Small-fiber neuropathy Nav1.8 mutation shifts activation to hyperpolarized potentials and increases excitability of dorsal root ganglion neurons

Journal of Neuroscience

Volumn 33, Issue 35, 2013, Pages 14087-14097

  Huang, Jianying ^a,b   Yang, Yang ^a,b   Zhao, Peng ^a,b   Gerrits, Monique M ^c   Hoeijmakers, Janneke G J ^c   Bekelaar, Kim ^c   Merkies, Ingemar S J ^c,d   Faber, Catharina G ^c   Dib Hajj, Sulayman D ^a,b   Waxman, Stephen G ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^d Infection and Immunology   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ISOLEUCINE; LIDOCAINE ETHOBROMIDE; SODIUM CHANNEL NAV1.8;

ADULT; AMPLITUDE MODULATION; ANIMAL EXPERIMENT; ARTICLE; CASE REPORT; CONTROLLED STUDY; DEPOLARIZATION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; HYPERPOLARIZATION; MALE; MISSENSE MUTATION; MOUSE; NERVE CONDUCTION; NERVE EXCITABILITY; NERVE POTENTIAL; NONHUMAN; PATCH CLAMP; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SENSORY NERVE CELL; SEQUENCE ANALYSIS; SKIN BIOPSY; SMALL FIBER NEUROPATHY; SPINAL GANGLION;

ACTION POTENTIALS; AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; GANGLIA, SPINAL; HUMANS; ION CHANNEL GATING; MALE; MEMBRANE POTENTIALS; MICE; MICE, TRANSGENIC; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; NAV1.8 VOLTAGE-GATED SODIUM CHANNEL; NEURONS; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84882950464     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2710-13.2013     Document Type: Article

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