-
2
-
-
0029118115
-
Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure
-
Aittomäki K, Dieguez Lucena J, Pakarinen P, Sistonen P, Tapanainen J, Gromoll J, Kaskikari R, Sankila E, Lehväslaiho H, Engel A, et al. 1995 Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure. Cell 82 959–968. (doi:10.1016/0092-8674(95)90275-9)
-
(1995)
Cell
, vol.82
, pp. 959-968
-
-
Aittomäki, K.1
Dieguez Lucena, J.2
Pakarinen, P.3
Sistonen, P.4
Tapanainen, J.5
Gromoll, J.6
Kaskikari, R.7
Sankila, E.8
Lehväslaiho, H.9
Engel, A.10
-
3
-
-
0037323640
-
A novel loss of function mutation in exon 10 of the FSH receptor gene causing hypergondotrophic hypogonadism: Clinical and molecular characteristics
-
Allen L, Achermann J, Pakarinen P, Kotlar T, Huhtaniemi I & Jameson J 2003 A novel loss of function mutation in exon 10 of the FSH receptor gene causing hypergondotrophic hypogonadism: clinical and molecular characteristics. Human Reproduction 18 251–256. (doi:10.1093/humrep/deg046)
-
(2003)
Human Reproduction
, vol.18
, pp. 251-256
-
-
Allen, L.1
Achermann, J.2
Pakarinen, P.3
Kotlar, T.4
Huhtaniemi, I.5
Jameson, J.6
-
4
-
-
0024282581
-
Pituitary glycoprotein hormone oligosaccharides – structure, synthesis and function of the asparagine-linked oligosaccharides on lutropin, follitropin and thyrotropin
-
Baenziger JU & Green ED 1988 Pituitary glycoprotein hormone oligosaccharides – structure, synthesis and function of the asparagine-linked oligosaccharides on lutropin, follitropin and thyrotropin. Biochimica et Biophysica Acta 947 287–306. (doi:10.1016/0304-4157(88)90012-3)
-
(1988)
Biochimica Et Biophysica Acta
, vol.947
, pp. 287-306
-
-
Baenziger, J.U.1
Green, E.D.2
-
5
-
-
0032190476
-
A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor
-
Beau I, Touraine P, Meduri G, Gougeon A, Desroches A & Matuchansky C 1998 A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor. Journal of Clinical Investigation 102 1352–1359. (doi:10.1172/JCI3795)
-
(1998)
Journal of Clinical Investigation
, vol.102
, pp. 1352-1359
-
-
Beau, I.1
Touraine, P.2
Meduri, G.3
Gougeon, A.4
Desroches, A.5
Matuchansky, C.6
-
6
-
-
84890612296
-
Hypo-glycosylated human follicle-stimulating hormone (HFSH(21/18)) is much more active in vitro than fully-glycosylated hFSH (hFSH(24)
-
Bousfield GR, Butnev VY, Butnev VY, Hiromasa Y, Harvey DJ & May JV 2014 Hypo-glycosylated human follicle-stimulating hormone (hFSH(21/18)) is much more active in vitro than fully-glycosylated hFSH (hFSH(24)). Molecular and Cellular Endocrinology 382 989–997. (doi:10.1016/j.mce.2013.11.008)
-
(2014)
Molecular and Cellular Endocrinology
, vol.382
, pp. 989-997
-
-
Bousfield, G.R.1
Butnev, V.Y.2
Butnev, V.Y.3
Hiromasa, Y.4
Harvey, D.J.5
May, J.V.6
-
7
-
-
23244440500
-
Thyrotropin receptor gene mutations and TSH resistance: variable expressivity in the heterozygotes
-
Camilot M, Teofoli F, Gandini A, Franceschi R, Rapa A, Corrias A, Bona G, Radetti G & Tatò L 2005 Thyrotropin receptor gene mutations and TSH resistance: variable expressivity in the heterozygotes. Clinical Endocrinology 63 146–151. (doi:10.1111/ j.1365-2265.2005.02314.x)
-
(2005)
Clinical Endocrinology
, vol.63
, pp. 146-151
-
-
Camilot, M.1
Teofoli, F.2
Gandini, A.3
Franceschi, R.4
Rapa, A.5
Corrias, A.6
Bona, G.7
Radetti, G.8
Tatò, L.9
-
8
-
-
0029802727
-
Evidence for negative cooperativity among human thyrotropin receptors overexpressed in mammalian cells
-
Chazenbalk GD, Kakinuma A, Jaume JC, McLachlan SM & Rapoport B 1996 Evidence for negative cooperativity among human thyrotropin receptors overexpressed in mammalian cells. Endocrinology 137 4586–4591. (doi:10.1210/endo.137.11.8895321)
-
(1996)
Endocrinology
, vol.137
, pp. 4586-4591
-
-
Chazenbalk, G.D.1
Kakinuma, A.2
Jaume, J.C.3
McLachlan, S.M.4
Rapoport, B.5
-
9
-
-
27844482098
-
A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling
-
Claus M, Jaeschke H, Kleinau G, Neumann S, Krause G & Paschke R 2005 A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling. Molecular Endocrinology 146 5197–5203. (doi:10.1210/en.2005-0713)
-
(2005)
Molecular Endocrinology
, vol.146
, pp. 5197-5203
-
-
Claus, M.1
Jaeschke, H.2
Kleinau, G.3
Neumann, S.4
Krause, G.5
Paschke, R.6
-
10
-
-
62149105580
-
