메뉴 건너뛰기




Volumn 124, Issue 4, 2016, Pages 251-256

Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels

Author keywords

cardiovascular; diabetes; L carnitine; trimethylamine N oxide

Indexed keywords

CARNITINE; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; ORAL ANTIDIABETIC AGENT; TRIACYLGLYCEROL; TRIMETHYLAMINE OXIDE; METHYLAMINE; TRIMETHYLOXAMINE;

EID: 84964670746     PISSN: 09477349     EISSN: 14393646     Source Type: Journal    
DOI: 10.1055/s-0035-1569330     Document Type: Article
Times cited : (191)

References (31)
  • 1
    • 79953733693 scopus 로고    scopus 로고
    • Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
    • Wang Z., Klipfell E., Bennett B. J. et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature: 2011; 472 57 63
    • (2011) Nature , vol.472 , pp. 57-63
    • Wang, Z.1    Klipfell, E.2    Bennett, B.J.3
  • 2
    • 84888187402 scopus 로고    scopus 로고
    • Gut microbiota metabolism of L-carnitine and cardiovascular risk
    • Ussher J. R., Lopaschuk G. D., Arduini A. Gut microbiota metabolism of L-carnitine and cardiovascular risk. Atherosclerosis: 2013; 231 456 461
    • (2013) Atherosclerosis , vol.231 , pp. 456-461
    • Ussher, J.R.1    Lopaschuk, G.D.2    Arduini, A.3
  • 3
    • 84918565300 scopus 로고    scopus 로고
    • Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study
    • Lever M., George P. M., Slow S. et al. Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study. PLoS One: 2014; 9 e114969
    • (2014) PLoS One , vol.9 , pp. e114969
    • Lever, M.1    George, P.M.2    Slow, S.3
  • 4
    • 84877331372 scopus 로고    scopus 로고
    • Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
    • Koeth R. A., Wang Z., Levison B. S. et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med: 2013; 19 576 585
    • (2013) Nat Med , vol.19 , pp. 576-585
    • Koeth, R.A.1    Wang, Z.2    Levison, B.S.3
  • 5
    • 84899457029 scopus 로고    scopus 로고
    • Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry
    • Wang Z., Levison B. S., Hazen J. E. et al. Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry. Anal Biochem: 2014; 455 35 40
    • (2014) Anal Biochem , vol.455 , pp. 35-40
    • Wang, Z.1    Levison, B.S.2    Hazen, J.E.3
  • 6
    • 19944387962 scopus 로고    scopus 로고
    • Trimethylamine: Metabolic, pharmacokinetic and safety aspects
    • Bain M. A., Fornasini G., Evans A. M. Trimethylamine: metabolic, pharmacokinetic and safety aspects. Curr Drug Metab: 2005; 6 227 240
    • (2005) Curr Drug Metab , vol.6 , pp. 227-240
    • Bain, M.A.1    Fornasini, G.2    Evans, A.M.3
  • 7
    • 33748653981 scopus 로고    scopus 로고
    • Disposition and metabolite kinetics of oral L-carnitine in humans
    • Bain M. A., Milne R. W., Evans A. M. Disposition and metabolite kinetics of oral L-carnitine in humans. J Clin Pharmacol: 2006; 46 1163 1170
    • (2006) J Clin Pharmacol , vol.46 , pp. 1163-1170
    • Bain, M.A.1    Milne, R.W.2    Evans, A.M.3
  • 8
    • 10644229056 scopus 로고    scopus 로고
    • Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism
    • Rebouche C. J. Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism. Ann N Y Acad Sci: 2004; 1033 30 41
    • (2004) Ann N y Acad Sci , vol.1033 , pp. 30-41
    • Rebouche, C.J.1
  • 9
    • 84876563088 scopus 로고    scopus 로고
    • Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
    • Tang W. H., Wang Z., Levison B. S. et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med: 2013; 368 1575 1584
    • (2013) N Engl J Med , vol.368 , pp. 1575-1584
    • Tang, W.H.1    Wang, Z.2    Levison, B.S.3
  • 10
    • 84872139636 scopus 로고    scopus 로고
    • Trimethylamine-N-oxide, a metaboliteassociated with atherosclerosis, exhibits complex genetic and dietary regulation
    • Bennett B. J., de Aguiar Vallim T. Q., Wang Z. et al. Trimethylamine-N-oxide, a metaboliteassociated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab: 2013; 17 49 60
    • (2013) Cell Metab , vol.17 , pp. 49-60
    • Bennett, B.J.1    De Aguiar Vallim, T.Q.2    Wang, Z.3
  • 11
