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Volumn 59, Issue 3, 2013, Pages 153-156

Is the GAIN Act a turning point in new antibiotic discovery?

Author keywords

Antibacterial; Antibiotic; Antibiotic resistance; Drug discovery

Indexed keywords

ANTIBIOTIC AGENT;

EID: 84875657153     PISSN: 00084166     EISSN: 14803275     Source Type: Journal    
DOI: 10.1139/cjm-2013-0089     Document Type: Article
Times cited : (35)

References (35)
  • 1
    • 44149113314 scopus 로고    scopus 로고
    • Epidemiology of methicillin-resistant Staphylococcus aureus
    • doi:10.1086/ 533590
    • Boucher, H.W., and Corey, G.R. 2008. Epidemiology of methicillin-resistant Staphylococcus aureus. Clin. Infect. Dis. 46(Suppl. 5): S344-S349. doi:10.1086/ 533590.
    • (2008) Clin. Infect. Dis. , vol.46 , Issue.SUPPL. 5
    • Boucher, H.W.1    Corey, G.R.2
  • 2
    • 57749107808 scopus 로고    scopus 로고
    • Bad bugs, no drugs: No ESKAPE! An update from the Infectious Diseases Society of America
    • doi:10.1086/595011. PMID:19035777
    • Boucher, H.W., Talbot, G.H., Bradley, J.S., Edwards, J.E., Jr., Gilbert, D., Rice, L.B., et al. 2009. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin. Infect. Dis. 48(1): 1-12. doi:10.1086/595011. PMID:19035777.
    • (2009) Clin. Infect. Dis. , vol.48 , Issue.1 , pp. 1-12
    • Boucher, H.W.1    Talbot, G.H.2    Bradley, J.S.3    Edwards, J.E.4    Gilbert, D.5    Rice, L.B.6
  • 3
    • 14944375311 scopus 로고    scopus 로고
    • New targets and screening approaches in antimicrobial drug discovery
    • doi:10.1021/ cr030116o. PMID:15700964
    • Brown, E.D., and Wright, G.D. 2005. New targets and screening approaches in antimicrobial drug discovery. Chem. Rev. 105: 759-774. doi:10.1021/ cr030116o. PMID:15700964.
    • (2005) Chem. Rev. , vol.105 , pp. 759-774
    • Brown, E.D.1    Wright, G.D.2
  • 4
    • 75649111192 scopus 로고    scopus 로고
    • The genetic landscape of a cell
    • doi:10.1126/ science.1180823. PMID:20093466
    • Costanzo, M., Baryshnikova, A., Bellay, J., Kim, Y., Spear, E.D., Sevier, C.S., et al. 2010. The genetic landscape of a cell. Science, 327(5964): 425-431. doi:10.1126/ science.1180823. PMID:20093466.
    • (2010) Science , vol.327 , Issue.5964 , pp. 425-431
    • Costanzo, M.1    Baryshnikova, A.2    Bellay, J.3    Kim, Y.4    Spear, E.D.5    Sevier, C.S.6
  • 5
    • 70349330771 scopus 로고    scopus 로고
    • Are essential genes really essential?
    • doi:10.1016/j.tim.2009.08.005. PMID:19765999
    • D'Elia, M.A., Pereira, M.P., and Brown, E.D. 2009a. Are essential genes really essential? Trends Microbiol. 17: 433-438. doi:10.1016/j.tim.2009.08.005. PMID:19765999.
    • (2009) Trends Microbiol. , vol.17 , pp. 433-438
    • D'Elia, M.A.1    Pereira, M.P.2    Brown, E.D.3
  • 6
    • 65749092724 scopus 로고    scopus 로고
    • Probing teichoic acid genetics with bioactive molecules reveals new interactions among diverse processes in bacterial cell wall biogenesis
    • doi:10.1016/j.chembiol.2009.04.009. PMID:19477419
    • D'Elia, M.A., Millar, K.E., Bhavsar, A.P., Tomljenovic, A.M., Hutter, B., Schaab, C., et al. 2009b. Probing teichoic acid genetics with bioactive molecules reveals new interactions among diverse processes in bacterial cell wall biogenesis. Chem. Biol. 16: 548-556. doi:10.1016/j.chembiol.2009.04.009. PMID:19477419.
