Architecture and pore block of eukaryotic voltage-gated sodium channels in view of NavAb bacterial sodium channel structure

Molecular Pharmacology

Volumn 82, Issue 1, 2012, Pages 97-104

  Tikhonov, Denis B ^a   Zhorov, Boris S ^a,b  

^a SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CARBOXYLIC ACID; TETRODOTOXIN; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL NAVAB;

ARTICLE; EUKARYOTE; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; CALCIUM CHANNELS; EUKARYOTA; ION CHANNEL GATING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SODIUM CHANNELS; TETRODOTOXIN;

EID: 84862561580     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.078212     Document Type: Article

References (46)

1. Ahern CA, Eastwood AL, Dougherty DA, and Horn R (2008) Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels. Circ Res 102:86-94.
2. Becker S, Prusak-Sochaczewski E, Zamponi G, Beck-Sickinger AG, Gordon RD, and French RJ (1992) Action of derivatives of mu-conotoxin GIIIA on sodium channels. Single amino acid substitutions in the toxin separately affect association and dissociation rates. Biochemistry 31:8229-8238.
3. Bruhova I, Tikhonov DB, and Zhorov BS (2008) Access and binding of local anesthetics in the closed sodium channel. Mol Pharmacol 74:1033-1045.
4. Capes DL, Arcisio-Miranda M, Jarecki BW, French RJ, and Chanda B (2012) Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor. Proc Natl Acad Sci USA 109:2648-2653.
5. Chahine M, Chen LQ, Barchi RL, Kallen RG, and Horn R (1992) Lidocaine block of human heart sodium channels expressed in Xenopus oocytes. J Mol Cell Cardiol 24:1231-1236. (Pubitemid 23016047)
6. Choudhary G, Aliste MP, Tieleman DP, French RJ, and Dudley SC Jr (2007) Docking of mu-conotoxin GIIIA in the sodium channel outer vestibule. Channels (Austin) 1:344-352.
7. Clayton GM, Altieri S, Heginbotham L, Unger VM, and Morais-Cabral JH (2008) Structure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channel. Proc Natl Acad Sci USA 105:1511-1515. (Pubitemid 351346545)
8. Dewar MJS, Zoebisch EG, Healy EF, and Stewart JJP (1985) Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular model. J Am Chem Soc 107:3902-3909.
9. + conduction and selectivity. Science 280:69-77.
10. 2+ channel with only one 6TM motif per subunit. Biochem Biophys Res Commun 281:741-746.
11. Fozzard HA and Lipkind GM (2010) The tetrodotoxin binding site is within the outer vestibule of the sodium channel. Mar Drugs 8:219-234.
12. Fozzard HA, Sheets MF, and Hanck DA (2011) The sodium channel as a target for local anesthetic drugs. Front Pharmacol 2:68.
13. Hille B (1977) Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol 69:497-515.
14. Kondratiev A and Tomaselli GF (2003) Altered gating and local anesthetic block mediated by residues in the I-S6 and II-S6 transmembrane segments of voltage-dependent Na+ channels. Mol Pharmacol 64:741-752. (Pubitemid 37048579)
15. Kuo A, Gulbis JM, Antcliff JF, Rahman T, Lowe ED, Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, and Doyle DA (2003) Crystal structure of the potassium channel KirBac1.1 in the closed state. Science 300:1922-1926. (Pubitemid 36734594)
16. Lazaridis T and Karplus M (1999) Effective energy function for proteins in solution. Proteins 35:133-152. (Pubitemid 29165128)
17. Lee PJ, Sunami A, and Fozzard HA (2001) Cardiac-specific external paths for lidocaine, defined by isoform-specific residues, accelerate recovery from use-dependent block. Circ Res 89:1014-1021. (Pubitemid 34640868)
18. +channels. PLoS Biol 7:e47.
19. Li HL, Galue A, Meadows L, and Ragsdale DS (1999) A molecular basis for the different local anesthetic affinities of resting versus open and inactivated states of the sodium channel. Mol Pharmacol 55:134-141. (Pubitemid 29042531)
20. Li Z and Scheraga HA (1987) Monte Carlo-minimization approach to the multiple-minima problem in protein folding. Proc Natl Acad Sci USA 84:6611-6615.
21. Lipkind GM and Fozzard HA (1994) A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel. Biophys J 66:1-13. (Pubitemid 24016478)