    • 84885164095 scopus 로고    scopus 로고
    • Meldonium decreases the diet-increased plasma levels of trimethylamine N-oxide, a metabolite associated with atherosclerosis
    • Dambrova M., Skapare-Makarova E., Konrade I. et al. Meldonium decreases the diet-increased plasma levels of trimethylamine N-oxide, a metabolite associated with atherosclerosis. J Clin Pharmacol: 2013; 53 1095 1098
    • (2013) J Clin Pharmacol , vol.53 , pp. 1095-1098
    • Dambrova, M.1    Skapare-Makarova, E.2    Konrade, I.3
  • 13
    • 84901335706 scopus 로고    scopus 로고
    • Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine
    • Hartiala J., Bennett B. J., Tang W. H. et al. Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine. Arterioscler Thromb Vasc Biol: 2014; 34 1307 1313
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 1307-1313
    • Hartiala, J.1    Bennett, B.J.2    Tang, W.H.3
  • 14
    • 84876494766 scopus 로고    scopus 로고
    • Metabolic effects of L-carnitine on type 2 diabetes mellitus: Systematic review and meta-analysis
    • Vidal-Casariego A., Burgos-Pelaez R., Martinez-Faedo C. et al. Metabolic effects of L-carnitine on type 2 diabetes mellitus: systematic review and meta-analysis. Exp Clin Endocrinol Diabetes: 2013; 121 234 238
    • (2013) Exp Clin Endocrinol Diabetes , vol.121 , pp. 234-238
    • Vidal-Casariego, A.1    Burgos-Pelaez, R.2    Martinez-Faedo, C.3
  • 15
    • 84923357877 scopus 로고    scopus 로고
    • Risks and benefits of carnitine supplementation in diabetes
    • Dambrova M., Liepinsh E. Risks and benefits of carnitine supplementation in diabetes. Exp Clin Endocrinol Diabetes: 2015; 123 95 100
    • (2015) Exp Clin Endocrinol Diabetes , vol.123 , pp. 95-100
    • Dambrova, M.1    Liepinsh, E.2
  • 16
    • 84861716714 scopus 로고    scopus 로고
    • High L-carnitine concentrations do not prevent late diabetic complications in type 1 and 2 diabetic patients
    • Liepinsh E., Skapare E., Vavers E. et al. High L-carnitine concentrations do not prevent late diabetic complications in type 1 and 2 diabetic patients. Nutr Res: 2012; 32 320 327
    • (2012) Nutr Res , vol.32 , pp. 320-327
    • Liepinsh, E.1    Skapare, E.2    Vavers, E.3
  • 17
    • 0034844049 scopus 로고    scopus 로고
    • Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes
    • Morrish N. J., Wang S. L., Stevens L. K. et al. Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia: 2001; 44 02 S14 S21
    • (2001) Diabetologia , vol.44 , Issue.2 , pp. S14-S21
    • Morrish, N.J.1    Wang, S.L.2    Stevens, L.K.3
  • 18
    • 84899526532 scopus 로고    scopus 로고
    • Epidemiology of cardiovascular disease in patients with type 1 diabetes: European perspective
    • Matteucci E., Giampietro O. Epidemiology of cardiovascular disease in patients with type 1 diabetes: European perspective. Exp Clin Endocrinol Diabetes: 2014; 122 208 214
    • (2014) Exp Clin Endocrinol Diabetes , vol.122 , pp. 208-214
    • Matteucci, E.1    Giampietro, O.2
  • 19
    • 0031851293 scopus 로고    scopus 로고
    • Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
    • Alberti K. G., Zimmet P. Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med: 1998; 15 539 553
    • (1998) Diabet Med , vol.15 , pp. 539-553
    • Alberti, K.G.1    Zimmet, P.Z.2
  • 20
    • 84862302432 scopus 로고    scopus 로고
    • Prediabetes: A high-risk state for diabetes development
    • Tabak A. G., Herder C., Rathmann W. et al. Prediabetes: a high-risk state for diabetes development. Lancet: 2012; 379 2279 2290
    • (2012) Lancet , vol.379 , pp. 2279-2290
    • Tabak, A.G.1    Herder, C.2    Rathmann, W.3
  • 21
    • 84943659696 scopus 로고    scopus 로고
    • Determination of trimethylamine-N-oxide in combination with l-carnitine and γ-butyrobetaine in human plasma by UPLC/MS/MS
    • Grinberga S., Dambrova M., Latkovskis G. et al. Determination of trimethylamine-N-oxide in combination with l-carnitine and γ-butyrobetaine in human plasma by UPLC/MS/MS. Biomed Chromatogr: 2015; 29 1670 1674
    • (2015) Biomed Chromatogr , vol.29 , pp. 1670-1674
