang S, Hai X, Melamed ML, Banerjee T, Coresh J, Hostetter TH. Trimethylamine N-oxide and cardiovascular events in hemodialysis patients. J Am Soc Nephrol 2016; pii: ASN.2016030374.
-
(2016)
J Am Soc Nephrol
-
-
Shafi, T.1
Powe, N.R.2
Meyer, T.W.3
Hwang, S.4
Hai, X.5
Melamed, M.L.6
Banerjee, T.7
Coresh, J.8
Hostetter, T.H.9
-
35
-
-
84946565998
-
Plasma levels of trimethylamine-N-oxide are confounded by impaired kidney function and poor metabolic control
-
Mueller DM, Allenspach M, Othman A, Saely CH, Muendlein A, Vonbank A, Drexel H, von Eckardstein A. Plasma levels of trimethylamine-N-oxide are confounded by impaired kidney function and poor metabolic control. Atherosclerosis 2015;243:638-644.
-
(2015)
Atherosclerosis
, vol.243
, pp. 638-644
-
-
Mueller, D.M.1
Allenspach, M.2
Othman, A.3
Saely, C.H.4
Muendlein, A.5
Vonbank, A.6
Drexel, H.7
Von Eckardstein, A.8
-
36
-
-
84930824245
-
Associations of trimethylamine N-oxide with nutritional and inflammatory biomarkers and cardiovascular outcomes in patients new to dialysis
-
Kaysen GA, Johansen KL, Chertow GM, Dalrymple LS, Kornak J, Grimes B, Dwyer T, Chassy AW, Fiehn O. Associations of trimethylamine N-oxide with nutritional and inflammatory biomarkers and cardiovascular outcomes in patients new to dialysis. J Ren Nutr 2015;25:351-356.
-
(2015)
J Ren Nutr
, vol.25
, pp. 351-356
-
-
Kaysen, G.A.1
Johansen, K.L.2
Chertow, G.M.3
Dalrymple, L.S.4
Kornak, J.5
Grimes, B.6
Dwyer, T.7
Chassy, A.W.8
Fiehn, O.9
-
37
-
-
84983460359
-
Association of FMO3 variants and trimethylamine N-oxide concentration, disease progression, and mortality in CKD patients
-
Robinson-Cohen C, Newitt R, Shen DD, Rettie AE, Kestenbaum BR, Himmelfarb J, Yeung CK. Association of FMO3 variants and trimethylamine N-oxide concentration, disease progression, and mortality in CKD patients. PLoS One 2016;11:e0161074.
-
(2016)
PLoS One
, vol.11
, pp. e0161074
-
-
Robinson-Cohen, C.1
Newitt, R.2
Shen, D.D.3
Rettie, A.E.4
Kestenbaum, B.R.5
Himmelfarb, J.6
Yeung, C.K.7
-
38
-
-
84950297830
-
Non-lethal Inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis
-
Wang Z, Roberts AB, Buffa JA, Levison BS, Zhu W, Org E, Gu X, Huang Y, Zamanian-Daryoush M, Culley MK, DiDonato AJ, Fu X, Hazen JE, Krajcik D, DiDonato JA, Lusis AJ, Hazen SL. Non-lethal Inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis. Cell 2015;163: 1585-1595.
-
(2015)
Cell
, vol.163
, pp. 1585-1595
-
-
Wang, Z.1
Roberts, A.B.2
Buffa, J.A.3
Levison, B.S.4
Zhu, W.5
Org, E.6
Gu, X.7
Huang, Y.8
Zamanian-Daryoush, M.9
Culley, M.K.10
DiDonato, A.J.11
Fu, X.12
Hazen, J.E.13
Krajcik, D.14
DiDonato, J.A.15
Lusis, A.J.16
Hazen, S.L.17
-
39
-
-
84927126803
-
Flavincontaining monooxygenase 3 as a potential player in diabetes-associated atherosclerosis
-
Morbid Obesity Study G
-
Miao J, Ling AV, Manthena PV, Gearing ME, Graham MJ, Crooke RM, Croce KJ, Esquejo RM, Clish CB, Morbid Obesity Study G, Vicent D, Biddinger SB. Flavincontaining monooxygenase 3 as a potential player in diabetes-associated atherosclerosis. Nat Commun 2015;6:6498.
