Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells

Oncology Reports

Volumn 37, Issue 2, 2017, Pages 1132-1140

  Bo, Wang ^a,b   Zhao, Xin Huai ^a  

^a NORTHEAST AGRICULTURAL UNIVERSITY   (China)

^b HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Apigenin; Apoptotic mechanism; Cytotoxic effect; Endoplasmic reticulum stress; Human colon carcinoma cells; Reactive oxygen species

Indexed keywords

APIGENIN; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DEATH RECEPTOR 5; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROTEIN BID; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC AGENT; CALCIUM; DDIT3 PROTEIN, HUMAN; MATRIX METALLOPROTEINASE; TNFRSF10B PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL VIABILITY; COLON CARCINOMA; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; HCT 116 CELL LINE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MORPHOLOGY; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; CELL CYCLE CHECKPOINT; DOSE RESPONSE; DRUG EFFECTS; GENETICS; METABOLISM; PHYSIOLOGY;

ANTINEOPLASTIC AGENTS; APIGENIN; APOPTOSIS; CALCIUM; CELL CYCLE CHECKPOINTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM STRESS; HCT116 CELLS; HUMANS; MATRIX METALLOPROTEINASES; MEMBRANE POTENTIAL, MITOCHONDRIAL; REACTIVE OXYGEN SPECIES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION FACTOR CHOP;

EID: 85011881638     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2016.5303     Document Type: Article

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