New discoveries on the biology and detection of human chorionic gonadotropin
-
Cole LA 2009 New discoveries on the biology and detection of human chorionic gonadotropin. Reproductive Biology and Endocrinology 7 8. (doi:10.1186/1477-7827-7-8)
-
(2009)
Reproductive Biology and Endocrinology
, vol.7
, pp. 8
-
-
Cole, L.A.1
-
11
-
-
0037084011
-
Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors
-
Costagliola S, Panneels V, Bonomi M, Koch J, Many MC, Smits G & Vassart G 2002 Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors. EMBO Journal 21 504–513. (doi:10.1093/emboj/21.4.504)
-
(2002)
EMBO Journal
, vol.21
, pp. 504-513
-
-
Costagliola, S.1
Panneels, V.2
Bonomi, M.3
Koch, J.4
Many, M.C.5
Smits, G.6
Vassart, G.7
-
12
-
-
0018099357
-
Binding of thyroid stimulators to guinea pig testis and thyroid
-
Davies TF, Rees Smith B & Hall R 1978 Binding of thyroid stimulators to guinea pig testis and thyroid. Endocrinology 103 6–10. (doi:10.1210/ endo-103-1-6)
-
(1978)
Endocrinology
, vol.103
, pp. 6-10
-
-
Davies, T.F.1
Rees Smith, B.2
Hall, R.3
-
13
-
-
84891409070
-
Allosteric modulators hit the TSH receptor
-
Davies TF, Ali MR & Latif R 2014 Allosteric modulators hit the TSH receptor. Endocrinology 155 1–5. (doi:10.1210/en.2013-2079)
-
(2014)
Endocrinology
, vol.155
, pp. 1-5
-
-
Davies, T.F.1
Ali, M.R.2
Latif, R.3
-
14
-
-
0028883286
-
Identification of the sites of N-linked glycosylation on the follicle-stimulating hormone (FSH) receptor and assessment of their role in FSH receptor function
-
Davis DP, Liu X & Segaloff DL 1995 Identification of the sites of N-linked glycosylation on the follicle-stimulating hormone (FSH) receptor and assessment of their role in FSH receptor function. Molecular Endocrinology 9 159–170. (doi:10.1210/ me.9.2.159)
-
(1995)
Molecular Endocrinology
, vol.9
, pp. 159-170
-
-
Davis, D.P.1
Liu, X.2
Segaloff, D.L.3
-
15
-
-
0030948572
-
The six N-linked carbohydrates of the lutropin/choriogonadotropin receptor are not absolutely required for correct folding, cell surface expression, hormone binding, or signal transduction
-
Davis DP, Rozell TG, Liu X & Segaloff DL 1997 The six N-linked carbohydrates of the lutropin/choriogonadotropin receptor are not absolutely required for correct folding, cell surface expression, hormone binding, or signal transduction. Molecular Endocrinology 11 550–562. (doi:10.1210/mend.11.5.9927)
-
(1997)
Molecular Endocrinology
, vol.11
, pp. 550-562
-
-
Davis, D.P.1
Rozell, T.G.2
Liu, X.3
Segaloff, D.L.4
-
16
-
-
66749116183
-
-
San Carlos, CA, USA: DeLano Scientific
-
De Lano WL 2002 The PyMOL Molecular Graphics System. San Carlos, CA, USA: DeLano Scientific. (available at: http://sourceforge.net/ projects/pymol/).
-
(2002)
The Pymol Molecular Graphics System
-
-
De Lano, W.L.1
-
17
-
-
10544240361
-
Four families with loss of function mutations of the thyrotropin receptor
-
de Roux N, Misrahi M, Brauner R, Houang M, Carel JC, Granier M, Le Bouc Y, Ghinea N, Boumedienne A, Toublanc JE, et al. 1996 Four families with loss of function mutations of the thyrotropin receptor. Journal of Clinical Endocrinology and Metabolism 81 4229–4235. (doi:10.1210/jc.81.12.4229)
-
(1996)
Journal of Clinical Endocrinology and Metabolism
, vol.81
, pp. 4229-4235
-
-
De Roux, N.1
Misrahi, M.2
Brauner, R.3
Houang, M.4
Carel, J.C.5
Granier, M.6
Le Bouc, Y.7
Ghinea, N.8
Boumedienne, A.9
Toublanc, J.E.10
-
18
-
-
0030805829
-
Constitutive activation of the TSH receptor by spontaneous mutations affecting the N-terminal extracellular domain
-
Duprez L, Parma J, Costagliola S, Hermans J, Van-Sande J, Dumont JE & Vassart G 1997 Constitutive activation of the TSH receptor by spontaneous mutations affecting the N-terminal extracellular domain. FEBS Letters 409 469–474. (doi:10.1016/S0014-5793(97)00532-2)
-
(1997)
FEBS Letters
, vol.409
, pp. 469-474
-
-
Duprez, L.1
Parma, J.2
Costagliola, S.3
Hermans, J.4
Van-Sande, J.5
Dumont, J.E.6
Vassart, G.7
-
19
-
-
12744280744
-
Structure of human follicle-stimulating hormone in complex with its receptor
-
Fan QR & Hendrickson WA 2005 Structure of human follicle-stimulating hormone in complex with its receptor. Nature 433 269–277. (doi:10.1038/nature03206)
-
(2005)
Nature
, vol.433
, pp. 269-277
-
-
Fan, Q.R.1
Hendrickson, W.A.2
