Blood brain barrier breakdown was found in non-infarcted area after 2-h MCAO

Journal of the Neurological Sciences

Volumn 363, Issue , 2016, Pages 63-68

  Wang, Xiaona ^a   Liu, Yushan ^a   Sun, Yanyun ^a   Liu, Wenlan ^b   Jin, Xinchun ^a  

^a THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b SHENZHEN UNIVERSITY   (China)

Author keywords

Blood brain barrier; Cerebral ischemia; Injury; MMP 2; Tight junction protein

Indexed keywords

CLAUDIN 5; EVANS BLUE; ILOMASTAT; IMMUNOGLOBULIN G; OCCLUDIN; TRIPHENYLTETRAZOLIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN INFARCTION; BRAIN SLICE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORPUS STRIATUM; HEMISPHERE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; REPERFUSION INJURY; STAINING; TISSUE INJURY; ANIMAL; BRAIN; BRAIN ISCHEMIA; CEREBRAL ARTERY DISEASE; DRUG EFFECT; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; TIME FACTOR;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN ISCHEMIA; EVANS BLUE; INFARCTION, MIDDLE CEREBRAL ARTERY; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 84961202913     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2016.02.035     Document Type: Article

References (29)

1. J.M. Simard, T.A. Kent, M. Chen, K.V. Tarasov, and V. Gerzanich Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications Lancet Neurol. 6 2007 258 268
2. S. Warach, and L.L. Latour Evidence of reperfusion injury, exacerbated by thrombolytic therapy, in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruption Stroke 35 2004 2659 2661
3. N. Hjort, O. Wu, M. Ashkanian, C. Solling, K. Mouridsen, S. Christensen, and et al. MRI detection of early blood-brain barrier disruption: parenchymal enhancement predicts focal hemorrhagic transformation after thrombolysis Stroke 39 2008 1025 1028
4. L. Sun, W. Zhou, C. Mueller, C. Sommer, S. Heiland, A.T. Bauer, and et al. Oxygen therapy reduces secondary hemorrhage after thrombolysis in thromboembolic cerebral ischemia J. Cereb. Blood Flow Metab. 30 2010 1651 1660
5. J. Hom, J.W. Dankbaar, B.P. Soares, T. Schneider, S.C. Cheng, J. Bredno, and et al. Blood-brain barrier permeability assessed by perfusion CT predicts symptomatic hemorrhagic transformation and malignant edema in acute ischemic stroke AJNR Am. J. Neuroradiol. 32 2011 41 48
6. S. Wu, R.E. Thornhill, S. Chen, W. Rammo, D.J. Mikulis, and A. Kassner Relative recirculation: A fast, model-free surrogate for the measurement of blood-brain barrier permeability and the prediction of hemorrhagic transformation in acute ischemic stroke Investig. Radiol. 44 2009 662 668
7. X. Jin, J. Liu, and W. Liu Early ischemic blood brain barrier damage: A potential indicator for hemorrhagic transformation following tissue plasminogen activator (tPA) thrombolysis? Curr. Neurovasc. Res. 11 2014 254 262
8. X. Jin, J. Liu, Y. Yang, K.J. Liu, and W. Liu Spatiotemporal evolution of blood brain barrier damage and tissue infarction within the first 3 h after ischemia onset Neurobiol. Dis. 48 2012 309 316
9. X. Jin, J. Liu, K.J. Liu, G.A. Rosenberg, Y. Yang, and W. Liu Normobaric hyperoxia combined with minocycline provides greater neuroprotection than either alone in transient focal cerebral ischemia Exp. Neurol. 240 2013 9 16
10. L.C. Schmued, C. Albertson, and W. Slikker Jr. Fluoro-Jade: A novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration Brain Res. 751 1997 37 46
11. F. Liu, D.P. Schafer, and L.D. McCullough TTC, fluoro-Jade B and NeuN staining confirm evolving phases of infarction induced by middle cerebral artery occlusion J. Neurosci. Methods 179 2009 1 8
12. J. Liu, X. Jin, K.J. Liu, and W. Liu Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage J. Neurosci. 32 2012 3044 3057
13. F.Y. Jalal, Y. Yang, J. Thompson, A.C. Lopez, and G.A. Rosenberg Myelin loss associated with neuroinflammation in hypertensive rats Stroke 43 2012 1115 1122
14. J.B. Bederson, L.H. Pitts, S.M. Germano, M.C. Nishimura, R.L. Davis, and H.M. Bartkowski Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats Stroke 17 1986 1304 1308
15. M.T. Vivaldi, R.A. Kloner, and F.J. Schoen Triphenyltetrazolium staining of irreversible ischemic injury following coronary artery occlusion in rats Am. J. Pathol. 121 1985 522 530
16. W. Liu, J. Hendren, X.J. Qin, J. Shen, and K.J. Liu Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia J. Neurochem. 108 2009 811 820
17. Y. Yang, E.Y. Estrada, J.F. Thompson, W. Liu, and G.A. Rosenberg Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat J. Cereb. Blood Flow Metab. 27 2007 697 709
18. B.W. McColl, N.J. Rothwell, and S.M. Allan Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice J. Neurosci. 28 2008 9451 9462
19. M. Lischper, S. Beuck, G. Thanabalasundaram, C. Pieper, and H.J. Galla Metalloproteinase mediated occludin cleavage in the cerebral microcapillary endothelium under pathological conditions Brain Res. 1326 2010 114 127
20. O.Y. Bang, B.H. Buck, J.L. Saver, J.R. Alger, S.R. Yoon, S. Starkman, and et al. Prediction of hemorrhagic transformation after recanalization therapy using T2∗-permeability magnetic resonance imaging Ann. Neurol. 62 2007 170 176
21. A. Kassner, T.P. Roberts, B. Moran, F.L. Silver, and D.J. Mikulis Recombinant tissue plasminogen activator increases blood-brain barrier disruption in acute ischemic stroke: An MR imaging permeability study AJNR Am. J. Neuroradiol. 30 2009 1864 1869
22. D. Dewar, S.M. Underhill, and M.P. Goldberg Oligodendrocytes and ischemic brain injury J. Cereb. Blood Flow Metab. 23 2003 263 274
23. S. Namura, J. Zhu, K. Fink, M. Endres, A. Srinivasan, K.J. Tomaselli, and et al. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia J. Neurosci. 18 1998 3659 3668
24. Y. Yang, and G.A. Rosenberg Matrix metalloproteinases as therapeutic targets for stroke Brain Res. 2015 1623 30 38
25. A.M. Romanic, R.F. White, A.J. Arleth, E.H. Ohlstein, and F.C. Barone Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size Stroke 29 1998 1020 1030
26. X. Wang, S.R. Lee, K. Arai, S.R. Lee, K. Tsuji, G.W. Rebeck, and et al. Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator Nat. Med. 9 2003 1313 1317
27. H. Kamada, F. Yu, C. Nito, and P.H. Chan Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats: relation to blood-brain barrier dysfunction Stroke 38 2007 1044 1049
28. S.J. Giebel, G. Menicucci, P.G. McGuire, and A. Das Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood-retinal barrier Lab. Investig. 85 2005 597 607
29. M. Walberer, N. Ritschel, M. Nedelmann, K. Volk, C. Mueller, M. Tschernatsch, and et al. Aggravation of infarct formation by brain swelling in a large territorial stroke: A target for neuroprotection? J. Neurosurg. 109 2008 287 293