Activation of AMP-activated protein kinase alleviates High-glucose-induced dysfunction of brain microvascular endothelial cell tight-junction dynamics

Free Radical Biology and Medicine

Volumn 53, Issue 6, 2012, Pages 1213-1221

  Liu, Chao ^a,b   Wu, Jiliang ^a   Zou, Ming Hui ^b  

^a HUBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

AMPK; Blood brain barrier; Diabetes; Free radicals; NAD(P)H oxidase; Tight junctions

Indexed keywords

ADENOVIRUS VECTOR; AMIDE; AMINO 4 IMIDAZOLE CARBOXAMIDE RIBOSIDE; APOCYNIN; CATALASE; CLAUDIN 5; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; OCCLUDIN; PROTEIN ZO1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ADENOVIRUS; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN CELL; BRAIN DYSFUNCTION; CELL DISRUPTION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; ELECTRIC RESISTANCE; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE OVEREXPRESSION; GLUCOSE BRAIN LEVEL; HUMAN; HUMAN CELL; MICROVASCULARIZATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TIGHT JUNCTION; TRANSENDOTHELIAL ELECTRICAL RESISTANCE;

ACETOPHENONES; ADENYLATE KINASE; BLOOD-BRAIN BARRIER; CATALASE; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; GENE EXPRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; HUMANS; MICROVESSELS; NADPH OXIDASE; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; SUPEROXIDES; TIGHT JUNCTIONS;

EID: 84865300131     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.07.003     Document Type: Article

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