-
20
-
-
33646108350
-
The role of O-linked and N-linked oligosaccharides on the structure-function of glycoprotein hormones: Development of agonists and antagonists
-
Fares F 2006 The role of O-linked and N-linked oligosaccharides on the structure-function of glycoprotein hormones: development of agonists and antagonists. Biochimica et Biophysica Acta 1760 560–567. (doi:10.1016/j.bbagen.2005.12.022)
-
(2006)
Biochimica Et Biophysica Acta
, vol.1760
, pp. 560-567
-
-
Fares, F.1
-
21
-
-
0029053448
-
The role of N-glycans in the secretory pathway
-
Fiedler K & Simons K 1995 The role of N-glycans in the secretory pathway. Cell 81 309–312. (doi:10.1016/0092-8674(95)90380-1)
-
(1995)
Cell
, vol.81
, pp. 309-312
-
-
Fiedler, K.1
Simons, K.2
-
22
-
-
84969509193
-
Human chorionic gonadotropin: Different glycoforms and biological activity depending on its source of production
-
Fournier T 2016 Human chorionic gonadotropin: different glycoforms and biological activity depending on its source of production. Annales d’Endocrinologie 77 75–81. (doi:10.1016/j.ando.2016.04.012)
-
(2016)
Annales d’Endocrinologie
, vol.77
, pp. 75-81
-
-
Fournier, T.1
-
23
-
-
0035105355
-
Three-dimensional structure of human follicle-stimulating hormone
-
Fox KM, Dias JA & vanRoey P 2001 Three-dimensional structure of human follicle-stimulating hormone. Molecular Endocrinology 15 378–389. (doi:10.1210/mend.15.3.0603)
-
(2001)
Molecular Endocrinology
, vol.15
, pp. 378-389
-
-
Fox, K.M.1
Dias, J.A.2
Vanroey, P.3
-
25
-
-
43449089203
-
A new silent germline mutation of the TSH receptor: Coexpression in a hyperthyroid family member with a second activating somatic mutation
-
Gozu HI, Mueller S, Bircan R, Krohn K, Ekinci G, Yavuzer D, Sargin H, Sargin M, Ones T, Gezen C, et al. 2008 A new silent germline mutation of the TSH receptor: coexpression in a hyperthyroid family member with a second activating somatic mutation. Thyroid 18 499–508. (doi:10.1089/thy.2007.0335)
-
(2008)
Thyroid
, vol.18
, pp. 499-508
-
-
Gozu, H.I.1
Mueller, S.2
Bircan, R.3
Krohn, K.4
Ekinci, G.5
Yavuzer, D.6
Sargin, H.7
Sargin, M.8
Ones, T.9
Gezen, C.10
-
26
-
-
0029794790
-
Multimeric complex formation by the thyrotropin receptor in solubilized thyroid membranes
-
Graves PN, Vlase H, Bobovnikova Y & Davies TF 1996 Multimeric complex formation by the thyrotropin receptor in solubilized thyroid membranes. Endocrinology 137 3915–3920. (doi:10.1210/ en.137.9.3915)
-
(1996)
Endocrinology
, vol.137
, pp. 3915-3920
-
-
Graves, P.N.1
Vlase, H.2
Bobovnikova, Y.3
Davies, T.F.4
-
27
-
-
0036854403
-
Homozygous mutation within the conserved Ala-Phe-Asn-Glu-Thr motif of exon 7 of the LH receptor causes male pseudohermaphroditism
-
Gromoll J, Schulz A, Borta H, Gudermann T, Teerds KJ, Greschniok A, Nieschlag E & Seif FJ 2002 Homozygous mutation within the conserved Ala-Phe-Asn-Glu-Thr motif of exon 7 of the LH receptor causes male pseudohermaphroditism. European Journal of Endocrinology 147 597–608. (doi:10.1530/eje.0.1470597)
-
(2002)
European Journal of Endocrinology
, vol.147
, pp. 597-608
-
-
Gromoll, J.1
Schulz, A.2
Borta, H.3
Gudermann, T.4
Teerds, K.J.5
Greschniok, A.6
Nieschlag, E.7
Seif, F.J.8
-
28
-
-
0028805384
-
Expression of human thyrotropin in cell lines with different glycosylation patterns combined with mutagenesis of specific glycosylation sites. Characterization of a novel role for the oligosaccharides in the in vitro and in vivo bioactivity
-
Grossmann M, Szkudlinski MW, Tropea JE, Bishop LA, Thotakura NR, Schofield PR & Weintraub BD 1995 Expression of human thyrotropin in cell lines with different glycosylation patterns combined with mutagenesis of specific glycosylation sites. Characterization of a novel role for the oligosaccharides in the in vitro and in vivo bioactivity. Journal of Biological Chemistry 270 29378–29385. (doi:10.1074/jbc.270.49.29378)
-
(1995)
Journal of Biological Chemistry
, vol.270
, pp. 29378-29385
-
-
Grossmann, M.1
Szkudlinski, M.W.2
Tropea, J.E.3
Bishop, L.A.4
Thotakura, N.R.5
Schofield, P.R.6
Weintraub, B.D.7
-
29
-
-
0030852648
-
Novel insights into the molecular mechanisms of human thyrotropin action: Structural, and therapeutic implications for the glycoprotein hormone family