    • (2009) Chem. Biol. , vol.16 , pp. 548-556
    • D'Elia, M.A.1    Millar, K.E.2    Bhavsar, A.P.3    Tomljenovic, A.M.4    Hutter, B.5    Schaab, C.6
  • 7
    • 84872712864 scopus 로고    scopus 로고
    • Multitarget ligands in antibacterial research: Progress and opportunities
    • doi:10.1517/ 17460441.2013.743991. PMID:23252414
    • East, S.P., and Silver, L.L. 2013. Multitarget ligands in antibacterial research: progress and opportunities. Expert Opin. Drug Discov. 8: 143-156. doi:10.1517/ 17460441.2013.743991. PMID:23252414.
    • (2013) Expert Opin. Drug Discov. , vol.8 , pp. 143-156
    • East, S.P.1    Silver, L.L.2
  • 8
    • 79956107885 scopus 로고    scopus 로고
    • Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy
    • doi:10.1038/nchembio. 559. PMID:21516114
    • Ejim, L., Farha, M.A., Falconer, S.B., Wildenhain, J., Coombes, B.K., Tyers, M., et al. 2011. Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. Nat. Chem. Biol. 7: 348-350. doi:10.1038/nchembio. 559. PMID:21516114.
    • (2011) Nat. Chem. Biol. , vol.7 , pp. 348-350
    • Ejim, L.1    Farha, M.A.2    Falconer, S.B.3    Wildenhain, J.4    Coombes, B.K.5    Tyers, M.6
  • 9
    • 77957817625 scopus 로고    scopus 로고
    • ECDC/EMEA Joint technical report
    • European Centre for Disease Prevention and Control, European Centre for Disease Prevention and Control, Stockholm, Sweden. Available from, [accessed 4 February 2013]
    • European Centre for Disease Prevention and Control. 2009. ECDC/EMEA Joint technical report. The bacterial challenge: time to react. A call to narrow the gap between mutidrug-resistant bacteria in the EU and the development of new antibacterial agents. European Centre for Disease Prevention and Control, Stockholm, Sweden. Available from http://www.ecdc.europa. eu/en/publications/Publications/0909_TER_The_Bacterial_Challenge_ Time_to_React.pdf [accessed 4 February 2013].
    • (2009) The bacterial challenge: Time to react. A call to narrow the gap between mutidrug-resistant bacteria in the EU and the development of new antibacterial agents
  • 10
    • 70349971143 scopus 로고    scopus 로고
    • New screens and targets in antibacterial drug discovery
    • doi:10.1016/j.mib.2009.07. 001. PMID:19651534
    • Falconer, S.B., and Brown, E.D. 2009. New screens and targets in antibacterial drug discovery. Curr. Opin. Microbiol. 12: 497-504. doi:10.1016/j.mib.2009.07. 001. PMID:19651534.
    • (2009) Curr. Opin. Microbiol. , vol.12 , pp. 497-504
    • Falconer, S.B.1    Brown, E.D.2
  • 11
    • 84872572985 scopus 로고    scopus 로고
    • Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to σ-lactams
    • doi:10.1021/ cb300413m. PMID:23062620
    • Farha, M.A., Leung, A., Sewell, E.W., D'Elia, M.A., Allison, S.E., Ejim, L., et al. 2013. Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to σ-lactams. ACS Chem. Biol. 8: 226-233. doi:10.1021/ cb300413m. PMID:23062620.
    • (2013) ACS Chem. Biol. , vol.8 , pp. 226-233
    • Farha, M.A.1    Leung, A.2    Sewell, E.W.3    D'Elia, M.A.4    Allison, S.E.5    Ejim, L.6
  • 12
    • 77956307436 scopus 로고    scopus 로고
    • The antibiotics market
    • doi:10.1038/nrd3267. PMID:20811374
    • Hamad, B. 2010. The antibiotics market. Nat. Rev. Drug Discov. 9: 675-676. doi:10.1038/nrd3267. PMID:20811374.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 675-676
    • Hamad, B.1
  • 13
    • 42349100173 scopus 로고    scopus 로고
    • The chemical genomic portrait of yeast: Uncovering a phenotype for all genes
    • doi:10.1126/science.1150021. PMID: 18420932
    • Hillenmeyer, M.E., Fung, E., Wildenhain, J., Pierce, S.E., Hoon, S., Lee, W., et al. 2008. The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science, 320(5874): 362-365. doi:10.1126/science.1150021. PMID: 18420932.
