Hypo-glycosylated human follicle-stimulating hormone (hFSH21/18) is much more active in vitro than fully-glycosylated hFSH (hFSH24)

Molecular and Cellular Endocrinology

Volumn 382, Issue 2, 2014, Pages 989-997

  Bousfield, George R ^a   Butnev, Vladimir Y ^a   Butnev, Viktor Y ^a   Hiromasa, Yasuaki ^b   Harvey, David J ^c   May, Jeffrey V ^a  

^a WICHITA STATE UNIVERSITY   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

FSH isoforms; FSHR; Oligosaccharide

Indexed keywords

CHORIONIC GONADOTROPIN ALPHA SUBUNIT; FOLLITROPIN; FOLLITROPIN RECEPTOR; FULLY GLYCOSYLATED HUMAN FOLLICLE STIMULATING HORMONE 24; GLYCAN; HETERODIMER; HYPOGLYCOSYLATED HUMAN FOLLICLE STIMULATING HORMONE 21/18; LUTEINIZING HORMONE; MANNOSE OLIGOSACCHARIDE; TRACER; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING COMPETITION; BINDING SITE; CONTROLLED STUDY; DRUG ACTIVITY; GEL FILTRATION; GLYCOSYLATION; HORMONE ACTION; HORMONE BINDING; IMMUNOAFFINITY CHROMATOGRAPHY; IN VITRO STUDY; INCUBATION TIME; LIGAND BINDING; PRIORITY JOURNAL; RADIOASSAY;

FSH ISOFORMS; FSHR; OLIGOSACCHARIDE;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, GEL; FOLLICLE STIMULATING HORMONE, HUMAN; GLYCOPROTEIN HORMONES, ALPHA SUBUNIT; GLYCOSYLATION; HUMANS; IODINE RADIOISOTOPES; LUTEINIZING HORMONE; MANNOSE; PROTEIN BINDING; PROTEIN MULTIMERIZATION; RADIOLIGAND ASSAY; RATS; RECEPTORS, FSH; SEQUENCE ANALYSIS, PROTEIN;

EID: 84890612296     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2013.11.008     Document Type: Article

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