-
(2015)
Nat Commun
, vol.6
, pp. 6498
-
-
Miao, J.1
Ling, A.V.2
Manthena, P.V.3
Gearing, M.E.4
Graham, M.J.5
Crooke, R.M.6
Croce, K.J.7
Esquejo, R.M.8
Clish, C.B.9
Vicent, D.10
Biddinger, S.B.11
-
40
-
-
84920704729
-
Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis
-
Shih DM, Wang Z, Lee R, Meng Y, Che N, Charugundla S, Qi H, Wu J, Pan C, Brown JM, Vallim T, Bennett BJ, Graham M, Hazen SL, Lusis AJ. Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. J Lipid Res 2015;56:22-37.
-
(2015)
J Lipid Res
, vol.56
, pp. 22-37
-
-
Shih, D.M.1
Wang, Z.2
Lee, R.3
Meng, Y.4
Che, N.5
Charugundla, S.6
Qi, H.7
Wu, J.8
Pan, C.9
Brown, J.M.10
Vallim, T.11
Bennett, B.J.12
Graham, M.13
Hazen, S.L.14
Lusis, A.J.15
-
41
-
-
84921362010
-
The TMAOgenerating enzyme flavin monooxygenase 3 is a central regulator of cholesterol balance
-
Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, Brown AL, Marshall S, McDaniel A, Schugar RC, Wang Z, Sacks J, Rong X, Vallim TA, Chou J, Ivanova PT, Myers DS, Brown HA, Lee RG, Crooke RM, Graham MJ, Liu X, Parini P, Tontonoz P, Lusis AJ, Hazen SL, Temel RE, Brown JM. The TMAOgenerating enzyme flavin monooxygenase 3 is a central regulator of cholesterol balance. Cell Rep 2015;10:326-338.
-
(2015)
Cell Rep
, vol.10
, pp. 326-338
-
-
Warrier, M.1
Shih, D.M.2
Burrows, A.C.3
Ferguson, D.4
Gromovsky, A.D.5
Brown, A.L.6
Marshall, S.7
McDaniel, A.8
Schugar, R.C.9
Wang, Z.10
Sacks, J.11
Rong, X.12
Vallim, T.A.13
Chou, J.14
Ivanova, P.T.15
Myers, D.S.16
Brown, H.A.17
Lee, R.G.18
Crooke, R.M.19
Graham, M.J.20
Liu, X.21
Parini, P.22
Tontonoz, P.23
Lusis, A.J.24
Hazen, S.L.25
Temel, R.E.26
Brown, J.M.27
more..
-
42
-
-
84955278869
-
Choline diet and its gut microbe-derived metabolite, trimethylamine N-oxide, exacerbate pressure overload-induced heart failure
-
Organ CL, Otsuka H, Bhushan S, Wang Z, Bradley J, Trivedi R, Polhemus DJ, Tang WH, Wu Y, Hazen SL, Lefer DJ. Choline diet and its gut microbe-derived metabolite, trimethylamine N-oxide, exacerbate pressure overload-induced heart failure. Circ Heart Fail 2016;9:e002314.
-
(2016)
Circ Heart Fail
, vol.9
, pp. e002314
-
-
Organ, C.L.1
Otsuka, H.2
Bhushan, S.3
Wang, Z.4
Bradley, J.5
Trivedi, R.6
Polhemus, D.J.7
Tang, W.H.8
Wu, Y.9
Hazen, S.L.10
Lefer, D.J.11
-
43
-
-
84977070332
-
Dietary phosphatidylcholine and risk of all-cause and cardiovascular-specific mortality among US women and men
-
Zheng Y, Li Y, Rimm EB, Hu FB, Albert CM, Rexrode KM, Manson JE, Qi L. Dietary phosphatidylcholine and risk of all-cause and cardiovascular-specific mortality among US women and men. Am J Clin Nutr 2016;104:173-180.