-
Grossmann M, Weintraub BD & Szkudlinski MW 1997 Novel insights into the molecular mechanisms of human thyrotropin action: structural, and therapeutic implications for the glycoprotein hormone family. Endocrine Reviews 18 476–501. (doi:10.1210/ edrv.18.4.0305)
-
(1997)
Endocrine Reviews
, vol.18
, pp. 476-501
-
-
Grossmann, M.1
Weintraub, B.D.2
Szkudlinski, M.W.3
-
31
-
-
0031772403
-
Severe congenital hyperthyroidism caused by a germ-line neo mutation in the extracellular portion of the thyrotropin receptor
-
Gruters A, Schoneberg T, Biebermann H, Krude H, Krohn HP, Dralle H & Gudermann T 1998 Severe congenital hyperthyroidism caused by a germ-line neo mutation in the extracellular portion of the thyrotropin receptor. Journal of Clinical Endocrinology and Metabolism 83 1431–1436. (doi:10.1210/jc.83.5.1431)
-
(1998)
Journal of Clinical Endocrinology and Metabolism
, vol.83
, pp. 1431-1436
-
-
Gruters, A.1
Schoneberg, T.2
Biebermann, H.3
Krude, H.4
Krohn, H.P.5
Dralle, H.6
Gudermann, T.7
-
32
-
-
0034464024
-
The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): Identification of LGR6 and LGR7 and the signaling mechanism for LGR7
-
Hsu SY, Kudo M, Chen T, Nakabayashi K, Bhalla A, van der Spek PJ, van Duin M & Hsueh AJ 2000 The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. Molecular Endocrinology 14 1257–1271. (doi:10.1210/mend.14.8.0510)
-
(2000)
Molecular Endocrinology
, vol.14
, pp. 1257-1271
-
-
Hsu, S.Y.1
Kudo, M.2
Chen, T.3
Nakabayashi, K.4
Bhalla, A.5
Van Der Spek, P.J.6
Van Duin, M.7
Hsueh, A.J.8
-
33
-
-
84864502784
-
Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor
-
Jiang X, Liu H, Chen X, Chen PH, Fischer D, Sriraman V, Yu HN, Arkinstall S & He X 2012 Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor. PNAS 109 12491–12496. (doi:10.1073/pnas.1206643109)
-
(2012)
PNAS
, vol.109
, pp. 12491-12496
-
-
Jiang, X.1
Liu, H.2
Chen, X.3
Chen, P.H.4
Fischer, D.5
Sriraman, V.6
Yu, H.N.7
Arkinstall, S.8
He, X.9
-
34
-
-
84888287689
-
Structural biology of glycoprotein hormones and their receptors: Insights to signaling
-
Jiang X, Dias JA & He X 2014 Structural biology of glycoprotein hormones and their receptors: Insights to signaling. Molecular and Cellular Endocrinology 382 424–451. (doi:10.1016/j.mce.2013.08.021)
-
(2014)
Molecular and Cellular Endocrinology
, vol.382
, pp. 424-451
-
-
Jiang, X.1
Dias, J.A.2
He, X.3
-
35
-
-
84922896573
-
Single molecule analysis of functionally asymmetric G protein-coupled receptor (GPCR) oligomers reveals diverse spatial and structural assemblies
-
Jonas KC, Fanelli F, Huhtaniemi IT & Hanyaloglu AC 2015 Single molecule analysis of functionally asymmetric G protein-coupled receptor (GPCR) oligomers reveals diverse spatial and structural assemblies. Journal of Biological Chemistry 290 3875–3892. (doi:10.1074/jbc.M114.622498)
-
(2015)
Journal of Biological Chemistry
, vol.290
, pp. 3875-3892
-
-
Jonas, K.C.1
Fanelli, F.2
Huhtaniemi, I.T.3
Hanyaloglu, A.C.4
-
36
-
-
10944228424
-
Identification of a novel epitope in the thyroidstimulating hormone receptor ectodomain acting as intramolecular signaling interface
-
Kleinau G, Jäschke H, Neumann S, Lättig J, Paschke R & Krause G 2004 Identification of a novel epitope in the thyroidstimulating hormone receptor ectodomain acting as intramolecular signaling interface. Journal of Biological Chemistry 279 51590–51600. (doi:10.1074/jbc. M404748200)
-
(2004)
Journal of Biological Chemistry
, vol.279
, pp. 51590-51600
-
-
Kleinau, G.1
Jäschke, H.2
Neumann, S.3
Lättig, J.4
Paschke, R.5
Krause, G.6
-
37
-
-
0021891884
-
Assembly of asparagine-linked oligosaccharides
-
Kornfeld R & Kornfeld S 1985 Assembly of asparagine-linked oligosaccharides. Annual Review of Biochemistry 54 631–664. (doi:10.1146/annurev.bi.54.070185.003215)
-
(1985)
Annual Review of Biochemistry
, vol.54
, pp. 631-664
-
-
Kornfeld, R.1
Kornfeld, S.2
-
38
-
-
0026002412
-
Site-directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors. Relationship of functional and immunogenic domains
-
Kosugi S, Ban T, Akamizu T & Kohn LD 1991a Site-directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors. Relationship of functional and immunogenic domains. Journal of Biological Chemistry 266 19413–19418.
