Hesperidin from Citrus seed induces human hepatocellular carcinoma HepG2 cell apoptosis via both mitochondrial and death receptor pathways

Tumor Biology

Volumn 37, Issue 1, 2016, Pages 227-237

  Banjerdpongchai, Ratana ^a   Wudtiwai, Benjawan ^a   Khaw on, Patompong ^a   Rachakhom, Wasitta ^a   Duangnil, Natthachai ^a   Kongtawelert, Prachya ^a  

^a Faculty of Medicine Chiang Mai University   (Thailand)

Author keywords

Apoptosis; Cancer; Citrus seeds; Flavonoids; HepG2 cells; Hesperidin

Indexed keywords

3,3' DIHEXYLOXACARBOCYANINE; AURANTIIN; BIOFLAVONOID; CASPASE 3; CASPASE 8; CASPASE 9; DEATH RECEPTOR; FLAVONOID; HESPERIDIN; HISTONE DEACETYLASE; NARINGENIN; NEOHESPERIDIN; PHOSPHATIDYLSERINE; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL XL; PROTEIN BID; REACTIVE OXYGEN METABOLITE; BAK1 PROTEIN, HUMAN; BAX PROTEIN, HUMAN; BCL2L1 PROTEIN, HUMAN; CASP3 PROTEIN, HUMAN; CASP8 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; FLAVANONE DERIVATIVE; PROTEIN BCL X;

APOPTOSIS; ARTICLE; CELL MEMBRANE; CITRUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; FLOW RATE; G2 PHASE CELL CYCLE CHECKPOINT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC50; LIVER CANCER CELL LINE; LIVER CELL CARCINOMA; M PHASE CELL CYCLE CHECKPOINT; MITOCHONDRIAL MEMBRANE POTENTIAL; PHYTOCHEMISTRY; PLANT SEED; PRIORITY JOURNAL; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; HEP-G2 CELL LINE; LIVER TUMOR; METABOLISM; MITOCHONDRION; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CASPASE 8; CASPASE 9; CELL LINE, TUMOR; CITRUS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVANONES; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HESPERIDIN; HUMANS; INHIBITORY CONCENTRATION 50; LIVER NEOPLASMS; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; RECEPTORS, DEATH DOMAIN;

EID: 84937622393     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-015-3774-7     Document Type: Article

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