Oblongifolin C and guttiferone K extracted from Garcinia yunnanensis fruit synergistically induce apoptosis in human colorectal cancer cells in vitro

Acta Pharmacologica Sinica

Volumn 38, Issue 2, 2017, Pages 252-263

  Li, Hui ^a,b   Meng, Xiao Xiao ^a,b   Zhang, Li ^a,b   Zhang, Bao Jun ^a,b   Liu, Xin Yu ^a,b   Fu, Wen Wei ^a,b   Tan, Hong Sheng ^a,b   Lao, Yuan Zhi ^a,b   Xu, Hong Xi ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b China State Institute of Pharmaceutical Industry   (China)

Author keywords

Apoptosis; Autophagy; Colorectal cancer; Garcinia yunnanensis Hu; Guttiferone K; HCT116 cells; JNK; Oblongifolin C; ROS

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; GARCINIA YUNNANENSIS EXTRACT; GUTTIFERONE K; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OBLONGIFOLIN C; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; BENZOPHENONE DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; TERPENE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER INHIBITION; CELL VIABILITY; COLORECTAL CANCER; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; FLOW CYTOMETRY; FRUIT; GARCINIA; GARCINIA YUNNANENSIS; HCT 116 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; ISOLATION AND PURIFICATION; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BENZOPHENONES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG SYNERGISM; FRUIT; GARCINIA; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; PLANT EXTRACTS; TERPENES;

EID: 85011710533     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2016.101     Document Type: Article

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