Blood lactate functions as a signal for enhancing fatty acid metabolism during exercise via TGF-β in the brain

Journal of Nutritional Science and Vitaminology

Volumn 58, Issue 2, 2012, Pages 88-95

  Yamada, Hiroyuki ^a   Iwaki, Yoko ^a   Kitaoka, Ryo ^a   Fujitani, Mina ^a   Shibakusa, Tetsuro ^a   Fujikawa, Teppei ^a   Matsumura, Shigenobu ^a   Fushiki, Tohru ^a   Inoue, Kazuo ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Exercise; Lactate; Respiratory gas analysis; Spontaneous motor activity; TGF

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ARTICLE; BRAIN METABOLISM; CONTROLLED STUDY; ENERGY METABOLISM; EXERCISE; EXERCISE INTENSITY; FATTY ACID METABOLISM; FATTY ACID OXIDATION; LACTATE BLOOD LEVEL; LUNG GAS EXCHANGE; MALE; MOTOR ACTIVITY; NONHUMAN; PROTEIN CEREBROSPINAL FLUID LEVEL; RAT; RESPIRATORY EXCHANGE RATIO; RUNNING; SIGNAL TRANSDUCTION; SPONTANEOUS MOTOR ACTIVITY; TREADMILL EXERCISE;

ANIMALS; BRAIN; ENERGY METABOLISM; FATTY ACIDS; LACTIC ACID; MALE; PHYSICAL EXERTION; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

RATTUS;

EID: 84863809186     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.58.88     Document Type: Article

References (29)