22. McArthur JR, Singh G, McMaster D, Winkfein R, Tieleman DP, and French RJ (2011a) Interactions of key charged residues contributing to selective block of neuronal sodium channels by μ-conotoxin KIIIA. Mol Pharmacol 80:573-584.
23. McArthur JR, Singh G, O'Mara ML, McMaster D, Ostroumov V, Tieleman DP, and French RJ (2011b) Orientation of μ-conotoxin PIIIA in a sodium channel vestibule, based on voltage dependence of its binding. Mol Pharmacol 80:219-227.
24. McArthur JR, Zhang MM, Azam L, Luo S, Olivera BM, Yoshikami D, Bulaj G, Levinson SR, and French RJ (2009) Molecular determinants of μ-conotoxin KIIIA block of voltage-gated sodium channels. Biophys J 96:248a.
25. +channels. J Membr Biol 201:1-8.
26. Payandeh J, Scheuer T, Zheng N, and Catterall WA (2011) The crystal structure of a voltage-gated sodium channel. Nature 475:353-358.
27. Qu Y, Rogers J, Tanada T, Scheuer T, and Catterall WA (1995) Molecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na+ channel. Proc Natl Acad Sci USA 92:11839-11843. (Pubitemid 26014205)
28. Ren D, Navarro B, Xu H, Yue L, Shi Q, and Clapham DE (2001) A prokaryotic voltage-gated sodium channel. Science 294:2372-2375. (Pubitemid 33140564)
29. Santarelli VP, Eastwood AL, Dougherty DA, Horn R, and Ahern CA (2007) A cation-pi interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block. J Biol Chem 282:8044-8051. (Pubitemid 47093591)
30. Shafrir Y, Durell SR, and Guy HR (2008) Models of the structure and gating mechanisms of the pore domain of the NaChBac ion channel. Biophys J 95:3650-3662.
31. Sobolevsky AI, Rosconi MP, and Gouaux E (2009) X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature 462:745-756.
32. Terlau H, Heinemann SH, Stühmer W, Pusch M, Conti F, Imoto K, and Numa S (1991) Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II. FEBS Lett 293:93-96.
33. Tikhonov DB, Bruhova I, and Zhorov BS (2006) Atomic determinants of state-dependent block of sodium channels by charged local anesthetics and benzocaine. FEBS Lett 580:6027-6032. (Pubitemid 44666813)
34. Tikhonov DB and Zhorov BS (2005) Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands. Biophys J 88:184-197. (Pubitemid 40070668)
35. Tikhonov DB and Zhorov BS (2007) Sodium channels: ionic model of slow inactivation and state-dependent drug binding. Biophys J 93:1557-1570. (Pubitemid 47403298)
36. Tikhonov DB and Zhorov BS (2011) Possible roles of exceptionally conserved residues around the selectivity filters of sodium and calcium channels. J Biol Chem 286:2998-3006.
37. Wang SY, Mitchell J, Tikhonov DB, Zhorov BS, and Wang GK (2006) How batrachotoxin modifies the sodium channel permeation pathway: computer modeling and site-directed mutagenesis. Mol Pharmacol 69:788-795. (Pubitemid 43363853)
38. Weiner SJ, Kollman PA, Case DA, Singh UC, Ghio C, Alagona G, Profeta S, and Weiner P (1984) A new force field for molecular mechanical simulation of nucleic acids and proteins. J Am Chem Soc 106:765-784.
39. Weiner SJ, Kollman PA, Nguyen DT, and Case DA (1986) An all atom force field for simulations of proteins and nucleic acids. J Comput Chem 7:230-252.
40. + channel agonists. Mol Pharmacol 64:235-248.
41. Yarov-Yarovoy V, Brown J, Sharp EM, Clare JJ, Scheuer T, and Catterall WA (2001) Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na+ channel α subunit. J Biol Chem 276:20-27. (Pubitemid 32050283)
42. + channel α subunit in voltage-dependent gating and drug block. J Biol Chem 277:35393-35401.
43. Yue L, Navarro B, Ren D, Ramos A, and Clapham DE (2002) The cation selectivity filter of the bacterial sodium channel, NaChBac. J Gen Physiol 120:845-853. (Pubitemid 35435016)
44. Zhang MM, McArthur JR, Azam L, Bulaj G, Olivera BM, French RJ, and Yoshikami D (2009) Synergistic and antagonistic interactions between tetrodotoxin and muconotoxin in blocking voltage-gated sodium channels. Channels (Austin) 3:32-38.
45. 2+ channel modulation by agonists and antagonists. Arch Biochem Biophys 393:22-41.
46. Zhorov BS and Tikhonov DB (2004) Potassium, sodium, calcium and glutamate-gated channels: pore architecture and ligand action. J Neurochem 88:782-799. (Pubitemid 38199299)