Structure-based assessment of disease-related mutations in human voltage-gated sodium channels

Protein and Cell

Volumn 8, Issue 6, 2017, Pages 401-438

  Huang, Weiyun ^a   Liu, Minhao ^a   Yan, S Frank ^b   Yan, Nieng ^a  

^a Tsinghua University   (China)

^b Roche Innovation Center Shanghai   (China)

Author keywords

channelopathy; Nav channels; Nav1.7; pain; structure modeling

Indexed keywords

AMINO ACID; ISOLEUCINE; METHIONINE; NEUROTOXIN; PHENYLALANINE; POTASSIUM CHANNEL; THREONINE; VOLTAGE GATED SODIUM CHANNEL; CALCIUM CHANNEL L TYPE; SCN1A PROTEIN, HUMAN; SCN5A PROTEIN, HUMAN; SCN9A PROTEIN, HUMAN; SODIUM CHANNEL NAV1.1; SODIUM CHANNEL NAV1.5; SODIUM CHANNEL NAV1.7;

BRAIN DISEASE; CHANNELOPATHY; CRYOELECTRON MICROSCOPY; ELECTROPHYSIOLOGY; EPILEPSY; GENE MUTATION; HUMAN; MUSCLE; MYOPATHY; NERVE; NEUROMUSCULAR DISEASE; PAIN; PRIORITY JOURNAL; REVIEW; ANIMAL; CHEMISTRY; GENETICS; METABOLISM; MUTATION; PROTEIN DOMAIN; RABBITS AND HARES; STRUCTURE ACTIVITY RELATION;

ANIMALS; CALCIUM CHANNELS, L-TYPE; CHANNELOPATHIES; HUMANS; MUTATION; NAV1.1 VOLTAGE-GATED SODIUM CHANNEL; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; NAV1.7 VOLTAGE-GATED SODIUM CHANNEL; PROTEIN DOMAINS; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85011294805     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-017-0372-z     Document Type: Review

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