    • Grinberga, S.1    Dambrova, M.2    Latkovskis, G.3
  • 22
    • 84871240216 scopus 로고    scopus 로고
    • Serum metabolic variables associated with impaired glucose tolerance induced by high-fat-high-cholesterol diet in Macaca mulatta
    • Li X., Chen Y., Liu J. et al. Serum metabolic variables associated with impaired glucose tolerance induced by high-fat-high-cholesterol diet in Macaca mulatta. Exp Biol Med (Maywood): 2012; 237 1310 1321
    • (2012) Exp Biol Med (Maywood) , vol.237 , pp. 1310-1321
    • Li, X.1    Chen, Y.2    Liu, J.3
  • 23
    • 84921636319 scopus 로고    scopus 로고
    • Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet
    • Gao X., Liu X., Xu J. et al. Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet. J Biosci Bioeng: 2014; 118 476 481
    • (2014) J Biosci Bioeng , vol.118 , pp. 476-481
    • Gao, X.1    Liu, X.2    Xu, J.3
  • 24
    • 84874415720 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress plays a key role in the pathogenesis of diabetic peripheral neuropathy
    • Lupachyk S., Watcho P., Stavniichuk R. et al. Endoplasmic reticulum stress plays a key role in the pathogenesis of diabetic peripheral neuropathy. Diabetes: 2013; 62 944 952
    • (2013) Diabetes , vol.62 , pp. 944-952
    • Lupachyk, S.1    Watcho, P.2    Stavniichuk, R.3
  • 25
    • 84930436272 scopus 로고    scopus 로고
    • Variation of betaine, N,N-dimethylglycine, choline, glycerophosphorylcholine, taurine and trimethylamine-N-oxide in the plasma and urine of overweight people with type 2 diabetes over a two-year period
    • McEntyre C. J., Lever M., Chambers S. T. et al. Variation of betaine, N,N-dimethylglycine, choline, glycerophosphorylcholine, taurine and trimethylamine-N-oxide in the plasma and urine of overweight people with type 2 diabetes over a two-year period. Ann Clin Biochem: 2015; 52 352 360
    • (2015) Ann Clin Biochem , vol.52 , pp. 352-360
    • McEntyre, C.J.1    Lever, M.2    Chambers, S.T.3
  • 26
    • 84898859680 scopus 로고    scopus 로고
    • Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide
    • Wang Z., Tang W. H., Buffa J. A. et al. Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide. Eur Heart J: 2014; 35 904 910
    • (2014) Eur Heart J , vol.35 , pp. 904-910
    • Wang, Z.1    Tang, W.H.2    Buffa, J.A.3
  • 27
    • 84893707135 scopus 로고    scopus 로고
    • Intestinal microbiota, diet and health
    • Power S. E., O'Toole P. W., Stanton C. et al. Intestinal microbiota, diet and health. Br J Nutr: 2014; 111 387 402
    • (2014) Br J Nutr , vol.111 , pp. 387-402
    • Power, S.E.1    O'Toole, P.W.2    Stanton, C.3
  • 28
    • 84964651315 scopus 로고    scopus 로고
    • Health behavior among Latvian adult population
    • Health behavior among Latvian adult population. FINBALT Health Monitoring: 2012
    • (2012) FINBALT Health Monitoring
  • 29
    • 84942364182 scopus 로고    scopus 로고
    • TMAO: A small molecule of great expectations
    • Ufnal M., Zadlo A., Ostaszewski R. TMAO: A small molecule of great expectations. Nutrition: 2015; 31 1317 1323
    • (2015) Nutrition , vol.31 , pp. 1317-1323
    • Ufnal, M.1    Zadlo, A.2    Ostaszewski, R.3
  • 30
    • 80053176442 scopus 로고    scopus 로고
    • Use of mass spectrometry fingerprinting to identify urinary metabolites after consumption of specific foods
    • Lloyd A. J., Fave G., Beckmann M. et al. Use of mass spectrometry fingerprinting to identify urinary metabolites after consumption of specific foods. Am J Clin Nutr: 2011; 94 981 991
    • (2011) Am J Clin Nutr , vol.94 , pp. 981-991
    • Lloyd, A.J.1    Fave, G.2    Beckmann, M.3
  • 31
    • 84907313170 scopus 로고    scopus 로고
    • Effect of egg ingestion on trimethylamine-N-oxide production in humans: A randomized, controlled, dose-response study
    • Miller C. A., Corbin K. D., da Costa K. A. et al. Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study. Am J Clin Nutr: 2014; 100 778 786
    • (2014) Am J Clin Nutr , vol.100 , pp. 778-786
    • Miller, C.A.1    Corbin, K.D.2    Da Costa, K.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.