A sodium channel mutation linked to epilepsy increases ramp and persistent current of Nav1.3 and induces hyperexcitability in hippocampal neurons

Experimental Neurology

Volumn 224, Issue 2, 2010, Pages 362-368

  Estacion, Mark ^a   Gasser, Andreas ^a   Dib Hajj, Sulayman D ^a   Waxman, Stephen G ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

Current clamp; Epilepsy; Hippocampal neuron; Sodium channel; Voltage clamp

Indexed keywords

ISOPROTEIN; SODIUM CHANNEL NAV1.3;

ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DEPOLARIZATION; EPILEPSY; FUNCTIONAL ASSESSMENT; GENE MUTATION; HIPPOCAMPUS; MUTANT; NERVE EXCITABILITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SODIUM CURRENT;

ANIMALS; EPILEPSY; HIPPOCAMPUS; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS; TRANSFECTION;

EID: 77954658120     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2010.04.012     Document Type: Article

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