    • (2008) Science , vol.320 , Issue.5874 , pp. 362-365
    • Hillenmeyer, M.E.1    Fung, E.2    Wildenhain, J.3    Pierce, S.E.4    Hoon, S.5    Lee, W.6
  • 14
    • 0037050004 scopus 로고    scopus 로고
    • Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
    • doi:10.1038/415180a. PMID: 11805837
    • Ho, Y., Gruhler, A., Heilbut, A., Bader, G.D., Moore, L., Adams, S.-L., et al. 2002. Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature, 415: 180-183. doi:10.1038/415180a. PMID: 11805837.
    • (2002) Nature , vol.415 , pp. 180-183
    • Ho, Y.1    Gruhler, A.2    Heilbut, A.3    Bader, G.D.4    Moore, L.5    Adams, S.-L.6
  • 15
    • 77950255824 scopus 로고    scopus 로고
    • The 10 × '20 initiative': Pursuing a global commitment to develop 10 new antibacterial drugs by 2020
    • doi:10.1086/652237. PMID:20214473., Infectious Disease Society of America
    • Infectious Disease Society of America. 2010. The 10 × '20 initiative': pursuing a global commitment to develop 10 new antibacterial drugs by 2020. Clin. Infect. Dis. 50(8): 1081-1083. doi:10.1086/652237. PMID:20214473.
    • (2010) Clin. Infect. Dis. , vol.50 , Issue.8 , pp. 1081-1083
  • 16
    • 84866666082 scopus 로고    scopus 로고
    • White paper: Recommendations on the conduct of superiority and organism-specific clinical trials of antibacterial agents for the treatment of infections caused by drug-resistant bacterial pathogens
    • Infectious Disease Society of America, doi:10.1093/cid/cis688. PMID: 22891041
    • Infectious Disease Society of America. 2012. White paper: recommendations on the conduct of superiority and organism-specific clinical trials of antibacterial agents for the treatment of infections caused by drug-resistant bacterial pathogens. Clin. Infect. Dis. 55(8): 1031-1046. doi:10.1093/cid/cis688. PMID: 22891041.
    • (2012) Clin. Infect. Dis. , vol.55 , Issue.8 , pp. 1031-1046
  • 17
    • 84869438365 scopus 로고    scopus 로고
    • In vivo validation of thymidylate kinase (TMK) with a rationally designed, selective antibacterial compound
    • doi:10.1021/cb300316n. PMID:22908966
    • Keating, T.A., Newman, J.V., Olivier, N.B., Otterson, L.G., Andrews, B., Boriack-Sjodin, P.A., et al. 2012. In vivo validation of thymidylate kinase (TMK) with a rationally designed, selective antibacterial compound. ACS Chem. Biol. 7(11): 1866-1872. doi:10.1021/cb300316n. PMID:22908966.
    • (2012) ACS Chem. Biol. , vol.7 , Issue.11 , pp. 1866-1872
    • Keating, T.A.1    Newman, J.V.2    Olivier, N.B.3    Otterson, L.G.4    Andrews, B.5    Boriack-Sjodin, P.A.6
  • 18
    • 84862303965 scopus 로고    scopus 로고
    • Europe to boost development of new antimicrobial drugs
    • doi:10.1016/S0140-6736(12)60964-7. PMID:22715506
    • Kirby, T. 2012. Europe to boost development of new antimicrobial drugs. Lancet, 379: 2229-2230. doi:10.1016/S0140-6736(12)60964-7. PMID:22715506.
    • (2012) Lancet , vol.379 , pp. 2229-2230
    • Kirby, T.1
  • 19
    • 31044456290 scopus 로고    scopus 로고
    • Changes in the epidemiology of methicillin-resistant Staphylococcus aureus in intensive care units in US hospitals, 1992-2003
    • doi:10.1086/499367. PMID:16392087
    • Klevens, R.M., Edwards, J.R., Tenover, F.C., McDonald, L.C., Horan, T., and Gaynes, R. 2006. Changes in the epidemiology of methicillin-resistant Staphylococcus aureus in intensive care units in US hospitals, 1992-2003. Clin. Infect. Dis. 42: 389-391. doi:10.1086/499367. PMID:16392087.