-
(1991)
Journal of Biological Chemistry
, vol.266
, pp. 19413-19418
-
-
Kosugi, S.1
Ban, T.2
Akamizu, T.3
Kohn, L.D.4
-
39
-
-
0025721846
-
Further characterization of a high affinity thyrotropin binding site on the rat thyrotropin receptor which is an epitope for blocking antibodies from idiopathic myxedema patients but not thyroid stimulating antibodies from Graves’ patients
-
Kosugi S, Ban T, Akamizu T & Kohn LD 1991b Further characterization of a high affinity thyrotropin binding site on the rat thyrotropin receptor which is an epitope for blocking antibodies from idiopathic myxedema patients but not thyroid stimulating antibodies from Graves’ patients. Biochemical and Biophysical Research Communications 180 1118–1124. (doi:10.1016/S0006-291X(05)81182-9)
-
(1991)
Biochemical and Biophysical Research Communications
, vol.180
, pp. 1118-1124
-
-
Kosugi, S.1
Ban, T.2
Akamizu, T.3
Kohn, L.D.4
-
40
-
-
0027532027
-
Identification of thyroid-stimulating antibody-specific interaction sites in the N-terminal region of the thyrotropin receptor
-
Kosugi S, Ban T & Kohn LD 1993 Identification of thyroid-stimulating antibody-specific interaction sites in the N-terminal region of the thyrotropin receptor. Molecular Endocrinology 7 114–130. (doi:10.1210/mend.7.1.8095322)
-
(1993)
Molecular Endocrinology
, vol.7
, pp. 114-130
-
-
Kosugi, S.1
Ban, T.2
Kohn, L.D.3
-
41
-
-
84871648298
-
Extended and structurally supported insights into extracellular hormone binding, signal transduction and organization of the thyrotropin receptor
-
Krause G, Kreuchwig A & Kleinau G 2012 Extended and structurally supported insights into extracellular hormone binding, signal transduction and organization of the thyrotropin receptor. PLoS ONE 7 e52920. (doi:10.1371/journal.pone.0052920)
-
(2012)
Plos ONE
, vol.7
-
-
Krause, G.1
Kreuchwig, A.2
Kleinau, G.3
-
42
-
-
0028239813
-
Crystal structure of human chorionic gonadotropin
-
Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FL & Isaacs NW 1994 Crystal structure of human chorionic gonadotropin. Nature 369 455–461. (doi:10.1038/369455a0)
-
(1994)
Nature
, vol.369
, pp. 455-461
-
-
Lapthorn, A.J.1
Harris, D.C.2
Littlejohn, A.3
Lustbader, J.W.4
Canfield, R.E.5
Machin, K.J.6
Morgan, F.L.7
Isaacs, N.W.8
-
43
-
-
0035976910
-
Oligomerization of the human thyrotropin receptor: Fluorescent protein-tagged hTSHR reveals post-translational complexes
-
Latif R, Graves P & Davies TF 2001 Oligomerization of the human thyrotropin receptor: fluorescent protein-tagged hTSHR reveals post-translational complexes. Journal of Biological Chemistry 276 45217–45224. (doi:10.1074/jbc.M103727200)
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 45217-45224
-
-
Latif, R.1
Graves, P.2
Davies, T.F.3
-
44
-
-
77949700065
-
A tyrosine residue on the TSH receptor stabilizes multimer formation
-
Latif R, Michalek K, Morshed SA & Davies TF 2010 A tyrosine residue on the TSH receptor stabilizes multimer formation. PLoS ONE 5 e9449. (doi:10.1371/journal.pone.0009449)
-
(2010)
Plos ONE
, vol.5
-
-
Latif, R.1
Michalek, K.2
Morshed, S.A.3
Davies, T.F.4
-
45
-
-
84921671292
-
Transmembrane domains of attraction on the TSH receptor
-
Latif R, Ali MR, Mezei M & Davies TF 2014 Transmembrane domains of attraction on the TSH receptor. Endocrinology 156 488–498. (doi:10.1210/en.2014-1509)
-
(2014)
Endocrinology
, vol.156
, pp. 488-498
-
-
Latif, R.1
Ali, M.R.2
Mezei, M.3
Davies, T.F.4
-
46
-
-
0027251256
-
A structural superfamily of growth factors containing a cystine knot motif
-
McDonald NQ & Hendrickson WA 1993 A structural superfamily of growth factors containing a cystine knot motif. Cell 73 421–424. (doi:10.1016/0092-8674(93)90127-C)
-
(1993)
Cell
, vol.73
, pp. 421-424
-
-
McDonald, N.Q.1
Hendrickson, W.A.2
-
47
-
-
85003126219
-
The bioassay of thyrotropin in serum
-
McKenzie JM 1958 The bioassay of thyrotropin in serum. Endocrinology 63 372–382. (doi:10.1210/endo-63-3-372)
-
(1958)
Endocrinology
, vol.63
, pp. 372-382
-
-
McKenzie, J.M.1
-
48
-
-
84906306629
-
Protective hinge in insulin opens to enable its receptor engagement
-
Menting JG, Yang Y, Chan SJ, Phillips NB, Smith BJ, Whittaker J, Wickramasinghe NP, Whittaker LJ, Pandyarajan V, Wan ZL, et al. 2014 Protective hinge in insulin opens to enable its receptor engagement. PNAS 111 E3395–E3404. (doi:10.1073/ pnas.1412897111)
-
(2014)
PNAS
, vol.111
, pp. E3395-E3404
-
-
Menting, J.G.1
Yang, Y.2
Chan, S.J.3
Phillips, N.B.4
Smith, B.J.5
Whittaker, J.6
Wickramasinghe, N.P.7
Whittaker, L.J.8
Pandyarajan, V.9
Wan, Z.L.10
-
49
-
-
43049109876
-
The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction
-
Mizutori Y, Chen CR, McLachlan SM & Rapoport B 2008 The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction. Molecular Endocrinology 22 1171–1182. (doi:10.1210/ me.2007-0407)
-
(2008)
Molecular Endocrinology
, vol.22
, pp. 1171-1182
-
-
Mizutori, Y.1
Chen, C.R.2
McLachlan, S.M.3
Rapoport, B.4
-
50
-
-
0016819546
-
Role of carbohydrate of human chorionic gonadotropin in the mechanism of hormone action
-
Moyle WR, Bahl OP & März L 1975 Role of carbohydrate of human chorionic gonadotropin in the mechanism of hormone action. Journal of Biological Chemistry 250 9163–9169.
