Stability of novel siderophore cephalosporin S-649266 against clinically relevant carbapenemases

Antimicrobial Agents and Chemotherapy

Volumn 60, Issue 7, 2016, Pages 4384-4386

  Ito Horiyama, Tsukasa ^a   Ishii, Yoshikazu ^b   Ito, Akinobu ^a   Sato, Takafumi ^a   Nakamura, Rio ^a   Fukuhara, Norio ^a   Tsuji, Masakatsu ^a   Yamano, Yoshinori ^a   Yamaguchi, Keizo ^b   Tateda, Kazuhiro ^b  

^a SHIONOGI AND CO LTD   (Japan)

^b TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEMASE; CEFEPIME; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE; MEROPENEM; NITROCEFIN; S 649266; SIDEROPHORE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; THIENAMYCIN DERIVATIVE;

ACINETOBACTER BAUMANNII; ANTIBACTERIAL ACTIVITY; ARTICLE; CARBAPENEMASE PRODUCING ENTEROBACTERIACEAE; CATALYTIC EFFICIENCY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG STABILITY; ESCHERICHIA COLI; HYDROLYSIS; KLEBSIELLA PNEUMONIAE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STENOTROPHOMONAS MALTOPHILIA; ANTAGONISTS AND INHIBITORS; CHEMISTRY;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CEPHALOSPORINS; DRUG STABILITY; SIDEROPHORES; THIENAMYCINS;

EID: 84977110010     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.03098-15     Document Type: Article

References (14)

1. Queenan AM, Bush K. 2007. Carbapenemases: the versatile β-lactamases. Clin Microbiol Rev 20:440-458. http://dx.doi.org/10.1128/CMR.00001-07.
2. Walsh TR. 2010. Emerging carbapenemases: a global perspective. Int J Antimicrob Agents 36(Suppl 3):S8-S14. http://dx.doi.org/10.1016/S0924-8579(10)70004-2.
3. Nordmann P. 2014. Carbapenemase-producing Enterobacteriaceae: overview of a major public health challenge. Med Mal Infect 44:51-56. http://dx.doi.org/10.1016/j.medmal.2013.11.007.
4. Tängdén T, Giske CG. 2015. Global dissemination of extensively drug-resistant carbapenemase-producing Enterobacteriaceae: clinical perspectives on detection, treatment and infection control. J Intern Med 277:501-512. http://dx.doi.org/10.1111/joim.12342.
5. Peleg AY, Seifert H, Paterson DL. 2008. Acinetobacter baumannii: emergence of a successful pathogen. Clin Microbiol Rev 21:538-582. http://dx.doi.org/10.1128/CMR.00058-07.
6. Evansa BA, Amyes SGB. 2014. OXA β-lactamases. Clin Microbiol Rev 27:241-263. http://dx.doi.org/10.1128/CMR.00117-13.
7. Ito A, Kohira N, Bouchillon SK, West J, Rittenhouse S, Sader HS, Rhomberg PR, Jones RN, Yoshizawa H, Nakamura R, Tsuji M, Yamano Y. 2016. In vitro antimicrobial activity of S-649266, a catechol substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria. J Antimicrob Chemother 71:670-677. http://dx.doi.org/10.1093/jac/dkv402.
8. Kohira N, West J, Ito A, Ito-Horiyama T, Nakamura R, Sato T, Rittenhouse S, Tsuji M, Yamano Y. 2015. In vitro antimicrobial activity of siderophore cephalosporin S-649266 against Enterobacteriaceae clinical isolates including carbapenem-resistant strains. Antimicrob Agents Chemother 60:729-734. http://dx.doi.org/10.1128/AAC.01695-15.
9. Nakamura R, Toba S, Tsuji M, Yamano Y, Shimada J. 2014. A novel siderophore cephalosporin: IV. In vivo efficacy in various murine infection models, abstr F-1558. 54th Intersci Conf Antimicrob Agents Chemother. ASM Press, Washington, DC.
10. Clinical and Laboratory Standards Institute. 2012. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically - 9th ed. CLSI M07-A9. Clinical and Laboratory Standards Institute, Wayne, PA.
11. Otto BR, Verweij-van Vught AM, MacLaren DM. 1992. Transferrins and heme-compounds as iron sources for pathogenic bacteria. Crit Rev Microbiol 18:217-233. http://dx.doi.org/10.3109/10408419209114559.
12. Docquier JD, Lamotte-Brasseur J, Galleni M, Amicosante G, Frère JM, Rossolini GM. 2003. On functional and structural heterogeneity of VIM-type metallo-β-lactamases. J Antimicrob Chemother 51:257-266. http://dx.doi.org/10.1093/jac/dkg067.
13. Bebrone C, Moali C, Mahy F, Rival S, Docquier JD, Rossolini GM, Fastrez J, Pratt RF, Frère JM, Galleni M. 2001. CENTA as a chromogenic substrate for studying β-lactamases. Antimicrob Agents Chemother 45: 1868-1871. http://dx.doi.org/10.1128/AAC.45.6.1868-1871.2001.
14. Ambler RP. 1980. The structure of β-lactamases. Philos Trans R Soc Lond B Biol Sci 289:321-331. http://dx.doi.org/10.1098/rstb.1980.0049.