    • (2006) Clin. Infect. Dis. , vol.42 , pp. 389-391
    • Klevens, R.M.1    Edwards, J.R.2    Tenover, F.C.3    McDonald, L.C.4    Horan, T.5    Gaynes, R.6
  • 20
    • 34248998479 scopus 로고    scopus 로고
    • Diarylquinolines target subunit c of mycobacterial ATP synthase
    • doi:10. 1038/nchembio884. PMID:17496888
    • Koul, A., Dendouga, N., Vergauwen, K., et al. 2007. Diarylquinolines target subunit c of mycobacterial ATP synthase. Nat. Chem. Biol. 3: 323-324. doi:10. 1038/nchembio884. PMID:17496888.
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 323-324
    • Koul, A.1    Dendouga, N.2    Vergauwen, K.3
  • 21
    • 77955917495 scopus 로고    scopus 로고
    • Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: A molecular, biological, and epidemiological study
    • doi:10. 1016/S1473-3099(10)70143-2. PMID:20705517
    • Kumarasamy, K.K., Toleman, M.A., Walsh, T.R., et al. 2010. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect. Dis. 10: 597-602. doi:10. 1016/S1473-3099(10)70143-2. PMID:20705517.
    • (2010) Lancet Infect. Dis. , vol.10 , pp. 597-602
    • Kumarasamy, K.K.1    Toleman, M.A.2    Walsh, T.R.3
  • 22
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • doi:10.1016/S0169-409X(96)00423-1. PMID:11259830
    • Lipinski, C.A., Lombardo, F., Dominy, B.W., and Feeney, P.J. 1997. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 23: 3-25. doi:10.1016/S0169-409X(96)00423-1. PMID:11259830.
    • (1997) Adv. Drug Deliv. Rev. , vol.23 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 23
    • 80051703609 scopus 로고    scopus 로고
    • Discovery research: The scientific challenge of finding new antibiotics
    • doi:10.1093/jac/dkr262. PMID:21700626
    • Livermore, D.M. 2011. Discovery research: the scientific challenge of finding new antibiotics. J. Antimicrob. Chemother. 66: 1941-1944. doi:10.1093/jac/dkr262. PMID:21700626.
    • (2011) J. Antimicrob. Chemother. , vol.66 , pp. 1941-1944
    • Livermore, D.M.1
  • 24
    • 9644295892 scopus 로고    scopus 로고
    • National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004
    • National Nosocomial Infections Surveillance, doi:10.1016/j.ajic.2004.10.001. PMID:15573054
    • National Nosocomial Infections Surveillance. 2004. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am. J. Infect. Control, 32(8): 470-485. doi:10.1016/j.ajic.2004.10.001. PMID:15573054.
    • (2004) Am. J. Infect. Control , vol.32 , Issue.8 , pp. 470-485
  • 25
    • 80053084113 scopus 로고    scopus 로고
    • Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors
    • doi:10.1073/pnas.1109208108. PMID:21876172
    • Parsons, J.B., Frank, M.W., Subramanian, C., Saenkham, P., and Rock, C.O. 2011. Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors. Proc. Natl. Acad. Sci. U.S.A. 108: 15378-15383. doi:10.1073/pnas.1109208108. PMID:21876172.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 15378-15383
    • Parsons, J.B.1    Frank, M.W.2    Subramanian, C.3    Saenkham, P.4    Rock, C.O.5
  • 26
    • 33845903833 scopus 로고    scopus 로고
    • Drugs for bad bugs: Confronting the challenges of antibacterial discovery
    • doi:10.1038/nrd2201. PMID:17159923
    • Payne, D.J., Gwynn, M.N., Holmes, D.J., and Pompliano, D.L. 2007. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 6: 29-40. doi:10.1038/nrd2201. PMID:17159923.
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 29-40
    • Payne, D.J.1    Gwynn, M.N.2    Holmes, D.J.3    Pompliano, D.L.4
  • 27
    • 84857195282 scopus 로고    scopus 로고
    • The crisis of no new antibiotics-What is the way forward?