-
(1975)
Journal of Biological Chemistry
, vol.250
, pp. 9163-9169
-
-
Moyle, W.R.1
Bahl, O.P.2
März, L.3
-
51
-
-
33845999291
-
Significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor
-
Mueller S, Kleinau G, Jaeschke H, Neumann S, Krause G & Paschke R 2006 Significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor. Journal of Biological Chemistry 281 31638–31646. (doi:10.1074/jbc. M604770200)
-
(2006)
Journal of Biological Chemistry
, vol.281
, pp. 31638-31646
-
-
Mueller, S.1
Kleinau, G.2
Jaeschke, H.3
Neumann, S.4
Krause, G.5
Paschke, R.6
-
52
-
-
49649125175
-
Extended hormone binding site of the human thyroid stimulating hormone receptor: Distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation
-
Mueller S, Kleinau G, Jaeschke H, Paschke R & Krause G 2008 Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation. Journal of Biological Chemistry 283 18048–18055. (doi:10.1074/jbc.M800449200)
-
(2008)
Journal of Biological Chemistry
, vol.283
, pp. 18048-18055
-
-
Mueller, S.1
Kleinau, G.2
Jaeschke, H.3
Paschke, R.4
Krause, G.5
-
53
-
-
33645790319
-
Traditional biomolecular structure determination by NMR spectroscopy allows for major errors
-
Nabuurs SB, Spronk CA, Vuister GW & Vriend G 2006 Traditional biomolecular structure determination by NMR spectroscopy allows for major errors. PLoS Computational Biology 2 e9. (doi:10.1371/ journal.pcbi.0020009)
-
(2006)
Plos Computational Biology
, vol.2
-
-
Nabuurs, S.B.1
Spronk, C.A.2
Vuister, G.W.3
Vriend, G.4
-
54
-
-
0026568620
-
The thyrotropin receptor 25 years after its discovery: New insight after its molecular cloning
-
Nagayama Y & Rapoport B 1992 The thyrotropin receptor 25 years after its discovery: new insight after its molecular cloning. Molecular Endocrinology 6 145–156. (doi:10.1210/me.6.2.145)
-
(1992)
Molecular Endocrinology
, vol.6
, pp. 145-156
-
-
Nagayama, Y.1
Rapoport, B.2
-
55
-
-
0023804632
-
Criteria that discriminate between native proteins and incorrectly folded models
-
Novotn’y J, Rashin AA & Bruccoleri RE 1988 Criteria that discriminate between native proteins and incorrectly folded models. Proteins 4 19–30. (doi:10.1002/prot.340040105)
-
(1988)
Proteins
, vol.4
, pp. 19-30
-
-
Novotn’Y, J.1
Rashin, A.A.2
Bruccoleri, R.E.3
-
56
-
-
84866427649
-
Similarities and differences in interactions of thyroid stimulating and blocking autoantibodies with the TSH receptor
-
Núñez Miguel R, Sanders J, Sanders P, Young S, Clark J, Kabelis K, Wilmot J, Evans M, Roberts E, Hu X, et al. 2012 Similarities and differences in interactions of thyroid stimulating and blocking autoantibodies with the TSH receptor. Journal of Molecular Endocrinology 49 137–151. (doi:10.1530/jme-12-0040)
-
(2012)
Journal of Molecular Endocrinology
, vol.49
, pp. 137-151
-
-
Núñez Miguel, R.1
Sanders, J.2
Sanders, P.3
Young, S.4
Clark, J.5
Kabelis, K.6
Wilmot, J.7
Evans, M.8
Roberts, E.9
Hu, X.10
-
58
-
-
0029895627
-
Critical relationship between autoantibody recognition and thyrotropin receptor maturation as reflected in the acquisition of complex carbohydrate
-
Rapoport B, McLachlan SM, Kakinuma A & Chazenbalk GD 1996 Critical relationship between autoantibody recognition and thyrotropin receptor maturation as reflected in the acquisition of complex carbohydrate. Journal of Clinical Endocrinology and Metabolism 81 2525–2533. (doi:10.1210/jc.81.7.2525)
-
(1996)
Journal of Clinical Endocrinology and Metabolism
, vol.81
, pp. 2525-2533
-
-
Rapoport, B.1
McLachlan, S.M.2
Kakinuma, A.3
Chazenbalk, G.D.4
-
59
-
-
43249098905
-
B receptor extracellular domain revealed by glycan wedge scanning
-
B receptor extracellular domain revealed by glycan wedge scanning. EMBO Journal 27 1321–1332. (doi:10.1038/ emboj.2008.64)
-
(2008)
EMBO Journal
, vol.27
, pp. 1321-1332
