Bmp induces osteoblast differentiation through both Smad4 and mTORC1 signaling

Molecular and Cellular Biology

Volumn 37, Issue 4, 2017, Pages

  Karner, Courtney M ^a,b   Lee, Seung Yon ^a   Long, Fanxin ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Atf4; Bone morphogenic proteins (BMPs); ER stress; Mineralization; MTOR; MTORC1; Osteoblast; Perk; Protein anabolism; Smad4

Indexed keywords

ABELSON KINASE; ACTIVATING TRANSCRIPTION FACTOR 4; AKP2 PROTEIN; ASNS PROTEIN; BETA GALACTOSIDASE; BGLAP PROTEIN; BONE MORPHOGENETIC PROTEIN 2; CHAC1 PROTEIN; COL1A1 PROTEIN; ERO1L PROTEIN; FIBROBLAST GROWTH FACTOR RECEPTOR 2; GLYCINE TRANSPORTER 1; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; IBSP PROTEIN; INITIATION FACTOR 4E BINDING PROTEIN 1; LARS PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHO1 PROTEIN; PROTEIN; RNA 18S; SMAD4 PROTEIN; SP7 PROTEIN; STC2 PROTEIN; TARS PROTEIN; TRANSCRIPTION FACTOR 7; TRANSFER RNA; UNCLASSIFIED DRUG; WNT PROTEIN; YARS PROTEIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PERK KINASE; PROTEIN KINASE R; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MARROW STROMA CELL; BONE MINERALIZATION; CELL DIFFERENTIATION; CONTROLLED STUDY; ENCHONDRAL OSSIFICATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE EXPRESSION; GENE INDUCTION; HUMAN; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; RNA SEQUENCE; UNFOLDED PROTEIN RESPONSE; ANIMAL; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION PROFILING; METABOLISM; SIGNAL TRANSDUCTION;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION PROFILING; HUMANS; MICE; MULTIPROTEIN COMPLEXES; OSTEOBLASTS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN BIOSYNTHESIS; PROTO-ONCOGENE PROTEINS C-ABL; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; TOR SERINE-THREONINE KINASES; WNT PROTEINS;

EID: 85012106654     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00253-16     Document Type: Article

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