The metabolism and disposition of GSK2140944 in healthy human subjects

Xenobiotica

Volumn 46, Issue 8, 2016, Pages 683-702

  Negash, Kitaw ^a   Andonian, Clara ^a   Felgate, Clive ^b   Chen, Cathy ^a   Goljer, Igor ^a   Squillaci, Bianca ^b   Nguyen, Dung ^a   Pirhalla, Jill ^a   Lev, Mally ^a   Schubert, Ernest ^a   Tiffany, Courtney ^a   Hossain, Mohammad ^a   Ho, May ^a  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Excretion; GSK2140944; human absorption; metabolism; pharmacokinetics

Indexed keywords

DRUG METABOLITE; GEPOTIDACIN; ACENAPHTHENE DERIVATIVE; ANTIINFECTIVE AGENT; DNA TOPOISOMERASE INHIBITOR; FUSED HETEROCYCLIC RINGS;

ACCELERATOR MASS SPECTROMETRY; ADULT; AREA UNDER THE CURVE; ARTICLE; BACTERIAL INFECTION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG FECES LEVEL; DRUG HYDROLYSIS; DRUG HYDROXYLATION; DRUG INFUSION; DRUG METABOLISM; DRUG OXIDATION; DRUG URINE LEVEL; ELIMINATION HALF-LIFE; ELIMINATION RATE CONSTANT; FIRST PASS EFFECT; FLATULENCE; HETERONUCLEAR MULTIPLE BOND CORRELATION; HUMAN; HUMAN EXPERIMENT; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NORMAL HUMAN; OPEN STUDY; PLASMA CONCENTRATION-TIME CURVE; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VOLUME OF DISTRIBUTION AT STEADY-STATE; METABOLISM; TISSUE DISTRIBUTION; URINE;

ACENAPHTHENES; ADULT; ANTI-BACTERIAL AGENTS; HEALTHY VOLUNTEERS; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MALE; TISSUE DISTRIBUTION; TOPOISOMERASE INHIBITORS;

EID: 84964687175     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2015.1112933     Document Type: Article

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