-
-
Rondard, P.1
Huang, S.2
Monnier, C.3
Tu, H.4
Blanchard, B.5
Oueslati, N.6
Malhaire, F.7
Li, Y.8
Trinquet, E.9
Labesse, G.10
-
60
-
-
0027136282
-
Comparative protein modelling by satisfaction of spatial restraints
-
Sali A & Blundell TL 1993 Comparative protein modelling by satisfaction of spatial restraints. Journal of Molecular Biology 234 779–815. (doi:10.1006/jmbi.1993.1626)
-
(1993)
Journal of Molecular Biology
, vol.234
, pp. 779-815
-
-
Sali, A.1
Blundell, T.L.2
-
61
-
-
33846156211
-
Effects of TSH receptor mutations on binding and biological activity of monoclonal antibodies and TSH
-
Sanders J, Bolton J, Sanders P, Jeffreys J, Nakatake N, Richards T, Evans M, Kiddie A, Summerhayes S, Roberts E, et al. 2006 Effects of TSH receptor mutations on binding and biological activity of monoclonal antibodies and TSH. Thyroid 16 1195–1206. (doi:10.1089/thy.2006.16.1195)
-
(2006)
Thyroid
, vol.16
, pp. 1195-1206
-
-
Sanders, J.1
Bolton, J.2
Sanders, P.3
Jeffreys, J.4
Nakatake, N.5
Richards, T.6
Evans, M.7
Kiddie, A.8
Summerhayes, S.9
Roberts, E.10
-
62
-
-
34249941108
-
Crystal structure of the TSH receptor in complex with a thyroid stimulating autoantibody
-
Sanders J, Chirgadze DY, Sanders P, Baker S, Sullivan A, Bhardwaja A, Bolton J, Reeve M, Nakatake N, Evans M, et al. 2007 Crystal structure of the TSH receptor in complex with a thyroid stimulating autoantibody. Thyroid 17 395–410. (doi:10.1089/thy.2007.0034)
-
(2007)
Thyroid
, vol.17
, pp. 395-410
-
-
Sanders, J.1
Chirgadze, D.Y.2
Sanders, P.3
Baker, S.4
Sullivan, A.5
Bhardwaja, A.6
Bolton, J.7
Reeve, M.8
Nakatake, N.9
Evans, M.10
-
63
-
-
79953675359
-
Crystal structure of the TSH receptor (TSHR) bound to a blocking-type TSHR autoantibody
-
Sanders P, Young S, Sanders J, Kabelis K, Baker S, Sullivan A, Evans M, Clark J, Wilmot J, Hu X, et al. 2011 Crystal structure of the TSH receptor (TSHR) bound to a blocking-type TSHR autoantibody. Journal of Molecular Endocrinology 46 81–99. (doi:10.1530/jme-10-0127)
-
(2011)
Journal of Molecular Endocrinology
, vol.46
, pp. 81-99
-
-
Sanders, P.1
Young, S.2
Sanders, J.3
Kabelis, K.4
Baker, S.5
Sullivan, A.6
Evans, M.7
Clark, J.8
Wilmot, J.9
Hu, X.10
-
64
-
-
84908577894
-
Influence of the hinge region and its adjacent domains on binding and signaling patterns of the thyrotropin and follitropin receptor
-
Schaarschmidt J, Huth S, Meier R, Paschke R & Jaeschke H 2014 Influence of the hinge region and its adjacent domains on binding and signaling patterns of the thyrotropin and follitropin receptor. PLoS ONE 9 e111570. (doi:10.1371/journal.pone.0111570)
-
(2014)
Plos ONE
, vol.9
-
-
Schaarschmidt, J.1
Huth, S.2
Meier, R.3
Paschke, R.4
Jaeschke, H.5
-
65
-
-
0027158153
-
The lutropin/choriogonadotropin receptor.. 4 years later
-
Segaloff DL & Ascoli M 1993 The lutropin/choriogonadotropin receptor.. 4 years later. Endocrine Reviews 14 324–347. (doi:10.1210/er.14.3.324)
-
(1993)
Endocrine Reviews
, vol.14
, pp. 324-347
-
-
Segaloff, D.L.1
Ascoli, M.2
-
66
-
-
84947058289
-
New frontier in glycoprotein hormones and their receptors structure-function
-
Szkudlinski MW 2015 New frontier in glycoprotein hormones and their receptors structure-function. Frontiers in Endocrinology 6 155. (doi:10.3389/fendo.2015.00155)
-
(2015)
Frontiers in Endocrinology
, vol.6
, pp. 155
-
-
Szkudlinski, M.W.1
-
67
-
-
0029785186
-
Engineering human glycoprotein hormone superactive analogues
-
Szkudlinski MW, Teh NG, Grossmann M, Tropea JE & Weintraub BD 1996 Engineering human glycoprotein hormone superactive analogues. Nature Biotechnology 14 1257–1263. (doi:10.1038/nbt1096-1257)
-
(1996)
Nature Biotechnology
, vol.14
, pp. 1257-1263
-
-
Szkudlinski, M.W.1
Teh, N.G.2
Grossmann, M.3
Tropea, J.E.4
Weintraub, B.D.5
-
68
-
-
0031916727