1. Wyss MT, Jolivet R, Buck A, Magistretti PJ, Weber B. 2011. In vivo evidence for lactate as a neuronal energy source. J Neurosci 31: 7477-7485.
2. Bergersen LH. 2007. Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle. Neuroscience 145: 11-19.
3. Song Z, Routh VH. 2005. Differential effects of glucose and lactate on glucosensing neurons in the ventromedial hypothalamic nucleus. Diabetes 54: 15-22.
4. Patil GD, Briski KP. 2005. Lactate is a critical "sensed" variable in caudal hindbrain monitoring of CNS metabolic stasis. Am J Physiol Regul Integr Comp Physiol 289: R1777-1786.
5. Patil GD, Briski KP. 2005. Transcriptional activation of nucleus tractus solitarii/area postrema catecholaminergic neurons by pharmacological inhibition of caudal hindbrain monocarboxylate transporter function. Neuroendocrinology 81: 96-102.
6. Inoue K, Yamasaki S, Fushiki T, Kano T, Moritani T, Itoh K, Sugimoto E. 1993. Rapid increase in the number of androgen receptors following electrical stimulation of the rat muscle. Eur J Appl Physiol 66: 134-140.
7. Shibakusa T, Mizunoya W, Okabe Y, Matsumura S, Iwaki Y, Okuno A, Shibata K, Inoue K, Fushiki T. 2007. Transforming growth factor-beta in the brain is activated by exercise and increases mobilization of fat-related energy substrates in rats. Am J Physiol Regul Integr Comp Physiol 292: R1851-1861.
8. Inoue K, Yamazaki H, Manabe Y, Fukuda C, Hanai K, Fushiki T. 1999. Transforming growth factor-beta activated during exercise in brain depresses spontaneous motor activity of animals. Relevance to central fatigue. Brain Res 846: 145-153.
9. Yamazaki H, Arai M, Matsumura S, Inoue K, Fushiki T. 2002. Intracranial administration of transforming growth factor-beta 3 (TGF-_3) increases fat oxidation in rats. Am J Physiol Endocrinol Metab 283: E536-544.
10. Bouman HJ, van Wimersma Greidanus TB. 1979. A rapid and simple cannulation technique for repeated sampling of cerebrospinal fluid in freely moving rats. Brain Res Bull 4: 575-577.
11. Abe M, Harpel JG, Metz CN, Nunes I, Loskutoff DJ, Rifkin DB. 1994. An assay for transforming growth factor-using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal Biochem 216: 276-284.
12. Ishikawa T, Mizunoya W, Shibakusa T, Inoue K, Fushiki T. 2006. Transforming growth factor-beta in the brain regulates fat metabolism during endurance exercise. Am J Physiol Endocrinol Metab 291: E1151-1159.
13. Lombardi AM, Fabris R, Bassetto F, Serra R, Leturque A, Federspil G, Girard J, Vettor R. 1999. Hyperlactatemia reduces muscle glucose uptake and GLUT-4 mRNA while increasing (E1alpha)PDH gene expression in rat. Am J Physiol 276: E922-929.
14. Miller BF, Fattor JA, Jacobs KA, Horning MA, Suh SH, Navazio F, Brooks GA. 2002. Metabolic and cardiorespiratory responses to "the lactate clamp." Am J Physiol Endocrinol Metab 283: E889-898.
15. Fattor JA, Miller BF, Jacobs KA, Brooks GA. 2005. Catecholamine response is attenuated during moderateintensity exercise in response to the "lactate clamp." Am J Physiol Endocrinol Metab 288: E143-147.
16. Himmi T, Perrin J, Dallaporta M, Orsini JC. 2001. Effects of lactate on glucose-sensing neurons in the solitary tract nucleus. Physiol Behav 74: 391-397.
17. Borg MA, Tamborlane WV, Shulman GI, Sherwin RS. 2003. Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic counterregulation. Diabetes 52: 663-666.
18. Matveyenko AV, Donovan CM. 2006. Metabolic sensors mediate hypoglycemic detection at the portal vein. Diabetes 55: 1276-1282.
19. Fujikawa T, Matsumura S, Yamada H, Inoue K, Fushiki T. 2007. Transforming growth factor-beta in the brain enhances fat oxidation via noradrenergic neurons in the ventromedial and paraventricular hypothalamic nucleus. Brain Res 1173: 92-101.
20. Fujikawa T, Fujita R, Iwaki Y, Matsumura S, Fushiki T, Inoue K. 2010. Inhibition of fatty acid oxidation activates transforming growth factor-beta in cerebrospinal fluid and decreases spontaneous motor activity. Physiol Behav 101: 370-375.
21. Kitaoka R, Fujikawa T, Miyaki T, Matsumura S, Fushiki T, Inoue K. 2010. Increased noradrenergic activity in the ventromedial hypothalamus during treadmill running in rats. J Nutr Sci Vitaminol 56: 185-190.
22. Brooks GA. 1998. Mammalian fuel utilization during sustained exercise. Comp Biochem Physiol Part B 120: 89-107.
23. Jeukendrup AE. 2002. Regulation of fat metabolism in skeletal muscle. Ann NY Acad Sci 967: 217-235.
24. Brooks GA, Brauner KE, Cassens RG. 1973. Glycogen synthesis and metabolism of lactic acid after exercise. Am J Physiol 224: 1162-1166.
25. McMaster WC, Stoddard T, Duncan W. 1989 Enhancement of blood lactate clearance following maximal swimming. Effect of velocity of recovery swimming. Am J Sports Med 17: 472-477.
26. Koli K, Saharinen J, Hyytiainen M, Penttinen C, Keski-Oja J. 2001. Latency, activation, and binding proteins of TGF-beta. Microsc Res Tech 52: 354-362.
27. Annes JP, Munger JS, Rifkin DB. 2003. Making sense of latent TGF-beta activation. J Cell Sci 116: 217-224.
28. Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, Springer TA. 2011. Latent TGF-beta structure and activation. Nature 474: 343-349.
29. Arai M, Yamazaki H, Inoue K, Fushiki T. 2002. Effects of intracranial injection of transforming growth factorbeta relevant to central fatigue on the waking electroencephalogram of rats. Comparison with effects of exercise. Prog Neuro-Psychopharmacol Biol Psychiatry 26: 307-312.