    • doi:10.1016/S1473-3099(11)70316-4. PMID: 22101066
    • Piddock, L.J.V. 2012. The crisis of no new antibiotics-What is the way forward? Lancet Infect. Dis. 12: 249-253. doi:10.1016/S1473-3099(11)70316-4. PMID: 22101066.
    • (2012) Lancet Infect. Dis. , vol.12 , pp. 249-253
    • Piddock, L.J.V.1
  • 28
    • 0242291985 scopus 로고    scopus 로고
    • Why is big Pharma getting out of antibacterial drug discovery?
    • doi:10.1016/j.mib.2003.08.003. PMID: 14572532
    • Projan, S.J. 2003. Why is big Pharma getting out of antibacterial drug discovery? Curr. Opin. Microbiol. 6: 427-430. doi:10.1016/j.mib.2003.08.003. PMID: 14572532.
    • (2003) Curr. Opin. Microbiol. , vol.6 , pp. 427-430
    • Projan, S.J.1
  • 29
    • 78751477224 scopus 로고    scopus 로고
    • Challenges of antibacterial discovery
    • doi:10.1128/CMR.00030-10. PMID:21233508
    • Silver, L.L. 2011. Challenges of antibacterial discovery. Clin. Microbiol. Rev. 24: 71-109. doi:10.1128/CMR.00030-10. PMID:21233508.
    • (2011) Clin. Microbiol. Rev. , vol.24 , pp. 71-109
    • Silver, L.L.1
  • 31
    • 68649102987 scopus 로고    scopus 로고
    • The use of ribosomal crystal structures in antibiotic drug design
    • PMID:19649920
    • Wimberly, B.T. 2009. The use of ribosomal crystal structures in antibiotic drug design. Curr. Opin. Investig. Drugs, 10: 750-765. PMID:19649920.
    • (2009) Curr. Opin. Investig. Drugs , vol.10 , pp. 750-765
    • Wimberly, B.T.1
  • 32
    • 84875659385 scopus 로고    scopus 로고
    • Insight Report
    • World Economic Forum, 8th ed. World Economic Forum, Geneva, Switzerland. Available from, [accessed 4 February 2013]
    • World Economic Forum. 2013. Insight Report. Global Risks 2013. 8th ed. World Economic Forum, Geneva, Switzerland. Available from http://www3. weforum.org/docs/WEF_GlobalRisks_Report_2013.pdf [accessed 4 February 2013].
    • (2013) Global Risks 2013
  • 33
    • 79955006138 scopus 로고    scopus 로고
    • Molecular mechanisms of antibiotic resistance
    • doi:10.1039/c0cc05111j. PMID:21286630
    • Wright, G.D. 2011. Molecular mechanisms of antibiotic resistance. Chem. Commun. (Camb.), 47: 4055-4061. doi:10.1039/c0cc05111j. PMID:21286630.
    • (2011) Chem. Commun. (Camb.) , vol.47 , pp. 4055-4061
    • Wright, G.D.1
  • 34
    • 12144291286 scopus 로고    scopus 로고
    • A global approach to identify novel broad-spectrum antibacterial targets among proteins of unknown function
    • doi:10.1159/000076741. PMID:15044829
    • Zalacain, M., Biswas, S., Ingraham, K.A., Ambrad, J., Bryant, A., Chalker, A.F., et al. 2003. A global approach to identify novel broad-spectrum antibacterial targets among proteins of unknown function. J. Mol. Microbiol. Biotechnol. 6: 109-126. doi:10.1159/000076741. PMID:15044829.
    • (2003) J. Mol. Microbiol. Biotechnol. , vol.6 , pp. 109-126
    • Zalacain, M.1    Biswas, S.2    Ingraham, K.A.3    Ambrad, J.4    Bryant, A.5    Chalker, A.F.6
  • 35
    • 37549071045 scopus 로고    scopus 로고
    • Drug discovery beyond the 'rule-of-five'
    • doi:10.1016/j.copbio.2007.10.005. PMID: 18035532
    • Zhang, M.-Q., and Wilkinson, B. 2007. Drug discovery beyond the 'rule-of-five'. Curr. Opin. Biotechnol. 18: 478-488. doi:10.1016/j.copbio.2007.10.005. PMID: 18035532.
    • (2007) Curr. Opin. Biotechnol. , vol.18 , pp. 478-488
    • Zhang, M.-Q.1    Wilkinson, B.2


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