Guttiferone K induces autophagy and sensitizes cancer cells to nutrient stress-induced cell death

Phytomedicine

Volumn 22, Issue 10, 2015, Pages 902-910

  Wu, Man ^a,b   Lao, Yuanzhi ^a,b   Xu, Naihan ^c   Wang, Xiaoyu ^a,b   Tan, Hongsheng ^a,b   Fu, Wenwei ^a,b   Lin, Zhixiu ^d   Xu, Hongxi ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery   (China)

^c TSINGHUA UNIVERSITY   (China)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Apoptosis; Autophagy; Guttiferone K; Natural compound; Starvation

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE; GUTTIFERONE K; HYDROXYCHLOROQUINE; LIGHT CHAIN 3 II; LIPOCORTIN 5; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN; PLANT MEDICINAL PRODUCT; PROPIDIUM IODIDE; PROTEIN; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BENZOPHENONE DERIVATIVE; CULTURE MEDIUM; MAP1LC3A PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; P62 PROTEIN, HUMAN; RNA BINDING PROTEIN; TARGET OF RAPAMYCIN KINASE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DRUG EXPOSURE; DRUG INHIBITION; FEMALE; FLOW CYTOMETRY; GARCINIA; GARCINIA YUNNANENSIS; HELA CELL LINE; HUMAN; HUMAN CELL; MEDICINAL PLANT; MTT ASSAY; NUTRIENT; PRIORITY JOURNAL; PROPIDIUM IODIDE ASSAY; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAINING; STARVATION; STRESS; WESTERN BLOTTING; CHEMISTRY; CULTURE MEDIUM; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; AUTOPHAGY; BENZOPHENONES; CELL DEATH; CELL LINE, TUMOR; CULTURE MEDIA; HELA CELLS; HUMANS; HYDROXYCHLOROQUINE; MICROTUBULE-ASSOCIATED PROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84938329204     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2015.06.008     Document Type: Article

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