-
(2016)
Am J Clin Nutr
, vol.104
, pp. 173-180
-
-
Zheng, Y.1
Li, Y.2
Rimm, E.B.3
Hu, F.B.4
Albert, C.M.5
Rexrode, K.M.6
Manson, J.E.7
Qi, L.8
-
44
-
-
84992533219
-
High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome
-
De Filippis F, Pellegrini N, Vannini L, Jeffery IB, La Storia A, Laghi L, Serrazanetti DI, Di Cagno R, Ferrocino I, Lazzi C, Turroni S, Cocolin L, Brigidi P, Neviani E, Gobbetti M, O'toole PW, Ercolini D. High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome. Gut 2016;65:1812-1821.
-
(2016)
Gut
, vol.65
, pp. 1812-1821
-
-
De Filippis, F.1
Pellegrini, N.2
Vannini, L.3
Jeffery, I.B.4
La Storia, A.5
Laghi, L.6
Serrazanetti, D.I.7
Di Cagno, R.8
Ferrocino, I.9
Lazzi, C.10
Turroni, S.11
Cocolin, L.12
Brigidi, P.13
Neviani, E.14
Gobbetti, M.15
O'Toole, P.W.16
Ercolini, D.17
-
45
-
-
84910129274
-
Gamma-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of Lcarnitine to TMAO
-
Koeth RA, Levison BS, Culley MK, Buffa JA, Wang Z, Gregory JC, Org E, Wu Y, Li L, Smith JD, Tang WH, DiDonato JA, Lusis AJ, Hazen SL. gamma-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of Lcarnitine to TMAO. Cell Metab 2014;20:799-812.
-
(2014)
Cell Metab
, vol.20
, pp. 799-812
-
-
Koeth, R.A.1
Levison, B.S.2
Culley, M.K.3
Buffa, J.A.4
Wang, Z.5
Gregory, J.C.6
Org, E.7
Wu, Y.8
Li, L.9
Smith, J.D.10
Tang, W.H.11
DiDonato, J.A.12
Lusis, A.J.13
Hazen, S.L.14
-
46
-
-
84963811536
-
Intervention trials with the Mediterranean diet in cardiovascular prevention: Understanding potential mechanisms through metabolomic profiling
-
Martinez-Gonzalez MA, Ruiz-Canela M, Hruby A, Liang L, Trichopoulou A, Hu FB. Intervention trials with the Mediterranean diet in cardiovascular prevention: understanding potential mechanisms through metabolomic profiling. J Nutr 2016;146(suppl):913S-919S.
-
(2016)
J Nutr
, vol.146
, pp. 913S-919S
-
-
Martinez-Gonzalez, M.A.1
Ruiz-Canela, M.2
Hruby, A.3
Liang, L.4
Trichopoulou, A.5
Hu, F.B.6
-
47
-
-
84893017875
-
Dietary patterns, Mediterranean diet, and cardiovascular disease
-
Martinez-Gonzalez MA, Bes-Rastrollo M. Dietary patterns, Mediterranean diet, and cardiovascular disease. Curr Opin Lipidol 2014;25:20-26.
-
(2014)
Curr Opin Lipidol
, vol.25
, pp. 20-26
-
-
Martinez-Gonzalez, M.A.1
Bes-Rastrollo, M.2
-
48
-
-
84936938968
-
Benefits of the Mediterranean diet: Insights from the PREDIMED study
-
Martinez-Gonzalez MA, Salas-Salvado J, Estruch R, Corella D, Fito M, Ros E, Predimed I. Benefits of the Mediterranean diet: insights from the PREDIMED study. Prog Cardiovasc Dis 2015;58:50-60.
-
(2015)
Prog Cardiovasc Dis
, vol.58
, pp. 50-60
-
-
Martinez-Gonzalez, M.A.1
Salas-Salvado, J.2
Estruch, R.3
Corella, D.4
Fito, M.5
Ros, E.6
Predimed, I.7
-
49
-
-
84921417572
-
The gut microbial endocrine organ: Bacterially derived signals driving cardiometabolic diseases
-
Brown JM, Hazen SL. The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases. Annu Rev Med 2015;66:343-359.
-
(2015)
Annu Rev Med
, vol.66
, pp. 343-359
-
-
Brown, J.M.1
Hazen, S.L.2
|