Trimethylamine N-oxide promotes vascular inflammation through signaling of mitogen-activated protein kinase and nuclear factor-κb

Journal of the American Heart Association

Volumn 5, Issue 2, 2016, Pages

  Seldin, Marcus M ^a   Meng, Yonghong ^a   Qi, Hongxiu ^a   Zhu, Wei Fei ^b   Wang, Zeneng ^b   Hazen, Stanley L ^b   Lusis, Aldons J ^a   Shih, Diana M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Atherosclerosis; Cardiovascular disease; Endothelial cell; Inflammation; Leukocyte adhesion; Nuclear factor B signaling; Trimethylamine N oxide; Vascular smooth muscle cell

Indexed keywords

CYCLOOXYGENASE 2; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; TRIMETHYLAMINE OXIDE; TUMOR NECROSIS FACTOR; CHOLINE; LOW DENSITY LIPOPROTEIN RECEPTOR; METHYLAMINE; TRIMETHYLOXAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTIC ENDOTHELIAL CELL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CELL FUNCTION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKOCYTE ADHERENCE; MOUSE; NONHUMAN; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; AORTA; AORTITIS; C57BL MOUSE; CELL ADHESION; CELL CULTURE; CHEMICALLY INDUCED; COCULTURE; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; ENDOTHELIUM CELL; ENZYMOLOGY; GENETIC PREDISPOSITION; GENETICS; KNOCKOUT MOUSE; LEUKOCYTE; METABOLISM; PATHOLOGY; PHENOTYPE; SMOOTH MUSCLE CELL; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; AORTITIS; ATHEROSCLEROSIS; CELL ADHESION; CELLS, CULTURED; CHOLINE; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LEUKOCYTES; METHYLAMINES; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NF-KAPPA B; PHENOTYPE; RECEPTORS, LDL; SIGNAL TRANSDUCTION;

EID: 85002925090     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.115.002767     Document Type: Article

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