-
Thyrotropin receptor cleavage at site 1 does not involve a specific amino acid motif but instead depends on the presence of the unique, 50 amino acid insertion
-
Tanaka K, Chazenbalk GD, McLachlan SM & Rapoport B 1998 Thyrotropin receptor cleavage at site 1 does not involve a specific amino acid motif but instead depends on the presence of the unique, 50 amino acid insertion. Journal of Biological Chemistry 273 1959–1963. (doi:10.1074/jbc.273.4.1959)
-
(1998)
Journal of Biological Chemistry
, vol.273
, pp. 1959-1963
-
-
Tanaka, K.1
Chazenbalk, G.D.2
McLachlan, S.M.3
Rapoport, B.4
-
69
-
-
84911453369
-
Quantitative method for the assignment of hinge and shear mechanism in protein domain movements
-
Taylor D, Cawley G & Hayward S 2014 Quantitative method for the assignment of hinge and shear mechanism in protein domain movements. Bioinformatics 30 3189–3196. (doi:10.1093/ bioinformatics/btu506)
-
(2014)
Bioinformatics
, vol.30
, pp. 3189-3196
-
-
Taylor, D.1
Cawley, G.2
Hayward, S.3
-
70
-
-
0027968068
-
CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
-
Thompson JD, Higgins DG & Gibson TJ 1994 CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Research 22 4673–4680. (doi:10.1093/ nar/22.22.4673)
-
(1994)
Nucleic Acids Research
, vol.22
, pp. 4673-4680
-
-
Thompson, J.D.1
Higgins, D.G.2
Gibson, T.J.3
-
71
-
-
21244460359
-
Glycoprotein hormone receptors: Link between receptor homodimerization and negative cooperativity
-
Urizar E, Montanelli L, Loy T, Bonomi M, Swillens S, Gales C, Bouvier M, Smits G, Vassart G & Costagliola S 2005 Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity. EMBO Journal 24 1954–1964. (doi:10.1038/ sj.emboj.7600686)
-
(2005)
EMBO Journal
, vol.24
, pp. 1954-1964
-
-
Urizar, E.1
Montanelli, L.2
Loy, T.3
Bonomi, M.4
Swillens, S.5
Gales, C.6
Bouvier, M.7
Smits, G.8
Vassart, G.9
Costagliola, S.10
-
72
-
-
0036304963
-
A new crystal form of the NK1 splice variant of HGF/SF demonstrates extensive hinge movement and suggests that the NK1 dimer originates by domain swapping
-
Watanabe K, Chirgadze DY, Lietha D, de Jonge H, Blundell TL & Gherardi E 2002 A new crystal form of the NK1 splice variant of HGF/SF demonstrates extensive hinge movement and suggests that the NK1 dimer originates by domain swapping. Journal of Molecular Biology 319 283–288. (doi:10.1016/S0022-2836(02)00199-7)
-
(2002)
Journal of Molecular Biology
, vol.319
, pp. 283-288
-
-
Watanabe, K.1
Chirgadze, D.Y.2
Lietha, D.3
De Jonge, H.4
Blundell, T.L.5
Gherardi, E.6
-
73
-
-
0032799753
-
Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: Its occurrence and role
-
Wheatley M & Hawtin SR 1999 Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: its occurrence and role. Human Reproduction Update 5 356–364. (doi:10.1093/humupd/5.4.356)
-
(1999)
Human Reproduction Update
, vol.5
, pp. 356-364
-
-
Wheatley, M.1
Hawtin, S.R.2
-
74
-
-
0025976986
-
NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin
-
Weisshaar G, Hiyama J, Renwick AGC & Nimtz M 1991 NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin. European Journal of Biochemistry 195 257–268. (doi:10.1111/j.1432-1033.1991. tb15702.x)
-
(1991)
European Journal of Biochemistry
, vol.195
, pp. 257-268
-
-
Weisshaar, G.1
Hiyama, J.2
Renwick, A.G.C.3
Nimtz, M.4
-
75
-
-
0028773646
-
Structure of human chorionic gonadotropin at 2.6 angstroms resolution from MAD analysis of the selenomethionyl protein
-
Wu H, Lustbader JW, Liu Y, Canfield RE & Hendrickson WA 1994 Structure of human chorionic gonadotropin at 2.6 angstroms resolution from MAD analysis of the selenomethionyl protein. Structure 2 545–558. (doi:10.1016/S0969-2126(00)00054-X)
-
(1994)
Structure
, vol.2
, pp. 545-558
-
-
Wu, H.1
Lustbader, J.W.2
Liu, Y.3
Canfield, R.E.4
Hendrickson, W.A.5
|